메뉴 건너뛰기




Volumn 7, Issue 5, 2014, Pages 579-590

Nintedanib for the treatment of patients with advanced non-small-cell lung cancer

Author keywords

anti angiogenesis; biomarker; docetaxel; nintedanib; pemetrexed; second line treatment

Indexed keywords

AFATINIB; BIOLOGICAL MARKER; CARBOPLATIN; DOCETAXEL; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; NINTEDANIB; PACLITAXEL; PEMETREXED; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; TAXOID; TUMOR MARKER;

EID: 84906278949     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/17512433.2014.945430     Document Type: Article
Times cited : (10)

References (67)
  • 1
    • 84905647229 scopus 로고    scopus 로고
    • International Agency for Research on Cancer (IARC), IARC; Lyon, France
    • International Agency for Research on Cancer (IARC). Latest world. cancer statistics. IARC; Lyon, France: 2013
    • (2013) Latest World. Cancer Statistics
  • 2
    • 84866597083 scopus 로고    scopus 로고
    • Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Peters S, Adjei AA, Gridelli C, et al. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012;23(Suppl 7): vii56-64
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 7
    • Peters, S.1    Adjei, A.A.2    Gridelli, C.3
  • 3
    • 76149135054 scopus 로고    scopus 로고
    • Trends in stage distribution for patients with non-small cell lung cancer: A National Cancer Database survey
    • Morgensztern D, Ng SH, Gao F, Govindan R. Trends in stage distribution for patients with non-small cell lung cancer: a National Cancer Database survey. J Thorac Oncol 2010;5(1):29-33
    • (2010) J Thorac Oncol , vol.5 , Issue.1 , pp. 29-33
    • Morgensztern, D.1    Ng, S.H.2    Gao, F.3    Govindan, R.4
  • 4
    • 80054871420 scopus 로고    scopus 로고
    • Delays in the diagnosis of lung cancer
    • Ellis PM, Vandermeer R. Delays in the diagnosis of lung cancer. J Thorac Dis 2011;3(3):183-8
    • (2011) J Thorac Dis , vol.3 , Issue.3 , pp. 183-188
    • Ellis, P.M.1    Vandermeer, R.2
  • 5
    • 84875701531 scopus 로고    scopus 로고
    • Systemic therapy of advanced non-small cell lung cancer: Major-developments of the last 5-years
    • Cufer T, Ovcaricek T, O'Brien ME. Systemic therapy of advanced non-small cell lung cancer: major-developments of the last 5-years. Eur J Cancer 2013;49(6):1216-25
    • (2013) Eur J Cancer , vol.49 , Issue.6 , pp. 1216-1225
    • Cufer, T.1    Ovcaricek, T.2    O'brien, M.E.3
  • 6
    • 0346560025 scopus 로고    scopus 로고
    • Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: A phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group - EORTC 08975
    • Smit EF, van Meerbeeck JP, Lianes P, et al. Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group - EORTC 08975. J Clin Oncol 2003;21(21):3909-17
    • (2003) J Clin Oncol , vol.21 , Issue.21 , pp. 3909-3917
    • Smit, E.F.1    Van Meerbeeck, J.P.2    Lianes, P.3
  • 7
    • 10444237218 scopus 로고    scopus 로고
    • Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: A meta-analysis of survival outcomes
    • Le Chevalier T, Scagliotti G, Natale R, et al. Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. Lung Cancer 2005; 47(1):69-80
    • (2005) Lung Cancer , vol.47 , Issue.1 , pp. 69-80
    • Le Chevalier, T.1    Scagliotti, G.2    Natale, R.3
  • 8
    • 84883234036 scopus 로고    scopus 로고
    • Second-line therapy for advanced NSCLC
    • Weiss JM, Stinchcombe TE. Second-line therapy for advanced NSCLC. Oncologist 2013;18(8):947-53
    • (2013) Oncologist , vol.18 , Issue.8 , pp. 947-953
    • Weiss, J.M.1    Stinchcombe, T.E.2
  • 13
    • 84906254433 scopus 로고    scopus 로고
    • Pfizer Inc., prescribing information, Pfizer Inc., NY, USA
    • Pfizer Inc., prescribing information, Xalkori (crizotinib),. . Pfizer Inc., NY, USA. 2013
    • (2013) Xalkori (Crizotinib)
  • 14
    • 80052221852 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation, ZYKADIA (ceritinib) Novartis Pharmaceuticals Corp., USA
    • Novartis Pharmaceuticals Corporation. prescribing information, ZYKADIA (ceritinib) Novartis Pharmaceuticals Corp., USA. 2014
