The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody

Pharmaceutical Research

Volumn 14, Issue 5, 1997, Pages 596-600

  Duddu, Sarma P ^a   Zhang, Guangzhong ^b   Dal Monte, Paul R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Fragility of glasses; Molecular mobility below glass transition; Protein aggregation; Sucrose; Trehalose; Vogel Tamman Fulcher (VTF) equation

Indexed keywords

CHIMERIC ANTIBODY; MONOCLONAL ANTIBODY; SUCROSE; TREHALOSE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; ENTHALPY; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN AGGREGATION; RELAXATION TIME; SPECTROSCOPY; STORAGE; TEMPERATURE;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; PROTEINS; SUCROSE; TEMPERATURE; THERMODYNAMICS; TREHALOSE;

EID: 0031006531     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012196826905     Document Type: Article

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