Chemical stability of amorphous materials: Specific and general media effects in the role of water in the degradation of freeze-dried zoniporide

Journal of Pharmaceutical Sciences

Volumn 101, Issue 9, 2012, Pages 3110-3123

  Luthra, Suman A ^a,b,d   Shalaev, Evgenyi Y ^b   Medek, Ales ^c   Hong, Jinyang ^b   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b PFIZER INC   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Amorphous; Calorimetry (DSC); Dielectric constant; Global mobility; Hydrolysis; Kinetics; Local mobility; Plasticization; Solid state NMR; Stability

Indexed keywords

ORGANIC SOLVENT; PLASTICIZER; SODIUM CHLORIDE; SORBITOL; SUCROSE; WATER; ZONIPORIDE;

ACIDITY; AMPLITUDE MODULATION; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSE REFLECTANCE SPECTROSCOPY; DRUG DEGRADATION; DRUG FORMULATION; DRUG POTENCY; DRUG PURITY; DRUG STABILITY; EQUILIBRIUM CONSTANT; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; HYDROLYSIS; ISOTHERMAL MICROCALORIMETRY; LYOPHILISATE; MICROCALORIMETRY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLID; SOLID STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAVIOLET VISIBLE DIFFUSE REFLECTANCE SPECTROSCOPY;

EID: 84864047265     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23128     Document Type: Article

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