    • (2014) Prescribing Information
  • 17
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013;368(25):2385-94
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 18
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353(2):123-32
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 19
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUMELung 1): A phase 3, double-blind, randomised controlled trial
    • Reck M, Kaiser R, Mellemgaard A, et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUMELung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol 2014;15(2):143-55
    • (2014) Lancet Oncol , vol.15 , Issue.2 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 20
    • 84886393615 scopus 로고    scopus 로고
    • Lume-lung 2: A multicenter, randomized, double-blind, phase III study of nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy
    • Hanna NH, Kaiser R, Sullivan RN, et al. Lume-lung 2: a multicenter, randomized, double-blind, phase III study of nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy. J Clin Oncol 2013; 31(15 Suppl):8034
    • (2013) J Clin Oncol , vol.31 , Issue.15 SUPPL. , pp. 8034
    • Hanna, N.H.1    Kaiser, R.2    Sullivan, R.N.3
  • 21
    • 84878715539 scopus 로고    scopus 로고
    • The impact of second-line agents on patients' health-related quality of life in the treatment for non-small cell lung cancer: A systematic review
    • Ganguli A, Wiegand P, Gao X, et al. The impact of second-line agents on patients' health-related quality of life in the treatment for non-small cell lung cancer: a systematic review. Qual Life Res 2013;22(5):1015-26
    • (2013) Qual Life Res , vol.22 , Issue.5 , pp. 1015-1026
    • Ganguli, A.1    Wiegand, P.2    Gao, X.3
  • 22
    • 79951862254 scopus 로고    scopus 로고
    • The evolving role of histology in the management of advanced non-small-cell lung cancer
    • Langer CJ, Besse B, Gualberto A, et al. The evolving role of histology in the management of advanced non-small-cell lung cancer. J Clin Oncol 2010;28(36): 5311-20
    • (2010) J Clin Oncol , vol.28 , Issue.36 , pp. 5311-5320
    • Langer, C.J.1    Besse, B.2    Gualberto, A.3
  • 23
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22(11): 2184-91
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 24
    • 84883055532 scopus 로고    scopus 로고
    • Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): A randomised controlled trial
    • Garassino MC, Martelli O, Broggini M, et al. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol 2013;14(10):981-8
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 981-988
    • Garassino, M.C.1    Martelli, O.2    Broggini, M.3
  • 25
    • 84857501696 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study
    • Ciuleanu T, Stelmakh L, Cicenas S, et al. Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study. Lancet Oncol 2012;13(3): 300-8
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 300-308
    • Ciuleanu, T.1    Stelmakh, L.2    Cicenas, S.3
  • 26
    • 84874009536 scopus 로고    scopus 로고
    • Erlotinib versus pemetrexed for pretreated non-squamous non-small cell lung cancer patients in clinical practice
    • Zugazagoitia J, Puente J, Gonzalez-Larriba JL, et al. Erlotinib versus pemetrexed for pretreated non-squamous non-small cell lung cancer patients in clinical practice. Oncology 2013;84(5): 255-64
    • (2013) Oncology , vol.84 , Issue.5 , pp. 255-264
    • Zugazagoitia, J.1    Puente, J.2    Gonzalez-Larriba, J.L.3
  • 27
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355(24):2542-50
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 28
    • 84866520947 scopus 로고    scopus 로고
    • Multitargeted anti-angiogenic agents and NSCLC: Clinical update and future directions
    • Ellis PM, Al-Saleh K. Multitargeted anti-angiogenic agents and NSCLC: clinical update and future directions. Crit Rev Oncol Hematol 2012;84(1):47-58
    • (2012) Crit Rev Oncol Hematol , vol.84 , Issue.1 , pp. 47-58
    • Ellis, P.M.1    Al-Saleh, K.2
  • 29
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
