Solid state chemistry of proteins: II. The correlation of storage stability of freeze-dried human growth hormone (hGH) with structure and dynamics in the glassy solid

Journal of Pharmaceutical Sciences

Volumn 97, Issue 12, 2008, Pages 5106-5121

  Pikal, Michael J ^a,b   Rigsbee, Daniel ^b   Roy, Michael L ^b   Galreath, Dawn ^b   Kovach, Karl J ^b   Wang, Bingquan ^a   Carpenter, John F ^c   Cicerone, Marcus T ^d  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

Fast dynamics; Freeze drying; Glass transition temperature; Human growth hormone; Protein stability; Protein stability and secondary structure; Structural relaxation time

Indexed keywords

DISACCHARIDE; HUMAN GROWTH HORMONE; SUCROSE; TREHALOSE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; NEUTRON SCATTERING; PROTEIN SECONDARY STRUCTURE; SOLID STATE; STORAGE TEMPERATURE;

EID: 57349122408     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21374     Document Type: Article

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