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Volumn 594, Issue 18, 2016, Pages 5105-5123

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RELATED RECEPTOR ALPHA; GA BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 6; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

EID: 84947714054     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP270659     Document Type: Article
Times cited : (121)

References (173)
  • 1
    • 0029959922 scopus 로고    scopus 로고
    • Weight training improves walking endurance in healthy elderly persons
    • Ades PA, Ballor DL, Ashikaga T, Utton JL & Nair KS (1996). Weight training improves walking endurance in healthy elderly persons. Ann Intern Med 124, 568–572.
    • (1996) Ann Intern Med , vol.124 , pp. 568-572
    • Ades, P.A.1    Ballor, D.L.2    Ashikaga, T.3    Utton, J.L.4    Nair, K.S.5
  • 2
    • 50349084852 scopus 로고    scopus 로고
    • Mitochondria in skeletal muscle: adaptable rheostats of apoptotic susceptibility
    • Adhihetty PJ, O'Leary MF & Hood DA (2008). Mitochondria in skeletal muscle: adaptable rheostats of apoptotic susceptibility. Exerc Sport Sci Rev 36, 116–121.
    • (2008) Exerc Sport Sci Rev , vol.36 , pp. 116-121
    • Adhihetty, P.J.1    O'Leary, M.F.2    Hood, D.A.3
  • 4
    • 0023882449 scopus 로고
    • Age-related changes in the skeletal muscle cells
    • Beregi E, Regius O, Huttl T & Gobl Z (1988). Age-related changes in the skeletal muscle cells. Z Gerontol 21, 83–86.
    • (1988) Z Gerontol , vol.21 , pp. 83-86
    • Beregi, E.1    Regius, O.2    Huttl, T.3    Gobl, Z.4
  • 5
    • 69249089756 scopus 로고    scopus 로고
    • Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function
    • Betik AC, Thomas MM, Wright KJ, Riel CD & Hepple RT (2009). Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function. Am J Physiol Regul Integr Comp Physiol 297, R744–755.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , pp. R744-755
    • Betik, A.C.1    Thomas, M.M.2    Wright, K.J.3    Riel, C.D.4    Hepple, R.T.5
  • 7
    • 0037029132 scopus 로고    scopus 로고
    • Mitochondrial DNA repair of oxidative damage in mammalian cells
    • Bohr VA, Stevnsner T & de Souza-Pinto NC (2002). Mitochondrial DNA repair of oxidative damage in mammalian cells. Gene 286, 127–134.
    • (2002) Gene , vol.286 , pp. 127-134
    • Bohr, V.A.1    Stevnsner, T.2    de Souza-Pinto, N.C.3
  • 10
    • 33748643416 scopus 로고    scopus 로고
    • Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibres
    • Bua E, Johnson J, Herbst A, Delong B, McKenzie D, Salamat S & Aiken JM (2006). Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibres. Am J Hum Genet 79, 469–480.
    • (2006) Am J Hum Genet , vol.79 , pp. 469-480
    • Bua, E.1    Johnson, J.2    Herbst, A.3    Delong, B.4    McKenzie, D.5    Salamat, S.6    Aiken, J.M.7
  • 11
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E & Davies KJ (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29, 222–230.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 12
    • 1842636438 scopus 로고    scopus 로고
    • Ubiquitin expression is up-regulated in human and rat skeletal muscles during aging
    • Cai D, Lee KK, Li M, Tang MK & Chan KM (2004). Ubiquitin expression is up-regulated in human and rat skeletal muscles during aging. Arch Biochem Biophys 425, 42–50.
    • (2004) Arch Biochem Biophys , vol.425 , pp. 42-50
    • Cai, D.1    Lee, K.K.2    Li, M.3    Tang, M.K.4    Chan, K.M.5
  • 16
    • 84929580195 scopus 로고    scopus 로고
    • Mitochondria, muscle health, and exercise with advancing age
    • Carter HN, Chen CC & Hood DA (2015). Mitochondria, muscle health, and exercise with advancing age. Physiology (Bethesda) 30, 208–223.
    • (2015) Physiology (Bethesda) , vol.30 , pp. 208-223
    • Carter, H.N.1    Chen, C.C.2    Hood, D.A.3
  • 19
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H & Boveris A (1979). Hydroperoxide metabolism in mammalian organs. Physiol Rev 59, 527–605.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 26
    • 2642573579 scopus 로고    scopus 로고
    • Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
    • Collins LV, Hajizadeh S, Holme E, Jonsson IM & Tarkowski A (2004). Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol 75, 995–1000.
