Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Cytokine and Growth Factor Reviews

Volumn 16, Issue 2 SPEC. ISS., 2005, Pages 159-178

  Presta, Marco ^a   Dell'Era, Patrizia ^a   Mitola, Stefania ^a   Moroni, Emanuela ^a   Ronca, Roberto ^a   Rusnati, Marco ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Angiogenesis; Endothelium; FGF; FGF receptors; Tumor

Indexed keywords

ALPHA 2 MACROGLOBULIN; CYTOKINE; FIBRINOGEN; FIBROBLAST GROWTH FACTOR; GANGLIOSIDE; HEPARIN; PENTRAXIN; RECOMBINANT FIBROBLAST GROWTH FACTOR; THROMBOSPONDIN 1;

ANGIOGENESIS; CELL PROLIFERATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HEART MUSCLE ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; TUMOR VASCULARIZATION;

EID: 18144364350     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2005.01.004     Document Type: Article

References (254)

1. P. Carmeliet, and R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249 257
2. D. Hanahan, and J. Folkman Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 1996 353 364
3. J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other disease Nat Med 1 1995 27 31
4. P. Carmeliet Mechanisms of angiogenesis and arteriogenesis Nat Med 6 2000 389 395
5. J. Folkman, E. Merler, C. Abernathy, and G. Williams Isolation of a tumor factor responsible or angiogenesis J Exp Med 133 1971 275 288
6. Y. Shing, J. Folkman, R. Sullivan, C. Butterfield, J. Murray, and M. Klagsbrun Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor Science 223 1984 1296 1299
7. T. Maciag, T. Mehlman, R. Friesel, and A.B. Schreiber Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain Science 225 1984 932 935
8. N. Itoh, and D.M. Ornitz Evolution of the Fgf and Fgfr gene families Trends Genet 20 2004 563 569
9. M. Bastaki, E.E. Nelli, P. Dell'Era, M. Rusnati, M.P. Molinari-Tosatti, and S. Parolini Basic fibroblast growth factor-induced angiogenic phenotype in mouse endothelium. A study of aortic and microvascular endothelial cell lines Arterioscler Thromb Vasc Biol 17 1997 454 464
10. S. Javerzat, P. Auguste, and A. Bikfalvi The role of fibroblast growth factors in vascular development Trends Mol Med 8 2002 483 489
11. P. Dell'Era, M. Belleri, H. Stabile, M.L. Massardi, D. Ribatti, and M. Presta Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells Oncogene 20 2001 2655 2663
12. R.L. Nachman, and E.A. Jaffe Endothelial cell culture: beginnings of modern vascular biology J Clin Invest 114 1973 1037 1040
13. C. Garlanda, and E. Dejana Heterogeneity of endothelial cells. Specific markers Arterioscler Thromb Vasc Biol 17 1997 1193 1202
14. S.A. McCarthy, I. Kuzu, K.C. Gatter, and R. Bicknell Heterogeneity of the endothelial cell and its role in organ preference of tumour metastasis Trends Pharmacol Sci 12 1991 462 467
15. J.T. Chi, H.Y. Chang, G. Haraldsen, F.L. Jahnsen, O.G. Troyanskaya, and D.S. Chang Endothelial cell diversity revealed by global expression profiling Proc Natl Acad Sci USA 100 2003 10623 10628
16. M.J. Cross, and L. Claesson-Welsh FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition Trends Pharmacol Sci 22 2001 201 207
17. M.M. Mattila, J.K. Ruohola, E.M. Valve, M.J. Tasanen, J.A. Seppanen, and P.L. Harkonen FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells Oncogene 20 2001 2791 2804
18. M. Presta, L. Tiberio, M. Rusnati, P. Dell'Era, and G. Ragnotti Basic fibroblast growth factor requires a long-lasting activation of protein kinase C to induce cell proliferation in transformed fetal bovine aortic endothelial cells Cell Regul 2 1991 719 726
19. P. Dell'Era, M. Mohammadi, and M. Presta Different tyrosine autophosphorylation requirements in fibroblast growth factor receptor-1 mediate urokinase-type plasminogen activator induction and mitogenesis Mol Biol Cell 10 1999 23 33
20. L.A. Liotta, P.S. Steeg, and W.G. Stetler-Stevenson Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation Cell 64 1991 327 336
21. N. Hiraoka, E. Allen, I.J. Apel, M.R. Gyetko, and S.J. Weiss Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins Cell 95 1998 365 377
22. P. Mignatti, and D.B. Rifkin Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology Adv Cancer Res 78 2000 103 157
23. T. Kaneko, S. Fujii, A. Matsumoto, D. Goto, N. Ishimori, and K. Watano Induction of plasminogen activator inhibitor-1 in endothelial cells by basic fibroblast growth factor and its modulation by fibric acid Arterioscler Thromb Vasc Biol 22 2002 855 860
24. B.A. Konkle, P.R. Kollros, and M.D. Kelly Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C-mediated pathways J Biol Chem 265 1990 21867 21873
25. M.S. Pepper, A.P. Sappino, R. Montesano, L. Orci, and J.D. Vassalli Plasminogen activator inhibitor-1 is induced in migrating endothelial cells J Cell Physiol 153 1992 129 139
26. G. Taraboletti, S. D'Ascenzo, P. Borsotti, R. Giavazzi, A. Pavan, and V. Dolo Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells Am J Pathol 160 2002 673 680
27. V.P. Terranova, R. DiFlorio, R.M. Lyall, S. Hic, R. Friesel, and T. Maciag Human endothelial cells are chemotactic to endothelial cell growth factor and heparin J Cell Biol 101 1985 2330 2334
28. C.L. Stokes, M.A. Rupnick, S.K. Williams, and D.A. Lauffenburger Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor Lab Invest 63 1990 657 668
29. P. Gillis, U. Savla, O.V. Volpert, B. Jimenez, C.M. Waters, and R.J. Panos Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function J Cell Sci 112 Pt 12 1999 2049 2057
30. T. Shono, H. Kanetake, and S. Kanda The role of mitogen-activated protein kinase activation within focal adhesions in chemotaxis toward FGF-2 by murine brain capillary endothelial cells Exp Cell Res 264 2001 275 283
