Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells

Oncology Reports

Volumn 31, Issue 6, 2014, Pages 2683-2691

  Ham, Sunyoung ^a   Kim, Ki Hong ^a   Kwon, Tae Ho ^a,b   Bak, Yesol ^a   Lee, Dong Hun ^a,c   Song, Yong Seok ^a   Park, Su Ho ^a   Park, Yun Sun ^a   Kim, Man Sub ^a   Kang, Jeong Woo ^a   Hong, Jin Tae ^c   Yoon, Do Young ^a  

^a Konkuk University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Apoptosis; Cervical cancer; Human papillomavirus; Luteolin

Indexed keywords

CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; DEATH RECEPTOR 5; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLUORESCEIN ISOTHIOCYANATE; LUTEOLIN; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN E6; PROTEIN E7; DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; E7 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; ONCOPROTEIN; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ASSAY; CELL MEDIATED CYTOTOXICITY; CERVICAL CANCER CELL LINE; CONTROLLED STUDY; DRUG INHIBITION; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; GENE ACTIVATION; GENE AMPLIFICATION; GENE INACTIVATION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 18; INCUBATION TIME; MITOCHONDRIAL MEMBRANE POTENTIAL; ONCOGENE; ONCOGENE E6; ONCOGENE E7; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAINING; VIRUS EXPRESSION; WESTERN BLOTTING; BIOSYNTHESIS; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM; PAPILLOMAVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; UTERINE CERVIX TUMOR; VIROLOGY;

APOPTOSIS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HUMAN PAPILLOMAVIRUS 18; HUMANS; LUTEOLIN; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS INFECTIONS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

EID: 84902195731     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3157     Document Type: Article

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