    • (2004) J Leukoc Biol , vol.75 , pp. 995-1000
    • Collins, L.V.1    Hajizadeh, S.2    Holme, E.3    Jonsson, I.M.4    Tarkowski, A.5
  • 27
    • 0034234773 scopus 로고    scopus 로고
    • Oxidative capacity and ageing in human muscle
    • Conley KE, Jubrias SA & Esselman PC (2000). Oxidative capacity and ageing in human muscle. J Physiol 526, 203–210.
    • (2000) J Physiol , vol.526 , pp. 203-210
    • Conley, K.E.1    Jubrias, S.A.2    Esselman, P.C.3
  • 28
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Cortopassi GA, Shibata D, Soong NW & Arnheim N (1992). A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 89, 7370–7374.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1    Shibata, D.2    Soong, N.W.3    Arnheim, N.4
  • 31
    • 84902759731 scopus 로고    scopus 로고
    • Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats
    • Crescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G & Iossa S (2014). Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats. BMC Geriatr 14, 79.
    • (2014) BMC Geriatr , vol.14 , pp. 79
    • Crescenzo, R.1    Bianco, F.2    Mazzoli, A.3    Giacco, A.4    Liverini, G.5    Iossa, S.6
  • 33
    • 84883055118 scopus 로고    scopus 로고
    • Isolated hearts treated with skeletal muscle homogenates exhibit altered function
    • Di Battista AP & Locke M (2013). Isolated hearts treated with skeletal muscle homogenates exhibit altered function. Cell Stress Chaperones 18, 675–681.
    • (2013) Cell Stress Chaperones , vol.18 , pp. 675-681
    • Di Battista, A.P.1    Locke, M.2
  • 34
    • 20344366079 scopus 로고    scopus 로고
    • Mitochondrial DNA and disease
    • Dimauro S & Davidzon G (2005). Mitochondrial DNA and disease. Ann Med 37, 222–232.
    • (2005) Ann Med , vol.37 , pp. 222-232
    • Dimauro, S.1    Davidzon, G.2
  • 37
    • 21244496302 scopus 로고    scopus 로고
    • Apoptosis in muscle atrophy: relevance to sarcopenia
    • Dupont-Versteegden EE (2005). Apoptosis in muscle atrophy: relevance to sarcopenia. Exp Gerontol 40, 473–481.
    • (2005) Exp Gerontol , vol.40 , pp. 473-481
    • Dupont-Versteegden, E.E.1
  • 41
    • 84870206960 scopus 로고    scopus 로고
    • Mitochondria: master regulators of danger signalling
    • Galluzzi L, Kepp O & Kroemer G (2012). Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol 13, 780–788.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 780-788
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 44
    • 5444223401 scopus 로고    scopus 로고
    • Oxidative stress and the mitochondrial theory of aging in human skeletal muscle
    • Gianni P, Jan KJ, Douglas MJ, Stuart PM & Tarnopolsky MA (2004). Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol 39, 1391–1400.
    • (2004) Exp Gerontol , vol.39 , pp. 1391-1400
    • Gianni, P.1    Jan, K.J.2    Douglas, M.J.3    Stuart, P.M.4    Tarnopolsky, M.A.5
  • 45
    • 80052078622 scopus 로고    scopus 로고
    • The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease
    • Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS & Nimmo MA (2011). The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 11, 607–615.
    • (2011) Nat Rev Immunol , vol.11 , pp. 607-615
    • Gleeson, M.1    Bishop, N.C.2    Stensel, D.J.3    Lindley, M.R.4    Mastana, S.S.5    Nimmo, M.A.6
  • 47
    • 50949115617 scopus 로고    scopus 로고
    • High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy
    • Gomes LC & Scorrano L (2008). High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta 1777, 860–866.
    • (2008) Biochim Biophys Acta , vol.1777 , pp. 860-866
    • Gomes, L.C.1    Scorrano, L.2
  • 49
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: biological insights and disease relevance
    • Haigis MC & Sinclair DA (2010). Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5, 253–295.
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 50
    • 0015319592 scopus 로고
    • The biologic clock: the mitochondria?
    • Harman D (1972). The biologic clock: the mitochondria? J Am Geriatr Soc 20, 145–147.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 51
    • 0031021864 scopus 로고    scopus 로고
    • Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study
    • Harris TB, Kiel D, Roubenoff R, Langlois J, Hannan M, Havlik R & Wilson P (1997). Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study. J Am Geriatr Soc 45, 133–139.
