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Volumn 25, Issue 1, 2016, Pages 65-76

Molecular targets of luteolin in cancer

Author keywords

cell cycle arrest; DNA methylation; Histone modification; PI3K Akt TOR pathway; Wnt catenin signaling

Indexed keywords

BETA CATENIN; BETA1 INTEGRIN; CISPLATIN; DNA TOPOISOMERASE; FOCAL ADHESION KINASE; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K RAS PROTEIN; LUTEOLIN; MAMMALIAN TARGET OF RAPAMYCIN; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UVOMORULIN; WNT PROTEIN;

EID: 84948661517     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0000000000000128     Document Type: Article
Times cited : (140)

References (126)
  • 1
    • 84924972374 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling pathway inhibitors: A promising cancer therapy
    • Abdel-Magid AF (2014). Wnt/beta-catenin signaling pathway inhibitors: a promising cancer therapy. ACS Med Chem Lett 5:956-957.
    • (2014) ACS Med Chem Lett , vol.5 , pp. 956-957
    • Abdel-Magid, A.F.1
  • 2
    • 77955736995 scopus 로고    scopus 로고
    • Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells
    • Aleksic T, Chitnis MM, Perestenko OV, Gao S, Thomas PH, Turner GD, et al. (2010). Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res 70:6412-6419.
    • (2011) Cancer Res , vol.70 , pp. 6412-6419
    • Aleksic, T.1    Chitnis, M.M.2    Perestenko, O.V.3    Gao, S.4    Thomas, P.H.5    Turner, G.D.6
  • 3
    • 78049398239 scopus 로고    scopus 로고
    • Enhanced anti-tumor activity by the combination of the natural compounds (? )-epigallocatechin-3-gallate and luteolin: Potential role of 53
    • Amin AR, Wang D, Zhang H, Peng S, Shin HJ, Brandes JC, et al. (2010). Enhanced anti-tumor activity by the combination of the natural compounds (? )-epigallocatechin-3-gallate and luteolin: potential role of 53. J Biol Chem 285:34557-34565.
    • (2011) J Biol Chem , vol.285 , pp. 34557-34565
    • Amin, A.R.1    Wang, D.2    Zhang, H.3    Peng, S.4    Shin, H.J.5    Brandes, J.C.6
  • 4
    • 78650676828 scopus 로고    scopus 로고
    • Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells
    • Attoub S, Hassan AH, Vanhoecke B, Iratni R, Takahashi T, Gaben AM, et al. (2011). Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells. Eur J Pharmacol 651:18-25.
    • (2011) Eur J Pharmacol , vol.651 , pp. 18-25
    • Attoub, S.1    Hassan, A.H.2    Vanhoecke, B.3    Iratni, R.4    Takahashi, T.5    Gaben, A.M.6
  • 5
    • 58649121962 scopus 로고    scopus 로고
    • Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death
    • Beck R, Verrax J, Gonze T, Zappone M, Pedrosa RC, Taper H, et al. (2009). Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death. Biochem Pharmacol 77:375-383.
    • (2009) Biochem Pharmacol , vol.77 , pp. 375-383
    • Beck, R.1    Verrax, J.2    Gonze, T.3    Zappone, M.4    Pedrosa, R.C.5    Taper, H.6
  • 6
    • 0031060572 scopus 로고    scopus 로고
    • Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact
    • Borchers AH, Sanders LA, Bowden GT (1997). Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact. J Cancer Res Clin Oncol 123:13-20.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 13-20
    • Borchers, A.H.1    Sanders, L.A.2    Bowden, G.T.3
  • 7
    • 84860408601 scopus 로고    scopus 로고
    • Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells
    • Cai X, Ye T, Liu C, Lu W, Lu M, Zhang J, et al. (2011). Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicol In Vitro 25:1385-1391.
    • (2011) Toxicol in Vitro , vol.25 , pp. 1385-1391
    • Cai, X.1    Ye, T.2    Liu, C.3    Lu, W.4    Lu, M.5    Zhang, J.6
  • 8
    • 84866462314 scopus 로고    scopus 로고
    • The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells
    • Cai X, Lu W, Ye T, Lu M, Wang J, Huo J, et al. (2012). The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells. Oncol Rep 28:1353-1361.
    • (2012) Oncol Rep , vol.28 , pp. 1353-1361
    • Cai, X.1    Lu, W.2    Ye, T.3    Lu, M.4    Wang, J.5    Huo, J.6
  • 9
    • 84887897466 scopus 로고    scopus 로고
    • Eliminative signaling by Janus kinases: Role in the downregulation of associated receptors
    • Carbone CJ, Fuchs SY (2014). Eliminative signaling by Janus kinases: role in the downregulation of associated receptors. J Cell Biochem 115:8-16.
    • (2014) J Cell Biochem , vol.115 , pp. 8-16
    • Carbone, C.J.1    Fuchs, S.Y.2
  • 10
    • 13444282282 scopus 로고    scopus 로고
    • Increase of Bax/Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line
    • Chang J, Hsu Y, Kuo P, Kuo Y, Chiang L, Lin C (2005). Increase of Bax/Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line. Life Sci 76:1883-1893.
    • (2005) Life Sci , vol.76 , pp. 1883-1893
    • Chang, J.1    Hsu, Y.2    Kuo, P.3    Kuo, Y.4    Chiang, L.5    Lin, C.6
  • 11
    • 84883275639 scopus 로고    scopus 로고
    • Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity
    • Cheng WY, Chiao MT, Liang YJ, Yang YC, Shen CC, Yang CY (2013). Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity. Mol Biol Rep 40:5315-5326.
    • (2013) Mol Biol Rep , vol.40 , pp. 5315-5326
    • Cheng, W.Y.1    Chiao, M.T.2    Liang, Y.J.3    Yang, Y.C.4    Shen, C.C.5    Yang, C.Y.6
  • 12
    • 84897528102 scopus 로고    scopus 로고
    • Targeting FASN in breast cancer and the discovery of promising inhibitors from natural products derived from traditional Chinese medicine
    • Cheng CS, Wang Z, Chen J (2014). Targeting FASN in breast cancer and the discovery of promising inhibitors from natural products derived from traditional chinese medicine. Evid Based Complement Alternat Med 2014:232946.
    • (2014) Evid Based Complement Alternat Med , pp. 232946
    • Cheng, C.S.1    Wang, Z.2    Chen, J.3
  • 13
    • 77955801632 scopus 로고    scopus 로고
    • E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation
    • Chen T, Yuan D, Wei B, Jiang J, Kang J, Ling K, et al. (2010). E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells 28:1315-1325.