31. I. Daviet, J.M. Herbert, and J.P. Maffrand Involvement of protein kinase C in the mitogenic and chemotaxis effects of basic fibroblast growth factor on bovine cerebral cortex capillary endothelial cells FEBS Lett 259 1990 315 317
32. E. Landgren, P. Klint, K. Yokote, and L. Claesson-Welsh Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding Oncogene 17 1998 283 291
33. S. Kanda, E.C. Lerner, S. Tsuda, T. Shono, H. Kanetake, and T.E. Smithgall The nonreceptor protein-tyrosine kinase c-Fes is involved in fibroblast growth factor-2-induced chemotaxis of murine brain capillary endothelial cells J Biol Chem 275 2000 10105 10111
34. T. Shono, Y. Mochizuki, H. Kanetake, and S. Kanda Inhibition of FGF-2-mediated chemotaxis of murine brain capillary endothelial cells by cyclic RGDfV peptide through blocking the redistribution of c-Src into focal adhesions Exp Cell Res 268 2001 169 178
35. R.F. Nicosia, and A. Ottinetti Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: a comparative study of angiogenesis in matrigel, collagen, fibrin, and plasma clot In Vitro Cell Dev Biol 26 1990 119 128
36. R. Montesano, L. Orci, and P. Vassalli In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices J Cell Biol 97 1983 1648 1652
37. R. Montesano, J.D. Vassalli, A. Baird, R. Guillemin, and L. Orci Basic fibroblast growth factor induces angiogenesis in vitro Proc Natl Acad Sci USA 83 1986 7297 7301
38. T. Matsumoto, I. Turesson, M. Book, P. Gerwins, and L. Claesson-Welsh p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis J Cell Biol 156 2002 149 160
39. M.S. Pepper, D. Belin, R. Montesano, L. Orci, and J.D. Vassalli Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro J Cell Biol 111 1990 743 755
40. C.M. Gajdusek, Z. Luo, and M.R. Mayberg Basic fibroblast growth factor and transforming growth factor beta-1: synergistic mediators of angiogenesis in vitro J Cell Physiol 157 1993 133 144
41. C.A. Henke, U. Roongta, D.J. Mickelson, J.R. Knutson, and J.B. McCarthy CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix J Clin Invest 97 1996 2541 2552
42. A. Takei, Y. Tashiro, Y. Nakashima, and K. Sueishi Effects of fibrin on the angiogenesis in vitro of bovine endothelial cells in collagen gel In Vitro Cell Dev Biol Anim 31 1995 467 472
43. P.A. Underwood, P.A. Bean, and J.R. Gamble Rate of endothelial expansion is controlled by cell:cell adhesion Int J Biochem Cell Biol 34 2002 55 69
44. J.B. Hoying, and S.K. Williams Effects of basic fibroblast growth factor on human microvessel endothelial cell migration on collagen I correlates inversely with adhesion and is cell density dependent J Cell Physiol 168 1996 294 304
45. S. Klein, F.G. Giancotti, M. Presta, S.M. Albelda, C.A. Buck, and D.B. Rifkin Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells Mol Biol Cell 4 1993 973 982
46. G. Collo, and M.S. Pepper Endothelial cell integrin alpha5beta1 expression is modulated by cytokines and during migration in vitro J Cell Sci 112 Pt 4 1999 569 578
47. N.T. Sepp, L.J. Li, K.H. Lee, E.J. Brown, S.W. Caughman, and T.J. Lawley Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells J Invest Dermatol 103 1994 295 299
48. L. Zhou, A. Dosanjh, H. Chen, and M. Karasek Divergent effects of extracellular oxygen on the growth, morphology, and function of human skin microvascular endothelial cells J Cell Physiol 182 2000 134 140
49. M.E. Gerritsen, R. Soriano, S. Yang, C. Zlot, G. Ingle, and K. Toy Branching out: a molecular fingerprint of endothelial differentiation into tube-like structures generated by Affymetrix oligonucleotide arrays Microcirculation 10 2003 63 81
50. R. Kumar, J. Yoneda, C.D. Bucana, and I.J. Fidler Regulation of distinct steps of angiogenesis by different angiogenic molecules Int J Oncol 12 1998 749 757
51. H.W. Schnaper, D.S. Grant, W.G. Stetler-Stevenson, R. Fridman, G. D'Orazi, and A.N. Murphy Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro J Cell Physiol 156 1993 235 246
52. H.W. Schnaper, E.S. Barnathan, A. Mazar, S. Maheshwari, S. Ellis, and S.L. Cortez Plasminogen activators augment endothelial cell organization in vitro by two distinct pathways J Cell Physiol 165 1995 107 118
53. G.E. Davis, and C.W. Camarillo Regulation of endothelial cell morphogenesis by integrins, mechanical forces, and matrix guidance pathways Exp Cell Res 216 1995 113 123
54. N. Sheibani, P.J. Newman, and W.A. Frazier Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis Mol Biol Cell 8 1997 1329 1341
55. J.O. Connolly, N. Simpson, L. Hewlett, and A. Hall Rac regulates endothelial morphogenesis and capillary assembly Mol Biol Cell 13 2002 2474 2485
56. S. Kanda, Y. Miyata, and H. Kanetake Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt J Biol Chem 279 2004 4007 4016
57. A. Gualandris, M. Rusnati, M. Belleri, E.E. Nelli, M. Bastaki, and M.P. Molinari-Tosatti Basic fibroblast growth factor overexpression in endothelial cells: an autocrine mechanism for angiogenesis and angioproliferative diseases Cell Growth Differ 7 1996 147 160
58. B. Ensoli, R. Gendelman, P. Markham, V. Fiorelli, S. Colombini, and M. Raffeld Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma Nature 371 1994 674 680
59. K. Takahashi, J.B. Mulliken, H.P. Kozakewich, R.A. Rogers, J. Folkman, and R.A. Ezekowitz Cellular markers that distinguish the phases of hemangioma during infancy and childhood J Clin Invest 93 1994 2357 2364
60. S. Kiuru-Kuhlefelt, M. Sarlomo-Rikala, M.L. Larramendy, M. Soderlund, K. Hedman, and M. Miettinen FGF4 and INT2 oncogenes are amplified and expressed in Kaposi's sarcoma Mod Pathol 13 2000 433 437