    • (1997) J Am Geriatr Soc , vol.45 , pp. 133-139
    • Harris, T.B.1    Kiel, D.2    Roubenoff, R.3    Langlois, J.4    Hannan, M.5    Havlik, R.6    Wilson, P.7
  • 53
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H, Kaisho T, Takeda K & Akira S (2003). The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 170, 3059–3064.
    • (2003) J Immunol , vol.170 , pp. 3059-3064
    • Hemmi, H.1    Kaisho, T.2    Takeda, K.3    Akira, S.4
  • 56
    • 0014198263 scopus 로고
    • Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle
    • Holloszy JO (1967). Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem 242, 2278–2282.
    • (1967) J Biol Chem , vol.242 , pp. 2278-2282
    • Holloszy, J.O.1
  • 57
    • 0035112481 scopus 로고    scopus 로고
    • Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle
    • Hood DA (2001). Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 90, 1137–1157.
    • (2001) J Appl Physiol , vol.90 , pp. 1137-1157
    • Hood, D.A.1
  • 58
    • 33947364369 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle
    • Hutter E, Skovbro M, Lener B, Prats C, Rabol R, Dela F & Jansen-Durr P (2007). Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6, 245–256.
    • (2007) Aging Cell , vol.6 , pp. 245-256
    • Hutter, E.1    Skovbro, M.2    Lener, B.3    Prats, C.4    Rabol, R.5    Dela, F.6    Jansen-Durr, P.7
  • 60
    • 84885175686 scopus 로고    scopus 로고
    • Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse
    • Iqbal S, Ostojic O, Singh K, Joseph AM & Hood DA (2013). Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse. Muscle Nerve 48, 963–970.
    • (2013) Muscle Nerve , vol.48 , pp. 963-970
    • Iqbal, S.1    Ostojic, O.2    Singh, K.3    Joseph, A.M.4    Hood, D.A.5
  • 62
    • 84864885324 scopus 로고    scopus 로고
    • Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise
    • &, a
    • Jamart C, Benoit N, Raymackers JM, Kim HJ, Kim CK & Francaux M (2012a). Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise. Eur J Appl Physiol 112, 3173–3177.
    • (2012) Eur J Appl Physiol , vol.112 , pp. 3173-3177
    • Jamart, C.1    Benoit, N.2    Raymackers, J.M.3    Kim, H.J.4    Kim, C.K.5    Francaux, M.6
  • 63
    • 84862082711 scopus 로고    scopus 로고
    • Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running
    • &, b
    • Jamart C, Francaux M, Millet GY, Deldicque L, Frere D & Feasson L (2012b). Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running. J Appl Physiol 112, 1529–1537.
    • (2012) J Appl Physiol , vol.112 , pp. 1529-1537
    • Jamart, C.1    Francaux, M.2    Millet, G.Y.3    Deldicque, L.4    Frere, D.5    Feasson, L.6
  • 64
    • 0035028427 scopus 로고    scopus 로고
    • Exercise at old age: does it increase or alleviate oxidative stress?
    • Ji LL (2001). Exercise at old age: does it increase or alleviate oxidative stress? Ann NY Acad Sci 928, 236–247.
    • (2001) Ann NY Acad Sci , vol.928 , pp. 236-247
    • Ji, L.L.1
  • 66
    • 85003475378 scopus 로고    scopus 로고
    • Chronically endurance-trained individuals preserve skeletal muscle mitochondrial gene expression with age but differences within age groups remain
    • &, b
    • Johnson ML, Lanza IR, Short DK, Asmann YW & Nair KS (2014b). Chronically endurance-trained individuals preserve skeletal muscle mitochondrial gene expression with age but differences within age groups remain. Physiol Rep 2, e12239.
    • (2014) Physiol Rep , vol.2
    • Johnson, M.L.1    Lanza, I.R.2    Short, D.K.3    Asmann, Y.W.4    Nair, K.S.5
  • 69
    • 0035059633 scopus 로고    scopus 로고
    • Large energetic adaptations of elderly muscle to resistance and endurance training
    • Jubrias SA, Esselman PC, Price LB, Cress ME & Conley KE (2001). Large energetic adaptations of elderly muscle to resistance and endurance training. J Appl Physiol 90, 1663–1670.
