Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I

Biochemical Journal

Volumn 366, Issue 2, 2002, Pages 653-661

  Chowdhury, Arnab Roy ^a   Sharma, Shalini ^a   Mandal, Suparna ^a   Goswami, Anindya ^a   Mukhopadhyay, Sibabrata ^a   Majumder, Hemanta K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Cleavable complex; DNA intercalator; Inhibitor; Topoisomerase poison

Indexed keywords

DNA; DRUG PRODUCTS; ELECTROPHORESIS; ENZYME INHIBITION; FLUORESCENCE;

APOPTOSIS;

ENZYMES;

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CONCANAVALIN A; DNA; DNA TOPOISOMERASE; FLAVONOID; LUTEOLIN;

ANIMAL CELL; ARTICLE; CELL STIMULATION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG EFFECT; DRUG POTENCY; DRUG PROTEIN BINDING; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; EUKARYOTE; FLUORESCENCE; GENOTOXICITY; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RAT; SPLEEN CELL;

AMSACRINE; ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CATALYSIS; CELL NUCLEUS; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; ENZYME INHIBITORS; ETOPOSIDE; FLAVONOIDS; KINETICS; LIVER; LUTEOLIN; NUCLEIC ACID DENATURATION; OLIGODEOXYRIBONUCLEOTIDES; PLANT LEAVES; QUERCETIN; RATS; SPECTROMETRY, FLUORESCENCE; TRITERPENES;

ANIMALIA; EUKARYOTA;

EID: 0036711591     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020098     Document Type: Article

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