A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Journal of Pharmaceutical Sciences

Volumn 90, Issue 3, 2001, Pages 310-321

  Cleland, Jeffrey L ^a   Lam, Xanthe ^a   Kendrick, Brent ^b   Yang, Janet ^a   Yang, Tzung Horng ^c   Overcashier, David ^a   Brooks, Dennis ^a   Hsu, Chung ^a   Carpenter, John F ^c  

^a GENENTECH INC   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Aggregation; Lyophilization; Monoclonal antibody; Protein stability; Sugars

Indexed keywords

M PROTEIN; MANNITOL; MONOCLONAL ANTIBODY; SUCROSE; TREHALOSE;

ARTICLE; DEAMINATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; INFRARED SPECTROSCOPY; OXIDATION; PROTEIN AGGREGATION; PROTEIN DENATURATION; SHELF LIFE;

EID: 0035096123     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200103)90:3<310::AID-JPS6>3.0.CO;2-R     Document Type: Article

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