-
1
-
-
0037447488
-
Translation of highly promising basic science research into clinical applications
-
Contopoulos-Ioannidis DG, Ntzani E, Ioannidis JP. Translation of highly promising basic science research into clinical applications. Am J Med. 2003;114:477-84.
-
(2003)
Am J Med.
, vol.114
, pp. 477-484
-
-
Contopoulos-Ioannidis, D.G.1
Ntzani, E.2
Ioannidis, J.P.3
-
2
-
-
84892370974
-
Biomedical research: increasing value, reducing waste
-
Macleod MR, Michie S, Roberts I, Dirnagl U, Chalmers I, Ioannidis JP, et al. Biomedical research: increasing value, reducing waste. Lancet. 2014;383:101-4.
-
(2014)
Lancet.
, vol.383
, pp. 101-104
-
-
Macleod, M.R.1
Michie, S.2
Roberts, I.3
Dirnagl, U.4
Chalmers, I.5
Ioannidis, J.P.6
-
3
-
-
82255179546
-
Drug development in the light of translational science: shine or shade?
-
Wehling M. Drug development in the light of translational science: shine or shade? Drug Discov Today. 2011;16:1076-83.
-
(2011)
Drug Discov Today.
, vol.16
, pp. 1076-1083
-
-
Wehling, M.1
-
4
-
-
84901706695
-
Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
-
Pound P, Bracken MB. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ. 2014;348:g3387.
-
(2014)
BMJ.
, vol.348
, pp. g3387
-
-
Pound, P.1
Bracken, M.B.2
-
5
-
-
67650069258
-
Assessing the translatability of drug projects: what needs to be scored to predict success?
-
Wehling M. Assessing the translatability of drug projects: what needs to be scored to predict success? Nat Rev Drug Discov. 2009;8:541-6.
-
(2009)
Nat Rev Drug Discov.
, vol.8
, pp. 541-546
-
-
Wehling, M.1
-
6
-
-
77956651943
-
The translatability of animal models for clinical development: biomarkers and disease models
-
Wendler A, Wehling M. The translatability of animal models for clinical development: biomarkers and disease models. Curr Opin Pharmacol. 2010;10:601-6.
-
(2010)
Curr Opin Pharmacol.
, vol.10
, pp. 601-606
-
-
Wendler, A.1
Wehling, M.2
-
7
-
-
84857708998
-
Translatability scoring in drug development: eight case studies
-
Wendler A, Wehling M. Translatability scoring in drug development: eight case studies. J Transl Med. 2012;10:39.
-
(2012)
J Transl Med.
, vol.10
, pp. 39
-
-
Wendler, A.1
Wehling, M.2
-
8
-
-
84901946024
-
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
-
Cook D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G, et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nat Rev Drug Discov. 2014;13:419-31.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 419-431
-
-
Cook, D.1
Brown, D.2
Alexander, R.3
March, R.4
Morgan, P.5
Satterthwaite, G.6
-
10
-
-
84941588620
-
-
EMEA: Guideline On Clinical Investigation Of Medicinal Products Used In The Treatment Of Osteoarthritis. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003443.pdf .
-
-
-
-
11
-
-
62849097457
-
Imaging the painful osteoarthritic knee joint: what have we learned?
-
Wenham CY, Conaghan PG. Imaging the painful osteoarthritic knee joint: what have we learned? Nat Clin Pract Rheumatol. 2009;5:149-58.
-
(2009)
Nat Clin Pract Rheumatol.
, vol.5
, pp. 149-158
-
-
Wenham, C.Y.1
Conaghan, P.G.2
-
13
-
-
79955875528
-
OARSI-FDA initiative: defining the disease state of osteoarthritis
-
Lane NE, Brandt K, Hawker G, Peeva E, Schreyer E, Tsuji W, et al. OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthritis Cartilage. 2011;19:478-82.
-
(2011)
Osteoarthritis Cartilage
, vol.19
, pp. 478-482
-
-
Lane, N.E.1
Brandt, K.2
Hawker, G.3
Peeva, E.4
Schreyer, E.5
Tsuji, W.6
-
14
-
-
82155163808
-
Osteoarthritis subpopulations and implications for clinical trial design
-
Bierma-Zeinstra SM, Verhagen AP. Osteoarthritis subpopulations and implications for clinical trial design. Arthritis Res Ther. 2011;13:213.
-
(2011)
Arthritis Res Ther.
, vol.13
, pp. 213
-
-
Bierma-Zeinstra, S.M.1
Verhagen, A.P.2
-
15
-
-
84873411377
-
Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies
-
Conaghan PG. Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies. Nat Rev Rheumatol. 2013;9:68-70.
-
(2013)
Nat Rev Rheumatol.
, vol.9
, pp. 68-70
-
-
Conaghan, P.G.1
-
16
-
-
70349378297
-
Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
-
Herrero-Beaumont G, Roman-Blas JA, Castaneda S, Jimenez SA. Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics. Semin Arthritis Rheum. 2009;39:71-80.
-
(2009)
Semin Arthritis Rheum.
, vol.39
, pp. 71-80
-
-
Herrero-Beaumont, G.1
Roman-Blas, J.A.2
Castaneda, S.3
Jimenez, S.A.4
-
18
-
-
77949678912
-
The anatomical basis for a novel classification of osteoarthritis and allied disorders
-
McGonagle D, Tan AL, Carey J, Benjamin M. The anatomical basis for a novel classification of osteoarthritis and allied disorders. J Anat. 2010;216:279-91.
-
(2010)
J Anat.
, vol.216
, pp. 279-291
-
-
McGonagle, D.1
Tan, A.L.2
Carey, J.3
Benjamin, M.4
-
19
-
-
79959341732
-
Osteoarthritis: an update with relevance for clinical practice
-
Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:2115-26.
-
(2011)
Lancet.
, vol.377
, pp. 2115-2126
-
-
Bijlsma, J.W.1
Berenbaum, F.2
Lafeber, F.P.3
-
20
-
-
80055099774
-
Identification of phenotypes with different clinical outcomes in knee osteoarthritis: data from the Osteoarthritis Initiative
-
Knoop J, van der Leeden M, Thorstensson CA, Roorda LD, Lems WF, Knol DL, et al. Identification of phenotypes with different clinical outcomes in knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2011;63:1535-42.
-
(2011)
Arthritis Care Res (Hoboken)
, vol.63
, pp. 1535-1542
-
-
Knoop, J.1
Leeden, M.2
Thorstensson, C.A.3
Roorda, L.D.4
Lems, W.F.5
Knol, D.L.6
-
21
-
-
84858624231
-
What constitutes an 'animal model of osteoarthritis' - the need for consensus?
-
Little CB, Zaki S. What constitutes an 'animal model of osteoarthritis' - the need for consensus? Osteoarthritis Cartilage. 2012;20:261-7.
-
(2012)
Osteoarthritis Cartilage.
, vol.20
, pp. 261-267
-
-
Little, C.B.1
Zaki, S.2
-
22
-
-
84881189186
-
Post-traumatic osteoarthritis: from mouse models to clinical trials
-
Little CB, Hunter DJ. Post-traumatic osteoarthritis: from mouse models to clinical trials. Nat Rev Rheumatol. 2013;9:485-97.
-
(2013)
Nat Rev Rheumatol.
