Keratinocyte growth factor is required for hair development but not for wound healing

Genes and Development

Volumn 10, Issue 2, 1996, Pages 165-175

  Guo, Lifei ^a   Degenstein, Linda ^a   Fuchs, Elaine ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

epidermis; gene knockout; hair; KGF; TGF ; wound healing

Indexed keywords

KERATINOCYTE GROWTH FACTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 2; CONTROLLED STUDY; EMBRYO; EPIDERMIS; GENE MUTATION; HAIR FOLLICLE; HAIR GROWTH; HAIR ROOT; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; STEM CELL; WOUND HEALING;

ANIMALIA;

EID: 0030028984     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.2.165     Document Type: Article

References (44)

1. Alarid, E.T., J.S. Rubin, P. Young, M. Chedid, D. Ron, S.A. Aaronson, and G.R. Cunha. 1994. Keratinocyte growth factor functions in epithelial induction during seminal vesicle development. Proc. Natl. Acad. Sci. 91: 1074-1078.
2. Barrandon, Y. and H. Green. 1987. Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-alpha and epidermal growth factor. Cell 50: 1131-1137.
3. Brauchle, M., R. Fassler, and S. Werner. 1995. Suppression of keratinocyte growth factor expression by glucorcorticoids in vitro and during wound-healing. J. Invest. Dermatol. 105: 579-584.
4. Clark, R.A.F. 1985. Cutaneous tissue repair. Basic biologic considerations. J. Am. Acad. Dermatol. 13: 701-710.
5. Culig, Z., A. Hobixch, M.V. Cronauer, C. Radmayr, J. Trapman, A. Hittmair, G. Bartxch, and H. Klocker. 1994. Androgen receptor activation in prostatic tumor cell lines by indulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 54: 5474-5478.
6. Dry, F.W. 1926. The coat of the mouse (Mus musculus). J. Genet. 16: 287-340.
7. Falconer, D.S. and G.D. Snell. 1953. Two new hair mutants: rough and frizzy. J. Hered. 43: 53-57.
8. Finch, P.W., J.S. Rubin, T. Miki, D. Ron, and S.A. Aaronson. 1989. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245: 752-755.
9. Finch, P.W., G.R. Cunha, J.S. Rubin, J. Wong, and D. Ron. 1995. Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions. Dev. Dynam. 203: 223-240.
10. Greenhalgh, D.G., K.H. Sprugel, M.J. Murray, and R. Ross. 1990. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am. J. Pathol. 136: 1235-1246.
11. Guo, L., Q.-C. Yu, and E. Fuchs. 1993. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J. 12: 973-986.
12. Hebert, J., T. Rosenquist, J. Gotz, and G. Martin. 1994. FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations. Cell 78: 1017-1025.
13. Housley, R., C.F. Morris, W. Boyle, B. Ring, R. Biltz, J.E. Tarpley, S. Aukerman, P.L. Devine, R.H. Whitehead, and G.F. Pierce. 1994. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J. Clin. Invest. 94: 1764-1777.
14. Johnson, D.E. and L.T. Williams. 1993. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60: 1-41.
15. Kelley, M.J., M. Pech, H. Seuanez, J. Rubin, S. O'Brien, and S.A. Aaronson. 1992. Emergence of the keratinocyte growth factor multigene family during the great ape radiation. Proc. Natl. Acad. Sci. 89: 9287-9291.
16. Liang, T., S. Hoyer, R. Yu, K. Soltani, A. Lorincz, R.A. Hiipakka, and S. Liao. 1993. Immunocytochemical localization of androgen receptors in human skin using monoclonal antibodies against the androgen receptor. Soc. Invest. Dermatol. 100: 663-666.
17. Luetteke, N.C., T.H. Liu, R.L. Peiffer, P. Oliver, O. Smithies, and D.C. Lee. 1993. TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73: 263-278.
18. Lyon, M.F. and S.G. Hawkes. 1972. X-linked gene for testicular feminization in the mouse. Nature 227: 1217-1219.
19. Mann, G.B., K.J Fowler, A. Babriel, E.C. Nice, R.L. Williams, and A.R. Dunn. 1993. Mice with a null mutation of the TGFα gene have abnormal architecture, wavy, and curly whiskers and often develop corneal inflammation. Cell 73: 249-261.
20. Mason, I.J., F. Fuller-Pace, R. Smith, and C. Dickson. 1994. FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions. Mech. Dev. 45: 15-30.
21. Mattei, M.-G., O. deLapeyriere, J. Bresnick, C. Dickson, D. Birnbaum, and I. Mason. 1995. Mouse FGF7 (fibroblast growth factor 7) and FGF8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. Mamm. Genet. 6: 196-197.