61. D. Ribatti, A. Gualandris, M. Belleri, L. Massardi, B. Nico, and M. Rusnati Alterations of blood vessel development by endothelial cells overexpressing fibroblast growth factor-2 J Pathol 189 1999 590 599
62. P. Dell'Era, L. Coco, R. Ronca, B. Sennino, and M. Presta Gene expression profile in fibroblast growth factor 2-transformed endothelial cells Oncogene 21 2002 2433 2440
63. A. Gualandris, C. Urbinati, M. Rusnati, M. Ziche, and M. Presta Interaction of high-molecular-weight basic fibroblast growth factor with endothelium: biological activity and intracellular fate of human recombinant M(r) 24,000 bFGF J Cell Physiol 161 1994 149 159
64. P. Mignatti, T. Morimoto, and D.B. Rifkin Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex J Cell Physiol 151 1992 81 93
65. S. Taverna, G. Ghersi, A. Ginestra, S. Rigogliuso, S. Pecorella, and G. Alaimo Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells J Biol Chem 278 2003 51911 51919
66. A. Bikfalvi, S. Klein, G. Pintucci, N. Quarto, P. Mignatti, and D.B. Rifkin Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms J Cell Biol 129 1995 233 243
67. R.Z. Florkiewicz, A. Baird, and A.M. Gonzalez Multiple forms of bFGF: differential nuclear and cell surface localization Growth Factors 4 1991 265 275
68. N. Quarto, D. Talarico, R. Florkiewicz, and D.B. Rifkin Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells Cell Regul 2 1991 699 708
69. D. Talarico, and C. Basilico The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathway Mol Cell Biol 11 1991 1138 1145
70. C.R. Partridge, J.R. Hawker Jr., and R. Forough Overexpression of a secretory form of FGF-1 promotes MMP-1-mediated endothelial cell migration J Cell Biochem 78 2000 487 499
71. A.M. Gonzalez, D.J. Hill, A. Logan, P.A. Maher, and A. Baird Distribution of fibroblast growth factor (FGF)-2 and FGF receptor-1 messenger RNA expression and protein presence in the mid-trimester human fetus Pediatr Res 39 1996 375 385
72. E. Arany, and D.J. Hill Fibroblast growth factor-2 and fibroblast growth factor receptor-1 mRNA expression and peptide localization in placentae from normal and diabetic pregnancies Placenta 19 1998 133 142
73. S.Y. Yoon, A. Tefferi, and C.Y. Li Cellular distribution of platelet-derived growth factor, transforming growth factor-beta, basic fibroblast growth factor, and their receptors in normal bone marrow Acta Haematol 104 2000 151 157
74. T.P. Yamaguchi, K. Harpal, M. Henkemeyer, and J. Rossant fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation Genes Dev 8 1994 3032 3044
75. C.X. Deng, A. Wynshaw-Boris, M.M. Shen, C. Daugherty, D.M. Ornitz, and P. Leder Murine FGFR-1 is required for early postimplantation growth and axial organization Genes Dev 8 1994 3045 3057
76. S.H. Lee, D.J. Schloss, and J.L. Swain Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor J Biol Chem 275 2000 33679 33687
77. X. Xu, M. Weinstein, C. Li, M. Naski, R.I. Cohen, and D.M. Ornitz Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction Development 125 1998 753 765
78. J.S. Colvin, B.A. Bohne, G.W. Harding, D.G. McEwen, and D.M. Ornitz Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3 Nat Genet 12 1996 390 397
79. M. Weinstein, X. Xu, K. Ohyama, and C.X. Deng FGFR-3 FGFR-4 function cooperatively to direct alveogenesis in the murine lung Development 125 1998 3615 3623
80. D. Ribatti, A. Vacca, L. Roncali, and F. Dammacco The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis Curr Pharm Biotechnol 1 2000 73 82
81. J.M. Herbert, M.C. Laplace, and J.P. Maffrand Effect of heparin on the angiogenic potency of basic and acidic fibroblast growth factors in the rabbit cornea assay Int J Tissue React 10 1988 133 139
82. G. Seghezzi, S. Patel, C.J. Ren, A. Gualandris, G. Pintucci, and E.S. Robbins Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis J Cell Biol 141 1998 1659 1673
83. A. Passaniti, R.M. Taylor, R. Pili, Y. Guo, P.V. Long, and J.A. Haney A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor Lab Invest 67 1992 519 528
84. D. Ribatti, B. Nico, L. Morbidelli, S. Donnini, M. Ziche, and A. Vacca Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis J Vasc Res 38 2001 389 397
85. D. Ribatti, and M. Presta The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane J Cell Mol Med 6 2002 439 446
86. P. Parsons-Wingerter, K.E. Elliott, J.I. Clark, and A.G. Farr Fibroblast growth factor-2 selectively stimulates angiogenesis of small vessels in arterial tree Arterioscler Thromb Vasc Biol 20 2000 1250 1256
87. M. Zhou, R.L. Sutliff, R.J. Paul, J.N. Lorenz, J.B. Hoying, and C.C. Haudenschild Fibroblast growth factor 2 control of vascular tone Nat Med 4 1998 201 207
88. T. Tobe, S. Ortega, J.D. Luna, H. Ozaki, N. Okamoto, and N.L. Derevjanik Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model Am J Pathol 153 1998 1641 1646
89. H. Ozaki, N. Okamoto, S. Ortega, M. Chang, K. Ozaki, and S. Sadda Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization Am J Pathol 153 1998 757 765
90. D.L. Fulgham, S.R. Widhalm, S. Martin, and J.D. Coffin FGF-2 dependent angiogenesis is a latent phenotype in basic fibroblast growth factor transgenic mice Endothelium 6 1999 185 195
91. D.L. Miller, S. Ortega, O. Bashayan, R. Basch, and C. Basilico Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice Mol Cell Biol 20 2000 2260 2268
92. M. Costa, R. Danesi, C. Agen, A. Di Paolo, F. Basolo, and S. Del Bianchi MCF-10A cells infected with the int-2 oncogene induce angiogenesis in the chick chorioallantoic membrane and in the rat mesentery Cancer Res 54 1994 9 11
