메뉴 건너뛰기




Volumn 5, Issue 10, 2014, Pages 3184-3196

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

(17)  Müller, Sylvia a   Chen, Yuan b   Ginter, Torsten a   Schäfer, Claudia a   Buchwald, Marc a   Schmitz, Lienhard M c   Klitzsch, Jana d   Schütz, Alexander d   Haitel, Andrea e   Schmid, Katharina f   Moriggl, Richard g,h   Kenner, Lukas e,g,h   Friedrich, Karlheinz i   Haan, Claude j   Petersen, Iver b   Heinzel, Thorsten a   Krämer, Oliver H k  


Author keywords

Lung cancer; SIAH2; STAT3; TYK2; UBCH8

Indexed keywords

ALPHA INTERFERON; FOCAL ADHESION KINASE 1; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; PROTEIN P53; SEVEN IN ABSENTIA 2 PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; PROTEIN KINASE TYK2; SEVEN IN ABSENTIA PROTEINS; STAT3 PROTEIN, HUMAN; TYK2 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

EID: 84902081342     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1899     Document Type: Article
Times cited : (32)

References (58)
  • 1
    • 33750522675 scopus 로고    scopus 로고
    • Jaks and cytokine receptors-an intimate relationship
    • Haan C, Kreis S, Margue C, Behrmann I. Jaks and cytokine receptors-an intimate relationship. Biochem Pharmacol. 2006; 72: 1538-1546.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1538-1546
    • Haan, C.1    Kreis, S.2    Margue, C.3    Behrmann, I.4
  • 2
    • 84860281015 scopus 로고    scopus 로고
    • Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity
    • Strobl B, Stoiber D, Sexl V, Mueller M. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front Biosci (Landmark Ed). 2011; 16: 3214-3232.
    • (2011) Front Biosci (Landmark Ed) , vol.16 , pp. 3214-3232
    • Strobl, B.1    Stoiber, D.2    Sexl, V.3    Mueller, M.4
  • 4
    • 63649086487 scopus 로고    scopus 로고
    • Targeting the ubiquitin system in cancer therapy
    • Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy. Nature. 2009; 458: 438-444.
    • (2009) Nature , vol.458 , pp. 438-444
    • Hoeller, D.1    Dikic, I.2
  • 7
    • 69449087032 scopus 로고    scopus 로고
    • SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling
    • Haan S, Wüller S, Kaczor J, Rolvering C, Nocker T, Behrmann I, Haan C. SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling. Oncogene. 2009; 28: 3069-3080.
    • (2009) Oncogene , vol.28 , pp. 3069-3080
    • Haan, S.1    Wüller, S.2    Kaczor, J.3    Rolvering, C.4    Nocker, T.5    Behrmann, I.6    Haan, C.7
  • 8
    • 0036233985 scopus 로고    scopus 로고
    • Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1
    • Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol. 2002; 22: 3316-3326.
    • (2002) Mol Cell Biol , vol.22 , pp. 3316-3326
    • Ungureanu, D.1    Saharinen, P.2    Junttila, I.3    Hilton, D.J.4    Silvennoinen, O.5
  • 9
    • 34249660614 scopus 로고    scopus 로고
    • SOCS proteins, cytokine signalling and immune regulation
    • Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol. 2007; 7: 454-465.
    • (2007) Nat Rev Immunol , vol.7 , pp. 454-465
    • Yoshimura, A.1    Naka, T.2    Kubo, M.3
  • 10
    • 80053210241 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2
    • Piganis RA, De Weerd NA, Gould JA, Schindler CW, Mansell A, Nicholson SE, Hertzog PJ. Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J Biol Chem. 2011; 286: 33811-33818.
    • (2011) J Biol Chem , vol.286 , pp. 33811-33818
    • Piganis, R.A.1    De Weerd, N.A.2    Gould, J.A.3    Schindler, C.W.4    Mansell, A.5    Nicholson, S.E.6    Hertzog, P.J.7
  • 11
    • 34247882657 scopus 로고    scopus 로고
    • The role of STATs in lung carcinogenesis: an emerging target for novel therapeutics
    • Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG. The role of STATs in lung carcinogenesis: an emerging target for novel therapeutics. J Mol Med 2007; 85: 427-436.
    • (2007) J Mol Med , vol.85 , pp. 427-436
    • Karamouzis, M.V.1    Konstantinopoulos, P.A.2    Papavassiliou, A.G.3
  • 12
    • 77953019852 scopus 로고    scopus 로고
    • Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches
    • Lai SY, Johnson FM. Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches. Drug Resist Updat. 2010; 13: 67-78.
