Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 61, Issue 4, 2006, Pages 388-393

  McFarlin, Brian K ^a   Flynn, Michael G ^b   Campbell, Wayne W ^c   Craig, Bruce A ^d   Robinson, J Paul ^c   Stewart, Laura K ^b   Timmerman, Kyle L ^b   Coen, Paul M ^b  

^a UNIVERSITY OF HOUSTON   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CACHEXIA; CARDIOVASCULAR DISEASE; CHRONIC INFLAMMATION; CYTOKINE RELEASE; DAILY LIFE ACTIVITY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; FLOW CYTOMETRY; HUMAN; INFLAMMATION; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SCREENING; TREADMILL;

EID: 33646010308     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/61.4.388     Document Type: Article

References (19)

1. Bermudez EA, Rifai N, Buring J, Manson JE, Ridker PM. Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women. Arterioscler Thromb Vasc Biol. 2002;22:1668-1673.
2. Scheidt-Nave C, Bismar H, Leidig-Bruckner G, et al. Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopause. J Clin Endocrinol Metab. 2001;86:2032-2042.
3. Flynn MG, McFarlin BK, Phillips MD, Stewart LK, Timmerman KL. Toll-like receptor 4 and CD14 mRNA expression are lower in resistive exercise trained, elderly women. J Appl Physiol. 2003;95:1833-1842.
4. McFarlin BK, Flynn MG, Campbell WW, Stewart LK, Timmerman KL. TLR4 is lower in resistance-trained older women and related to inflammatory cytokines. Med Sci Sports Exerc. 2004;36:1876-1883.
5. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA. 1999;281:1722-1727.
6. Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol Med Sci. 2000;55A:M709-M715.
7. Cesari M, Penninx BS, Pahor M, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol Biol Sci Med Sci. 2004;59A:242-248.
8. Pedersen BK, Bruunsgaard H, Ostrowski K, et al. Cytokines in aging and exercise. Int J Sports Med. 2000;21 Suppl 1:S4-S9.
9. Reuben DB, Judd-Hamilton L, Harris TB, Seeman TE. The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging. J Am Geriatr Soc. 2003;51:1125-1130.
10. Gielen S, Adams V, Mobius-Winkler S, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003;42:861-868.
11. Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J. 2001;15:475-482.
12. Kalis C, Kanzler B, Lembo A, Poltorak A, Galanos C, Freudenberg MA. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur J Immunol. 2003;33:798-805.
13. Wang PL, Oido-Mori M, Fujii T, et al. Heterogeneous expression of Toll-like receptor 4 and downregulation of Toll-like receptor 4 expression on human gingival fibroblasts by Porphyromonas gingivalis lipopolysaccharide. Biochem Biophys Res Commun. 2001;288:863-867.
14. Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, et al. Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. J Immunol. 2005;175:3594-3602.
15. Paffenbarger RS Jr, Blair SN, Lee IM, Hyde RT. Measurement of physical activity to assess health effects in free-living populations. Med Sci Sports Exerc. 1993;25:60-70.
16. American College of Sports Medicine, Whaley MH, Brubaker PH, Otto RM, Armstrong LE. ACSM's Guidelines for Exercise Testing and Prescription. 7th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2005.
17. Harris JA, Benedict FG. A biometric study of basal metabolism in man. 1919; Camegie Institute of Washington Publication No. 279.
18. McFarlin BK, Flynn MG, Stewart LK, Timmerman KL. Carbohydrate intake during endurance exercise increases natural killer cell responsiveness to IL-2. J Appl Physiol. 2004;96:271-275.
19. McGeer PL, McGeer EG. Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci. 2004;1035:104-116.