, vol.9
, pp. 485-497
-
-
Little, C.B.1
Hunter, D.J.2
-
23
-
-
84858962777
-
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
-
van Lent PL, Blom AB, Schelbergen RF, Sloetjes A, Lafeber FP, Lems WF, et al. Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum. 2012;64:1466-76.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 1466-1476
-
-
Lent, P.L.1
Blom, A.B.2
Schelbergen, R.F.3
Sloetjes, A.4
Lafeber, F.P.5
Lems, W.F.6
-
24
-
-
84954239011
-
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis
-
Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, et al. Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis. Ann Rheum Dis. 2014; doi: 10.1136/annrheumdis-2014-205480 .
-
(2014)
Ann Rheum Dis
-
-
Schelbergen, R.F.1
de Munter, W.2
van den Bosch, M.H.3
Lafeber, F.P.4
Sloetjes, A.5
Vogl, T.6
-
25
-
-
80052333632
-
Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice
-
Ryu JH, Yang S, Shin Y, Rhee J, Chun CH, Chun JS. Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum. 2011;63:2732-43.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 2732-2743
-
-
Ryu, J.H.1
Yang, S.2
Shin, Y.3
Rhee, J.4
Chun, C.H.5
Chun, J.S.6
-
26
-
-
12144255852
-
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging
-
de Hooge AS, van de Loo FA, Bennink MB, Arntz OJ, de Hooge P, van den Berg WB. Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage. 2005;13:66-73.
-
(2005)
Osteoarthritis Cartilage.
, vol.13
, pp. 66-73
-
-
Hooge, A.S.1
Loo, F.A.2
Bennink, M.B.3
Arntz, O.J.4
Hooge, P.5
Berg, W.B.6
-
27
-
-
84871226206
-
Aging processes and the development of osteoarthritis
-
Loeser RF. Aging processes and the development of osteoarthritis. Curr Opin Rheumatol. 2013;25:108-13.
-
(2013)
Curr Opin Rheumatol.
, vol.25
, pp. 108-113
-
-
Loeser, R.F.1
-
28
-
-
34548566958
-
The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
-
Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 2007;15:1061-9.
-
(2007)
Osteoarthritis Cartilage.
, vol.15
, pp. 1061-1069
-
-
Glasson, S.S.1
Blanchet, T.J.2
Morris, E.A.3
-
29
-
-
84857742047
-
Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
-
Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. 2012;64:705-17.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 705-717
-
-
Loeser, R.F.1
Olex, A.L.2
McNulty, M.A.3
Carlson, C.S.4
Callahan, M.F.5
Ferguson, C.M.6
-
32
-
-
84871233297
-
Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation
-
Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis. 2012;2:17470.
-
(2012)
Pathobiol Aging Age Relat Dis
, vol.2
, pp. 17470
-
-
Issa, R.I.1
Griffin, T.M.2
-
33
-
-
84860517649
-
High dietary fat and the development of osteoarthritis in a rabbit model
-
Brunner AM, Henn CM, Drewniak EI, Lesieur-Brooks A, Machan J, Crisco JJ, et al. High dietary fat and the development of osteoarthritis in a rabbit model. Osteoarthritis Cartilage. 2012;20:584-92.
-
(2012)
Osteoarthritis Cartilage
, vol.20
, pp. 584-592
-
-
Brunner, A.M.1
Henn, C.M.2
Drewniak, E.I.3
Lesieur-Brooks, A.4
Machan, J.5
Crisco, J.J.6
-
34
-
-
84866174268
-
Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice
-
Gierman LM, van der Ham F, Koudijs A, Wielinga PY, Kleemann R, Kooistra T, et al. Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice. Arthritis Rheum. 2012;64:1172-81.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 1172-1181
-
-
Gierman, L.M.1
Ham, F.2
Koudijs, A.3
Wielinga, P.Y.4
Kleemann, R.5
Kooistra, T.6
-
35
-
-
84876087523
-
Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: pivotal role of the IPFP as a cytokine fountain
-
Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, et al. Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: pivotal role of the IPFP as a cytokine fountain. PLoS One. 2013;8, e60706.
-
(2013)
PLoS One
, vol.8
-
-
Iwata, M.1
Ochi, H.2
Hara, Y.3
Tagawa, M.4
Koga, D.5
Okawa, A.6
-
36
-
-
84898769338
-
Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE * 3Leiden.CETP mice - a translational model for atherosclerosis
-
Gierman LM, Kuhnast S, Koudijs A, Pieterman EJ, Kloppenburg M, van Osch GJ, et al. Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE * 3Leiden.CETP mice - a translational model for atherosclerosis. Ann Rheum Dis. 2014;73:921-7.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 921-927
-
-
Gierman, L.M.1
Kuhnast, S.2
Koudijs, A.3
Pieterman, E.J.4
Kloppenburg, M.5
Osch, G.J.6
-
37
-
-
82755190435
-
High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
-
Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ. High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther. 2011;13:R198.
-
(2011)
Arthritis Res Ther.
, vol.13
, pp. R198
-
-
Mooney, R.A.1
Sampson, E.R.2
Lerea, J.3
Rosier, R.N.4
Zuscik, M.J.5
-
38
-
-
84869056284
-
Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice
-
Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. Arthritis Rheum. 2012;64:3220-30.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 3220-3230
-
-
Louer, C.R.1
Furman, B.D.2
Huebner, J.L.3
Kraus, V.B.4
Olson, S.A.5
Guilak, F.6
-
39
-
-
84872084088
-
Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
-
O'Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis. 2013;72:300-4.
-
(2013)
Ann Rheum Dis.
, vol.72
, pp. 300-304
-
-
O'Conor, C.J.1
Griffin, T.M.2
Liedtke, W.3
Guilak, F.4
-
40
-
-
78651417411
-
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
-
Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, et al. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther. 2010;12:R130.
-
(2010)
Arthritis Res Ther.
, vol.12
, pp. R130
-
-
Griffin, T.M.1
Fermor, B.2
Huebner, J.L.3
Kraus, V.B.4
Rodriguiz, R.M.5
Wetsel, W.C.6
-
41
-
-
77954920924
-
Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model
-
van der Kraan PM. Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model. Arthritis Res Ther. 2010;12:130.
-
(2010)
Arthritis Res Ther.
, vol.12
, pp. 130
-
-
Kraan, P.M.1
-
42
-
-
79952253318
-
Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
-
Yudoh K, Karasawa R. Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). Aging (Albany NY). 2010;2:990-8.
-
(2010)
Aging (Albany NY).
, vol.2
, pp. 990-998
-
-
Yudoh, K.1
Karasawa, R.2
-
43
-
-
84893725682
-
Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice
-
Wei W, Clockaerts S, Bastiaansen-Jenniskens YM, Gierman LM, Botter SM, Bierma-Zeinstra SM, et al. Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice. Osteoarthritis Cartilage. 2014;22:293-301.
-
(2014)
Osteoarthritis Cartilage.
, vol.22
, pp. 293-301
-
-
Wei, W.1
Clockaerts, S.2
Bastiaansen-Jenniskens, Y.M.3
Gierman, L.M.4
Botter, S.M.5
Bierma-Zeinstra, S.M.6
-
44
-
-
84859494190
-
Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study
-
Clockaerts S, Van Osch GJ, Bastiaansen-Jenniskens YM, Verhaar JA, Van Glabbeek F, Van Meurs JB, et al. Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study. Ann Rheum Dis. 2012;71:642-7.
-
(2012)
Ann Rheum Dis.