    • Shepherd FA, Dancey J, Ramlau R, et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000;18(10):2095-103
    • (2000) J Clin Oncol , vol.18 , Issue.10 , pp. 2095-2103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3
  • 30
    • 84894046261 scopus 로고    scopus 로고
    • AGO-Ovar 12: A randomized placebo-controlled GCIG/ENGOTintergroup phase III trial of standard frontline chemotherapy +/-nintedanib for advanced ovarian cancer
    • du Bois A, Kristensen G, Ray-Coquard I, et al. AGO-Ovar 12: a randomized placebo-controlled GCIG/ENGOTintergroup phase III trial of standard frontline chemotherapy +/-nintedanib for advanced ovarian cancer. Int J Gynecol Cancer 2013;23(8 Suppl 1):7-8
    • (2013) Int J Gynecol Cancer , vol.23 , Issue.8 SUPPL. 1 , pp. 7-8
    • Du Bois, A.1    Kristensen, G.2    Ray-Coquard, I.3
  • 31
    • 84901810710 scopus 로고    scopus 로고
    • Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
    • Richeldi L, du Bois RM, Raghu G, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med 2014;370(22):2071-82
    • (2014) N Engl J Med , vol.370 , Issue.22 , pp. 2071-2082
    • Richeldi, L.1    Du Bois, R.M.2    Raghu, G.3
  • 32
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008;68(12): 4774-82
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 33
    • 67650714103 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120)
    • Roth GJ, Heckel A, Colbatzky F, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem 2009;52(14): 4466-80
    • (2009) J Med Chem , vol.52 , Issue.14 , pp. 4466-4480
    • Roth, G.J.1    Heckel, A.2    Colbatzky, F.3
  • 34
    • 77953206902 scopus 로고    scopus 로고
    • Efficacy of BIBF 1120, a potent triple angiokinase inhibitor, in models of human non-small cell lung cancer is augmented by chemotherapy
    • Hilberg F, Brandstetter I. Efficacy of BIBF 1120, a potent triple angiokinase inhibitor, in models of human non-small cell lung cancer is augmented by chemotherapy. Eur J Cancer 2007;2:S380
    • (2007) Eur J Cancer , vol.2
    • Hilberg, F.1    Brandstetter, I.2
  • 35
    • 79952943038 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers
    • Stopfer P, Rathgen K, Bischoff D, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica 2011;41(4):297-311
    • (2011) Xenobiotica , vol.41 , Issue.4 , pp. 297-311
    • Stopfer, P.1    Rathgen, K.2    Bischoff, D.3
  • 39
    • 74949090791 scopus 로고    scopus 로고
    • Phase i study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors
    • Mross K, Stefanic M, Gmehling D, et al. Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors. Clin Cancer Res 2010;16(1):311-19
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 311-319
    • Mross, K.1    Stefanic, M.2    Gmehling, D.3
  • 40
    • 33845315778 scopus 로고    scopus 로고
    • A phase i study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)
    • Lee CP, Taylor NJ, Attard G, et al. A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) given continuously to patients with advanced solid tumours, incorporating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). J Clin Oncol 2006;24(18(Suppl):3015
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL. , pp. 3015
    • Lee, C.P.1    Taylor, N.J.2    Attard, G.3
  • 41
    • 77958038695 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors
    • Okamoto I, Kaneda H, Satoh T, et al. Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors. Mol Cancer Ther 2010;9(10):2825-33
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2825-2833
    • Okamoto, I.1    Kaneda, H.2    Satoh, T.3
  • 42
    • 77951466584 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) in advanced cancer patients
    • Abstract 73
    • Stopfer P, Roth W, Mross K, et al. Pharmacokinetic characterization of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) in advanced cancer patients. Eur J Cancer Suppl 2006;4(13):26 Abstract 73
    • (2006) Eur J Cancer Suppl , vol.4 , Issue.13 , pp. 26
    • Stopfer, P.1    Roth, W.2    Mross, K.3
  • 43
    • 84864955678 scopus 로고    scopus 로고