    • (2011) Stem Cells , vol.28 , pp. 1315-1325
    • Chen, T.1    Yuan, D.2    Wei, B.3    Jiang, J.4    Kang, J.5    Ling, K.6
  • 14
    • 84860665044 scopus 로고    scopus 로고
    • Luteolin induces mitochondria-dependent apoptosis in human lung adenocarcinoma cell
    • Chen Q, Liu S, Chen J, Zhang Q, Lin S, Chen Z, Jiang J (2012a). Luteolin induces mitochondria-dependent apoptosis in human lung adenocarcinoma cell. Nat Prod Commun 7:29-32.
    • (2012) Nat Prod Commun , vol.7 , pp. 29-32
    • Chen, Q.1    Liu, S.2    Chen, J.3    Zhang, Q.4    Lin, S.5    Chen, Z.6    Jiang, J.7
  • 15
    • 84870773213 scopus 로고    scopus 로고
    • Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats
    • Chen Z, Kong S, Song F, Li L, Jiang H (2012b). Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats. Fitoterapia 83:1616-1622.
    • (2012) Fitoterapia , vol.83 , pp. 1616-1622
    • Chen, Z.1    Kong, S.2    Song, F.3    Li, L.4    Jiang, H.5
  • 16
    • 84888294009 scopus 로고    scopus 로고
    • Luteolin attenuates TGF-beta1-induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-kappaB-Snail pathway
    • Chen KC, Chen CY, Lin CJ, Yang TY, Chen TH, Wu LC, Wu CC (2013). Luteolin attenuates TGF-beta1-induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-kappaB-Snail pathway. Life Sci 93:924-933.
    • (2013) Life Sci , vol.93 , pp. 924-933
    • Chen, K.C.1    Chen, C.Y.2    Lin, C.J.3    Yang, T.Y.4    Chen, T.H.5    Wu, L.C.6    Wu, C.C.7
  • 17
    • 84896895098 scopus 로고    scopus 로고
    • Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells
    • Chen R, Hollborn M, Grosche A, Reichenbach A, Wiedemann P, Bringmann A, Kohen L (2014). Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. Mol Vis 20: , 242-258.
    • (2014) Mol Vis , vol.20 , pp. 242-258
    • Chen, R.1    Hollborn, M.2    Grosche, A.3    Reichenbach, A.4    Wiedemann, P.5    Bringmann, A.6    Kohen, L.7
  • 18
    • 84899858360 scopus 로고    scopus 로고
    • Luteolin sensitizes two oxaliplatinresistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway
    • Chian S, Li YY, Wang XJ, Tang XW (2014a). Luteolin sensitizes two oxaliplatinresistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway. Asian Pac J Cancer Prev 15:2911-2916.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 2911-2916
    • Chian, S.1    Li, Y.Y.2    Wang, X.J.3    Tang, X.W.4
  • 19
    • 84900299717 scopus 로고    scopus 로고
    • Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo
    • Chian S, Thapa R, Chi Z, Wang XJ, Tang X (2014b). Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo. Biochem Biophys Res Commun 447:602-608.
    • (2014) Biochem Biophys Res Commun , vol.447 , pp. 602-608
    • Chian, S.1    Thapa, R.2    Chi, Z.3    Wang, X.J.4    Tang, X.5
  • 20
    • 34447338028 scopus 로고    scopus 로고
    • Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin
    • Chiang CT, Way TD, Lin JK (2007). Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin. Mol Cancer Ther 6:2127-2138.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2127-2138
    • Chiang, C.T.1    Way, T.D.2    Lin, J.K.3
  • 21
    • 84874658824 scopus 로고    scopus 로고
    • Flavonoids as receptor tyrosine kinase FLT3 inhibitors
    • Chin YW, Kong JY, Han SY (2013). Flavonoids as receptor tyrosine kinase FLT3 inhibitors. Bioorg Med Chem Lett 23:1768-1770.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 1768-1770
    • Chin, Y.W.1    Kong, J.Y.2    Han, S.Y.3
  • 23
    • 37449003469 scopus 로고    scopus 로고
    • Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts
    • Chiu FL, Lin JK (2008). Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts. Prostate 68:61-71.
    • (2008) Prostate , vol.68 , pp. 61-71
    • Chiu, F.L.1    Lin, J.K.2
  • 25
    • 58149492131 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation
    • Coleman DT, Bigelow R, Cardelli JA (2009). Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation. Mol Cancer Ther 8:214-224.
    • (2009) Mol Cancer Ther , vol.8 , pp. 214-224
    • Coleman, D.T.1    Bigelow, R.2    Cardelli, J.A.3
  • 26
    • 84903289338 scopus 로고    scopus 로고
    • Modelling the effect of phase II conjugations on topoisomerase i poisoning: Pilot study with luteolin and quercetin
    • Dellafiora L, Mena P, Del Rio D, Cozzini P (2014). Modelling the effect of phase II conjugations on topoisomerase I poisoning: pilot study with luteolin and quercetin. J Agric Food Chem 62:5881-5886.
    • (2014) J Agric Food Chem , vol.62 , pp. 5881-5886
    • Dellafiora, L.1    Mena, P.2    Del Rio, D.3    Cozzini, P.4
  • 27
    • 1542645680 scopus 로고    scopus 로고
    • Oncoprotein expression of E6 and E7 does not prevent 5-fluorouracil (5FU) mediated G1/S arrest and apoptosis in 5FU resistant carcinoma cell lines
    • Didelot C, Mirjolet JF, Barberi-Heyob M, Ramacci C, Teiten MH, Merlin JL (2003). Oncoprotein expression of E6 and E7 does not prevent 5-fluorouracil (5FU) mediated G1/S arrest and apoptosis in 5FU resistant carcinoma cell lines. Int J Oncol 23:81-87.
    • (2003) Int J Oncol , vol.23 , pp. 81-87
    • Didelot, C.1    Mirjolet, J.F.2    Barberi-Heyob, M.3    Ramacci, C.4    Teiten, M.H.5    Merlin, J.L.6
  • 28
    • 84898829049 scopus 로고    scopus 로고
    • Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest
    • Ding S, Hu A, Hu Y, Ma J, Weng P, Dai J (2014). Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest. Tumour Biol 35:3053-3060.
