Hypophosphatemia: An update on its etiology and treatment

American Journal of Medicine

Volumn 118, Issue 10, 2005, Pages 1094-1101

  Gaasbeek, Andreé ^a   Meinders, A Edo ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hypophosphatemia; Parathyroid hormone; Phosphate depletion; Phosphate regulation; Phosphates; Phosphatonins; Vitamin D

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; FRIZZLED PROTEIN; GLYCOPROTEIN; PARATHYROID HORMONE; PHOSPHATE; PHOSPHOPROTEIN; POTASSIUM DIHYDROGEN PHOSPHATE; SODIUM DIHYDROGEN PHOSPHATE; VITAMIN D;

ABSORPTION; BODY DISTRIBUTION; BONE DISEASE; BONE PAIN; CALCIFICATION; CARDIOVASCULAR DISEASE; CLINICAL FEATURE; DEPLETION; DIARRHEA; DIET SUPPLEMENTATION; HEART DISEASE; HEMATOLOGIC DISEASE; HEMOLYSIS; HOMEOSTASIS; HUMAN; HYPERKALEMIA; HYPERNATREMIA; HYPERPARATHYROIDISM; HYPERPHOSPHATEMIA; HYPOCALCEMIA; HYPOPHOSPHATEMIA; INCIDENCE; INTESTINE ABSORPTION; METABOLIC ACIDOSIS; MUSCLE WEAKNESS; MYOPATHY; NEUROLOGICAL COMPLICATION; NONHUMAN; PATHOPHYSIOLOGY; PATIENT CARE; PHOSPHATE BALANCE; PHOSPHATE DEFICIENCY; PHOSPHATE EXCRETION; PHOSPHATE METABOLISM; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATORY FAILURE; RESPIRATORY TRACT DISEASE; REVIEW; RHABDOMYOLYSIS; SUBSTITUTION THERAPY; URINARY EXCRETION;

EXTRACELLULAR MATRIX PROTEINS; FIBROBLAST GROWTH FACTORS; HOMEOSTASIS; HUMANS; HYPOPHOSPHATEMIA; INTESTINAL ABSORPTION; PHOSPHATES; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 25444528711     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2005.02.014     Document Type: Review

References (69)