    • A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancer
    • Doebele RC, Conkling P, Traynor AM, et al. A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancer. Ann Oncol 2012;23(8):2094-102
    • (2012) Ann Oncol , vol.23 , Issue.8 , pp. 2094-2102
    • Doebele, R.C.1    Conkling, P.2    Traynor, A.M.3
  • 44
    • 77952325749 scopus 로고    scopus 로고
    • Phase i open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients
    • Ellis PM, Kaiser R, Zhao Y, et al. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. Clin Cancer Res 2010;16(10):2881-9
    • (2010) Clin Cancer Res , vol.16 , Issue.10 , pp. 2881-2889
    • Ellis, P.M.1    Kaiser, R.2    Zhao, Y.3
  • 45
    • 84886394514 scopus 로고    scopus 로고
    • Safety and efficacy of nintedanib (BIBF 1120) plus pemetrexed in Japanese patients with advanced or recurrent non-small cell lung cancer (NSCLC): A phase i study
    • Daga H, Takeda K, Okada H, et al. Safety and efficacy of nintedanib (BIBF 1120) plus pemetrexed in Japanese patients with advanced or recurrent non-small cell lung cancer (NSCLC): a phase I study. J Clin Oncol 2013;31:8056
    • (2013) J Clin Oncol , vol.31 , pp. 8056
    • Daga, H.1    Takeda, K.2    Okada, H.3
  • 46
    • 84906240050 scopus 로고    scopus 로고
    • Phase i study of oral nintedanib combined with docetaxel in previously treated Japanese patients with advanced non-small cell lung cancer (NSCLC)
    • Okamoto I, Miyazaki M, Takeda M, et al. Phase I study of oral nintedanib combined with docetaxel in previously treated Japanese patients with advanced non-small cell lung cancer (NSCLC) Ann Oncol. 2013; 49(Suppl 2):S830-1
    • (2013) Ann Oncol. , vol.49 , Issue.SUPPL. 2
    • Okamoto, I.1    Miyazaki, M.2    Takeda, M.3
  • 47
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT00979576
    • ClinicalTrials.gov.
  • 48
    • 79957452054 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • Reck M, Kaiser R, Eschbach C, et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol 2011;22(6):1374-81
    • (2011) Ann Oncol , vol.22 , Issue.6 , pp. 1374-1381
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3
  • 49
    • 84906280136 scopus 로고    scopus 로고
    • Retrospective evaluation of the futility analysis in LUME Lung 2, a randomized, double-blind, placebo-controlled phase 3 trial of nintedanib (BIBF 1120) in combination with pemetrexed in NSCLC patients progressing after one prior first line chemotherapy
    • Hanna N, Kaiser R, Kim JH, et al. Retrospective evaluation of the futility analysis in LUME Lung 2, a randomized, double-blind, placebo-controlled phase 3 trial of nintedanib (BIBF 1120) in combination with pemetrexed in NSCLC patients progressing after one prior first line chemotherapy. Ann Oncol 2013; 49(Suppl 2):S802
    • (2013) Ann Oncol , vol.49 , Issue.SUPPL. 2
    • Hanna, N.1    Kaiser, R.2    Kim, J.H.3
  • 50
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT00805194
    • ClinicalTrials.gov.
  • 51
    • 67651171223 scopus 로고    scopus 로고
    • Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development
    • Wang Y, Sung C, Dartois C, et al. Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development. Clin Pharmacol Ther 2009;86(2):167-74
    • (2009) Clin Pharmacol Ther , vol.86 , Issue.2 , pp. 167-174
    • Wang, Y.1    Sung, C.2    Dartois, C.3
  • 52
    • 84893025537 scopus 로고    scopus 로고
    • Impact of tumor burden on the overall survival analysis of the LUME-Lung 1 study: A randomized, double-blind phase 3 trial of nintedanib (BIBF 1120) + docetaxel in NSCLC patients progressing after first-line chemotherapy
    • Reck M, Novello S, Mellemgaard A, et al. Impact of tumor burden on the overall survival analysis of the LUME-Lung 1 study: a randomized, double-blind phase 3 trial of nintedanib (BIBF 1120) + docetaxel in NSCLC patients progressing after first-line chemotherapy. J Thorac Oncol 2013;8:Suppl 2
    • (2013) J Thorac Oncol , vol.8 , Issue.SUPPL. 2
    • Reck, M.1    Novello, S.2    Mellemgaard, A.3
  • 53
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT00806819
    • ClinicalTrials.gov.