    • (2014) Tumour Biol , vol.35 , pp. 3053-3060
    • Ding, S.1    Hu, A.2    Hu, Y.3    Ma, J.4    Weng, P.5    Dai, J.6
  • 29
    • 84919443184 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates sequential fate decisions of murine cortical precursor cells
    • Draganova K, Zemke M, Zurkirchen L, Valenta T, Cantu C, Okoniewski M, et al. (2015). Wnt/beta-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells 33:170-182.
    • (2015) Stem Cells , vol.33 , pp. 170-182
    • Draganova, K.1    Zemke, M.2    Zurkirchen, L.3    Valenta, T.4    Cantu, C.5    Okoniewski, M.6
  • 31
    • 84880934991 scopus 로고    scopus 로고
    • Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
    • Erez N, Glanz S, Raz Y, Avivi C, Barshack I (2013). Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem Biophys Res Commun 437:397-402.
    • (2013) Biochem Biophys Res Commun , vol.437 , pp. 397-402
    • Erez, N.1    Glanz, S.2    Raz, Y.3    Avivi, C.4    Barshack, I.5
  • 32
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E (2006). Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 5:671-688.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 33
    • 34047110804 scopus 로고    scopus 로고
    • Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    • Fang J, Zhou Q, Shi XL, Jiang BH (2007). Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Carcinogenesis 28:713-723.
    • (2007) Carcinogenesis , vol.28 , pp. 713-723
    • Fang, J.1    Zhou, Q.2    Shi, X.L.3    Jiang, B.H.4
  • 34
    • 84900412412 scopus 로고    scopus 로고
    • DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes
    • Farkas SA, Vymetalkova V, Vodickova L, Vodicka P, Nilsson TK (2014). DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes. Epigenomics 6:179-191.
    • (2014) Epigenomics , vol.6 , pp. 179-191
    • Farkas, S.A.1    Vymetalkova, V.2    Vodickova, L.3    Vodicka, P.4    Nilsson, T.K.5
  • 35
    • 84869003163 scopus 로고    scopus 로고
    • Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3
    • Fu J, Chen D, Zhao B, Zhao Z, Zhou J, Xu Y, et al. (2012). Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. PLoS One 7:e49194.
    • (2012) PLoS One , vol.7 , pp. e49194
    • Fu, J.1    Chen, D.2    Zhao, B.3    Zhao, Z.4    Zhou, J.5    Xu, Y.6
  • 36
    • 79952092841 scopus 로고    scopus 로고
    • Hypomethylating agents and other novel strategies in myelodysplastic syndromes
    • Garcia-Manero G, Fenaux P (2011). Hypomethylating agents and other novel strategies in myelodysplastic syndromes. J Clin Oncol 29:516-523.
    • (2011) J Clin Oncol , vol.29 , pp. 516-523
    • Garcia-Manero, G.1    Fenaux, P.2
  • 37
    • 84903882101 scopus 로고    scopus 로고
    • An autophagic switch in the response of tumor cells to radiation and chemotherapy
    • Gewirtz DA (2014). An autophagic switch in the response of tumor cells to radiation and chemotherapy. Biochem Pharmacol 90:208-211.
    • (2014) Biochem Pharmacol , vol.90 , pp. 208-211
    • Gewirtz, D.A.1
  • 38
    • 84902097343 scopus 로고    scopus 로고
    • HGF/MET-directed therapeutics in gastroesophageal cancer: A review of clinical and biomarker development
    • Hack SP, Bruey JM, Koeppen H (2014). HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development. Oncotarget 5:2866-2880.
    • (2014) Oncotarget , vol.5 , pp. 2866-2880
    • Hack, S.P.1    Bruey, J.M.2    Koeppen, H.3
  • 39
    • 84902195731 scopus 로고    scopus 로고
    • Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells
    • Ham S, Kim KH, Kwon TH, Bak Y, Lee DH, Song YS, et al. (2014). Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells. Oncol Rep 31:2683-2691.
    • (2014) Oncol Rep , vol.31 , pp. 2683-2691
    • Ham, S.1    Kim, K.H.2    Kwon, T.H.3    Bak, Y.4    Lee, D.H.5    Song, Y.S.6
  • 40
    • 84902254860 scopus 로고    scopus 로고
    • Prognostic impact of fatty acid synthase expression in upper urinary tract urothelial carcinoma
    • Hamada S, Horiguchi A, Asano T, Kuroda K, Asakuma J, Ito K, et al. (2014). Prognostic impact of fatty acid synthase expression in upper urinary tract urothelial carcinoma. Jpn J Clin Oncol 44:486-492.
    • (2014) Jpn J Clin Oncol , vol.44 , pp. 486-492
    • Hamada, S.1    Horiguchi, A.2    Asano, T.3    Kuroda, K.4    Asakuma, J.5    Ito, K.6
  • 41
    • 0041822702 scopus 로고    scopus 로고
    • Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats
    • Hempel J, Pforte H, Raab B, Engst W, Böhm H, Jacobasch G (1999). Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats. Nahrung 43:201-204.
    • (1999) Nahrung , vol.43 , pp. 201-204
    • Hempel, J.1    Pforte, H.2    Raab, B.3    Engst, W.4    Böhm, H.5    Jacobasch, G.6
  • 43
    • 84864458147 scopus 로고    scopus 로고
    • Mechanism of growth inhibition effect of 3 , 4?, 5, 7-tetrahydroxyflavone on A549 cells
    • Hu C, Cai X, Hu T, Lu W, Cao P (2012). Mechanism of growth inhibition effect of 3?, 4?, 5, 7-tetrahydroxyflavone on A549 cells. Zhongguo Zhong Yao Za Zhi 37:1259-1264.
    • (2012) Zhongguo Zhong Yao Za Zhi , vol.37 , pp. 1259-1264
    • Hu, C.1    Cai, X.2    Hu, T.3    Lu, W.4    Cao, P.5
  • 44
    • 79955838953 scopus 로고    scopus 로고
    • Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-kappaB modulation in HepG2 hepatocarcinoma cells
    • Hwang JT, Park OJ, Lee YK, Sung MJ, Hur HJ, Kim MS, et al. (2011). Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-kappaB modulation in HepG2 hepatocarcinoma cells. Int J Mol Med 28:25-31.
    • (2011) Int J Mol Med , vol.28 , pp. 25-31
    • Hwang, J.T.1    Park, O.J.2    Lee, Y.K.3    Sung, M.J.4    Hur, H.J.5    Kim, M.S.6
  • 45
    • 84903287116 scopus 로고    scopus 로고
    • Antiinflammatory and antipruritic effects of luteolin from Perilla (P frutescens L) leaves
    • Jeon IH, Kim HS, Kang HJ, Lee HS, Jeong SI, Kim SJ, Jang SI (2014). Antiinflammatory and antipruritic effects of luteolin from Perilla (P. frutescens L.) leaves. Molecules 19:6941-6951.