1. J.S. Stoff Phosphate homeostasis and hypophosphatemia Am J Med 72 1982 489 495
2. N.C. Bugg, J.A. Jones Hypophosphataemia. Pathophysiology, effects and management on the intensive care unit Anaesthesia 53 1998 895 902
3. J.R. Weisinger, E. Bellorin-Font Magnesium and phosphorus Lancet 352 1998 391 396
4. R. Subramanian, R. Khardori Severe hypophosphatemia. Pathophysiologic implications, clinical presentations, and treatment Medicine (Baltimore) 79 2000 1 8
5. J.R. Shiber, A. Mattu Serum phosphate abnormalities in the emergency department J Emerg Med 23 2002 395 400
6. M. Levi Post-transplant hypophosphatemia Kidney Int 59 2001 2377 2387
7. S. Magagnin, A. Werner, D. Markovich Expression cloning of human and rat renal cortex Na/Pi cotransport Proc Natl Acad Sci U S A 90 1993 5979 5983
8. C.J. Boyer, A.D. Baines, E. Beaulieu, R. Beliveau Immunodetection of a type III sodium-dependent phosphate cotransporter in tissues and OK cells Biochim Biophys Acta 1368 1998 73 83
9. H.M. Kronenberg NPT2a - the key to phosphate homeostasis N Engl J Med 347 2002 1022 1024
10. S.C. Schiavi, R. Kumar The phosphatonin pathway new insights in phosphate homeostasis Kidney Int 65 2004 1 14
11. L.D. Quarles Evidence for a bone-kidney axis regulating phosphate homeostasis J Clin Invest 112 2003 642 646
12. L.D. Quarles FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization Am J Physiol Endocrinol Metab 285 2003 E1 E9
13. T. Berndt, T.A. Craig, A.E. Bowe Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent J Clin Invest 112 2003 785 794
14. ADHR Consortium Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 Nat Genet 26 2000 345 348
15. T. Shimada, H. Hasegawa, Y. Yamazaki FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis J Bone Miner Res 19 2004 429 435
16. E. Fiaccadori, E. Coffrini, N. Ronda Hypophosphatemia in course of chronic obstructive pulmonary disease. Prevalence, mechanisms, and relationships with skeletal muscle phosphorus content Chest 97 1990 857 868
17. P.E. Marik, M.K. Bedigian Refeeding hypophosphatemia in critically ill patients in an intensive care unit. A prospective study Arch Surg 131 1996 1043 1047
18. J. Halevy, S. Bulvik Severe hypophosphatemia in hospitalized patients Arch Intern Med 148 1988 153 155
19. L. Larsson, K. Rebel, B. Sorbo Severe hypophosphatemia - a hospital survey Acta Med Scand 214 1983 221 223
20. M.G. Betro, R.W. Pain Hypophosphataemia and hyperphosphataemia in a hospital population Br Med J 1 1972 273 276
21. R.S. Ryback, M.J. Eckardt, C.P. Pautler Clinical relationships between serum phosphorus and other blood chemistry values in alcoholics Arch Intern Med 140 1980 673 677
22. A.L. King, D.A. Sica, G. Miller, S. Pierpaoli Severe hypophosphatemia in a general hospital population South Med J 80 1987 831 835
23. W.H. Daily, A.S. Tonnesen, S.J. Allen Hypophosphatemia - incidence, etiology, and prevention in the trauma patient Crit Care Med 18 1990 1210 1214
24. J.F. Zazzo, G. Troche, P. Ruel, J. Maintenant High incidence of hypophosphatemia in surgical intensive care patients efficacy of phosphorus therapy on myocardial function Intensive Care Med 21 1995 826 831
25. V. Barak, A. Schwartz, I. Kalickman Prevalence of hypophosphatemia in sepsis and infection the role of cytokines Am J Med 104 1998 40 47
26. J.J. Pomposelli, E.A. Pomfret, D.L. Burns Life-threatening hypophosphatemia after right hepatic lobectomy for live donor adult liver transplantation Liver Transpl 7 2001 637 642
27. A. Chines, R. Pacifici Antacid and sucralfate-induced hypophosphatemic osteomalacia a case report and review of the literature Calcif Tissue Int 47 1990 291 295
28. M.A. Crook, V. Hally, J.V. Panteli The importance of the refeeding syndrome Nutrition 17 2001 632 637
29. C.R. Paterson Hypophosphataemia a dangerous disorder Nutrition 12 1996 540 541
30. L. Haglin Hypophosphataemia in anorexia nervosa Postgrad Med J 77 2001 305 311
31. M.A. Crook, D. Collins, R. Swaminathan Severe hypophosphatemia related to refeeding Nutrition 12 1996 538 539
32. R. Kebler, F.D. McDonald, P. Cadnapaphornchai Dynamic changes in serum phosphorus levels in diabetic ketoacidosis Am J Med 79 1985 571 576
33. J.T. Van Dissel, H.J. Gerritsen, A.E. Meinders Severe hypophosphatemia in a patient with anorexia nervosa during oral feeding Miner Electrolyte Metab 18 1992 365 369
34. J.P. Knochel Hypophosphatemia in the alcoholic Arch Intern Med 140 1980 613 615
35. S. De Marchi, E. Cecchin, A. Basile Renal tubular dysfunction in chronic alcohol abuse - effects of abstinence N Engl J Med 329 1993 1927 1934
36. R. Swaminathan, D.B. Morgan, M. Ionescu, G.L. Hill Hypophosphataemia and its consequences in patients following open heart surgery Anaesthesia 33 1978 601 605
37. A.E. Chudley, A. Ninan, G.B. Young Neurologic signs and hypophosphatemia with total parenteral nutrition Can Med Assoc J 125 1981 604 607