, vol.71
, pp. 642-647
-
-
Clockaerts, S.1
Osch, G.J.2
Bastiaansen-Jenniskens, Y.M.3
Verhaar, J.A.4
Glabbeek, F.5
Meurs, J.B.6
-
45
-
-
84897969077
-
Use of statins is associated with a lower prevalence of generalised osteoarthritis
-
Valdes AM, Zhang W, Muir K, Maciewicz RA, Doherty S, Doherty M. Use of statins is associated with a lower prevalence of generalised osteoarthritis. Ann Rheum Dis. 2014;73:943-5.
-
(2014)
Ann Rheum Dis.
, vol.73
, pp. 943-945
-
-
Valdes, A.M.1
Zhang, W.2
Muir, K.3
Maciewicz, R.A.4
Doherty, S.5
Doherty, M.6
-
46
-
-
84856368496
-
Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise
-
Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum. 2012;64:443-53.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 443-453
-
-
Griffin, T.M.1
Huebner, J.L.2
Kraus, V.B.3
Yan, Z.4
Guilak, F.5
-
47
-
-
84884619722
-
Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
-
Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310:1263-73.
-
(2013)
JAMA.
, vol.310
, pp. 1263-1273
-
-
Messier, S.P.1
Mihalko, S.L.2
Legault, C.3
Miller, G.D.4
Nicklas, B.J.5
DeVita, P.6
-
48
-
-
12144281641
-
Weight loss: the treatment of choice for knee osteoarthritis? A randomized trial
-
Christensen R, Astrup A, Bliddal H. Weight loss: the treatment of choice for knee osteoarthritis? A randomized trial. Osteoarthritis Cartilage. 2005;13:20-7.
-
(2005)
Osteoarthritis Cartilage.
, vol.13
, pp. 20-27
-
-
Christensen, R.1
Astrup, A.2
Bliddal, H.3
-
49
-
-
84871758696
-
Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: a cohort study
-
Riddle DL, Stratford PW. Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: a cohort study. Arthritis Care Res (Hoboken). 2013;65:15-22.
-
(2013)
Arthritis Care Res (Hoboken)
, vol.65
, pp. 15-22
-
-
Riddle, D.L.1
Stratford, P.W.2
-
50
-
-
70449721151
-
A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog
-
Marshall W, Bockstahler B, Hulse D, Carmichael S. A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog. Vet Comp Orthop Traumatol. 2009;22:339-45.
-
(2009)
Vet Comp Orthop Traumatol.
, vol.22
, pp. 339-345
-
-
Marshall, W.1
Bockstahler, B.2
Hulse, D.3
Carmichael, S.4
-
51
-
-
77954716675
-
The effect of weight loss on lameness in obese dogs with osteoarthritis
-
Marshall WG, Hazewinkel HA, Mullen D, De Meyer G, Baert K, Carmichael S. The effect of weight loss on lameness in obese dogs with osteoarthritis. Vet Res Commun. 2010;34:241-53.
-
(2010)
Vet Res Commun.
, vol.34
, pp. 241-253
-
-
Marshall, W.G.1
Hazewinkel, H.A.2
Mullen, D.3
Meyer, G.4
Baert, K.5
Carmichael, S.6
-
53
-
-
24644508428
-
A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
-
Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage. 2005;13:769-81.
-
(2005)
Osteoarthritis Cartilage.
, vol.13
, pp. 769-781
-
-
Srikanth, V.K.1
Fryer, J.L.2
Zhai, G.3
Winzenberg, T.M.4
Hosmer, D.5
Jones, G.6
-
54
-
-
84877111473
-
Reproductive status and sex show strong effects on knee OA in a baboon model
-
Macrini TE, Coan HB, Levine SM, Lerma T, Saks CD, Araujo DJ, et al. Reproductive status and sex show strong effects on knee OA in a baboon model. Osteoarthritis Cartilage. 2013;21:839-48.
-
(2013)
Osteoarthritis Cartilage.
, vol.21
, pp. 839-848
-
-
Macrini, T.E.1
Coan, H.B.2
Levine, S.M.3
Lerma, T.4
Saks, C.D.5
Araujo, D.J.6
-
55
-
-
84856590600
-
Differential age-related bone architecture changes between female and male STR/Ort mice
-
Uchida K, Urabe K, Naruse K, Kozai Y, Onuma K, Mikuni-Takagaki Y, et al. Differential age-related bone architecture changes between female and male STR/Ort mice. Exp Anim. 2012;61:59-66.
-
(2012)
Exp Anim.
, vol.61
, pp. 59-66
-
-
Uchida, K.1
Urabe, K.2
Naruse, K.3
Kozai, Y.4
Onuma, K.5
Mikuni-Takagaki, Y.6
-
56
-
-
77956937521
-
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig
-
Kraus VB, Huebner JL, DeGroot J, Bendele A. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig. Osteoarthritis Cartilage. 2010;18:S35-52.
-
(2010)
Osteoarthritis Cartilage.
, vol.18
, pp. S35-52
-
-
Kraus, V.B.1
Huebner, J.L.2
DeGroot, J.3
Bendele, A.4
-
57
-
-
42149112853
-
Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach
-
Sniekers YH, Weinans H, Bierma-Zeinstra SM, van Leeuwen JP, van Osch GJ. Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach. Osteoarthritis Cartilage. 2008;16:533-41.
-
(2008)
Osteoarthritis Cartilage.
, vol.16
, pp. 533-541
-
-
Sniekers, Y.H.1
Weinans, H.2
Bierma-Zeinstra, S.M.3
Leeuwen, J.P.4
Osch, G.J.5
-
58
-
-
34248590472
-
Osteoarthritis severity is sex dependent in a surgical mouse model
-
Ma HL, Blanchet TJ, Peluso D, Hopkins B, Morris EA, Glasson SS. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage. 2007;15:695-700.
-
(2007)
Osteoarthritis Cartilage.
, vol.15
, pp. 695-700
-
-
Ma, H.L.1
Blanchet, T.J.2
Peluso, D.3
Hopkins, B.4
Morris, E.A.5
Glasson, S.S.6
-
59
-
-
77950022936
-
ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization
-
Malfait AM, Ritchie J, Gil AS, Austin JS, Hartke J, Qin W, et al. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010;18:572-80.
-
(2010)
Osteoarthritis Cartilage.
, vol.18
, pp. 572-580
-
-
Malfait, A.M.1
Ritchie, J.2
Gil, A.S.3
Austin, J.S.4
Hartke, J.5
Qin, W.6
-
60
-
-
77955675653
-
The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats
-
Chang TK, Huang CH, Chen HC, Cheng CK. The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats. BMC Musculoskelet Disord. 2010;11:185.
-
(2010)
BMC Musculoskelet Disord.
, vol.11
, pp. 185
-
-
Chang, T.K.1
Huang, C.H.2
Chen, H.C.3
Cheng, C.K.4
-
61
-
-
84863258919
-
Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism
-
Funck-Brentano T, Lin H, Hay E, Ah Kioon MD, Schiltz C, Hannouche D, et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS One. 2012;7, e33543.
-
(2012)
PLoS One.
, vol.7
-
-
Funck-Brentano, T.1
Lin, H.2
Hay, E.3
Ah Kioon, M.D.4
Schiltz, C.5
Hannouche, D.6
-
62
-
-
84872814281
-
Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats
-
Zhu S, Chen K, Lan Y, Zhang N, Jiang R, Hu J. Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone. 2013;53:340-9.
-
(2013)
Bone.
