Effects of excipients on protein conformation in lyophilized solids by hydrogen/deuterium exchange mass spectrometry

Pharmaceutical Research

Volumn 25, Issue 2, 2008, Pages 259-267

  Li, Yunsong ^a   Williams, Todd D ^a   Topp, Elizabeth M ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

ESI mass spectrometry; Excipient; FTIR; Hydrogen deuterium exchange; Lyophilization; Protein

Indexed keywords

CALMODULIN; DEXTRAN 12000; DEXTRAN 5000; EXCIPIENT; GUANIDINE; MANNITOL; RAFFINOSE; SUCROSE; UNCLASSIFIED DRUG;

ADSORPTION; ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; DEUTERIUM HYDROGEN EXCHANGE; DIFFERENTIAL SCANNING CALORIMETRY; DIGESTION; ELECTROSPRAY MASS SPECTROMETRY; FREEZE DRYING; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SOLID; WATER VAPOR; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; CHEMISTRY, PHARMACEUTICAL; DEUTERIUM; EXCIPIENTS; FREEZE DRYING; HYDROGEN; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 39149141888     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9365-6     Document Type: Article

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