93. O. Brustle, A. Aguzzi, D. Talarico, C. Basilico, P. Kleihues, and O.D. Wiestler Angiogenic activity of the K-fgf/hst oncogene in neural transplants Oncogene 7 1992 1177 1183
94. T.T. Rissanen, J.E. Markkanen, K. Arve, J. Rutanen, M.I. Kettunen, and I. Vajanto Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model FASEB J 17 2003 100 102
95. F.J. Giordano, P. Ping, M.D. McKirnan, S. Nozaki, A.N. DeMaria, and W.H. Dillmann Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart Nat Med 2 1996 534 539
96. S. Zhao, and P.A. Overbeek Regulation of choroid development by the retinal pigment epithelium Mol Vis 7 2001 277 282
97. N. Ferrara, H.P. Gerber, and J. LeCouter The biology of VEGF and its receptors Nat Med 9 2003 669 676
98. J.C. Tille, J. Wood, S.J. Mandriota, C. Schnell, S. Ferrari, and J. Mestan Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro J Pharmacol Exp Ther 299 2001 1073 1085
99. P. Auguste, D.B. Gursel, S. Lemiere, D. Reimers, P. Cuevas, and F. Carceller Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms Cancer Res 61 2001 1717 1726
100. C. Gabler, A. Plath-Gabler, G.J. Killian, B. Berisha, and D. Schams Expression pattern of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) system members in bovine corpus luteum endothelial cells during treatment with FGF-2, VEGF or oestradiol Reprod Domest Anim 39 2004 321 327
101. R.J. Tomanek, A. Sandra, W. Zheng, T. Brock, R.J. Bjercke, and J.S. Holifield Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis Circ Res 88 2001 1135 1141
102. L. Xue, and H.P. Greisler Angiogenic effect of fibroblast growth factor-1 and vascular endothelial growth factor and their synergism in a novel in vitro quantitative fibrin-based 3-dimensional angiogenesis system Surgery 132 2002 259 267
103. R. Castellon, H.K. Hamdi, I. Sacerio, A.M. Aoki, M.C. Kenney, and A.V. Ljubimov Effects of angiogenic growth factor combinations on retinal endothelial cells Exp Eye Res 74 2002 523 535
104. M.S. Pepper, and S.J. Mandriota Regulation of vascular endothelial growth factor receptor-2 (Flk-1) expression in vascular endothelial cells Exp Cell Res 241 1998 414 425
105. B. Nico, G. de Falco, A. Vacca, L. Roncali, and D. Ribatti In vivo absence of synergism between fibroblast growth factor-2 and vascular endothelial growth factor J Hematother Stem Cell Res 10 2001 905 912
106. R. Giavazzi, B. Sennino, D. Coltrini, A. Garofalo, R. Dossi, and R. Ronca Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis Am J Pathol 162 2003 1913 1926
107. Y.J. Jih, W.H. Lien, W.C. Tsai, G.W. Yang, C. Li, and L.W. Wu Distinct regulation of genes by bFGF and VEGF-A in endothelial cells Angiogenesis 4 2001 313 321
108. M. Ho, E. Yang, G. Matcuk, D. Deng, N. Sampas, and A. Tsalenko Identification of endothelial cell genes by combined database mining and microarray analysis Physiol Genomics 13 2003 249 262
109. D.J. Kurz, Y. Hong, E. Trivier, H.L. Huang, S. Decary, and G.H. Zang Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells Arterioscler Thromb Vasc Biol 23 2003 748 754
110. L. Chang, A. Kaipainen, and J. Folkman Lymphangiogenesis new mechanisms Ann N Y Acad Sci 979 2002 111 119
111. L.K. Chang, G. Garcia-Cardena, F. Farnebo, M. Fannon, E.J. Chen, and C. Butterfield Dose-dependent response of FGF-2 for lymphangiogenesis Proc Natl Acad Sci USA 101 2004 11658 11663
112. R. Cao, A. Eriksson, H. Kubo, K. Alitalo, Y. Cao, and J. Thyberg Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability Circ Res 94 2004 664 670
113. P. Carmeliet Mechanisms of angiogenesis and arteriogenesis Nat Med 6 2000 389 395
114. T.J. Poole, E.B. Finkelstein, and C.M. Cox The role of FGF and VEGF in angioblast induction and migration during vascular development Dev Dyn 220 2001 1 17
115. I. Desbaillets, U. Ziegler, P. Groscurth, and M. Gassmann Embryoid bodies: an in vitro model of mouse embryogenesis Exp Physiol 85 2000 645 651
116. S. Kazemi, D. Wenzel, E. Kolossov, N. Lenka, A. Raible, and P. Sasse Differential role of bFGF and VEGF for vasculogenesis Cell Physiol Biochem 12 2002 55 62
117. P. Magnusson, C. Rolny, L. Jakobsson, C. Wikner, Y. Wu, and D.J. Hicklin Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development J Cell Sci 117 2004 1513 1523
118. A. Sahni, O.D. Altland, and C.W. Francis FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth J Thromb Haemost 1 2003 1304 1310
119. U. Lindahl, K. Lidholt, D. Spillmann, and L. Kjellen More to "heparin" than anticoagulation Thromb Res 75 1994 1 32
120. R.V. Iozzo, and J.D. San Antonio Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena J Clin Invest 108 2001 349 355
121. M. Rusnati, and M. Presta Interaction of angiogenic basic fibroblast growth factor with endothelial cell heparan sulfate proteoglycans. Biological implications in neovascularization Int J Clin Lab Res 26 1996 15 23
122. L. Pellegrini Role of heparan sulfate in fibroblast growth factor signalling: a structural view Curr Opin Struct Biol 11 2001 629 634
123. A.E. Eriksson, L.S. Cousens, L.H. Weaver, and B.W. Matthews Three-dimensional structure of human basic fibroblast growth factor Proc Natl Acad Sci USA 88 1991 3441 3445
124. M. Simons, and A. Horowitz Syndecan-4-mediated signalling Cell Signal 13 2001 855 862
125. M. Rusnati, C. Urbinati, and M. Presta Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells: role of the low affinity heparin-like bFGF receptors J Cell Physiol 154 1993 152 161
126. E. Hsia, T.P. Richardson, and M.A. Nugent Nuclear localization of basic fibroblast growth factor is mediated by heparan sulfate proteoglycans through protein kinase C signaling J Cell Biochem 88 2003 1214 1225