  • 54
    • 84906237688 scopus 로고    scopus 로고
    • Efficacy and safety of nintedanib vs sorafenib in Asian patients with advanced hepatocellular carcinoma (HCC): A randomised Phase II trial
    • Abstract 2580
    • Yen C, Kim TY, Feng YH, et al. Efficacy and safety of nintedanib vs sorafenib in Asian patients with advanced hepatocellular carcinoma (HCC): a randomised Phase II trial. Eur J Cancer 2013;49(Suppl 2):S612 Abstract 2580
    • (2013) Eur J Cancer , vol.49 , Issue.SUPPL. 2
    • Yen, C.1    Kim, T.Y.2    Feng, Y.H.3
  • 55
    • 84885599759 scopus 로고    scopus 로고
    • Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients
    • Abstract 4506
    • Eisen T, Shparyk Y, Jones R, et al. Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients. J Clin Oncol 2013;31(Suppl):Abstract 4506
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Eisen, T.1    Shparyk, Y.2    Jones, R.3
  • 56
    • 84884814024 scopus 로고    scopus 로고
    • Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II study
    • Eisen T, Shparyk Y, Macleod N, et al. Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II study. Investig New Drugs 2013;31(5): 1283-93
    • (2013) Investig New Drugs , vol.31 , Issue.5 , pp. 1283-1293
    • Eisen, T.1    Shparyk, Y.2    Macleod, N.3
  • 57
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT01948141
    • ClinicalTrials.gov.
  • 58
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT01684111
    • ClinicalTrials.gov.
  • 59
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT01683682
    • ClinicalTrials.gov.
  • 60
    • 80054122779 scopus 로고    scopus 로고
    • EGFR-and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies
    • Poindessous V, Ouaret D, El Ouadrani K, et al. EGFR-and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies. Clin Cancer Res 2011;17(20):6522-30
    • (2011) Clin Cancer Res , vol.17 , Issue.20 , pp. 6522-6530
    • Poindessous, V.1    Ouaret, D.2    El Ouadrani, K.3
  • 61
    • 84878653016 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: http://clinicaltrials.gov/show/ NCT00998296
    • ClinicalTrials.gov.
  • 62
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010;11(7): 619-26
    • (2010) Lancet Oncol , vol.11 , Issue.7 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 63
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial
    • de Boer RH, Arrieta O, Yang CH, et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. J Clin Oncol 2011;29(8):1067-74
    • (2011) J Clin Oncol , vol.29 , Issue.8 , pp. 1067-1074
    • De Boer, R.H.1    Arrieta, O.2    Yang, C.H.3
  • 64
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • Natale RB, Thongprasert S, Greco FA, et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011;29(8):1059-66
    • (2011) J Clin Oncol , vol.29 , Issue.8 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 65
    • 84867602821 scopus 로고    scopus 로고
    • Aflibercept and Docetaxel versus Docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: A randomized, controlled phase III trial
    • Ramlau R, Gorbunova V, Ciuleanu TE, et al. Aflibercept and Docetaxel versus Docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: a randomized, controlled phase III trial. J Clin Oncol 2012;30(29):3640-7
    • (2012) J Clin Oncol , vol.30 , Issue.29 , pp. 3640-3647
    • Ramlau, R.1    Gorbunova, V.2    Ciuleanu, T.E.3
  • 66
    • 79957823572 scopus 로고    scopus 로고
    • Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): A double-blind, placebo-controlled, phase 3 trial
    • Herbst RS, Ansari R, Bustin F, et al. Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial. Lancet 2011;377(9780):1846-54
    • (2011) Lancet , vol.377 , Issue.9780 , pp. 1846-1854
    • Herbst, R.S.1    Ansari, R.2    Bustin, F.3
  • 67
    • 84863936062 scopus 로고    scopus 로고
    • Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: A phase III trial
    • Scagliotti GV, Krzakowski M, Szczesna A, et al. Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: a phase III trial. J Clin Oncol 2012;30(17): 2070-8
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2070-2078
    • Scagliotti, G.V.1    Krzakowski, M.2    Szczesna, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.