Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

Molecular Cell

Volumn 57, Issue 5, 2015, Pages 860-872

  Ichim, Gabriel ^a,b   Lopez, Jonathan ^a,b   Ahmed, Shafiq U ^b   Muthalagu, Nathiya ^a,b   Giampazolias, Evangelos ^a,b   Delgado, M Eugenia ^c   Haller, Martina ^a,b   Riley, Joel S ^a,b   Mason, Susan M ^a   Athineos, Dimitris ^a   Parsons, Melissa J ^d,e   vandeKooij, Bert ^f   Bouchier Hayes, Lisa ^d,e   Chalmers, Anthony J ^b   Rooswinkel, Rogier W ^f   Oberst, Andrew ^g   Blyth, Karen ^a   Rehm, Markus ^c   Murphy, Daniel J ^a,b   Tait, Stephen W G ^a,b  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^d CENTER FOR CELL AND GENE THERAPY   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f NETHERLANDS CANCER INSTITUTE   (Netherlands)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; STRESS ACTIVATED PROTEIN KINASE; ABT-737; BIPHENYL DERIVATIVE; CASPASE; CDKN2D PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 2D; H2AFX PROTEIN, HUMAN; HISTONE; NITROPHENOL; PIPERAZINE DERIVATIVE; PROTEIN BCL 2; STAUROSPORINE; SULFONAMIDE;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DEATH; CELL PERMEABILIZATION; CELL STRESS; CELL TRANSFORMATION; DNA DAMAGE; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION; MITOCHONDRION; OUTER MEMBRANE; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CONFOCAL MICROSCOPY; CYTOLOGY; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; FIBROBLAST; GENETICS; HCT116 CELL LINE; HELA CELL LINE; KNOCKOUT MOUSE; MCF 7 CELL LINE; METABOLISM; MITOCHONDRIAL MEMBRANE; PERMEABILITY; PHYSIOLOGY; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P19; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; FIBROBLASTS; GENOMIC INSTABILITY; HCT116 CELLS; HELA CELLS; HISTONES; HUMANS; MCF-7 CELLS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MITOCHONDRIAL MEMBRANES; NITROPHENOLS; PERMEABILITY; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; STAUROSPORINE; SULFONAMIDES; TIME FACTORS;

EID: 84924030504     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.01.018     Document Type: Article

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