127. M. Presta, J.A. Maier, M. Rusnati, and G. Ragnotti Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form J Cell Physiol 140 1989 68 74
128. M. Presta, D. Leali, H. Stabile, R. Ronca, M. Camozzi, and L. Coco Heparin derivatives as angiogenesis inhibitors Curr Pharm Des 9 2003 553 566
129. V. Nurcombe, M.D. Ford, J.A. Wildschut, and P.F. Bartlett Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan Science 260 1993 103 106
130. P. Jaakkola, and M. Jalkanen Transcriptional regulation of Syndecan-1 expression by growth factors Prog Nucleic Acid Res Mol Biol 63 1999 109 138
131. I. Vlodavsky, G. Korner, R. Ishai-Michaeli, P. Bashkin, R. Bar-Shavit, and Z. Fuks Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis Cancer Metastasis Rev 9 1990 203 226
132. D. Ribatti, D. Leali, A. Vacca, R. Giuliani, A. Gualandris, and L. Roncali In vivo angiogenic activity of urokinase: role of endogenous fibroblast growth factor-2 J Cell Sci 112 Pt 23 1999 4213 4221
133. C. Ruegg, and A. Mariotti Vascular integrins: pleiotropic adhesion and signaling molecules in vascular homeostasis and angiogenesis Cell Mol Life Sci 60 2003 1135 1157
134. B.P. Eliceiri Integrin and growth factor receptor crosstalk Circ Res 89 2001 1104 1110
135. C.C. Kumar Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis Curr Drug Targets 4 2003 123 131
136. M. Rusnati, E. Tanghetti, P. Dell'Era, A. Gualandris, and M. Presta alphavbeta3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor (FGF-2) in cultured endothelial cells Mol Biol Cell 8 1997 2449 2461
137. E. Tanghetti, R. Ria, P. Dell'Era, C. Urbinati, M. Rusnati, and M.G. Ennas Biological activity of substrate-bound basic fibroblast growth factor (FGF2): recruitment of FGF receptor-1 in endothelial cell adhesion contacts Oncogene 21 2002 3889 3897
138. A. Sahni, and C.W. Francis Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires {alpha}v{beta}3 Blood 104 2004 3635 3641
139. M. Presta, P. Oreste, G. Zoppetti, M. Belleri, E. Tanghetti, and D. Leali Antiangiogenic activity of semisynthetic biotechnological heparins: low-molecular-weight-sulfated Escherichia coli K5 polysaccharide derivatives as fibroblast growth factor antagonists Arterioscler Thromb Vasc Biol 25 2005 71 76
140. M. Salmivirta, J. Heino, and M. Jalkanen Basic fibroblast growth factor-syndecan complex at cell surface or immobilized to matrix promotes cell growth J Biol Chem 267 1992 17606 17610
141. G. Conforti, C. Dominguez-Jimenez, A. Zanetti, M.A. Gimbrone Jr., O. Cremona, and P.C. Marchisio Human endothelial cells express integrin receptors on the luminal aspect of their membrane Blood 80 1992 437 446
142. M. Presta, M. Rusnati, C. Urbinati, A. Sommer, and G. Ragnotti Biologically active synthetic fragments of human basic fibroblast growth factor (bFGF): identification of two Asp-Gly-Arg-containing domains involved in the mitogenic activity of bFGF in endothelial cells J Cell Physiol 149 1991 512 524
143. C.C. Kumar, M. Malkowski, Z. Yin, E. Tanghetti, B. Yaremko, and T. Nechuta Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist Cancer Res 61 2001 2232 2238
144. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry Role of tumor-associated gangliosides in cancer progression Biochimie 85 2003 455 463
145. F. Chang, R. Li, and S. Ladisch Shedding of gangliosides by human medulloblastoma cells Exp Cell Res 234 1997 341 346
146. S. Koochekpour, A. Merzak, and G.J. Pilkington Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro Cancer Lett 102 1996 209 215
147. M. Rusnati, E. Tanghetti, C. Urbinati, G. Tulipano, S. Marchesini, and M. Ziche Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures Mol Biol Cell 10 1999 313 327
148. M. Rusnati, C. Urbinati, E. Tanghetti, P. Dell'Era, H. Lortat-Jacob, and M. Presta Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2 Proc Natl Acad Sci USA 99 2002 4367 4372
149. P. Bornstein, L.C. Armstrong, K.D. Hankenson, T.R. Kyriakides, and Z. Yang Thrombospondin 2, a matricellular protein with diverse functions Matrix Biol 19 2000 557 568
150. G. Taraboletti, D. Belotti, P. Borsotti, V. Vergani, M. Rusnati, and M. Presta The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor Cell Growth Differ 8 1997 471 479
151. B. Margosio, D. Marchetti, V. Vergani, R. Giavazzi, M. Rusnati, and M. Presta Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2 Blood 102 2003 4399 4406
152. C. Bossard, L. Van den Berghe, H. Laurell, C. Castano, M. Cerutti, and A.C. Prats Antiangiogenic properties of fibstatin, an extracellular FGF-2-binding polypeptide Cancer Res 64 2004 7507 7512
153. E. Tassi, A. Al-Attar, A. Aigner, M.R. Swift, K. McDonnell, and A. Karavanov Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein J Biol Chem 276 2001 40247 40253
154. F. Czubayko, E.D. Liaudet-Coopman, A. Aigner, A.T. Tuveson, G.J. Berchem, and A. Wellstein A secreted FGF-binding protein can serve as the angiogenic switch in human cancer Nat Med 3 1997 1137 1140
155. M. Mongiat, J. Otto, R. Oldershaw, F. Ferrer, J.D. Sato, and R.V. Iozzo Fibroblast growth factor-binding protein is a novel partner for perlecan protein core J Biol Chem 276 2001 10263 10271
156. A. Hanneken, and A. Baird Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid Invest Ophthalmol Vis Sci 36 1995 1192 1196
157. A. Hanneken, P.A. Maher, and A. Baird High affinity immunoreactive FGF receptors in the extracellular matrix of vascular endothelial cells - implications for the modulation of FGF-2 J Cell Biol 128 1995 1221 1228
158. L. Bergonzoni, P. Caccia, O. Cletini, P. Sarmientos, and A. Isacchi Characterization of a biologically active extracellular domain of fibroblast growth factor receptor 1 expressed in Escherichia coli Eur J Biochem 210 1992 823 829
