Marathon running alters the DNA base excision repair in human skeletal muscle

Life Sciences

Volumn 72, Issue 14, 2003, Pages 1627-1633

  Radák, Zsolt ^a   Apor, Peter ^b   Pucsok, Jozsef ^c   Berkes, Istvan ^c   Ogonovszky, Helga ^a   Pavlik, Gabor ^a   Nakamoto, Hideko ^d   Goto, Sataro ^d  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Pediatric Institute Svábhegy Szabadsághegy   (Hungary)

^c Research Dept   (Hungary)

^d TOHO UNIVERSITY   (Japan)

Author keywords

Adaptation; Base excision repair; DNA damage; DNA repair; Exercise; Oxidative stress

Indexed keywords

8 HYDROXYGUANINE; DNA BASE; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; EXCISION REPAIR; EXERCISE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MARATHON RUNNER; SEQUENCE HOMOLOGY; SKELETAL MUSCLE; TISSUE LEVEL;

MAMMALIA;

EID: 0037458406     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02476-1     Document Type: Article

References (26)

1. Hoeijmakers J.H.J. Genome maintenance mechanisms for preventing cancer. Nature. 411:2001;366-374.
2. Atamna H., Cheung I., Ames B.N. A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A. 97:2000;686-691.
3. Radicella J.P., Dherin C., Desmaze C., Fox M.S., Boiteux S. Cloning and characterization of hOGG1 gene of saccharomyces cerevisiae. Proc Natl Acad Sci USA. 94:1997;8010-8015.
4. Aspinwall R., Rothwell D.G., Roldan-Arjona T., Anselmino C., Ward C.J., Cheadle J.P., Sampson J.R., Lindahl T., Harris P.C., Hickson I.D. Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. Proc Natl Acad Sci USA. 94:1997;109-114.
5. Moller P., Loft S., Lundby C., Olsen N.V. Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans. FASEB J. 15:2001;1181-1186.
6. Poulsen H.E., Loft S., Vistisen K. Extreme exercise and oxidative DNA modification. J Sports Sci. 14:1996;343-346.
7. Radak Z., Pucsok J., Mecseki S., Csont T., Ferdinandy P. Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle. Free Radic Biol Med. 26:1999;1059-1063.
8. Radak Z., Taylor A.W., Ohno H., Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immun Rev. 7:2001;90-107.
9. Niess A.M., Hartmann A., Grunert-Fuchs M., Poch B., Speit G. DNA damage after exhaustive treadmill running in trained and untrained men. Int J Sports Med. 17:1996;397-403.
10. Niess A.M., Baumann M., Roecker K., Horstmann T., Mayer F., Dickhuth H.H. Effects of intensive endurance exercise on DNA damage in leucocytes. J Sports Med Phys Fitness. 38:1998;111-1115.
11. Radak Z., Kaneko T., Tahara S., Nakamoto H., Ohno H., Sasvari M., Nyakas C., Goto S. The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle: evidence for beneficial outcomes. Free Radic Biol Med. 27:1999;69-74.
12. Kim H.N., Morimoto Y., Tsuda T., Ootsuyama Y., Hirohashi M., Hirano T., Tanaka I., Lim Y., Yun I.G., Kasai H. Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos. Carcinogenesis. 22:2001;265-269.
13. Cardozo-Pelaez F., Brooks P.J., Stedeford T., Song S., Sanchez-Ramos J. DNA damage, repair, and antioxidant systems in brain regions: a correlative study. Free Radic Biol Med. 28:2000;779-785.
14. Stecca C., Gerber G.B. Adaptive response to DNA-damaging agents. Biochem Pharmacol. 55:1998;941-951.
15. Rosenquist T.A., Zharkov D.O., Grollman A.P. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci U S A. 94:1997;7429-7434.
16. Floyd R.A. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 11:1990;1447-1450.
17. Grollman A.P., Moriya M. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9:1993;246-249.
18. Asami S., Hirano T., Yamaguchi R., Itoh H., Kasai H. Reduction of 8-hydroxyguanine in human leukocyte DNA by physical exercise. Free Radic Res. 29:1998;581-585.
19. Nakamura J., Swenberg J.A. Endogenous apurinic/apyrimidic sites in genomic DNA of mammalian tissues. Cancer Res. 59:1999;2522-2526.
20. Srivastava D.K., Berg B.J., Prasad R., Molina J.T., Beard W.A., Tomkinson A.E., Wilson S.H. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. J. Biol. Chem. 273:1998;21203-21209.
21. Wallace S.S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat Res. 150:1998;S60-S79.
22. Lindahl T. Keynote: past, present, and future aspects of base excision repair. Prog Nucleic Acid Res. Mol. Biol. 68:2001;xvii-xxx.
23. Loeb L.A. Apurinic sites as mutagenic intermediates. Cell. 40:1985;483-484.
24. Kingma P.S., Osheroff N. Apurinic sites are position-specific topoisomerase II poisons. J. Biol. Chem. 272:1997;1148-1155.
25. Glassner B.J., Rasmussen L.J., Najarian M.T., Posnick L.M., Samson L.D. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair. Proc Natl Acad Sci U SA. 95:1998;9997-10002.
26. Matsumoto Y., Zhang Q.-M., Takao M., Yasui A., Yone S. Escherichia Coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxguanine/guanine mispairs in DNA. Nucl. Acid Res. 29:2001;1975-1981.