    • (2014) Molecules , vol.19 , pp. 6941-6951
    • Jeon, I.H.1    Kim, H.S.2    Kang, H.J.3    Lee, H.S.4    Jeong, S.I.5    Kim, S.J.6    Jang, S.I.7
  • 46
    • 84921322637 scopus 로고    scopus 로고
    • Inhibitory effect of luteolin on the angiogenesis of chick chorioallantoic membrane and invasion of breast cancer cells via downregulation of AEG-1 and MMP-2
    • Jiang Y, Xie KP, Huo HN, Wang LM, Zou W, Xie MJ (2013). Inhibitory effect of luteolin on the angiogenesis of chick chorioallantoic membrane and invasion of breast cancer cells via downregulation of AEG-1 and MMP-2. Sheng Li Xue Bao 65:513-518.
    • (2013) Sheng Li Xue Bao , vol.65 , pp. 513-518
    • Jiang, Y.1    Xie, K.P.2    Huo, H.N.3    Wang, L.M.4    Zou, W.5    Xie, M.J.6
  • 47
    • 84881525360 scopus 로고    scopus 로고
    • Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate antiproliferative effect on human pancreatic cancer cells, in vitro
    • Johnson JL, Gonzalez de Mejia E (2013). Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate antiproliferative effect on human pancreatic cancer cells, in vitro. Food Chem Toxicol 60: , 83-91.
    • (2013) Food Chem Toxicol , vol.60 , pp. 83-91
    • Johnson, J.L.1    Gonzalez De Mejia, E.2
  • 48
    • 34247512973 scopus 로고    scopus 로고
    • A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factoractivated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells
    • Ju W, Wang X, Shi H, Chen W, Belinsky SA, Lin Y (2007). A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factoractivated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol 71:1381-1388.
    • (2007) Mol Pharmacol , vol.71 , pp. 1381-1388
    • Ju, W.1    Wang, X.2    Shi, H.3    Chen, W.4    Belinsky, S.A.5    Lin, Y.6
  • 49
    • 84893858504 scopus 로고    scopus 로고
    • Positive feedback between NF-kappaB and TNF-alpha promotes leukemiainitiating cell capacity
    • Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S, et al. (2014). Positive feedback between NF-kappaB and TNF-alpha promotes leukemiainitiating cell capacity. J Clin Invest 124:528-542.
    • (2014) J Clin Invest , vol.124 , pp. 528-542
    • Kagoya, Y.1    Yoshimi, A.2    Kataoka, K.3    Nakagawa, M.4    Kumano, K.5    Arai, S.6
  • 50
    • 79952154960 scopus 로고    scopus 로고
    • Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis
    • Kang KP, Park SK, Kim DH, Sung MJ, Jung YJ, Lee AS, et al. (2011). Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrol Dial Transplant 26:814-822.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 814-822
    • Kang, K.P.1    Park, S.K.2    Kim, D.H.3    Sung, M.J.4    Jung, Y.J.5    Lee, A.S.6
  • 51
    • 14844293962 scopus 로고    scopus 로고
    • The role of insulin and IGF-1 signaling in longevity
    • Katic M, Kahn CR (2005). The role of insulin and IGF-1 signaling in longevity. Cell Mol Life Sci 62:320-343.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 320-343
    • Katic, M.1    Kahn, C.R.2
  • 52
    • 84897628397 scopus 로고    scopus 로고
    • Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: A mechanism for cancer chemopreventive action
    • Khan HY, Zubair H, Faisal M, Ullah MF, Farhan M, Sarkar FH, et al. (2014). Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action. Mol Nutr Food Res 58:437-446.
    • (2014) Mol Nutr Food Res , vol.58 , pp. 437-446
    • Khan, H.Y.1    Zubair, H.2    Faisal, M.3    Ullah, M.F.4    Farhan, M.5    Sarkar, F.H.6
  • 53
    • 84885652402 scopus 로고    scopus 로고
    • Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin
    • Kim HY, Jung SK, Byun S, Son JE, Oh MH, Lee J, et al. (2013). Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin. Phytother Res 27:1481-1488.
    • (2013) Phytother Res , vol.27 , pp. 1481-1488
    • Kim, H.Y.1    Jung, S.K.2    Byun, S.3    Son, J.E.4    Oh, M.H.5    Lee, J.6
  • 54
    • 0037039712 scopus 로고    scopus 로고
    • Effect of flavonoids on cell cycle progression in prostate cancer cells
    • Kobayashi T, Nakata T, Kuzumaki T (2002). Effect of flavonoids on cell cycle progression in prostate cancer cells. Cancer Lett 176:17-23.
    • (2002) Cancer Lett , vol.176 , pp. 17-23
    • Kobayashi, T.1    Nakata, T.2    Kuzumaki, T.3
  • 55
    • 84877862860 scopus 로고    scopus 로고
    • Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation
    • Krifa M, Alhosin M, Muller CD, Gies JP, Chekir-Ghedira L, Ghedira K, et al. (2013). Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation. J Exp Clin Cancer Res 32: , 30.
    • (2013) J Exp Clin Cancer Res , vol.32 , pp. 30
    • Krifa, M.1    Alhosin, M.2    Muller, C.D.3    Gies, J.P.4    Chekir-Ghedira, L.5    Ghedira, K.6
  • 56
    • 0036669812 scopus 로고    scopus 로고
    • Cancer preventive effects of flavonoids -A review
    • Le Marchand L (2002). Cancer preventive effects of flavonoids -a review. Biomed Pharmacother 56:296-301.
    • (2002) Biomed Pharmacother , vol.56 , pp. 296-301
    • Le Marchand, L.1
  • 57
    • 33644764655 scopus 로고    scopus 로고
    • Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways
    • LeeWJ, Wu LF, Chen WK, Wang CJ, Tseng TH (2006). Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chem Biol Interact 160:123-133.
    • (2006) Chem Biol Interact , vol.160 , pp. 123-133
    • Leewj Wu, L.F.1    Chen, W.K.2    Wang, C.J.3    Tseng, T.H.4
  • 58
    • 84866267838 scopus 로고    scopus 로고
    • Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells
    • Lee EJ, Oh SY, Sung MK (2012). Luteolin exerts anti-tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells. Food Chem Toxicol 50: 4136-4143.