, vol.53
, pp. 340-349
-
-
Zhu, S.1
Chen, K.2
Lan, Y.3
Zhang, N.4
Jiang, R.5
Hu, J.6
-
63
-
-
84899008185
-
Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour
-
Yang PY, Tang CC, Chang YC, Huang SY, Hsieh SP, Fan SS, et al. Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour. Eur J Pain. 2014;18:680-90.
-
(2014)
Eur J Pain.
, vol.18
, pp. 680-690
-
-
Yang, P.Y.1
Tang, C.C.2
Chang, Y.C.3
Huang, S.Y.4
Hsieh, S.P.5
Fan, S.S.6
-
64
-
-
84920982714
-
Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats
-
Cui Z, Xu C, Li X, Song J, Yu B. Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats. Bone. 2015;74C:37-47.
-
(2015)
Bone.
, vol.74C
, pp. 37-47
-
-
Cui, Z.1
Xu, C.2
Li, X.3
Song, J.4
Yu, B.5
-
65
-
-
35649018171
-
Studying sex and gender differences in pain and analgesia: a consensus report
-
Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain. 2007;132:S26-45.
-
(2007)
Pain.
, vol.132
, pp. S26-45
-
-
Greenspan, J.D.1
Craft, R.M.2
LeResche, L.3
Arendt-Nielsen, L.4
Berkley, K.J.5
Fillingim, R.B.6
-
66
-
-
84924865050
-
Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis
-
Silverwood V, Blagojevic-Bucknall M, Jinks C, Jordan JL, Protheroe J, Jordan KP. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23:507-15.
-
(2015)
Osteoarthritis Cartilage.
, vol.23
, pp. 507-515
-
-
Silverwood, V.1
Blagojevic-Bucknall, M.2
Jinks, C.3
Jordan, J.L.4
Protheroe, J.5
Jordan, K.P.6
-
67
-
-
84894900735
-
An OA phenotype may obtain major benefit from bone-acting agents
-
Roman-Blas JA, Castaneda S, Largo R, Lems WF, Herrero-Beaumont G. An OA phenotype may obtain major benefit from bone-acting agents. Semin Arthritis Rheum. 2014;43:421-8.
-
(2014)
Semin Arthritis Rheum.
, vol.43
, pp. 421-428
-
-
Roman-Blas, J.A.1
Castaneda, S.2
Largo, R.3
Lems, W.F.4
Herrero-Beaumont, G.5
-
68
-
-
1642576125
-
In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate
-
Morenko BJ, Bove SE, Chen L, Guzman RE, Juneau P, Bocan TM, et al. In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate. Contemp Top Lab Anim Sci. 2004;43:39-43.
-
(2004)
Contemp Top Lab Anim Sci.
, vol.43
, pp. 39-43
-
-
Morenko, B.J.1
Bove, S.E.2
Chen, L.3
Guzman, R.E.4
Juneau, P.5
Bocan, T.M.6
-
69
-
-
84884165424
-
Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort
-
Mohan G, Perilli E, Parkinson IH, Humphries JM, Fazzalari NL, Kuliwaba JS. Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort. Osteoarthritis Cartilage. 2013;21:1595-604.
-
(2013)
Osteoarthritis Cartilage.
, vol.21
, pp. 1595-1604
-
-
Mohan, G.1
Perilli, E.2
Parkinson, I.H.3
Humphries, J.M.4
Fazzalari, N.L.5
Kuliwaba, J.S.6
-
70
-
-
84863681565
-
Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model
-
Yu DG, Yu B, Mao YQ, Zhao X, Wang XQ, Ding HF, et al. Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model. Acta Pharmacol Sin. 2012;33:924-34.
-
(2012)
Acta Pharmacol Sin.
, vol.33
, pp. 924-934
-
-
Yu, D.G.1
Yu, B.2
Mao, Y.Q.3
Zhao, X.4
Wang, X.Q.5
Ding, H.F.6
-
71
-
-
77955438432
-
Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling
-
Kadri A, Funck-Brentano T, Lin H, Ea HK, Hannouche D, Marty C, et al. Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling. Ann Rheum Dis. 2010;69:1533-8.
-
(2010)
Ann Rheum Dis.
, vol.69
, pp. 1533-1538
-
-
Kadri, A.1
Funck-Brentano, T.2
Lin, H.3
Ea, H.K.4
Hannouche, D.5
Marty, C.6
-
72
-
-
84903759857
-
Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model
-
Iijima H, Aoyama T, Ito A, Tajino J, Nagai M, Zhang X, et al. Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model. Osteoarthritis Cartilage. 2014;22:1036-43.
-
(2014)
Osteoarthritis Cartilage.
, vol.22
, pp. 1036-1043
-
-
Iijima, H.1
Aoyama, T.2
Ito, A.3
Tajino, J.4
Nagai, M.5
Zhang, X.6
-
73
-
-
84905561631
-
Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels
-
Schelbergen RF, van Dalen S, ter Huurne M, Roth J, Vogl T, Noel D, et al. Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels. Osteoarthritis Cartilage. 2014;22:1158-66.
-
(2014)
Osteoarthritis Cartilage.
, vol.22
, pp. 1158-1166
-
-
Schelbergen, R.F.1
Dalen, S.2
Huurne, M.3
Roth, J.4
Vogl, T.5
Noel, D.6
-
74
-
-
84882680194
-
Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis
-
Mapp PI, Sagar DR, Ashraf S, Burston JJ, Suri S, Chapman V, et al. Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. Osteoarthritis Cartilage. 2013;21:1336-45.
-
(2013)
Osteoarthritis Cartilage
, vol.21
, pp. 1336-1345
-
-
Mapp, P.I.1
Sagar, D.R.2
Ashraf, S.3
Burston, J.J.4
Suri, S.5
Chapman, V.6
-
75
-
-
0034080616
-
Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee
-
Hannan MT, Felson DT, Pincus T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol. 2000;27:1513-7.
-
(2000)
J Rheumatol.
, vol.27
, pp. 1513-1517
-
-
Hannan, M.T.1
Felson, D.T.2
Pincus, T.3
-
77
-
-
84863825071
-
Zoledronic acid reduces knee pain and bone marrow lesions over 1year: a randomised controlled trial
-
Laslett LL, Dore DA, Quinn SJ, Boon P, Ryan E, Winzenberg TM, et al. Zoledronic acid reduces knee pain and bone marrow lesions over 1year: a randomised controlled trial. Ann Rheum Dis. 2012;71:1322-8.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1322-1328
-
-
Laslett, L.L.1
Dore, D.A.2
Quinn, S.J.3
Boon, P.4
Ryan, E.5
Winzenberg, T.M.6
-
78
-
-
84891746316
-
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial
-
Reginster JY. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial. Ann Rheum Dis. 2014;73, e8.
-
(2014)
Ann Rheum Dis.
, vol.73
-
-
Reginster, J.Y.1
-
79
-
-
84904888189
-
Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis
-
Bruyere O, Reginster JY, Bellamy N, Chapurlat R, Richette P, Cooper C. Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. Rheumatology (Oxford). 2014;53:1457-64.
-
(2014)
Rheumatology (Oxford)
, vol.53
, pp. 1457-1464
-
-
Bruyere, O.1
Reginster, J.Y.2
Bellamy, N.3
Chapurlat, R.4
Richette, P.5
Cooper, C.6
-
80
-
-
79953674495
-
Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
-
Zhang Y, Nevitt M, Niu J, Lewis C, Torner J, Guermazi A, et al. Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging. Arthritis Rheum. 2011;63:691-9.
