Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions

Journal of Biological Chemistry

Volumn 289, Issue 44, 2014, Pages 33470-33480

  Ge, Hongfei ^a   Zhang, Jun ^a   Gong, Yan ^a   Gupte, Jamila ^a   Ye, Jay ^a   Weiszmann, Jennifer ^a   Samayoa, Kim ^a   Coberly, Suzanne ^a   Gardner, Jonitha ^a   Wang, Huilan ^a   Corbin, Tim ^a   Chui, Danny ^a   Baribault, Helene ^a   Li, Yang ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CELL CULTURE; FIBROBLASTS; GLUCOSE; INSULIN; MAMMALS; PHYSIOLOGY;

DIET-INDUCED OBESITY; ENERGY METABOLISM; FIBROBLAST GROWTH FACTOR RECEPTORS; GLUCOSE METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; MECHANISM OF ACTION; METABOLIC CHANGES;

METABOLISM;

ADIPONECTIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN FUNCTION; WEIGHT REDUCTION;

EID: 84910077652     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.592022     Document Type: Article

References (23)

1. Zhao, Y., Dunbar, J. D., and Kharitonenkov, A. (2012) FGF21 as a therapeutic reagent. Adv. Exp. Med. Biol. 728, 214-228
2. Potthoff, M. J., Kliewer, S. A., and Mangelsdorf, D. J. (2012) Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev. 26, 312-324
3. Angelin, B., Larsson, T. E., and Rudling, M. (2012) Circulating fibroblast growth factors as metabolic regulators-a critical appraisal. CellMetab. 16, 693-705
4. Kuro-o, M. (2012) Klotho and βKlotho. Adv. Exp. Med. Biol. 728, 25-40
5. Zhang, J., and Li, Y. (2014) Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. Drug Discov. Today 19, 579-589
6. Plotnikov, A. N., Hubbard, S. R., Schlessinger, J., and Mohammadi, M. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101, 413-424
7. Johnson, D. E., and Williams, L. T. (1993) Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60, 1-41
8. Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., and Kuro-o, M. (2007) Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J. Biol. Chem. 282, 26687-26695
9. Wu, X., Ge, H., Baribault, H., Gupte, J., Weiszmann, J., Lemon, B., Gardner, J., Fordstrom, P., Tang, J., Zhou, M., Wang, M., and Li, Y. (2013) Dual actions of fibroblast growth factor 19 on lipid metabolism. J. Lipid Res. 54, 325-332
10. Jones, S. A. (2012) Physiology of FGF15/19. Adv. Exp. Med. Biol. 728, 171-182
11. Wu, X., Ge, H., Lemon, B., Weiszmann, J., Gupte, J., Hawkins, N., Li, X., Tang, J., Lindberg, R., and Li, Y. (2009) Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Proc. Natl. Acad. Sci. U. S. A. 106, 14379-14384
12. Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K. F., Donahee, M., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., Goodwin, B., and Jones, S. A. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 17, 1581-1591
13. Ge, H., Baribault, H., Vonderfecht, S., Lemon, B., Weiszmann, J., Gardner, J., Lee, K. J., Gupte, J., Mookherjee, P., Wang, M., Sheng, J., Wu, X., and Li, Y. (2012) Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism. PLoS One 7, e33603
14. Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M., Williams, P. M., Soriano, R., Corpuz, R., Moffat, B., Vandlen, R., Simmons, L., Foster, J., Stephan, J. P., Tsai, S. P., and Stewart, T. A. (2004) Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptindeficient diabetes. Endocrinology 145, 2594-2603
15. Wu, A. L., Coulter, S., Liddle, C., Wong, A., Eastham-Anderson, J., French, D. M., Peterson, A. S., and Sonoda, J. (2011) FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS One 6, e17868
16. Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., and Mangelsdorf, D. J. (2011) FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331, 1621-1624
17. Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., Burgess, S. C., Mangelsdorf, D. J., and Kliewer, S. A. (2011) FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway. Cell Metab. 13, 729-738
18. Huang, X., Yang, C., Luo, Y., Jin, C., Wang, F., and McKeehan, W. L. (2007) FGFR4 prevents hyperlipidemia and insulin resistance but underlies highfat diet induced fatty liver. Diabetes 56, 2501-2510
19. Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., and Schoonjans, K. (2008) Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov. 7, 678-693
20. Kobayashi, M., Ikegami, H., Fujisawa, T., Nojima, K., Kawabata, Y., Noso, S., Babaya, N., Itoi-Babaya, M., Yamaji, K., Hiromine, Y., Shibata, M., and Ogihara, T. (2007) Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes 56, 239-247
21. Lundåsen, T., Andersson, E. M., Snaith, M., Lindmark, H., Lundberg, J., Ö stlund-Lindqvist, A. M., Angelin, B., and Rudling, M. (2012) Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. PLoS One 7, e37787
22. Yu, X. X., Watts, L. M., Manchem, V. P., Chakravarty, K., Monia, B. P., McCaleb, M. L., and Bhanot, S. (2013) Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice. PLoS One 8, e66923
23. Cyphert, H. A., Ge, X., Kohan, A. B., Salati, L. M., Zhang, Y., and Hillgartner, F. B. (2012) Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21. J. Biol. Chem. 287, 25123-25138