159. H. Ueno, M. Gunn, K. Dell, A. Tseng Jr., and L. Williams A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor J Biol Chem 267 1992 1470 1476
160. A. Sahni, S.K. Sahni, P.J. Simpson-Haidaris, and C.W. Francis Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells J Thromb Haemost 2 2004 1629 1636
161. I.R. Asplin, S.M. Wu, S. Mathew, G. Bhattacharjee, and S.V. Pizzo Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis Blood 97 2001 3450 3457
162. S. Mathew, S. Arandjelovic, W.F. Beyer, S.L. Gonias, and S.V. Pizzo Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions Biochem J 374 2003 123 129
163. P.A. Dennis, O. Saksela, P. Harpel, and D.B. Rifkin Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor J Biol Chem 264 1989 7210 7216
164. B. Bottazzi, V. Vouret-Craviari, A. Bastone, L. De Gioia, C. Matteucci, and G. Peri Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component J Biol Chem 272 1997 32817 32823
165. F. Breviario, E.M. d'Aniello, J. Golay, G. Peri, B. Bottazzi, and A. Bairoch Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component J Biol Chem 267 1992 22190 22197
166. M. Rusnati, M. Camozzi, E. Moroni, B. Bottazzi, G. Peri, and S. Indraccolo Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis Blood 104 2004 92 99
167. A. Salustri, C. Garlanda, E. Hirsch, M. De Acetis, A. Maccagno, and B. Bottazzi PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization Development 131 2004 1577 1586
168. K. Russo, R. Ragone, A.M. Facchiano, M.C. Capogrossi, and A. Facchiano Platelet-derived growth factor-BB and basic fibroblast growth factor directly interact in vitro with high affinity J Biol Chem 277 2002 1284 1291
169. F. De Marchis, D. Ribatti, C. Giampietri, A. Lentini, D. Faraone, and M. Scoccianti Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its alpha receptor Blood 99 2002 2045 2053
170. C. Perollet, Z.C. Han, C. Savona, J.P. Caen, and A. Bikfalvi Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization Blood 91 1998 3289 3299
171. R.M. Lozano, M. Redondo-Horcajo, M.A. Jimenez, L. Zilberberg, P. Cuevas, and A. Bikfalvi Solution structure and interaction with basic and acidic fibroblast growth factor of a 3-kDa human platelet factor-4 fragment with antiangiogenic activity J Biol Chem 276 2001 35723 35734
172. N.S. Chadderton, and S.E. Stringer Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparan sulphate Int J Biochem Cell Biol 35 2003 1052 1055
173. K.J. Brown, and C.R. Parish Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor Biochemistry 33 1994 13918 13927
174. D. Moscatelli, M. Presta, J. Joseph-Silverstein, and D.B. Rifkin Both normal and tumor cells produce basic fibroblast growth factor J Cell Physiol 129 1986 273 276
175. M. Presta, D. Moscatelli, J. Joseph-Silverstein, and D.B. Rifkin Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration Mol Cell Biol 6 1986 4060 4066
176. J. Kandel, E. Bossy-Wetzel, F. Radvanyi, M. Klagsbrun, J. Folkman, and D. Hanahan Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma Cell 66 1991 1095 1104
177. Y. Wang, and D. Becker Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth Nat Med 3 1997 887 893
178. R.K. Singh, M. Gutman, C.D. Bucana, R. Sanchez, N. Llansa, and I.J. Fidler Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas Proc Natl Acad Sci USA 92 1995 4562 4566
179. A. Baird, P. Mormede, and P. Bohlen Immunoreactive fibroblast growth factor (FGF) in a transplantable chondrosarcoma: inhibition of tumor growth by antibodies to FGF J Cell Biochem 30 1986 79 85
180. J.L. Gross, W.F. Herblin, B.A. Dusak, P. Czerniak, M.D. Diamond, and T. Sun Effects of modulation of basic fibroblast growth factor on tumor growth in vivo J Natl Cancer Inst 85 1993 121 131
181. A. Hori, R. Sasada, E. Matsutani, K. Naito, Y. Sakura, and T. Fujita Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor Cancer Res 51 1991 6180 6184
182. A. Compagni, P. Wilgenbus, M.A. Impagnatiello, M. Cotten, and G. Christofori Fibroblast growth factors are required for efficient tumor angiogenesis Cancer Res 60 2000 7163 7169
183. J. Rak, and R.S. Kerbel bFGF and tumor angiogenesis - back in the limelight? Nat Med 3 1997 1083 1084
184. A. Aigner, M. Butscheid, P. Kunkel, E. Krause, K. Lamszus, and A. Wellstein An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release Int J Cancer 92 2001 510 517
185. B. Souttou, C. Gamby, M. Crepin, and R. Hamelin Tumoral progression of human breast epithelial cells secreting FGF2 and FGF4 Int J Cancer 68 1996 675 681
186. N. Polnaszek, B. Kwabi-Addo, L.E. Peterson, M. Ozen, N.M. Greenberg, and S. Ortega Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer Cancer Res 63 2003 5754 5760
187. D. Coltrini, A. Gualandris, E.E. Nelli, S. Parolini, M.P. Molinari-Tosatti, and N. Quarto Growth advantage and vascularization induced by basic fibroblast growth factor overexpression in endometrial HEC-1-B cells: an export-dependent mechanism of action Cancer Res 55 1995 4729 4738
188. M.A. Konerding, E. Fait, C. Dimitropoulou, W. Malkusch, C. Ferri, and R. Giavazzi Impact of fibroblast growth factor-2 on tumor microvascular architecture. A tridimensional morphometric study Am J Pathol 152 1998 1607 1616
189. R. Giavazzi, R. Giuliani, D. Coltrini, M.R. Bani, C. Ferri, and B. Sennino Modulation of tumor angiogenesis by conditional expression of fibroblast growth factor-2 affects early but not established tumors Cancer Res 61 2001 309 317