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 691-699
-
-
Zhang, Y.1
Nevitt, M.2
Niu, J.3
Lewis, C.4
Torner, J.5
Guermazi, A.6
-
81
-
-
0029680070
-
Changes in synovial membrane and joint effusion volumes after intraarticular methylprednisolone. Quantitative assessment of inflammatory and destructive changes in arthritis by MRI
-
Ostergaard M, Stoltenberg M, Gideon P, Sorensen K, Henriksen O, Lorenzen I. Changes in synovial membrane and joint effusion volumes after intraarticular methylprednisolone. Quantitative assessment of inflammatory and destructive changes in arthritis by MRI. J Rheumatol. 1996;23:1151-61.
-
(1996)
J Rheumatol
, vol.23
, pp. 1151-1161
-
-
Ostergaard, M.1
Stoltenberg, M.2
Gideon, P.3
Sorensen, K.4
Henriksen, O.5
Lorenzen, I.6
-
82
-
-
84908181244
-
The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis
-
Wenham CY, Balamoody S, Grainger AJ, Hensor EM, Draycott S, Hodgson R, et al. The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis. Osteoarthritis Cartilage. 2014;22:1614-8.
-
(2014)
Osteoarthritis Cartilage
, vol.22
, pp. 1614-1618
-
-
Wenham, C.Y.1
Balamoody, S.2
Grainger, A.J.3
Hensor, E.M.4
Draycott, S.5
Hodgson, R.6
-
84
-
-
15844413814
-
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
-
Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005;434:644-8.
-
(2005)
Nature.
, vol.434
, pp. 644-648
-
-
Glasson, S.S.1
Askew, R.2
Sheppard, B.3
Carito, B.4
Blanchet, T.5
Ma, H.L.6
-
85
-
-
73249137617
-
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
-
Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009;60:3723-33.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 3723-3733
-
-
Little, C.B.1
Barai, A.2
Burkhardt, D.3
Smith, S.M.4
Fosang, A.J.5
Werb, Z.6
-
86
-
-
84924931349
-
The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone
-
Takebe K, Farooq Rai M, Schmidt E, Sandell L. The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone. Osteoarthritis Cartilage. 2015;23:454-61.
-
(2015)
Osteoarthritis Cartilage.
, vol.23
, pp. 454-461
-
-
Takebe, K.1
Farooq Rai, M.2
Schmidt, E.3
Sandell, L.4
-
87
-
-
77956936940
-
Histopathology atlas of animal model systems - overview of guiding principles
-
Aigner T, Cook JL, Gerwin N, Glasson SS, Laverty S, Little CB, et al. Histopathology atlas of animal model systems - overview of guiding principles. Osteoarthritis Cartilage. 2010;18:S2-6.
-
(2010)
Osteoarthritis Cartilage.
, vol.18
, pp. S2-S6
-
-
Aigner, T.1
Cook, J.L.2
Gerwin, N.3
Glasson, S.S.4
Laverty, S.5
Little, C.B.6
-
88
-
-
84862202243
-
Exercise and osteoarthritis: cause and effects
-
Bennell K, Hinman RS, Wrigley TV, Creaby MW, Hodges P. Exercise and osteoarthritis: cause and effects. Compr Physiol. 2011;1:1943-2008.
-
(2011)
Compr Physiol.
, vol.1
, pp. 1943-2008
-
-
Bennell, K.1
Hinman, R.S.2
Wrigley, T.V.3
Creaby, M.W.4
Hodges, P.5
-
89
-
-
78650980774
-
Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis
-
Roos EM, Herzog W, Block JA, Bennell KL. Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis. Nat Rev Rheumatol. 2011;7:57-63.
-
(2011)
Nat Rev Rheumatol.
, vol.7
, pp. 57-63
-
-
Roos, E.M.1
Herzog, W.2
Block, J.A.3
Bennell, K.L.4
-
90
-
-
84908260701
-
Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee
-
Egloff C, Sawatsky A, Leonard T, Hart DA, Valderrabano V, Herzog W. Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage. 2014;22:1886-93.
-
(2014)
Osteoarthritis Cartilage.
, vol.22
, pp. 1886-1893
-
-
Egloff, C.1
Sawatsky, A.2
Leonard, T.3
Hart, D.A.4
Valderrabano, V.5
Herzog, W.6
-
91
-
-
79959277624
-
Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model
-
Moreau M, Rialland P, Pelletier JP, Martel-Pelletier J, Lajeunesse D, Boileau C, et al. Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis Res Ther. 2011;13:R98.
-
(2011)
Arthritis Res Ther.
, vol.13
, pp. R98
-
-
Moreau, M.1
Rialland, P.2
Pelletier, J.P.3
Martel-Pelletier, J.4
Lajeunesse, D.5
Boileau, C.6
-
92
-
-
77956875270
-
Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease
-
Strassle BW, Mark L, Leventhal L, Piesla MJ, Jian Li X, Kennedy JD, et al. Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. Osteoarthritis Cartilage. 2010;18:1319-28.
-
(2010)
Osteoarthritis Cartilage.
, vol.18
, pp. 1319-1328
-
-
Strassle, B.W.1
Mark, L.2
Leventhal, L.3
Piesla, M.J.4
Jian Li, X.5
Kennedy, J.D.6
-
93
-
-
84903896382
-
Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis
-
Sagar DR, Ashraf S, Xu L, Burston JJ, Menhinick MR, Poulter CL, et al. Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis. Ann Rheum Dis. 2014;73:1558-65.
-
(2014)
Ann Rheum Dis.
, vol.73
, pp. 1558-1565
-
-
Sagar, D.R.1
Ashraf, S.2
Xu, L.3
Burston, J.J.4
Menhinick, M.R.5
Poulter, C.L.6
-
94
-
-
84863433008
-
Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
-
Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012;8:390-8.
-
(2012)
Nat Rev Rheumatol.
, vol.8
, pp. 390-398
-
-
Mapp, P.I.1
Walsh, D.A.2
-
96
-
-
78649499740
-
New trends in MRI of cartilage: advances and limitations in small animal studies
-
Goebel JC, Pinzano A, Grenier D, Perrier AL, Henrionnet C, Galois L, et al. New trends in MRI of cartilage: advances and limitations in small animal studies. Biomed Mater Eng. 2010;20:189-94.
-
(2010)
Biomed Mater Eng.
, vol.20
, pp. 189-194
-
-
Goebel, J.C.1
Pinzano, A.2
Grenier, D.3
Perrier, A.L.4
Henrionnet, C.5
Galois, L.6
-
97
-
-
84875912231
-
Imaging technologies for preclinical models of bone and joint disorders
-
Tremoleda JL, Khalil M, Gompels LL, Wylezinska-Arridge M, Vincent T, Gsell W. Imaging technologies for preclinical models of bone and joint disorders. EJNMMI Res. 2011;1:11.
-
(2011)
EJNMMI Res.
, vol.1
, pp. 11
-
-
Tremoleda, J.L.1
Khalil, M.2
Gompels, L.L.3
Wylezinska-Arridge, M.4
Vincent, T.5
Gsell, W.6
-
98
-
-
84908070606
-
Identifying and treating preclinical and early osteoarthritis
-
Felson DT, Hodgson R. Identifying and treating preclinical and early osteoarthritis. Rheum Dis Clin North Am. 2014;40:699-710.