    • (2012) Food Chem Toxicol , vol.50 , pp. 4136-4143
    • Lee, E.J.1    Oh, S.Y.2    Sung, M.K.3
  • 59
    • 84905392051 scopus 로고    scopus 로고
    • Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia
    • Lee YH, Morrison BL, Bottaro DP (2014). Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia. J Biol Chem 289:20448-20461.
    • (2014) J Biol Chem , vol.289 , pp. 20448-20461
    • Lee, Y.H.1    Morrison, B.L.2    Bottaro, D.P.3
  • 60
    • 84878364013 scopus 로고    scopus 로고
    • Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90 RSK2
    • Lim SH, Jung SK, Byun S, Lee EJ, Hwang JA, Seo SG, et al. (2013). Luteolin suppresses UVB-induced photoageing by targeting JNK1 and p90 RSK2. J Cell Mol Med 17:672-680.
    • (2013) J Cell Mol Med , vol.17 , pp. 672-680
    • Lim, S.H.1    Jung, S.K.2    Byun, S.3    Lee, E.J.4    Hwang, J.A.5    Seo, S.G.6
  • 61
    • 33846179993 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin
    • Lim do Y, Jeong Y, Tyner AL, Park JH (2007). Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. Am J Physiol Gastrointest Liver Physiol 292:G66-G75.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G66-G75
  • 62
    • 84862826072 scopus 로고    scopus 로고
    • Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells
    • Lim do Y, Cho HJ, Kim J, Nho CW, Lee KW, Park JH (2012). Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterol 12:9.
    • (2012) BMC Gastroenterol , vol.12 , pp. 9
  • 63
    • 3042836363 scopus 로고    scopus 로고
    • Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids
    • Limtrakul P, Anuchapreeda S, Buddhasukh D (2004). Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. BMC Cancer 4: 13.
    • (2004) BMC Cancer , vol.4 , pp. 13
    • Limtrakul, P.1    Anuchapreeda, S.2    Buddhasukh, D.3
  • 64
    • 55449124465 scopus 로고    scopus 로고
    • Luteolin, a flavonoid with potential for cancer prevention and therapy
    • Lin Y, Shi R, Wang X, Shen HM (2008). Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 8:634-646.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 634-646
    • Lin, Y.1    Shi, R.2    Wang, X.3    Shen, H.M.4
  • 65
    • 81155159628 scopus 로고    scopus 로고
    • Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells
    • Lin YS, Tsai PH, Kandaswami CC, Cheng CH, Ke FC, Lee PP, et al. (2011). Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells. Cancer Sci 102:1829-1839.
    • (2011) Cancer Sci , vol.102 , pp. 1829-1839
    • Lin, Y.S.1    Tsai, P.H.2    Kandaswami, C.C.3    Cheng, C.H.4    Ke, F.C.5    Lee, P.P.6
  • 66
    • 84882576094 scopus 로고    scopus 로고
    • Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells
    • Lin YC, Tsai PH, Lin CY, Cheng CH, Lin TH, Lee KP, et al. (2013). Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells. PLoS One 8:e71903.
    • (2013) PLoS One , vol.8 , pp. e71903
    • Lin, Y.C.1    Tsai, P.H.2    Lin, C.Y.3    Cheng, C.H.4    Lin, T.H.5    Lee, K.P.6
  • 67
    • 84901828081 scopus 로고    scopus 로고
    • Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells
    • Lin YC, Lin JC, Hung CM, Chen Y, Liu LC, Chang TC, et al. (2014). Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells. J Agric Food Chem 62:5061-5071.
    • (2014) J Agric Food Chem , vol.62 , pp. 5061-5071
    • Lin, Y.C.1    Lin, J.C.2    Hung, C.M.3    Chen, Y.4    Liu, L.C.5    Chang, T.C.6
  • 68
    • 84874288255 scopus 로고    scopus 로고
    • Inhibitory effects of luteolin on human gastric carcinoma xenografts in nude mice and its mechanism
    • Lu XY, Li YH, Xiao XW, Li XB (2013). Inhibitory effects of luteolin on human gastric carcinoma xenografts in nude mice and its mechanism. Zhonghua Yi Xue Za Zhi 93:142-146.
    • (2013) Zhonghua Yi Xue Za Zhi , vol.93 , pp. 142-146
    • Lu, X.Y.1    Li, Y.H.2    Xiao, X.W.3    Li, X.B.4
  • 69
    • 23844442112 scopus 로고    scopus 로고
    • Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: Pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB
    • Lun M, Zhang PL, Pellitteri PK, Law A, Kennedy TL, Brown RE (2005). Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB. Ann Clin Lab Sci 35:251-258.
    • (2005) Ann Clin Lab Sci , vol.35 , pp. 251-258
    • Lun, M.1    Zhang, P.L.2    Pellitteri, P.K.3    Law, A.4    Kennedy, T.L.5    Brown, R.E.6
  • 70
    • 84902548089 scopus 로고    scopus 로고
    • Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells
    • Mancini M, Gariboldi MB, Taiana E, Bonzi MC, Craparotta I, Pagin M, Monti E (2014). Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. Br J Cancer 110:2865-2873.
    • (2014) Br J Cancer , vol.110 , pp. 2865-2873
    • Mancini, M.1    Gariboldi, M.B.2    Taiana, E.3    Bonzi, M.C.4    Craparotta, I.5    Pagin, M.6    Monti, E.7
  • 71
    • 0034851475 scopus 로고    scopus 로고
    • Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants
    • Miean KH, Mohamed S (2001). Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 49:3106-3112.
    • (2001) J Agric Food Chem , vol.49 , pp. 3106-3112
    • Miean, K.H.1    Mohamed, S.2
  • 72
    • 84876084653 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins
    • Mirza S, Sharma G, Parshad R, Gupta SD, Pandya P, Ralhan R (2013). Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. J Breast Cancer 16:23-31.
    • (2013) J Breast Cancer , vol.16 , pp. 23-31
    • Mirza, S.1    Sharma, G.2    Parshad, R.3    Gupta, S.D.4    Pandya, P.5    Ralhan, R.6
  • 73
    • 84887835606 scopus 로고    scopus 로고
    • Antiproliferative activity and apoptosis induction of crude extract and fractions of Avicennia marina
    • Momtazi-Borojeni AA, Behbahani M, Sadeghi-Aliabadi H (2013). Antiproliferative activity and apoptosis induction of crude extract and fractions of Avicennia marina. Iran J Basic Med Sci 16:1203-1208.
