Is the pre-Tg DSC endotherm observed with solid state proteins associated with the protein internal dynamics? Investigation of bovine serum albumin by solid state hydrogen/deuterium exchange

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V

Volumn 85, Issue 2, 2013, Pages 170-176

  Mizuno, Masayasu ^a   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Amorphous; DSC; Freeze drying lyophilization; FTIR; Glass transition; Protein formulation; Protein internal dynamics; Solid state H D exchange

Indexed keywords

BOVINE SERUM ALBUMIN; DEUTERIUM; GLASS; HYDROGEN;

ANIMAL; BOVINAE; CHEMISTRY; FREEZE DRYING; MEDICINAL CHEMISTRY; PROCEDURES; TRANSITION TEMPERATURE;

ANIMALS; CATTLE; CHEMISTRY, PHARMACEUTICAL; DEUTERIUM; FREEZE DRYING; GLASS; HYDROGEN; SERUM ALBUMIN, BOVINE; TRANSITION TEMPERATURE;

EID: 84899774581     PISSN: None     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.04.019     Document Type: Article

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