-
(2014)
Rheum Dis Clin North Am.
, vol.40
, pp. 699-710
-
-
Felson, D.T.1
Hodgson, R.2
-
99
-
-
84901617622
-
Biomarkers for osteoarthritis: current position and steps towards further validation
-
Hunter DJ, Nevitt M, Losina E, Kraus V. Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol. 2014;28:61-71.
-
(2014)
Best Pract Res Clin Rheumatol.
, vol.28
, pp. 61-71
-
-
Hunter, D.J.1
Nevitt, M.2
Losina, E.3
Kraus, V.4
-
100
-
-
79955846044
-
Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
-
Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage. 2011;19:515-42.
-
(2011)
Osteoarthritis Cartilage.
, vol.19
, pp. 515-542
-
-
Kraus, V.B.1
Burnett, B.2
Coindreau, J.3
Cottrell, S.4
Eyre, D.5
Gendreau, M.6
-
101
-
-
84872088054
-
Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis
-
Kamm JL, Frisbie DD, McIlwraith CW, Orr KE. Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis. Am J Vet Res. 2013;74:115-21.
-
(2013)
Am J Vet Res.
, vol.74
, pp. 115-121
-
-
Kamm, J.L.1
Frisbie, D.D.2
McIlwraith, C.W.3
Orr, K.E.4
-
102
-
-
84864580172
-
1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep
-
Maher AD, Coles C, White J, Bateman JF, Fuller ES, Burkhardt D, et al. 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. J Proteome Res. 2012;11:4261-8.
-
(2012)
J Proteome Res.
, vol.11
, pp. 4261-4268
-
-
Maher, A.D.1
Coles, C.2
White, J.3
Bateman, J.F.4
Fuller, E.S.5
Burkhardt, D.6
-
103
-
-
84912022490
-
Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis
-
Mickiewicz B, Heard BJ, Chau JK, Chung M, Hart DA, Shrive NG, et al. Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis. J Orthop Res. 2015;33:71-7.
-
(2015)
J Orthop Res.
, vol.33
, pp. 71-77
-
-
Mickiewicz, B.1
Heard, B.J.2
Chau, J.K.3
Chung, M.4
Hart, D.A.5
Shrive, N.G.6
-
104
-
-
76849084506
-
Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model
-
Allen KD, Adams SB, Setton LA. Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. Tissue Eng Part B Rev. 2010;16:81-92.
-
(2010)
Tissue Eng Part B Rev.
, vol.16
, pp. 81-92
-
-
Allen, K.D.1
Adams, S.B.2
Setton, L.A.3
-
105
-
-
84882574568
-
Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model
-
Ruan MZ, Patel RM, Dawson BC, Jiang MM, Lee BH. Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model. Osteoarthritis Cartilage. 2013;21:1355-64.
-
(2013)
Osteoarthritis Cartilage.
, vol.21
, pp. 1355-1364
-
-
Ruan, M.Z.1
Patel, R.M.2
Dawson, B.C.3
Jiang, M.M.4
Lee, B.H.5
-
106
-
-
84912017984
-
Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis
-
Arendt-Nielsen L, Eskehave TN, Egsgaard LL, Petersen KK, Graven-Nielsen T, Hoeck HC, et al. Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis. Arthritis Rheumatol. 2014;66:3317-26.
-
(2014)
Arthritis Rheumatol.
, vol.66
, pp. 3317-3326
-
-
Arendt-Nielsen, L.1
Eskehave, T.N.2
Egsgaard, L.L.3
Petersen, K.K.4
Graven-Nielsen, T.5
Hoeck, H.C.6
-
107
-
-
84896300321
-
In vivo luminescence imaging of NF-kappaB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis
-
Bowles RD, Mata BA, Bell RD, Mwangi TK, Huebner JL, Kraus VB, et al. In vivo luminescence imaging of NF-kappaB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis. Arthritis Rheumatol. 2014;66:637-46.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 637-646
-
-
Bowles, R.D.1
Mata, B.A.2
Bell, R.D.3
Mwangi, T.K.4
Huebner, J.L.5
Kraus, V.B.6
-
109
-
-
20944436579
-
Osteoarthritis development in novel experimental mouse models induced by knee joint instability
-
Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage. 2005;13:632-41.
-
(2005)
Osteoarthritis Cartilage.
, vol.13
, pp. 632-641
-
-
Kamekura, S.1
Hoshi, K.2
Shimoaka, T.3
Chung, U.4
Chikuda, H.5
Yamada, T.6
-
110
-
-
77956875415
-
Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis
-
McDougall JJ, Schuelert N, Bowyer J. Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis. Osteoarthritis Cartilage. 2010;18:1355-7.
-
(2010)
Osteoarthritis Cartilage.
, vol.18
, pp. 1355-1357
-
-
McDougall, J.J.1
Schuelert, N.2
Bowyer, J.3
-
111
-
-
84858280968
-
Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs
-
Taniguchi S, Ryu J, Seki M, Sumino T, Tokuhashi Y, Esumi M. Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs. J Orthop Res. 2012;30:673-8.
-
(2012)
J Orthop Res.
, vol.30
, pp. 673-678
-
-
Taniguchi, S.1
Ryu, J.2
Seki, M.3
Sumino, T.4
Tokuhashi, Y.5
Esumi, M.6
-
112
-
-
84919336570
-
Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig
-
Horcajada MN, Sanchez C, Membrez Scalfo F, Drion P, Comblain F, Taralla S, et al. Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig. Osteoarthritis Cartilage. 2015;23:94-102.
-
(2015)
Osteoarthritis Cartilage.
, vol.23
, pp. 94-102
-
-
Horcajada, M.N.1
Sanchez, C.2
Membrez Scalfo, F.3
Drion, P.4
Comblain, F.5
Taralla, S.6
-
113
-
-
84884975754
-
Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis
-
Chiusaroli R, Visentini M, Galimberti C, Casseler C, Mennuni L, Covaceuszach S, et al. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage. 2013;21:1807-10.
-
(2013)
Osteoarthritis Cartilage.
, vol.21
, pp. 1807-1810
-
-
Chiusaroli, R.1
Visentini, M.2
Galimberti, C.3
Casseler, C.4
Mennuni, L.5
Covaceuszach, S.6
-
114
-
-
33747101281
-
Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis
-
Quasnichka HL, Anderson-MacKenzie JM, Bailey AJ. Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis. Biorheology. 2006;43:389-97.
-
(2006)
Biorheology.
, vol.43
, pp. 389-397
-
-
Quasnichka, H.L.1
Anderson-MacKenzie, J.M.2
Bailey, A.J.3
-
115
-
-
35348827545
-
Role of subchondral bone in osteoarthritis development: a comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis
-
Muraoka T, Hagino H, Okano T, Enokida M, Teshima R. Role of subchondral bone in osteoarthritis development: a comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis. Arthritis Rheum. 2007;56:3366-74.
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 3366-3374
-
-
Muraoka, T.1
Hagino, H.2
Okano, T.3
Enokida, M.4
Teshima, R.5
-
116
-
-
80053420330
-
Relationship between articular cartilage damage and subchondral bone properties and meniscal ossification in the Dunkin Hartley guinea pig model of osteoarthritis
-
Thomsen JS, Straarup TS, Danielsen CC, Oxlund H, Bruel A. Relationship between articular cartilage damage and subchondral bone properties and meniscal ossification in the Dunkin Hartley guinea pig model of osteoarthritis. Scand J Rheumatol. 2011;40:391-9.