    • (2010) Drug Resist Updat , vol.13 , pp. 67-78
    • Lai, S.Y.1    Johnson, F.M.2
  • 16
    • 28544438023 scopus 로고    scopus 로고
    • Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer
    • Haura EB, Zheng Z, Song L, Cantor A, Bepler G. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res. 2005; 11: 8288-8294.
    • (2005) Clin Cancer Res , vol.11 , pp. 8288-8294
    • Haura, E.B.1    Zheng, Z.2    Song, L.3    Cantor, A.4    Bepler, G.5
  • 17
    • 79955780881 scopus 로고    scopus 로고
    • JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling
    • Song L, Rawal B, Nemeth JA, Haura EB. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling. Mol Cancer Ther. 2011; 10: 481-494.
    • (2011) Mol Cancer Ther , vol.10 , pp. 481-494
    • Song, L.1    Rawal, B.2    Nemeth, J.A.3    Haura, E.B.4
  • 18
    • 84856478208 scopus 로고    scopus 로고
    • STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma
    • Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ, Mackeigan JP. STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma. PLoS One. 2012; 7: e30820.
    • (2012) PLoS One , vol.7
    • Looyenga, B.D.1    Hutchings, D.2    Cherni, I.3    Kingsley, C.4    Weiss, G.J.5    Mackeigan, J.P.6
  • 20
    • 84876986498 scopus 로고    scopus 로고
    • Siah: a promising anticancer target
    • Wong CS, Möller A. Siah: a promising anticancer target. Cancer Res. 2013; 73: 2400-2406.
    • (2013) Cancer Res , vol.73 , pp. 2400-2406
    • Wong, C.S.1    Möller, A.2
  • 22
    • 77955709330 scopus 로고    scopus 로고
    • Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation
    • Buchwald M, Pietschmann K, Müller JP, Böhmer FD, Heinzel T, Krämer OH. Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. Leukemia. 2010; 24: 1412-1421.
    • (2010) Leukemia , vol.24 , pp. 1412-1421
    • Buchwald, M.1    Pietschmann, K.2    Müller, J.P.3    Böhmer, F.D.4    Heinzel, T.5    Krämer, O.H.6
  • 23
    • 43249104204 scopus 로고    scopus 로고
    • Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha
    • Krämer OH, Müller S, Buchwald M, Reichardt S, Heinzel T. Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. Faseb J. 2008; 22: 1369-1379.
    • (2008) Faseb J , vol.22 , pp. 1369-1379
    • Krämer, O.H.1    Müller, S.2    Buchwald, M.3    Reichardt, S.4    Heinzel, T.5
  • 26
    • 0033527566 scopus 로고    scopus 로고
    • Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase
    • Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM. Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. J Biol Chem. 1999; 274: 32507-32511.
    • (1999) J Biol Chem , vol.274 , pp. 32507-32511
    • Rani, M.R.1    Leaman, D.W.2    Han, Y.3    Leung, S.4    Croze, E.5    Fish, E.N.6    Wolfman, A.7    Ransohoff, R.M.8
  • 30
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006; 66: 5542-5548.
    • (2006) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 31
    • 37849043127 scopus 로고    scopus 로고
    • Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
    • Kreis S, Munz GA, Haan S, Heinrich PC, Behrmann I. Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Mol Cancer Res. 2007; 5: 1331-1341.
    • (2007) Mol Cancer Res , vol.5 , pp. 1331-1341
    • Kreis, S.1    Munz, G.A.2    Haan, S.3    Heinrich, P.C.4    Behrmann, I.5
  • 33
    • 49649111204 scopus 로고    scopus 로고
    • Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif
    • Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY. Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. J Biol Chem. 2008; 283: 18566-18572.
    • (2008) J Biol Chem , vol.283 , pp. 18566-18572
    • Kumar, K.G.1    Varghese, B.2    Banerjee, A.3    Baker, D.P.4    Constantinescu, S.N.5    Pellegrini, S.6    Fuchs, S.Y.7
  • 34
    • 78650942150 scopus 로고    scopus 로고
    • A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer
    • Hart K, Landvik NE, Lind H, Skaug V, Haugen A, Zienolddiny S. A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer. Lung Cancer. 2011; 71: 123-129.
    • (2011) Lung Cancer , vol.71 , pp. 123-129
    • Hart, K.1    Landvik, N.E.2    Lind, H.3    Skaug, V.4    Haugen, A.5    Zienolddiny, S.6
  • 35
    • 79953880824 scopus 로고    scopus 로고
    • STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter
    • Zugowski C, Lieder F, Müller A, Gasch J, Corvinus FM, Moriggl R, Friedrich K. STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter. Biol Chem. 2011; 392: 449-459.
    • (2011) Biol Chem , vol.392 , pp. 449-459
    • Zugowski, C.1    Lieder, F.2    Müller, A.3    Gasch, J.4    Corvinus, F.M.5    Moriggl, R.6    Friedrich, K.7
  • 37
    • 78649368854 scopus 로고    scopus 로고
    • Should we continue to use the term non-small-cell lung cancer?
    • vii225-vii229
    • Gazdar AF. Should we continue to use the term non-small-cell lung cancer? Ann Oncol. 2010; 21 Suppl 7: vii225-229.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 7
    • Gazdar, A.F.1
  • 39
    • 58149354210 scopus 로고    scopus 로고
    • An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
    • Calzado MA, de la Vega L, Möller A, Bowtell DD, Schmitz ML. An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol. 2009; 11: 85-91.
    • (2009) Nat Cell Biol , vol.11 , pp. 85-91
    • Calzado, M.A.1    de la Vega, L.2    Möller, A.3    Bowtell, D.D.4    Schmitz, M.L.5
  • 40
    • 71549155940 scopus 로고    scopus 로고
    • Siah proteins: novel drug targets in the Ras and hypoxia pathways
    • House CM, Möller A, Bowtell DD. Siah proteins: novel drug targets in the Ras and hypoxia pathways. Cancer Res. 2009; 69: 8835-8838.
    • (2009) Cancer Res , vol.69 , pp. 8835-8838
    • House, C.M.1    Möller, A.2    Bowtell, D.D.3
  • 41
    • 71849101259 scopus 로고    scopus 로고
    • Phosphorylation-acetylation switch in the regulation of STAT1 signaling
    • Krämer OH, Heinzel T. Phosphorylation-acetylation switch in the regulation of STAT1 signaling. Mol Cell Endocrinol. 2010; 315: 40-48.
    • (2010) Mol Cell Endocrinol , vol.315 , pp. 40-48
    • Krämer, O.H.1    Heinzel, T.2
  • 48
    • 33744736979 scopus 로고    scopus 로고
    • Oxidants and signaling by mitogen-activated protein kinases in lung epithelium
    • Mossman BT, Lounsbury KM, Reddy SP. Oxidants and signaling by mitogen-activated protein kinases in lung epithelium. Am J Respir Cell Mol Biol. 2006; 34: 666-669.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 666-669
    • Mossman, B.T.1    Lounsbury, K.M.2    Reddy, S.P.3
  • 49
    • 84555202760 scopus 로고    scopus 로고
    • Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma
    • Jiang R, Jin Z, Liu Z, Sun L, Wang L, Li K. Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma. Mol Diagn Ther. 2011; 15: 347-352.
    • (2011) Mol Diagn Ther , vol.15 , pp. 347-352
    • Jiang, R.1    Jin, Z.2    Liu, Z.3    Sun, L.4    Wang, L.5    Li, K.6
  • 50
    • 84867188698 scopus 로고    scopus 로고
    • Pro-malignant properties of STAT3 during chronic inflammation
    • Demaria M, Poli V. Pro-malignant properties of STAT3 during chronic inflammation. Oncotarget. 2012; 3: 359-360.
    • (2012) Oncotarget , vol.3 , pp. 359-360
    • Demaria, M.1    Poli, V.2
  • 53
    • 84880271158 scopus 로고    scopus 로고
    • Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
    • Gordziel C, Bratsch J, Moriggl R, Knösel T, Friedrich K. Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br J Cancer. 2013; 109: 138-146.
    • (2013) Br J Cancer , vol.109 , pp. 138-146
    • Gordziel, C.1    Bratsch, J.2    Moriggl, R.3    Knösel, T.4    Friedrich, K.5
  • 54
    • 38749121729 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis
    • Krämer OH, Knauer SK, Zimmermann D, Stauber RH, Heinzel T. Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. Oncogene. 2008; 27: 732-740.
    • (2008) Oncogene , vol.27 , pp. 732-740
    • Krämer, O.H.1    Knauer, S.K.2    Zimmermann, D.3    Stauber, R.H.4    Heinzel, T.5
  • 56
    • 34247281958 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction
    • Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schutz A, Kovacic B, Friedrich K. Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia. 2007; 9: 279-291.
    • (2007) Neoplasia , vol.9 , pp. 279-291
    • Tsareva, S.A.1    Moriggl, R.2    Corvinus, F.M.3    Wiederanders, B.4    Schutz, A.5    Kovacic, B.6    Friedrich, K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.