Constitutive activation of nuclear factor jb contributes to cystic fibrosis transmembrane conductance regulator expression and promotes human cervical cancer progression and poor prognosis

International Journal of Gynecological Cancer

Volumn 23, Issue 5, 2013, Pages 906-915

  Wu, Zhao ^a,b,c   Peng, Xue ^a,b,c   Li, Jinke ^a,b,c   Zhang, Yi ^a,c   Hu, Lina ^a,b  

^a Laboratory of Biomedical Ultrasonics Gynecological Oncology Laboratory   (China)

^b SICHUAN UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Cervical cancer; Cystic fibrosis transmembrane conductance regulator; Nuclear factor JB; Prognostic factor; Progression

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINE; I KAPPA B; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR INVASION; UTERINE CERVIX CANCER;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE PROGRESSION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LUCIFERASES; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NF-KAPPA B; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SURVIVAL RATE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 84880442126     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e318292da82     Document Type: Article

References (31)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
2. Munger K, Baldwin A, Edwards KM, et al. Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 2004;78:11451-11460.
3. Sheppard DN, Welsh MJ. Structure and function of the CFTR chloride channel. Physiol Rev. 1999;79:S23-45.
4. Trezise AE, Buchwald M. In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator. Nature. 1991;353:434-437.
5. Hayslip CC, Hao E, Usala SJ. The cystic fibrosis transmembrane regulator gene is expressed in the human endocervix throughout the menstrual cycle. Fertil Steril. 1997;67:636-640.
6. Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. N Engl J Med. 2005;352:1992-2001.
7. Li Y, Sun Z, Wu Y, et al. Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer risk. Lung Cancer. 2010;70:14-21.
8. Padua RA, Warren N, Grimshaw D, et al. The cystic fibrosis delta F508 gene mutation and cancer. Hum Mutat. 1997;10:45-48.
9. Jacquot J, Tabary O, Le Rouzic P, et al. Airway epithelial cell inflammatory signalling in cystic fibrosis. Int J Biochem Cell Biol. 2008;40:1703-1715.
10. Vij N, Mazur S, Zeitlin PL. CFTR is a negative regulator of NF-JB mediated innate immune response. PLoS One. 2009;4:e4664.
11. Li J, Jia H, Xie L, et al. Association of constitutive nuclear factor-JB activation with aggressive aspects and poor prognosis in cervical cancer. Int J Gynecol Cancer. 2009;19:1421-1426.
12. Kim SH, Oh JM, No JH, et al. Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein. Carcinogenesis. 2009;30:753-757.
13. Brouillard F, Bouthier M, Leclerc T, et al. NF-kappa B mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1beta. J Biol Chem. 2001;276:9486-9491.
14. Zheng J, Wahlstrom T, Paavonen J, et al. Altered growth behavior of human cervical epithelial cells transfected by HPV type 16 and 18 DNA. Int J Cancer. 1994;58:713-720.
15. Naghashfar Z, DiPaolo JA, Woodworth CD, et al. Immortalization of human adult prostatic adenocarcinoma cells by human papilloma virus HPV16 and-18 DNA. Cancer Lett. 1996;100:47-54.
16. Lee BL, Lee HS, Jung J, et al. Nuclear factor-JB activation correlates with better prognosis and Akt activation in human gastric cancer. Clin Cancer Res. 2005;11:2518-2525.
17. Ramdass B, Maliekal TT, Lakshmi S, et al. Coexpression of Notch1 and NF-JB signaling pathway components in human cervical cancer progression. Gynecol Oncol. 2007;104:352-361.
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-408.
19. Mio K, Ogura T, Mio M, et al. Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain. J Biol Chem. 2008;283:30300-30310.
20. Nair A, Venkatraman M, Maliekal TT, et al. NF-JB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix. Oncogene. 2003;22:50-58.
21. Peng X, Wu Z, Yu L, et al. Overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) is associated with human cervical cancer malignancy, progression and prognosis. Gynecol Oncol. 2012;125:470-476.
22. Karin M, Greten FR. NF-JB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749-759.
23. Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res. 2006;4:221-233.
24. Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 2004;4:71-78.
25. McWilliams RR, Petersen GM, Rabe KG, et al. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinoma. Cancer. 2010;116:203-209.
26. Qiao D, Yi L, Hua L, et al. Cystic fibrosis transmembrane conductance regulator (CFTR) gene 5T allele may protect against prostate cancer: A case-control study in Chinese Han population. J Cyst Fibros. 2008;7:210-214.
27. Wine JJ, Dean M, Glavac D. Natural animal models of human genetic diseases. Methods Mol Med. 2002;70:31-46.
28. Cafferata EG, Guerrico AM, Pivetta OH, et al. NF-JB activation is involved in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) by interleukin-1beta. J Biol Chem. 2001;276:15441-15444.
29. Rottner M, Kunzelmann C, Mergey M, et al. Exaggerated apoptosis and NF-JB activation in pancreatic and tracheal cystic fibrosis cells. FASEB J. 2007;21:2939-2948.
30. Mauro C, Zazzeroni F, Papa S, et al. The NF-kappaB transcription factor pathway as a therapeutic target in cancer: Methods for detection of NF-JB activity. Methods Mol Biol. 2009;512:169-207.
31. Hunter MJ, Treharne KJ, Winter AK, et al. Expression of wild-type CFTR suppresses NF-JBYdriven inflammatory signalling. PLoS One. 2010;5:e11598.