Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration

Nature Genetics

Volumn 44, Issue 4, 2012, Pages 390-397

  Chiang, Colby ^a   Jacobsen, Jessie C ^a,b   Ernst, Carl ^a,b,j   Hanscom, Carrie ^a   Heilbut, Adrian ^a   Blumenthal, Ian ^a   Mills, Ryan E ^c   Kirby, Andrew ^a,d   Lindgren, Amelia M ^c   Rudiger, Skye R ^e   McLaughlan, Clive J ^e   Bawden, C Simon ^e   Reid, Suzanne J ^f,g   Faull, Richard L M ^f   Snell, Russell G ^f,g   Hall, Ira M ^h   Shen, Yiping ^a,i   Ohsumi, Toshiro K ^a   Borowsky, Mark L ^a   Daly, Mark J ^a,d   Lee, Charles ^c   Morton, Cynthia C ^c,d   MacDonald, Marcy E ^a,b,d   Gusella, James F ^a,b,d   Talkowski, Michael E ^a,b,d   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e SOUTH AUSTRALIAN RESEARCH AND DEVELOPMENT INSTITUTE   (Australia)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

^g UNIVERSITY OF AUCKLAND   (New Zealand)

^h UNIVERSITY OF VIRGINIA   (United States)

ⁱ BOSTON CHILDREN S HOSPITAL   (United States)

^j MCGILL UNIVERSITY   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; COPY NUMBER VARIATION; DNA END JOINING REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; DOUBLE STRANDED DNA BREAK; GENE DELETION; GENE SWITCHING; GENOME; GERM LINE; HIGH THROUGHPUT SEQUENCING; HOMOLOGOUS RECOMBINATION; HUMAN; KARYOTYPING; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHROMOSOME BREAKAGE; CHROMOSOME INVERSION; DNA END-JOINING REPAIR; GENE REARRANGEMENT; GERM-LINE MUTATION; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC;

ANIMALIA;

EID: 84862777955     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2202     Document Type: Article

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