38. M. Ravid, M. Robson Proximal myopathy caused by latrogenic phosphate depletion JAMA 236 1976 1380 1381
39. J.P. Knochel, C. Barcenas, J.R. Cotton Hypophosphatemia and rhabdomyolysis J Clin Invest 62 1978 1240 1246
40. P.C. Singhal, A. Kumar, L. Desroches Prevalence and predictors of rhabdomyolysis in patients with hypophosphatemia Am J Med 92 1992 458 464
41. J.P. Knochel Hypophosphatemia and rhabdomyolysis Am J Med 92 1992 455 457
42. J.R. Darsee, D.O. Nutter Reversible severe congestive cardiomyopathy in three cases of hypophosphatemia Ann Intern Med 89 1978 867 870
43. P. Ra'anani, M. Lahav, M. Prokocimer Life threatening hypophosphataemia in a patient with Philadelphia chromosome-positive chronic myelogenous leukaemia in acute blastic crisis Postgrad Med J 68 1992 283 286
44. A. Baars, R. Timmer, P.H. Slee [Metabolic disregulation after starting feeding: "refeeding" syndrome: the central role of phosphate] Ned Tijdschr Geneeskd 146 2002 906 909
45. P.E. Bollaert, B. Levy, L. Nace Hemodynamic and metabolic effects of rapid correction of hypophosphatemia in patients with septic shock Chest 107 1995 1698 1701
46. L.R. O'Connor, W.S. Wheeler, J.E. Bethune Effect of hypophosphatemia on myocardial performance in man N Engl J Med 297 1977 901 903
47. A. Schwartz, G. Gurman, G. Cohen Association between hypophosphatemia and cardiac arrhythmias in the early stages of sepsis Eur J Intern Med 13 2002 434
48. A. Ognibene, R. Ciniglio, A. Greifenstein Ventricular tachycardia in acute myocardial infarction the role of hypophosphatemia South Med J 87 1994 65 69
49. A.G. Agusti, A. Torres, R. Estopa, A. Agustividal Hypophosphatemia as a cause of failed weaning the importance of metabolic factors Crit Care Med 12 1984 142 143
50. M. Aubier, D. Murciano, Y. Lecocguic Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure N Engl J Med 313 1985 420 424
51. J.H. Newman, T.A. Neff, P. Ziporin Acute respiratory failure associated with hypophosphatemia N Engl J Med 296 1977 1101 1103
52. J.G. Prins, H. Schrijver, J.H. Staghouwer Hyperalimentation, hypophosphataemia, and coma Lancet 1 1973 1253 1254
53. H.A. Youssef Hypophosphatemic respiratory failure complicating total parenteral nutrition a potentially lethal iatrogenic hazard Int Surg 67 1982 371 372
54. L. Hasselstrom, P.D. Wimberley, V.G. Nielsen Hypophosphatemia and acute respiratory failure in a diabetic patient Intensive Care Med 12 1986 429 431
55. C.G. Gustavsson, L. Eriksson Acute respiratory failure in anorexia nervosa with hypophosphataemia J Intern Med 225 1989 63 64
56. J. Vanneste, J. Hage Acute severe hypophosphataemia mimicking Wernicke's encephalopathy Lancet 1 1986 44
57. M. Lotz, E. Zisman, F.C. Bartter Evidence for a phosphorus-depletion syndrome in man N Engl J Med 278 1968 409 415
58. S.F. Travis, H.J. Sugerman, R.L. Ruberg Alterations of red-cell glycolytic intermediates and oxygen transport as a consequence of hypophosphatemia in patients receiving intravenous hyperalimentation N Engl J Med 285 1971 763 768
59. J.L. Lee, W.J. Sibbald, R.L. Holliday, A.L. Linton Hypophosphatemia associated with coma Can Med Assoc J 119 1978 143 145
60. J.P. Laaban, L. Marsal, M. Waked Seizures related to severe hypophosphataemia induced by mechanical ventilation Intensive Care Med 16 1990 135 136
61. J.H. Havill, P.R. Rothwell Hypophosphataemia and paraesthesias during parenteral nutrition N Z Med J 83 1976 403 404
62. H.S. Jacob, T. Amsden Acute hemolytic anemia with rigid red cells in hypophosphatemia N Engl J Med 285 1971 1446 1450
63. J.D. Melvin, R.G. Watts Severe hypophosphatemia a rare cause of intravascular hemolysis Am J Hematol 69 2002 223 224
64. U. Kaiser, N. Barth Haemolytic anaemia in a patient with anorexia nervosa Acta Haematol 106 2001 133 135
65. P.R. Craddock, Y. Yawata, L. VanSanten Acquired phagocyte dysfunction. A complication of the hypophosphatemia of parenteral hyperalimentation N Engl J Med 290 1974 1403 1407
66. Y. Yawata, R.P. Hebbel, S. Silvis Blood cell abnormalities complicating the hypophosphatemia of hyperalimentation erythrocyte and platelet ATP deficiency associated with hemolytic anemia and bleeding in hyperalimented dogs J Lab Clin Med 84 1974 643 653
67. J.B. Vannatta, D.L. Andress, R. Whang, S. Papper High-dose intravenous phosphorus therapy for severe complicated hypophosphatemia South Med J 76 1983 1424 1426
68. G.H. Rosen, J.I. Boullata, E.A. O'Rangers Intravenous phosphate repletion regimen for critically ill patients with moderate hypophosphatemia Crit Care Med 23 1995 1204 1210
69. T. Charron, F. Bernard, Y. Skrobik Intravenous phosphate in the intensive care unit more aggressive repletion regimens for moderate and severe hypophosphatemia Intensive Care Med 29 2003 1273 1278