    • (2001) J Appl Physiol , vol.90 , pp. 1663-1670
    • Jubrias, S.A.1    Esselman, P.C.2    Price, L.B.3    Cress, M.E.4    Conley, K.E.5
  • 72
    • 84864033090 scopus 로고    scopus 로고
    • Autophagic response to a single bout of moderate exercise in murine skeletal muscle
    • Kim YA, Kim YS & Song W (2012). Autophagic response to a single bout of moderate exercise in murine skeletal muscle. J Physiol Biochem 68, 229–235.
    • (2012) J Physiol Biochem , vol.68 , pp. 229-235
    • Kim, Y.A.1    Kim, Y.S.2    Song, W.3
  • 76
    • 77955347446 scopus 로고    scopus 로고
    • Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis
    • Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F & Chang Y (2010). Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One 5, e11707.
    • (2010) PLoS One , vol.5
    • Kong, X.1    Wang, R.2    Xue, Y.3    Liu, X.4    Zhang, H.5    Chen, Y.6    Fang, F.7    Chang, Y.8
  • 77
    • 84884530383 scopus 로고    scopus 로고
    • Mitochondrial and skeletal muscle health with advancing age
    • Konopka AR & Nair KS (2013). Mitochondrial and skeletal muscle health with advancing age. Mol Cell Endocrinol 379, 19–29.
    • (2013) Mol Cell Endocrinol , vol.379 , pp. 19-29
    • Konopka, A.R.1    Nair, K.S.2
  • 78
    • 84898974238 scopus 로고    scopus 로고
    • Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training
    • Konopka AR, Suer MK, Wolff CA & Harber MP (2014). Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci 69, 371–378.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 371-378
    • Konopka, A.R.1    Suer, M.K.2    Wolff, C.A.3    Harber, M.P.4
  • 79
    • 0029890534 scopus 로고    scopus 로고
    • A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process
    • Kowald A & Kirkwood TB (1996). A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat Res 316, 209–236.
    • (1996) Mutat Res , vol.316 , pp. 209-236
    • Kowald, A.1    Kirkwood, T.B.2
  • 82
    • 84877922143 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutations and free radicals in disease and ageing
    • Lagouge M & Larsson NG (2013). The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med 273, 529–543.
    • (2013) J Intern Med , vol.273 , pp. 529-543
    • Lagouge, M.1    Larsson, N.G.2
  • 84
    • 53449090425 scopus 로고    scopus 로고
    • Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
    • Lambert CP, Wright NR, Finck BN & Villareal DT (2008). Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol 105, 473–478.
    • (2008) J Appl Physiol , vol.105 , pp. 473-478
    • Lambert, C.P.1    Wright, N.R.2    Finck, B.N.3    Villareal, D.T.4
  • 87
    • 39449100832 scopus 로고    scopus 로고
    • Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation
    • Leger B, Derave W, De Bock K, Hespel P & Russell AP (2008). Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res 11, 163–175B.
    • (2008) Rejuvenation Res , vol.11 , pp. 163-175B
    • Leger, B.1    Derave, W.2    De Bock, K.3    Hespel, P.4    Russell, A.P.5
  • 88
    • 0023856536 scopus 로고
    • What is the cause of the ageing atrophy? Total number, size and proportion of different fibre types studied in whole vastus lateralis muscle from 15- to 83-year-old men
    • Lexell J, Taylor CC & Sjostrom M (1988). What is the cause of the ageing atrophy? Total number, size and proportion of different fibre types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 84, 275–294.
    • (1988) J Neurol Sci , vol.84 , pp. 275-294
    • Lexell, J.1    Taylor, C.C.2    Sjostrom, M.3
  • 89
    • 0035811496 scopus 로고    scopus 로고
    • Endonuclease G is an apoptotic DNase when released from mitochondria
    • Li LY, Luo X & Wang X (2001). Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412, 95–99.
    • (2001) Nature , vol.412 , pp. 95-99
    • Li, L.Y.1    Luo, X.2    Wang, X.3
  • 90
    • 84885145785 scopus 로고    scopus 로고
    • Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance
    • Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL & Yan Z (2013). Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J 27, 4184–4193.
    • (2013) FASEB J , vol.27 , pp. 4184-4193
    • Lira, V.A.1    Okutsu, M.2    Zhang, M.3    Greene, N.P.4    Laker, R.C.5    Breen, D.S.6    Hoehn, K.L.7    Yan, Z.8
  • 93
    • 0026319184 scopus 로고
    • Inducible isoform of HSP70 is constitutively expressed in a muscle fibre type specific pattern
    • Locke M, Noble EG & Atkinson BG (1991). Inducible isoform of HSP70 is constitutively expressed in a muscle fibre type specific pattern. Am J Physiol Cell Physiol 261, C774–779.