    • (2013) Iran J Basic Med Sci , vol.16 , pp. 1203-1208
    • Momtazi-Borojeni, A.A.1    Behbahani, M.2    Sadeghi-Aliabadi, H.3
  • 74
    • 80052498659 scopus 로고    scopus 로고
    • Marine natural products: A new wave of drugs?
    • Montaser R, Luesch H (2011). Marine natural products: a new wave of drugs? Future Med Chem 3:1475-1489.
    • (2011) Future Med Chem , vol.3 , pp. 1475-1489
    • Montaser, R.1    Luesch, H.2
  • 76
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000). Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103.
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 77
    • 77957963491 scopus 로고    scopus 로고
    • Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3beta-cyclin D1 pathway
    • Ong CS, Zhou J, Ong CN, Shen HM (2010). Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3beta-cyclin D1 pathway. Cancer Lett 298:167-175.
    • (2011) Cancer Lett , vol.298 , pp. 167-175
    • Ong, C.S.1    Zhou, J.2    Ong, C.N.3    Shen, H.M.4
  • 78
    • 2942565810 scopus 로고    scopus 로고
    • Natural products and combinatorial chemistry: Back to the future
    • Ortholand JY, Ganesan A (2004). Natural products and combinatorial chemistry: back to the future. Curr Opin Chem Biol 8:271-280.
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 271-280
    • Ortholand, J.Y.1    Ganesan, A.2
  • 80
    • 84897062715 scopus 로고    scopus 로고
    • Luteolin sensitizes human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis
    • Ou YC, Li JR, Kuan YH, Raung SL, Wang CC, Hung YY, et al. (2014). Luteolin sensitizes human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis. Life Sci 100:110-117.
    • (2014) Life Sci , vol.100 , pp. 110-117
    • Ou, Y.C.1    Li, J.R.2    Kuan, Y.H.3    Raung, S.L.4    Wang, C.C.5    Hung, Y.Y.6
  • 82
    • 84905996633 scopus 로고    scopus 로고
    • Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis
    • Pandurangan AK, Dharmalingam P, Sadagopan SK, Ganapasam S (2014). Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis. Hum Exp Toxicol 33:1176-1185.
    • (2014) Hum Exp Toxicol , vol.33 , pp. 1176-1185
    • Pandurangan, A.K.1    Dharmalingam, P.2    Sadagopan, S.K.3    Ganapasam, S.4
  • 83
    • 84872201733 scopus 로고    scopus 로고
    • Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production
    • Park SW, Cho CS, Jun HO, Ryu NH, Kim JH, Yu YS, et al. (2012). Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production. Invest Ophthalmol Vis Sci 53:7718-7726.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 7718-7726
    • Park, S.W.1    Cho, C.S.2    Jun, H.O.3    Ryu, N.H.4    Kim, J.H.5    Yu, Y.S.6
  • 84
    • 84874775471 scopus 로고    scopus 로고
    • Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells
    • Park SH, Park HS, Lee JH, Chi GY, Kim GY, Moon SK, et al. (2013a). Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells. Food Chem Toxicol 56: 100-109.
    • (2013) Food Chem Toxicol , vol.56 , pp. 100-109
    • Park, S.H.1    Park, H.S.2    Lee, J.H.3    Chi, G.Y.4    Kim, G.Y.5    Moon, S.K.6
  • 86
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M (2008). Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8:915-928.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 87
    • 84871729357 scopus 로고    scopus 로고
    • Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
    • Pratheeshkumar P, Son YO, Budhraja A, Wang X, Ding S, Wang L, et al. (2012). Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. PLoS One 7: e52279.
    • (2012) PLoS One , vol.7 , pp. e52279
    • Pratheeshkumar, P.1    Son, Y.O.2    Budhraja, A.3    Wang, X.4    Ding, S.5    Wang, L.6
  • 88
    • 41149142015 scopus 로고    scopus 로고
    • Epigenetics and complex disease: From etiology to new therapeutics
    • Ptak C, Petronis A (2008). Epigenetics and complex disease: from etiology to new therapeutics. Annu Rev Pharmacol Toxicol 48: , 257-276.
    • (2008) Annu Rev Pharmacol Toxicol , vol.48 , pp. 257-276
    • Ptak, C.1    Petronis, A.2
  • 89
    • 1842843860 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell death program
    • Rao RV, Ellerby HM, Bredesen DE (2004). Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11:372-380.
    • (2004) Cell Death Differ , vol.11 , pp. 372-380
    • Rao, R.V.1    Ellerby, H.M.2    Bredesen, D.E.3
  • 91
    • 84861603289 scopus 로고    scopus 로고
    • Inhibition of hypoxiainduced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells
    • Ruan J, Zhang L, Yan L, Liu Y, Yue Z, Chen L, et al. (2012a). Inhibition of hypoxiainduced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells. Mol Med Rep 6:232-238.
    • (2012) Mol Med Rep , vol.6 , pp. 232-238
    • Ruan, J.1    Zhang, L.2    Yan, L.3    Liu, Y.4    Yue, Z.5    Chen, L.6
  • 92
    • 84867193837 scopus 로고    scopus 로고
    • Luteolin reduces the invasive potential of malignant melanoma cells by targeting beta3 integrin and the epithelial-mesenchymal transition
    • Ruan JS, Liu YP, Zhang L, Yan LG, Fan FT, Shen CS, et al. (2012b). Luteolin reduces the invasive potential of malignant melanoma cells by targeting beta3 integrin and the epithelial-mesenchymal transition. Acta Pharmacol Sin 33: 1325-1331.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1325-1331
    • Ruan, J.S.1    Liu, Y.P.2    Zhang, L.3    Yan, L.G.4    Fan, F.T.5    Shen, C.S.6
  • 93
    • 70350336226 scopus 로고    scopus 로고
    • Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer
    • Rushworth SA, Micheau O (2009). Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. Br J Pharmacol 157: 1186-1188.
    • (2009) Br J Pharmacol , vol.157 , pp. 1186-1188
    • Rushworth, S.A.1    Micheau, O.2
  • 94
    • 7044236785 scopus 로고    scopus 로고
    • Luteolin sensitizes tumor necrosis factoralpha-induced apoptosis in human tumor cells
    • Shi RX, Ong CN, Shen HM (2004). Luteolin sensitizes tumor necrosis factoralpha-induced apoptosis in human tumor cells. Oncogene 23:7712-7721.
    • (2004) Oncogene , vol.23 , pp. 7712-7721
    • Shi, R.X.1    Ong, C.N.2    Shen, H.M.3
  • 95
    • 24744449776 scopus 로고    scopus 로고
    • Protein kinase C inhibition and X-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells
    • Shi RX, Ong CN, Shen HM (2005). Protein kinase C inhibition and X-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Cancer Res 65:7815-7823.
