First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors

Investigational New Drugs

Volumn 32, Issue 6, 2014, Pages 1204-1212

  Hong, D S ^a   Henary, H ^a   Falchook, G S ^a   Naing, A ^a   Fu, S ^a   Moulder, S ^a   Wheler, J J ^a   Tsimberidou, A ^a   Durand, J B ^a   Khan, R ^a   Yang, P ^a   Johansen, M ^a   Newman, R A ^a   Kurzrock, R ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

AKT; Nerium oleander; Oleandrin NF kB; PBI 05204; Phase I

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTINEOPLASTIC AGENT; CARDENOLIDE; FIBROBLAST GROWTH FACTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MTOR PROTEIN, HUMAN; OLEANDRIN; PLANT EXTRACT; PROTEIN KINASE B; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ADULT; AGED; ANTAGONISTS AND INHIBITORS; BLOOD; CLINICAL TRIAL; FEMALE; HUMAN; MALE; MAXIMUM TOLERATED DOSE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NEOPLASMS; NERIUM; PHASE 1 CLINICAL TRIAL; PHYTOTHERAPY;

ADULT; AGED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARDENOLIDES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; NEOPLASMS; NERIUM; NF-KAPPA B; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SODIUM-POTASSIUM-EXCHANGING ATPASE; TOR SERINE-THREONINE KINASES;

EID: 84938690353     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-014-0127-0     Document Type: Article

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