    • (1991) Am J Physiol Cell Physiol , vol.261 , pp. C774-779
    • Locke, M.1    Noble, E.G.2    Atkinson, B.G.3
  • 94
    • 84874765168 scopus 로고    scopus 로고
    • Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signalling in aged rats
    • Luo L, Lu AM, Wang Y, Hong A, Chen Y, Hu J, Li X & Qin ZH (2013). Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signalling in aged rats. Exp Gerontol 48, 427–436.
    • (2013) Exp Gerontol , vol.48 , pp. 427-436
    • Luo, L.1    Lu, A.M.2    Wang, Y.3    Hong, A.4    Chen, Y.5    Hu, J.6    Li, X.7    Qin, Z.H.8
  • 96
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney DJ, Parise G, Melov S, Safdar A & Tarnopolsky MA (2005). Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J 19, 1498–1500.
    • (2005) FASEB J , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 100
    • 80053073959 scopus 로고    scopus 로고
    • Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2
    • Mathur S, Walley KR, Wang Y, Indrambarya T & Boyd JH (2011). Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2. Circ J 75, 2445–2452.
    • (2011) Circ J , vol.75 , pp. 2445-2452
    • Mathur, S.1    Walley, K.R.2    Wang, Y.3    Indrambarya, T.4    Boyd, J.H.5
  • 102
    • 84866244791 scopus 로고    scopus 로고
    • Autophagy in protein and organelle turnover
    • Mizushima N (2011). Autophagy in protein and organelle turnover. Cold Spring Harb Symp Quant Biol 76, 397–402.
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 397-402
    • Mizushima, N.1
  • 104
    • 0022208546 scopus 로고
    • Mitochondrial alterations in aged rat adrenal cortical cells
    • Murakoshi M, Osamura Y & Watanabe K (1985). Mitochondrial alterations in aged rat adrenal cortical cells. Tokai J Exp Clin Med 10, 531–536.
    • (1985) Tokai J Exp Clin Med , vol.10 , pp. 531-536
    • Murakoshi, M.1    Osamura, Y.2    Watanabe, K.3
  • 106
    • 36549002757 scopus 로고    scopus 로고
    • Giant mitochondria do not fuse and exchange their contents with normal mitochondria
    • Navratil M, Terman A & Arriaga EA (2008). Giant mitochondria do not fuse and exchange their contents with normal mitochondria. Exp Cell Res 314, 164–172.
    • (2008) Exp Cell Res , vol.314 , pp. 164-172
    • Navratil, M.1    Terman, A.2    Arriaga, E.A.3
  • 107
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura M & Naito S (2005). Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 28, 886–892.
    • (2005) Biol Pharm Bull , vol.28 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 110
    • 0037108799 scopus 로고    scopus 로고
    • SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
    • Onyango P, Celic I, McCaffery JM, Boeke JD & Feinberg AP (2002). SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci USA 99, 13653–13658.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13653-13658
    • Onyango, P.1    Celic, I.2    McCaffery, J.M.3    Boeke, J.D.4    Feinberg, A.P.5
  • 111
    • 84902546353 scopus 로고    scopus 로고
    • Autophagy and protein turnover signalling in slow-twitch muscle during exercise
    • Pagano AF, Py G, Bernardi H, Candau RB & Sanchez AM (2014). Autophagy and protein turnover signalling in slow-twitch muscle during exercise. Med Sci Sports Exerc 46, 1314–1325.
    • (2014) Med Sci Sports Exerc , vol.46 , pp. 1314-1325
    • Pagano, A.F.1    Py, G.2    Bernardi, H.3    Candau, R.B.4    Sanchez, A.M.5
  • 112
    • 0032820186 scopus 로고    scopus 로고
    • Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle
    • Pansarasa O, Bertorelli L, Vecchiet J, Felzani G & Marzatico F (1999). Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic Biol Med 27, 617–622.
    • (1999) Free Radic Biol Med , vol.27 , pp. 617-622
    • Pansarasa, O.1    Bertorelli, L.2    Vecchiet, J.3    Felzani, G.4    Marzatico, F.5
  • 113
    • 0345708253 scopus 로고    scopus 로고
    • Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space
    • Payne AM, Dodd SL & Leeuwenburgh C (2003). Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space. J Appl Physiol 95, 2554–2562.