22. Miettien, P.J., J.E. Berger, J. Meneses, Y. Phung, R.A. Pedersen, Z. Werb, and R. Derynck. 1995. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376: 337-341.
23. Miki, T., T.P. Fleming, D.P. Bottaro, J.S. Rubin, D. Ron, and S.A. Aaronson. 1991. Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 251: 72-75.
24. Miki, T., D.P. Bottaro, T.P. Fleming, D.L. Smith, W.H. Burgess, A.M.-L. Chan, and S.A. Aaronson 1992. Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene. Proc. Natl. Acad. Sci. 89: 246-250.
25. Mohn, M.P. 1958. The effects of different hormonal states on the growth of hair in rats. In The biology of hair growth (ed. William Montagna and Richard Ellis), pp. 335-398. Academic Press, New York, NY.
26. Panos, R.S., J.S. Rubin, S.A. Aaronson, and R.J. Mason. 1993. Keratinocyte growth factor and hepatocyte growth factor/ scatter factor are heparin-binding growth factors for alveolar type II cells and fibroblast-conditioned medium. J. Clin. Invest. 92: 969-977.
27. Pierce, G.F., T.A. Mustoe, R.M. Senior, J. Reed, G.L. Griffin, A. Thomason, and T.F. Deuel. 1988. In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins. J. Exp. Med. 167: 974-987.
28. Pierce, G.F., J.E. Tarpley, R.M. Allman, P.S. Goode, C.M. Serdar, B. Morris, T.A. Mustoe, and J. Vande Berg. 1994. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB. Am. J. Pathol. 145: 1399-1410.
29. Rappolee, D.A., D. Mark, M.J. Banda, and Z. Werb. 1988. Wound macrophage express TGF-α and other growth factors in vivo: Analysis by mRNA phenotyping. Science 241: 708-712.
30. Rheinwald, J.G. and H. Green. 1975. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 6: 331-343.
31. Ron, D., D.P. Bottaro, P.W. Finch, D. Moms, J.S. Rubin, and S.A. Aaronson. 1993. Expression of biologically active recombinant keratinocyte growth factor. J. Biol. Chem. 268: 2984-2988.
32. Rosenquist, T.A. and G.R. Martin. 1996. FGF signalling in the hair growth cycle: Expression of the FGF receptor and ligand genes in the murine hair follicle Dev. Dynam. 205: in press).
33. Rubin, J.S., H. Osada, P.W. Finch, W.G. Taylor, S. Rudikoff, and S.A. Aaronson. 1989. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc. Natl. Acad. Sci. 86: 802-806.
34. Schultz, G.S., M. White, R. Mitchell, G. Brown, J. Lynch, D.R. Twardzik, and G.J. Todaro. 1987. Epithelial wound healing enhanced by transforming growth factor-α and vaccinia growth factor. Science 235: 350-352.
35. Sibilia, M. and E. Wagner. 1995. Strain-dependent epithelial defects in mice lacking the EGF receptor. 1995. Science 269: 234-238.
36. Siracusa, L.D. and C.M. Abbott. 1994. Chromosome 2. Mamm. Genet. 5: S22-S39.
37. Staiano-Coico, L., J.G. Krueger, J.S. Rubin, S. D'limi, V.P. Vallat, L. Valentino, T. Fahey III, G. Hawes, G. Kingston, M.R. Madden, M. Mathwich, A.B. Gottlieb, and S.A. Aaronson. 1993. Human keratinocyte growth factor effects in a porcine model of epidermal wound healing. J. Exp. Med. 178: 865-878.
38. Threadgill, D.W., A.A. Dlugosz, L.A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, R.C. Harris, J.A. Barnard, S.H. Yuspa, R.J. Coffey, and T. Magnuson. 1995. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269: 230-234.
39. Ulich, T., E.S. Yi, K. Longmuir, S. Yin, R. Blitz, C.F. Morris, R.M Housley, and G.F. Pierce. 1994. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J. Clin. Invest. 93: 1298-1306.
40. Vassar, R. and E Fuchs. 1991. Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation. Genes & Dev. 5: 714-727.
41. Werner, S., K.G. Peters, M.T. Longaker, F. Fuller-Pace, M.J. Banda, and L.T. Williams. 1992. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc. Natl. Acad. Sci. 89: 6896-6900.
42. Werner, S., H. Smola, X. Liao, M.T. Longaker, T. Krieg, P.H. Hofschneider, and L.T. Williams. 1994. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 266: 819-822.
43. Yan, G., Y. Fukabori, S. Nikolaropoulos, F. Wang, and W.L. McKeehan. 1992. Heparin-binding keratinocyte growth factor is a candidate stromal to epithelial cell andromedin. Mol. Endocrinol. 6: 2123-2128.
44. Yi, E.S., S. Yin, D.L. Harclerode, A. Bedoya, N.B. Bikhazi, R. Housley, S.L. Aukerman, C.F. Murris, G.F. Pierce, and T.R. Ulich. 1994. Keratinocyte growth factor induces pancreatic ductal epithelial proliferation. Am. J. Pathoi. 145: 80-85.