    • (2005) Cancer Res , vol.65 , pp. 7815-7823
    • Shi, R.X.1    Ong, C.N.2    Shen, H.M.3
  • 96
    • 34248174931 scopus 로고    scopus 로고
    • Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization
    • Shi R, Huang Q, Zhu X, Ong YB, Zhao B, Lu J, et al. (2007). Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Mol Cancer Ther 6:1338-1347.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1338-1347
    • Shi, R.1    Huang, Q.2    Zhu, X.3    Ong, Y.B.4    Zhao, B.5    Lu, J.6
  • 97
    • 0031738302 scopus 로고    scopus 로고
    • Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans
    • Shimoi K, Okada H, Furugori M, Goda T, Takase S, Suzuki M, et al. (1998). Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett 438:220-224.
    • (1998) FEBS Lett , vol.438 , pp. 220-224
    • Shimoi, K.1    Okada, H.2    Furugori, M.3    Goda, T.4    Takase, S.5    Suzuki, M.6
  • 98
    • 84890898992 scopus 로고    scopus 로고
    • Vitro action of flavonoids in the canine malignant histiocytic cell line DH82
    • Silva G, Fachin AL, Beleboni RO, França SC, Marins M (2013). In vitro action of flavonoids in the canine malignant histiocytic cell line DH82. Molecules 18:15448-15463.
    • (2013) Molecules , vol.18 , pp. 15448-15463
    • Silva, G.1    Fachin, A.L.2    Beleboni, R.O.3    França, S.C.4    Marins, M.5
  • 99
    • 70349865021 scopus 로고    scopus 로고
    • Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal
    • Soncin F, Mohamet L, Eckardt D, Ritson S, Eastham AM, Bobola N, et al. (2009). Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal. Stem Cells 27:2069-2080.
    • (2009) Stem Cells , vol.27 , pp. 2069-2080
    • Soncin, F.1    Mohamet, L.2    Eckardt, D.3    Ritson, S.4    Eastham, A.M.5    Bobola, N.6
  • 100
    • 33847789992 scopus 로고    scopus 로고
    • Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L)
    • Sun T, Xu Z, Wu CT, Janes M, Prinyawiwatkul W, No HK (2007). Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L.). J Food Sci 72:S98-S102.
    • (2007) J Food Sci , vol.72 , pp. S98-S102
    • Sun, T.1    Xu, Z.2    Wu, C.T.3    Janes, M.4    Prinyawiwatkul, W.5    No, H.K.6
  • 101
    • 84891753517 scopus 로고    scopus 로고
    • Luteolin sensitizes the antiproliferative effect of interferon ?/? by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells
    • Tai Z, Lin Y, He Y, Huang J, Guo J, Yang L, et al. (2014). Luteolin sensitizes the antiproliferative effect of interferon ?/? by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. Cell Signal 26:619-628.
    • (2014) Cell Signal , vol.26 , pp. 619-628
    • Tai, Z.1    Lin, Y.2    He, Y.3    Huang, J.4    Guo, J.5    Yang, L.6
  • 102
    • 65949114424 scopus 로고    scopus 로고
    • Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation
    • Blackwell
    • Thomas GS, Zhang L, Blackwell K, Habelhah H (2009). Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. Cancer Res 69:3665-3672.
    • (2009) Cancer Res , vol.69 , pp. 3665-3672
    • Thomas, G.S.1    Zhang, L.2    Blackwell, K.3    Habelhah, H.4
  • 103
    • 40549133248 scopus 로고    scopus 로고
    • Flavonoids in Helichrysum pamphylicum inhibit mammalian type i DNA topoisomerase
    • Topcu Z, Ozturk B, Kucukoglu O, Kilinc E (2008). Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase. Z Naturforsch C 63:69-74.
    • (2008) Z Naturforsch C , vol.63 , pp. 69-74
    • Topcu, Z.1    Ozturk, B.2    Kucukoglu, O.3    Kilinc, E.4
  • 104
    • 84859905254 scopus 로고    scopus 로고
    • Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells
    • Tsui KH, Chung LC, Feng TH, Chang PL, Juang HH (2012). Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. Int J Cancer 130:2812-2823.
    • (2012) Int J Cancer , vol.130 , pp. 2812-2823
    • Tsui, K.H.1    Chung, L.C.2    Feng, T.H.3    Chang, P.L.4    Juang, H.H.5
  • 105
    • 84880719548 scopus 로고    scopus 로고
    • Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells
    • Uekita T, Fujii S, Miyazawa Y, Hashiguchi A, Abe H, Sakamoto M, Sakai R (2013). Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells. Cancer Sci 104:865-870.
    • (2013) Cancer Sci , vol.104 , pp. 865-870
    • Uekita, T.1    Fujii, S.2    Miyazawa, Y.3    Hashiguchi, A.4    Abe, H.5    Sakamoto, M.6    Sakai, R.7
  • 106
    • 28444456705 scopus 로고    scopus 로고
    • The histone code at DNA breaks: A guide to repair?
    • Van Attikum H, Gasser SM (2005). The histone code at DNA breaks: a guide to repair? Nat Rev Mol Cell Biol 6:757-765.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 757-765
    • Van Attikum, H.1    Gasser, S.M.2
  • 107
    • 84868143291 scopus 로고    scopus 로고
    • Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells
    • Verschooten L, Barrette K, Van Kelst S, Rubio Romero N, Proby C, De Vos R, et al. (2012). Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. PLoS One 7:e48264.
    • (2012) PLoS One , vol.7 , pp. e48264
    • Verschooten, L.1    Barrette, K.2    Van Kelst, S.3    Rubio Romero, N.4    Proby, C.5    De Vos, R.6
  • 110
    • 84902494027 scopus 로고    scopus 로고
    • Role of autophagy in cisplatin resistance in ovarian cancer cells
    • Wang J, Wu GS (2014). Role of autophagy in cisplatin resistance in ovarian cancer cells. J Biol Chem 289:17163-17173.