    • (2003) J Appl Physiol , vol.95 , pp. 2554-2562
    • Payne, A.M.1    Dodd, S.L.2    Leeuwenburgh, C.3
  • 114
    • 0038137397 scopus 로고    scopus 로고
    • Possible beneficial role of exercise in modulating low-grade inflammation in the elderly
    • Pedersen BK & Bruunsgaard H (2003). Possible beneficial role of exercise in modulating low-grade inflammation in the elderly. Scand J Med Sci Sports 13, 56–62.
    • (2003) Scand J Med Sci Sports , vol.13 , pp. 56-62
    • Pedersen, B.K.1    Bruunsgaard, H.2
  • 115
    • 78649710608 scopus 로고    scopus 로고
    • Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle
    • Perry CG, Lally J, Holloway GP, Heigenhauser GJ, Bonen A & Spriet LL (2010). Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol 588, 4795–4810.
    • (2010) J Physiol , vol.588 , pp. 4795-4810
    • Perry, C.G.1    Lally, J.2    Holloway, G.P.3    Heigenhauser, G.J.4    Bonen, A.5    Spriet, L.L.6
  • 117
    • 84868277570 scopus 로고    scopus 로고
    • Skeletal muscle mitochondria and aging: a review
    • Peterson CM, Johannsen DL & Ravussin E (2012). Skeletal muscle mitochondria and aging: a review. J Aging Res 2012, 194821.
    • (2012) J Aging Res , vol.2012 , pp. 194821
    • Peterson, C.M.1    Johannsen, D.L.2    Ravussin, E.3
  • 118
    • 16344385647 scopus 로고    scopus 로고
    • Muscle fibre specific apoptosis and TNF-α signalling in sarcopenia are attenuated by life-long calorie restriction
    • Phillips T & Leeuwenburgh C (2005). Muscle fibre specific apoptosis and TNF-α signalling in sarcopenia are attenuated by life-long calorie restriction. FASEB J 19, 668–670.
    • (2005) FASEB J , vol.19 , pp. 668-670
    • Phillips, T.1    Leeuwenburgh, C.2
  • 122
    • 55949118714 scopus 로고    scopus 로고
    • Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    • Powers SK & Jackson MJ (2008). Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88, 1243–1276.
    • (2008) Physiol Rev , vol.88 , pp. 1243-1276
    • Powers, S.K.1    Jackson, M.J.2
  • 124
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator
    • Puigserver P & Spiegelman BM (2003). Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24, 78–90.
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 128
    • 0036452555 scopus 로고    scopus 로고
    • Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle
    • Radak Z, Naito H, Kaneko T, Tahara S, Nakamoto H, Takahashi R, Cardozo-Pelaez F & Goto S (2002). Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch 445, 273–278.
    • (2002) Pflugers Arch , vol.445 , pp. 273-278
    • Radak, Z.1    Naito, H.2    Kaneko, T.3    Tahara, S.4    Nakamoto, H.5    Takahashi, R.6    Cardozo-Pelaez, F.7    Goto, S.8
  • 129
    • 0042707789 scopus 로고    scopus 로고
    • Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria
    • Rasmussen UF, Krustrup P, Kjaer M & Rasmussen HN (2003). Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria. Exp Gerontol 38, 877–886.
    • (2003) Exp Gerontol , vol.38 , pp. 877-886
    • Rasmussen, U.F.1    Krustrup, P.2    Kjaer, M.3    Rasmussen, H.N.4
  • 131
    • 0042522866 scopus 로고    scopus 로고
    • The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging
    • Reuben DB, Judd-Hamilton L, Harris TB & Seeman TE (2003). The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging. J Am Geriatr Soc 51, 1125–1130.
    • (2003) J Am Geriatr Soc , vol.51 , pp. 1125-1130
    • Reuben, D.B.1    Judd-Hamilton, L.2    Harris, T.B.3    Seeman, T.E.4
  • 132
    • 0030451773 scopus 로고    scopus 로고
    • Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
    • Rooyackers OE, Adey DB, Ades PA & Nair KS (1996). Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci USA 93, 15364–15369.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15364-15369
    • Rooyackers, O.E.1    Adey, D.B.2    Ades, P.A.3    Nair, K.S.4
  • 135
    • 0014070709 scopus 로고
    • On the origin of mitosing cells
    • Sagan L (1967). On the origin of mitosing cells. J Theor Biol 14, 255–274.
    • (1967) J Theor Biol , vol.14 , pp. 255-274
    • Sagan, L.1
  • 136
    • 84893362301 scopus 로고    scopus 로고
    • p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise
    • Saleem A, Carter HN & Hood DA (2014). p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise. Am J Physiol Cell Physiol 306, C241–249.