190. B. Rousseau, F. Larrieu-Lahargue, S. Javerzat, F. Guilhem-Ducleon, F. Beermann, and A. Bikfalvi The tyrp1-Tag/tyrp1-FGFR1-DN bigenic mouse: a model for selective inhibition of tumor development, angiogenesis, and invasion into the neural tissue by blockade of fibroblast growth factor receptor activity Cancer Res 64 2004 2490 2495
191. T. Yamayoshi, T. Nagayasu, K. Matsumoto, T. Abo, Y. Hishikawa, and T. Koji Expression of keratinocyte growth factor/fibroblast growth factor-7 and its receptor in human lung cancer: correlation with tumour proliferative activity and patient prognosis J Pathol 204 2004 110 118
192. N. Weidner Intratumor microvessel density as a prognostic factor in cancer Am J Pathol 147 1995 9 19
193. H.C. Hollingsworth, E.C. Kohn, S.M. Steinberg, M.L. Rothenberg, and M.J. Merino Tumor angiogenesis in advanced stage ovarian carcinoma Am J Pathol 147 1995 33 41
194. A. Vacca, D. Ribatti, L. Ruco, F. Giacchetta, B. Nico, and F. Quondamatteo Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas Br J Cancer 79 1999 965 970
195. T. Padro, S. Ruiz, R. Bieker, H. Burger, M. Steins, and J. Kienast Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia Blood 95 2000 2637 2644
196. J. Folkman Angiogenesis-dependent diseases Semin Oncol 28 2001 536 542
197. N. Ferrara, and K. Alitalo Clinical applications of angiogenic growth factors and their inhibitors Nat Med 5 1999 1359 1364
198. R. Ria, M. Portaluri, F. Russo, T. Cirulli, G.D. Pietro, and S. Bambace Serum levels of angiogenic cytokines decrease after antineoplastic radiotherapy Cancer Lett 216 2004 103 107
199. M. Nguyen, H. Watanabe, A.E. Budson, J.P. Richie, D.F. Hayes, and J. Folkman Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers J Natl Cancer Inst 86 1994 356 361
200. L.Y. Dirix, P.B. Vermeulen, A. Pawinski, A. Prove, I. Benoy, and C. De Pooter Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients Br J Cancer 76 1997 238 243
201. R.T. Poon, S.T. Fan, and J. Wong Clinical implications of circulating angiogenic factors in cancer patients J Clin Oncol 19 2001 1207 1225
202. V.W. Li, R.D. Folkerth, H. Watanabe, C. Yu, M. Rupnick, and P. Barnes Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours Lancet 344 1994 82 86
203. R. Salgado, I. Benoy, P. Vermeulen, P. van Dam, E. Van Marck, and L. Dirix Circulating basic fibroblast growth factor is partly derived from the tumour in patients with colon, cervical and ovarian cancer Angiogenesis 7 2004 29 32
204. K. Kuwabara, S. Ogawa, M. Matsumoto, S. Koga, M. Clauss, and D.J. Pinsky Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells Proc Natl Acad Sci USA 92 1995 4606 4610
205. A. Baird, P. Mormede, and P. Bohlen Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor Biochem Biophys Res Commun 126 1985 358 364
206. S. Blotnick, G.E. Peoples, M.R. Freeman, T.J. Eberlein, and M. Klagsbrun T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells Proc Natl Acad Sci USA 91 1994 2890 2894
207. G.E. Peoples, S. Blotnick, K. Takahashi, M.R. Freeman, M. Klagsbrun, and T.J. Eberlein T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role Proc Natl Acad Sci USA 92 1995 6547 6551
208. D. Ribatti, E. Crivellato, L. Candussio, A. Vacca, B. Nico, and V. Benagiano Angiogenic activity of rat mast cells in the chick embryo chorioallantoic membrane is down-regulated by treatment with recombinant human alpha-2a interferon and partly mediated by fibroblast growth factor-2 Haematologica 87 2002 465 471
209. T. Gloe, H.Y. Sohn, G.A. Meininger, and U. Pohl Shear stress-induced release of basic fibroblast growth factor from endothelial cells is mediated by matrix interaction via integrin alpha(v)beta3 J Biol Chem 277 2002 23453 23458
210. M.E. Hartnett, C.M. Garcia, and P.A. D'Amore Release of bFGF, an endothelial cell survival factor, by osmotic shock Invest Ophthalmol Vis Sci 40 1999 2945 2951
211. F. Cozzolino, M. Torcia, M. Lucibello, L. Morbidelli, M. Ziche, and J. Platt Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth J Clin Invest 91 1993 2504 2512
212. H.T. Lee, J.G. Lee, M. Na, and E.P. Kay FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells J Biol Chem 279 2004 32325 32332
213. G. Walford, and J. Loscalzo Nitric oxide in vascular biology J Thromb Haemost 1 2003 2112 2118
214. L. Morbidelli, S. Donnini, and M. Ziche Role of nitric oxide in the modulation of angiogenesis Curr Pharm Des 9 2003 521 530
215. M. Ziche, L. Morbidelli, R. Choudhuri, H.T. Zhang, S. Donnini, and H.J. Granger Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis J Clin Invest 99 1997 2625 2634
216. M. Ziche, A. Parenti, F. Ledda, P. Dell'Era, H.J. Granger, and C.A. Maggi Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF Circ Res 80 1997 845 852
217. C.M. Gajdusek, and S. Carbon Injury-induced release of basic fibroblast growth factor from bovine aortic endothelium J Cell Physiol 139 1989 570 579
218. C.W. Pugh Oxygen sensing in cancer Ann Med 35 2003 380 390
219. J. Li, N.W. Shworak, and M. Simons Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites J Cell Sci 115 2002 1951 1959
220. L. Wang, M. Xiong, D. Che, S. Liu, C. Hao, and X. Zheng The effect of hypoxia on expression of basic fibroblast growth factor in pulmonary vascular pericytes J Tongji Med Univ 20 2000 265 267
221. C.P. Tiefenbacher, and W.M. Chilian Basic fibroblast growth factor and heparin influence coronary arteriolar tone by causing endothelium-dependent dilation Cardiovasc Res 34 1997 411 417
222. B. Reuss, R. Dono, and K. Unsicker Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants J Neurosci 23 2003 6404 6412
223. H. Zhang, and A.C. Issekutz Growth factor regulation of neutrophil-endothelial cell interactions J Leukoc Biol 70 2001 225 232