    • (2014) J Biol Chem , vol.289 , pp. 17163-17173
    • Wang, J.1    Wu, G.S.2
  • 111
    • 84873036300 scopus 로고    scopus 로고
    • Luteolin inhibits proliferation induced by IGF-1 pathway dependent ERalpha in human breast cancer MCF-7 cells
    • Wang LM, Xie KP, Huo HN, Shang F, Zou W, Xie MJ (2012a). Luteolin inhibits proliferation induced by IGF-1 pathway dependent ERalpha in human breast cancer MCF-7 cells. Asian Pac J Cancer Prev 13:1431-1437.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 1431-1437
    • Wang, L.M.1    Xie, K.P.2    Huo, H.N.3    Shang, F.4    Zou, W.5    Xie, M.J.6
  • 112
    • 84874033669 scopus 로고    scopus 로고
    • Luteolin induced-growth inhibition and apoptosis of human esophageal squamous carcinoma cell line Eca109 cells in vitro
    • Wang TT, Wang SK, Huang GL, Sun GJ (2012b). Luteolin induced-growth inhibition and apoptosis of human esophageal squamous carcinoma cell line Eca109 cells in vitro. Asian Pac J Cancer Prev 13:5455-5461.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 5455-5461
    • Wang, T.T.1    Wang, S.K.2    Huang, G.L.3    Sun, G.J.4
  • 113
    • 31544470589 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factorinduced lung cancer cell death by blocking the nuclear factor-kappaB pathway
    • Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y (2006). 17-Allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factorinduced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res 66:1089-1095.
    • (2006) Cancer Res , vol.66 , pp. 1089-1095
    • Wang, X.1    Ju, W.2    Renouard, J.3    Aden, J.4    Belinsky, S.A.5    Lin, Y.6
  • 114
    • 84862309686 scopus 로고    scopus 로고
    • Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities
    • Weng CJ, Yen GC (2012). Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Cancer Metastasis Rev 31:323-351.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 323-351
    • Weng, C.J.1    Yen, G.C.2
  • 115
    • 44449122711 scopus 로고    scopus 로고
    • Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line
    • Wu B, Zhang Q, Shen W, Zhu J (2008). Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line. Mol Cell Biochem 313:125-132.
    • (2008) Mol Cell Biochem , vol.313 , pp. 125-132
    • Wu, B.1    Zhang, Q.2    Shen, W.3    Zhu, J.4
  • 116
    • 74349115989 scopus 로고    scopus 로고
    • Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells
    • Wu YX, Fang X (2010). Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells. Planta Med 76:128-132.
    • (2011) Planta Med , vol.76 , pp. 128-132
    • Wu, Y.X.1    Fang, X.2
  • 117
    • 84880442126 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor kappaB contributes to cystic fibrosis transmembrane conductance regulator expression and promotes human cervical cancer progression and poor prognosis
    • Wu Z, Peng X, Li J, Zhang Y, Hu L (2013). Constitutive activation of nuclear factor kappaB contributes to cystic fibrosis transmembrane conductance regulator expression and promotes human cervical cancer progression and poor prognosis. Int J Gynecol Cancer 23:906-915.
    • (2013) Int J Gynecol Cancer , vol.23 , pp. 906-915
    • Wu, Z.1    Peng, X.2    Li, J.3    Zhang, Y.4    Hu, L.5
  • 118
    • 67349181288 scopus 로고    scopus 로고
    • Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells
    • Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C (2009). Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett 281:162-170.
    • (2009) Cancer Lett , vol.281 , pp. 162-170
    • Xavier, C.P.1    Lima, C.F.2    Preto, A.3    Seruca, R.4    Fernandes-Ferreira, M.5    Pereira-Wilson, C.6
  • 119
    • 82455175194 scopus 로고    scopus 로고
    • Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation
    • Xavier CP, Lima CF, Rohde M, Pereira-Wilson C (2011). Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. Cancer Chemother Pharmacol 68:1449-1457.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1449-1457
    • Xavier, C.P.1    Lima, C.F.2    Rohde, M.3    Pereira-Wilson, C.4
  • 120
    • 84855836595 scopus 로고    scopus 로고
    • Luteolin enhances TNF-related apoptosis-inducing ligand's anticancer activity in a lung cancer xenograft mouse model
    • Yan J, Wang Q, Zheng X, Sun H, Zhou Y, Li D, et al. (2012). Luteolin enhances TNF-related apoptosis-inducing ligand's anticancer activity in a lung cancer xenograft mouse model. Biochem Biophys Res Commun 417: 842-846.
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 842-846
    • Yan, J.1    Wang, Q.2    Zheng, X.3    Sun, H.4    Zhou, Y.5    Li, D.6
  • 121
    • 84895174074 scopus 로고    scopus 로고
    • Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3
    • Yang MY, Wang CJ, Chen NF, Ho WH, Lu FJ, Tseng TH (2014). Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3. Chem Biol Interact 213:60-68.
    • (2014) Chem Biol Interact , vol.213 , pp. 60-68
    • Yang, M.Y.1    Wang, C.J.2    Chen, N.F.3    Ho, W.H.4    Lu, F.J.5    Tseng, T.H.6
  • 122
    • 84873935096 scopus 로고    scopus 로고
    • Curcumin downregulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia
    • Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, et al. (2013). Curcumin downregulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS One 8:e55934.
    • (2013) PLoS One , vol.8 , pp. e55934
    • Yu, J.1    Peng, Y.2    Wu, L.C.3    Xie, Z.4    Deng, Y.5    Hughes, T.6
  • 123
    • 20544446881 scopus 로고    scopus 로고
    • Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis
    • Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa WC, Min W (2005). Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene 24:3954-3963.
    • (2005) Oncogene , vol.24 , pp. 3954-3963
    • Zhang, R.1    Luo, D.2    Miao, R.3    Bai, L.4    Ge, Q.5    Sessa, W.C.6    Min, W.7
  • 124
    • 84860390217 scopus 로고    scopus 로고
    • Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
    • Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B (2011). Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res 13:R52.
    • (2011) Breast Cancer Res , vol.13 , pp. R52
    • Zhang, Y.1    Moerkens, M.2    Ramaiahgari, S.3    De Bont, H.4    Price, L.5    Meerman, J.6    Van De Water, B.7
  • 125
    • 84907482367 scopus 로고    scopus 로고
    • Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: Implications for multiple myeloma therapy
    • Zhao JJ, Carrasco RD (2014). Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: implications for multiple myeloma therapy. Cancer Res 74:5351-5358.
    • (2014) Cancer Res , vol.74 , pp. 5351-5358
    • Zhao, J.J.1    Carrasco, R.D.2
  • 126
    • 67649383604 scopus 로고    scopus 로고
    • Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
    • Zhou Q, Yan B, Hu X, Li XB, Zhang J, Fang J (2009). Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Mol Cancer Ther 8: 1684-1691.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1684-1691
    • Zhou, Q.1    Yan, B.2    Hu, X.3    Li, X.B.4    Zhang, J.5    Fang, J.6


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