    • (2014) Am J Physiol Cell Physiol , vol.306 , pp. C241-249
    • Saleem, A.1    Carter, H.N.2    Hood, D.A.3
  • 137
    • 0021368054 scopus 로고
    • Autophagic response to strenuous exercise in mouse skeletal muscle fibres
    • Salminen A & Vihko V (1984). Autophagic response to strenuous exercise in mouse skeletal muscle fibres. Virchows Arch B Cell Pathol Incl Mol Pathol 45, 97–106.
    • (1984) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.45 , pp. 97-106
    • Salminen, A.1    Vihko, V.2
  • 138
    • 84908080008 scopus 로고    scopus 로고
    • Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise
    • Sanchez AM, Bernardi H, Py G & Candau RB (2014). Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise. Am J Physiol Regul Integr Comp Physiol 307, R956–969.
    • (2014) Am J Physiol Regul Integr Comp Physiol , vol.307 , pp. R956-969
    • Sanchez, A.M.1    Bernardi, H.2    Py, G.3    Candau, R.B.4
  • 139
    • 84855532023 scopus 로고    scopus 로고
    • AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1
    • Sanchez AM, Csibi A, Raibon A, Cornille K, Gay S, Bernardi H & Candau R (2012). AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. J Cell Biochem 113, 695–710.
    • (2012) J Cell Biochem , vol.113 , pp. 695-710
    • Sanchez, A.M.1    Csibi, A.2    Raibon, A.3    Cornille, K.4    Gay, S.5    Bernardi, H.6    Candau, R.7
  • 140
    • 77950479450 scopus 로고    scopus 로고
    • Autophagy in skeletal muscle
    • Sandri M (2010). Autophagy in skeletal muscle. FEBS Lett 584, 1411–1416.
    • (2010) FEBS Lett , vol.584 , pp. 1411-1416
    • Sandri, M.1
  • 142
    • 77955351652 scopus 로고    scopus 로고
    • New insights into the role of mitochondria in aging: mitochondrial dynamics and more
    • Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP & Leeuwenburgh C (2010). New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123, 2533–2542.
    • (2010) J Cell Sci , vol.123 , pp. 2533-2542
    • Seo, A.Y.1    Joseph, A.M.2    Dutta, D.3    Hwang, J.C.4    Aris, J.P.5    Leeuwenburgh, C.6
  • 144
  • 146
    • 21644459286 scopus 로고    scopus 로고
    • Response of XIAP, ARC, and FLIP apoptotic suppressors to 8 wk of treadmill running in rat heart and skeletal muscle
    • Siu PM, Bryner RW, Murlasits Z & Alway SE (2005). Response of XIAP, ARC, and FLIP apoptotic suppressors to 8 wk of treadmill running in rat heart and skeletal muscle. J Appl Physiol 99, 204–209.
    • (2005) J Appl Physiol , vol.99 , pp. 204-209
    • Siu, P.M.1    Bryner, R.W.2    Murlasits, Z.3    Alway, S.E.4
  • 147
    • 33646697753 scopus 로고    scopus 로고
    • Exercise training attenuates age-induced changes in apoptotic signalling in rat skeletal muscle
    • Song W, Kwak HB & Lawler JM (2006). Exercise training attenuates age-induced changes in apoptotic signalling in rat skeletal muscle. Antioxid Redox Signal 8, 517–528.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 517-528
    • Song, W.1    Kwak, H.B.2    Lawler, J.M.3
  • 149
    • 0033546997 scopus 로고    scopus 로고
    • Urinary incontinence in the elderly and age-dependent apoptosis of rhabdosphincter cells
    • Strasser H, Tiefenthaler M, Steinlechner M, Bartsch G & Konwalinka G (1999). Urinary incontinence in the elderly and age-dependent apoptosis of rhabdosphincter cells. Lancet 354, 918–919.
    • (1999) Lancet , vol.354 , pp. 918-919
    • Strasser, H.1    Tiefenthaler, M.2    Steinlechner, M.3    Bartsch, G.4    Konwalinka, G.5
  • 151
    • 77953036663 scopus 로고    scopus 로고
    • Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury
    • Szczesny B, Tann AW & Mitra S (2010). Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mech Ageing Dev 131, 330–337.
    • (2010) Mech Ageing Dev , vol.131 , pp. 330-337
    • Szczesny, B.1    Tann, A.W.2    Mitra, S.3
  • 152
    • 84882675717 scopus 로고    scopus 로고
    • Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant
    • Talbert EE, Smuder AJ, Min K, Kwon OS, Szeto HH & Powers SK (2013). Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant. J Appl Physiol 115, 529–538.
