Stabilization of proteins in solid form

Advanced Drug Delivery Reviews

Volumn 93, Issue , 2015, Pages 14-24

  Cicerone, Marcus T ^a,b   Pikal, Michael J ^c   Qian, Ken K ^a  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b University of Maryland   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Aggregation; Dynamic stabilization; Lyophilization; Protein stability; Water substitution

Indexed keywords

AGGLOMERATION; PROTEINS; STABILITY;

ACTIVE PROTEINS; BIOPHARMACEUTICAL PRODUCTS; DEGRADATION PROCESS; DELIVERY VEHICLE; DYNAMIC STABILIZATION; LYOPHILIZATION; PHYSICAL PRINCIPLES; PROTEIN STABILITY;

STABILIZATION;

PROTEIN; DELAYED RELEASE FORMULATION; HYDROBROMIC ACID;

DRUG SOLUBILITY; DRUG STABILITY; ENCAPSULATION; FREEZE DRYING; HYDROGEN BOND; IMMUNOGENICITY; PH; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; REVIEW; SURFACE AREA; THERMODYNAMICS; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; HUMAN; IMMUNOLOGY; MEDICINAL CHEMISTRY; PROCEDURES;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HUMANS; HYDROBROMIC ACID; PROTEINS;

EID: 84945487899     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2015.05.006     Document Type: Review

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