Evidence of partial unfolding of proteins at the ice/freeze-concentrate interface by infrared microscopy

Journal of Pharmaceutical Sciences

Volumn 98, Issue 9, 2009, Pages 3239-3246

  Schwegman, J Jeff ^a,c   Carpenter, John F ^b   Nail, Steven L ^a,d  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c AB BioTechnologies LLC   (United States)

^d Baxter Pharmaceutical Solutions LLC   (United States)

Author keywords

Biophysical characterization; Formulation; Freeze drying; FTIR; Immunoglobulin G; Lactate dehydrogenase; Polysorbate; Protein denaturation; Surfactants

Indexed keywords

IMMUNOGLOBULIN G; LACTATE DEHYDROGENASE; POLYSORBATE 80; SURFACTANT;

ARTICLE; BETA SHEET; CRYSTAL; DRUG FORMULATION; FREEZE DRYING; INFRARED SPECTROSCOPY; PROTEIN AGGREGATION; PROTEIN FOLDING; SURFACE PROPERTY;

EID: 68949128705     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21843     Document Type: Article

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