    • (2013) J Appl Physiol , vol.115 , pp. 529-538
    • Talbert, E.E.1    Smuder, A.J.2    Min, K.3    Kwon, O.S.4    Szeto, H.H.5    Powers, S.K.6
  • 153
    • 0022952650 scopus 로고
    • Studies on giant mitochondria
    • Tandler B & Hoppel CL (1986). Studies on giant mitochondria. Ann NY Acad Sci 488, 65–81.
    • (1986) Ann NY Acad Sci , vol.488 , pp. 65-81
    • Tandler, B.1    Hoppel, C.L.2
  • 154
    • 76549095846 scopus 로고    scopus 로고
    • Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading
    • Thalacker-Mercer AE, Dell'Italia LJ, Cui X, Cross JM & Bamman MM (2010). Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading. Physiol Genomics 40, 141–149.
    • (2010) Physiol Genomics , vol.40 , pp. 141-149
    • Thalacker-Mercer, A.E.1    Dell'Italia, L.J.2    Cui, X.3    Cross, J.M.4    Bamman, M.M.5
  • 160
    • 79961076148 scopus 로고    scopus 로고
    • Consequences of sarcopenia
    • Visser M & Schaap LA (2011). Consequences of sarcopenia. Clin Geriatr Med 27, 387–399.
    • (2011) Clin Geriatr Med , vol.27 , pp. 387-399
    • Visser, M.1    Schaap, L.A.2
  • 161
    • 0035127889 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fibre atrophy, fibre splitting, and oxidative damage in sarcopenia
    • Wanagat J, Cao Z, Pathare P & Aiken JM (2001). Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fibre atrophy, fibre splitting, and oxidative damage in sarcopenia. FASEB J 15, 322–332.
    • (2001) FASEB J , vol.15 , pp. 322-332
    • Wanagat, J.1    Cao, Z.2    Pathare, P.3    Aiken, J.M.4
  • 162
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
    • Wenz T, Rossi SG, Rotundo RL, Spiegelman BM & Moraes CT (2009). Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 106, 20405–20410.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 163
    • 25644432770 scopus 로고    scopus 로고
    • Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age
    • Whitman SA, Wacker MJ, Richmond SR & Godard MP (2005). Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age. Pflugers Arch 450, 437–446.
    • (2005) Pflugers Arch , vol.450 , pp. 437-446
    • Whitman, S.A.1    Wacker, M.J.2    Richmond, S.R.3    Godard, M.P.4
  • 165
    • 75049085555 scopus 로고    scopus 로고
    • Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise
    • Wohlgemuth SE, Seo AY, Marzetti E, Lees HA & Leeuwenburgh C (2010). Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol 45, 138–148.
    • (2010) Exp Gerontol , vol.45 , pp. 138-148
    • Wohlgemuth, S.E.1    Seo, A.Y.2    Marzetti, E.3    Lees, H.A.4    Leeuwenburgh, C.5
  • 166
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes FM & Van Houten B (1997). Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 94, 514–519.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 167
    • 84862863393 scopus 로고    scopus 로고
    • Exercise training-induced regulation of mitochondrial quality
    • Yan Z, Lira VA & Greene NP (2012). Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev 40, 159–164.
    • (2012) Exerc Sport Sci Rev , vol.40 , pp. 159-164
    • Yan, Z.1    Lira, V.A.2    Greene, N.P.3
  • 168
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: molecular machinery for self-eating
    • Yorimitsu T & Klionsky DJ (2005). Autophagy: molecular machinery for self-eating. Cell Death Differ 12(Suppl 2), 1542–1552.
    • (2005) Cell Death Differ , vol.12 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 170
    • 0026532722 scopus 로고
    • Multiple mitochondrial DNA deletions in an elderly human individual
    • Zhang C, Baumer A, Maxwell RJ, Linnane AW & Nagley P (1992). Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 297, 34–38.
    • (1992) FEBS Lett , vol.297 , pp. 34-38
    • Zhang, C.1    Baumer, A.2    Maxwell, R.J.3    Linnane, A.W.4    Nagley, P.5
  • 172
    • 41449113346 scopus 로고    scopus 로고
    • Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor
    • Zhao J, Brault JJ, Schild A & Goldberg AL (2008). Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy 4, 378–380.
    • (2008) Autophagy , vol.4 , pp. 378-380
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Goldberg, A.L.4


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