-
(2011)
Scand J Rheumatol.
, vol.40
, pp. 391-399
-
-
Thomsen, J.S.1
Straarup, T.S.2
Danielsen, C.C.3
Oxlund, H.4
Bruel, A.5
-
117
-
-
84874961072
-
Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis
-
Wang T, Wen CY, Yan CH, Lu WW, Chiu KY. Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis. Osteoarthritis Cartilage. 2013;21:574-81.
-
(2013)
Osteoarthritis Cartilage.
, vol.21
, pp. 574-581
-
-
Wang, T.1
Wen, C.Y.2
Yan, C.H.3
Lu, W.W.4
Chiu, K.Y.5
-
118
-
-
84869076212
-
Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
-
Poulet B, Ulici V, Stone TC, Pead M, Gburcik V, Constantinou E, et al. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis Rheum. 2012;64:3256-66.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 3256-3266
-
-
Poulet, B.1
Ulici, V.2
Stone, T.C.3
Pead, M.4
Gburcik, V.5
Constantinou, E.6
-
119
-
-
84880987097
-
Increase of circulating CD11b(+)Gr1(+) cells and recruitment into the synovium in osteoarthritic mice with hyperlipidemia
-
Uchida K, Naruse K, Satoh M, Onuma K, Ueno M, Takano S, et al. Increase of circulating CD11b(+)Gr1(+) cells and recruitment into the synovium in osteoarthritic mice with hyperlipidemia. Exp Anim. 2013;62:255-65.
-
(2013)
Exp Anim.
, vol.62
, pp. 255-265
-
-
Uchida, K.1
Naruse, K.2
Satoh, M.3
Onuma, K.4
Ueno, M.5
Takano, S.6
-
120
-
-
84868121444
-
Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis
-
ter Huurne M, Schelbergen R, Blattes R, Blom A, de Munter W, Grevers LC, et al. Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis Rheum. 2012;64:3604-13.
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 3604-3613
-
-
Huurne, M.1
Schelbergen, R.2
Blattes, R.3
Blom, A.4
Munter, W.5
Grevers, L.C.6
-
121
-
-
84875950652
-
A novel disease-modifying osteoarthritis drug candidate targeting Runx1
-
Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013;72:748-53.
-
(2013)
Ann Rheum Dis.
, vol.72
, pp. 748-753
-
-
Yano, F.1
Hojo, H.2
Ohba, S.3
Fukai, A.4
Hosaka, Y.5
Ikeda, T.6
-
122
-
-
0037975559
-
Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats
-
Renkiewicz R, Qiu L, Lesch C, Sun X, Devalaraja R, Cody T, et al. Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats. Arthritis Rheum. 2003;48:1742-9.
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 1742-1749
-
-
Renkiewicz, R.1
Qiu, L.2
Lesch, C.3
Sun, X.4
Devalaraja, R.5
Cody, T.6
-
123
-
-
79961009626
-
Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors
-
Mazurek SG, Li J, Nabozny GH, Reinhart GA, Muthukumarana AC, Harrison PC, et al. Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors. J Pharmacol Toxicol Methods. 2011;64:89-96.
-
(2011)
J Pharmacol Toxicol Methods
, vol.64
, pp. 89-96
-
-
Mazurek, S.G.1
Li, J.2
Nabozny, G.H.3
Reinhart, G.A.4
Muthukumarana, A.C.5
Harrison, P.C.6
-
124
-
-
84869186227
-
Control of arthritis pain with anti-nerve-growth factor: risk and benefit
-
Seidel MF, Lane NE. Control of arthritis pain with anti-nerve-growth factor: risk and benefit. Curr Rheumatol Rep. 2012;14:583-8.
-
(2012)
Curr Rheumatol Rep.
, vol.14
, pp. 583-588
-
-
Seidel, M.F.1
Lane, N.E.2
-
125
-
-
84901415559
-
Distinguishing between exploratory and confirmatory preclinical research will improve translation
-
Kimmelman J, Mogil JS, Dirnagl U. Distinguishing between exploratory and confirmatory preclinical research will improve translation. PLoS Biol. 2014;12, e1001863.
-
(2014)
PLoS Biol.
, vol.12
-
-
Kimmelman, J.1
Mogil, J.S.2
Dirnagl, U.3
-
126
-
-
78651430475
-
A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee
-
Chappell AS, Desaiah D, Liu-Seifert H, Zhang S, Skljarevski V, Belenkov Y, et al. A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee. Pain Pract. 2011;11:33-41.
-
(2011)
Pain Pract
, vol.11
, pp. 33-41
-
-
Chappell, A.S.1
Desaiah, D.2
Liu-Seifert, H.3
Zhang, S.4
Skljarevski, V.5
Belenkov, Y.6
-
127
-
-
65749106982
-
Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis
-
Chandran P, Pai M, Blomme EA, Hsieh GC, Decker MW, Honore P. Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis. Eur J Pharmacol. 2009;613:39-45.
-
(2009)
Eur J Pharmacol.
, vol.613
, pp. 39-45
-
-
Chandran, P.1
Pai, M.2
Blomme, E.A.3
Hsieh, G.C.4
Decker, M.W.5
Honore, P.6
-
128
-
-
84902061999
-
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis
-
Ishikawa G, Nagakura Y, Takeshita N, Shimizu Y. Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis. Eur J Pharmacol. 2014;738:111-7.
-
(2014)
Eur J Pharmacol.
, vol.738
, pp. 111-117
-
-
Ishikawa, G.1
Nagakura, Y.2
Takeshita, N.3
Shimizu, Y.4
-
129
-
-
79954616674
-
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis
-
Schuelert N, Johnson MP, Oskins JL, Jassal K, Chambers MG, McDougall JJ. Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. Pain. 2011;152:975-81.
-
(2011)
Pain.
, vol.152
, pp. 975-981
-
-
Schuelert, N.1
Johnson, M.P.2
Oskins, J.L.3
Jassal, K.4
Chambers, M.G.5
McDougall, J.J.6
-
130
-
-
84864577250
-
An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee
-
Huggins JP, Smart TS, Langman S, Taylor L, Young T. An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee. Pain. 2012;153:1837-46.
-
(2012)
Pain.
, vol.153
, pp. 1837-1846
-
-
Huggins, J.P.1
Smart, T.S.2
Langman, S.3
Taylor, L.4
Young, T.5
-
131
-
-
85027916656
-
Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis
-
Suokas AK, Sagar DR, Mapp PI, Chapman V, Walsh DA. Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis. Osteoarthritis Cartilage. 2014;22:1207-23.
-
(2014)
Osteoarthritis Cartilage.
, vol.22
, pp. 1207-1223
-
-
Suokas, A.K.1
Sagar, D.R.2
Mapp, P.I.3
Chapman, V.4
Walsh, D.A.5
-
132
-
-
84892372344
-
Animal models of human disease: challenges in enabling translation
-
McGonigle P, Ruggeri B. Animal models of human disease: challenges in enabling translation. Biochem Pharmacol. 2014;87:162-71.
-
(2014)
Biochem Pharmacol.
, vol.87
, pp. 162-171
-
-
McGonigle, P.1
Ruggeri, B.2
-
134
-
-
53049100118
-
Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards
-
Rice AS, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, Machin I, et al. Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain. 2008;139:243-7.
-
(2008)
Pain.