224. B. Barleon, S. Sozzani, D. Zhou, H.A. Weich, A. Mantovani, and D. Marme Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 Blood 87 1996 3336 3343
225. D. Leali, P. Dell'Era, H. Stabile, B. Sennino, A.F. Chambers, and A. Naldini Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis J Immunol 171 2003 1085 1093
226. F. Wempe, V. Lindner, and H.G. Augustin Basic fibroblast growth factor (bFGF) regulates the expression of the CC chemokine monocyte chemoattractant protein-1 (MCP-1) in autocrine-activated endothelial cells Arterioscler Thromb Vasc Biol 17 1997 2471 2478
227. K. Kage, N. Fujita, T. Oh-hara, E. Ogata, T. Fujita, and T. Tsuruo Basic fibroblast growth factor induces cyclooxygenase-2 expression in endothelial cells derived from bone Biochem Biophys Res Commun 254 1999 259 263
228. J.P. Shaw, N. Chuang, H. Yee, and P. Shamamian Polymorphonuclear neutrophils promote rFGF-2-induced angiogenesis in vivo J Surg Res 109 2003 37 42
229. H. Zhang, and A.C. Issekutz Down-modulation of monocyte transendothelial migration and endothelial adhesion molecule expression by fibroblast growth factor: reversal by the anti-angiogenic agent SU6668 Am J Pathol 160 2002 2219 2230
230. J. Kitayama, H. Nagawa, H. Yasuhara, N. Tsuno, W. Kimura, and Y. Shibata Suppressive effect of basic fibroblast growth factor on transendothelial emigration of CD4(+) T-lymphocyte Cancer Res 54 1994 4729 4733
231. U.R. Pendurthi, J.T. Williams, and L.V. Rao Acidic and basic fibroblast growth factors suppress transcriptional activation of tissue factor and other inflammatory genes in endothelial cells Arterioscler Thromb Vasc Biol 17 1997 940 946
232. A.W. Griffioen, C.A. Damen, G.H. Blijham, and G. Groenewegen Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium Blood 88 1996 667 673
233. A. Mantovani, P. Allavena, and A. Sica Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression Eur J Cancer 40 2004 1660 1667
234. M.J. Post, R. Laham, F.W. Sellke, and M. Simons Therapeutic angiogenesis in cardiology using protein formulations Cardiovasc Res 49 2001 522 531
235. F.W. Sellke, R.J. Laham, E.R. Edelman, J.D. Pearlman, and M. Simons Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results Ann Thorac Surg 65 1998 1540 1544
236. R.J. Laham, F.W. Sellke, E.R. Edelman, J.D. Pearlman, J.A. Ware, and D.L. Brown Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial Circulation 100 1999 1865 1871
237. E.F. Unger, L. Goncalves, S.E. Epstein, E.Y. Chew, C.B. Trapnell, and R.O. Cannon III Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris Am J Cardiol 85 2000 1414 1419
238. M. Simons, B.H. Annex, R.J. Laham, N. Kleiman, T. Henry, and H. Dauerman Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial Circulation 105 2002 788 793
239. D.F. Lazarous, E.F. Unger, S.E. Epstein, A. Stine, J.L. Arevalo, and E.Y. Chew Basic fibroblast growth factor in patients with intermittent claudication: results of a phase I trial J Am Coll Cardiol 36 2000 1239 1244
240. R.J. Lederman, F.O. Mendelsohn, R.D. Anderson, J.F. Saucedo, A.N. Tenaglia, and J.B. Hermiller Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial Lancet 359 2002 2053 2058
241. J.J. Lopez, E.R. Edelman, A. Stamler, M.G. Hibberd, P. Prasad, and R.P. Caputo Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters J Pharmacol Exp Ther 282 1997 385 390
242. H. Tabata, M. Silver, and J.M. Isner Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA Cardiovasc Res 35 1997 470 479
243. S.B. Freedman, and J.M. Isner Therapeutic angiogenesis for coronary artery disease Ann Intern Med 136 2002 54 71
244. A.J. Comerota, R.C. Throm, K.A. Miller, T. Henry, N. Chronos, and J. Laird Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end-stage unreconstructible lower extremity ischemia: preliminary results of a phase I trial J Vasc Surg 35 2002 930 936
245. H. Kasahara, E. Tanaka, N. Fukuyama, E. Sato, H. Sakamoto, and Y. Tabata Biodegradable gelatin hydrogel potentiates the angiogenic effect of fibroblast growth factor 4 plasmid in rabbit hindlimb ischemia J Am Coll Cardiol 41 2003 1056 1062
246. C. Grines, G.M. Rubanyi, N.S. Kleiman, P. Marrott, and M.W. Watkins Angiogenic gene therapy with adenovirus 5 fibroblast growth factor-4 (Ad5FGF-4): a new option for the treatment of coronary artery disease Am J Cardiol 92 2003 24N 31N
247. I.S. Syed, T.A. Sanborn, and T.K. Rosengart Therapeutic angiogenesis: a biologic bypass Cardiology 101 2004 131 143
248. R. Cao, E. Brakenhielm, R. Pawliuk, D. Wariaro, M.J. Post, and E. Wahlberg Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2 Nat Med 9 2003 604 613
249. H.J. Senn, M. Orth, E. Fitzke, H. Wieland, and W. Gerok Gangliosides in normal human serum. Concentration, pattern and transport by lipoproteins Eur J Biochem 181 1989 657 662
250. M.B. McCrohan, S.W. Huang, J.W. Sleasman, P.A. Klein, and K.J. Kao Plasma thrombospondin as an indicator of intravascular platelet activation in patients with vasculitis Thromb Haemost 58 1987 850 852
251. R. Latini, A.P. Maggioni, G. Peri, L. Gonzini, D. Lucci, and P. Mocarelli Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction Circulation 110 2004 2349 2354
252. A. Sahni, T. Odrljin, and C.W. Francis Binding of basic fibroblast growth factor to fibrinogen and fibrin J Biol Chem 273 1998 7554 7559
253. L.L. Gleich, L. Srivastava, and J.L. Gluckman Plasma platelet-derived growth factor: preliminary study of a potential marker in head and neck cancer Ann Otol Rhinol Laryngol 105 1996 710 712
254. G. Placanica, G. Migliau, G. Nasso, R. Rosso, and D. Tallarico Short-term effect of exercise on platelet factor 4 in normal subjects and in patients with coronary artery disease Cardiologia 44 1999 993 996