, vol.139
, pp. 243-247
-
-
Rice, A.S.1
Cimino-Brown, D.2
Eisenach, J.C.3
Kontinen, V.K.4
Lacroix-Fralish, M.L.5
Machin, I.6
-
135
-
-
84908207627
-
Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib may possess disease-modifying properties
-
Panahifar A, Jaremko JL, Tessier AG, Lambert RG, Maksymowych WP, Fallone BG, et al. Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib may possess disease-modifying properties. Osteoarthritis Cartilage. 2014;22:1639-50.
-
(2014)
Osteoarthritis Cartilage
, vol.22
, pp. 1639-1650
-
-
Panahifar, A.1
Jaremko, J.L.2
Tessier, A.G.3
Lambert, R.G.4
Maksymowych, W.P.5
Fallone, B.G.6
-
136
-
-
84907424687
-
Minimal clinically important difference: defining what really matters to patients
-
McGlothlin AE, Lewis RJ. Minimal clinically important difference: defining what really matters to patients. JAMA. 2014;312:1342-3.
-
(2014)
JAMA.
, vol.312
, pp. 1342-1343
-
-
McGlothlin, A.E.1
Lewis, R.J.2
-
137
-
-
84908261004
-
How good is 'evidence' from clinical studies of drug effects and why might such evidence fail in the prediction of the clinical utility of drugs?
-
Naci H, Ioannidis JP. How good is 'evidence' from clinical studies of drug effects and why might such evidence fail in the prediction of the clinical utility of drugs? Annu Rev Pharmacol Toxicol. 2015;55:169-89.
-
(2015)
Annu Rev Pharmacol Toxicol.
, vol.55
, pp. 169-189
-
-
Naci, H.1
Ioannidis, J.P.2
-
138
-
-
84890157151
-
An industry perspective on the role and utility of animal models of pain in drug discovery
-
Whiteside GT, Pomonis JD, Kennedy JD. An industry perspective on the role and utility of animal models of pain in drug discovery. Neurosci Lett. 2013;557:65-72.
-
(2013)
Neurosci Lett
, vol.557
, pp. 65-72
-
-
Whiteside, G.T.1
Pomonis, J.D.2
Kennedy, J.D.3
-
139
-
-
84858609570
-
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
-
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Osteoarthritis Cartilage. 2012;20:256-60.
-
(2012)
Osteoarthritis Cartilage.
, vol.20
, pp. 256-260
-
-
Kilkenny, C.1
Browne, W.J.2
Cuthill, I.C.3
Emerson, M.4
Altman, D.G.5
-
140
-
-
84899895006
-
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
-
Sena ES, Currie GL, McCann SK, Macleod MR, Howells DW. Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically. J Cereb Blood Flow Metab. 2014;34:737-42.
-
(2014)
J Cereb Blood Flow Metab.
, vol.34
, pp. 737-742
-
-
Sena, E.S.1
Currie, G.L.2
McCann, S.K.3
Macleod, M.R.4
Howells, D.W.5
-
141
-
-
84941588621
-
-
One Health Initiative
-
One Health Initiative. http://www.onehealthinitiative.com/index.php .
-
-
-
-
142
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J. Clinical development success rates for investigational drugs. Nat Biotechnol. 2014;32:40-51.
-
(2014)
Nat Biotechnol.
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
143
-
-
84928350430
-
Post-market safety warnings for drugs approved in Canada under the Notice of Compliance with conditions policy
-
Lexchin J. Post-market safety warnings for drugs approved in Canada under the Notice of Compliance with conditions policy. Br J Clin Pharmacol. 2015;79:847-59.
-
(2015)
Br J Clin Pharmacol.
, vol.79
, pp. 847-859
-
-
Lexchin, J.1
-
144
-
-
84900462132
-
How safe are new drugs? Market withdrawal of drugs approved in Canada between 1990 and 2009
-
Lexchin J. How safe are new drugs? Market withdrawal of drugs approved in Canada between 1990 and 2009. Open Med. 2014;28:e14-9.
-
(2014)
Open Med.
, vol.28
, pp. e14-e19
-
-
Lexchin, J.1
-
145
-
-
84924874610
-
Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials
-
Karsdal MA, Byrjalsen I, Alexandersen P, Bihlet A, Andersen JR, Riis BJ, et al. Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials. Osteoarthritis Cartilage. 2015;23:532-43.
-
(2015)
Osteoarthritis Cartilage.
, vol.23
, pp. 532-543
-
-
Karsdal, M.A.1
Byrjalsen, I.2
Alexandersen, P.3
Bihlet, A.4
Andersen, J.R.5
Riis, B.J.6
-
146
-
-
79952819173
-
Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover
-
Nielsen RH, Bay-Jensen AC, Byrjalsen I, Karsdal MA. Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover. Osteoarthritis Cartilage. 2011;19:466-73.
-
(2011)
Osteoarthritis Cartilage.
, vol.19
, pp. 466-473
-
-
Nielsen, R.H.1
Bay-Jensen, A.C.2
Byrjalsen, I.3
Karsdal, M.A.4
-
147
-
-
7744219600
-
Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis
-
El Hajjaji H, Williams JM, Devogelaer JP, Lenz ME, Thonar EJ, Manicourt DH. Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis. Osteoarthritis Cartilage. 2004;12:904-11.
-
(2004)
Osteoarthritis Cartilage.
, vol.12
, pp. 904-911
-
-
Hajjaji, H.1
Williams, J.M.2
Devogelaer, J.P.3
Lenz, M.E.4
Thonar, E.J.5
Manicourt, D.H.6
-
148
-
-
84855834663
-
Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus
-
Sondergaard BC, Catala-Lehnen P, Huebner AK, Bay-Jensen AC, Schinke T, Henriksen K, et al. Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus. Osteoarthritis Cartilage. 2012;20:136-43.
-
(2012)
Osteoarthritis Cartilage.
, vol.20
, pp. 136-143
-
-
Sondergaard, B.C.1
Catala-Lehnen, P.2
Huebner, A.K.3
Bay-Jensen, A.C.4
Schinke, T.5
Henriksen, K.6
-
149
-
-
84903455882
-
Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial
-
Lohmander LS, Hellot S, Dreher D, Krantz EF, Kruger DS, Guermazi A, et al. Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2014;66:1820-31.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 1820-1831
-
-
Lohmander, L.S.1
Hellot, S.2
Dreher, D.3
Krantz, E.F.4
Kruger, D.S.5
Guermazi, A.6
-
150
-
-
20944443514
-
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis
-
Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage. 2005;13:623-31.
-
(2005)
Osteoarthritis Cartilage
, vol.13
, pp. 623-631
-
-
Moore, E.E.1
Bendele, A.M.2
Thompson, D.L.3
Littau, A.4
Waggie, K.S.5
Reardon, B.6
-
151
-
-
84872091677
-
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
-
Reginster JY, Badurski J, Bellamy N, Bensen W, Chapurlat R, Chevalier X, et al. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis. 2013;72:179-86.
-
(2013)
Ann Rheum Dis.
, vol.72
, pp. 179-186
-
-
Reginster, J.Y.1
Badurski, J.2
Bellamy, N.3
Bensen, W.4
Chapurlat, R.5
Chevalier, X.6
-
152
-
-
84872070437
-
Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
-
Pelletier JP, Kapoor M, Fahmi H, Lajeunesse D, Blesius A, Maillet J, et al. Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium. Ann Rheum Dis. 2013;72:250-7.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 250-257
-
-
Pelletier, J.P.1
Kapoor, M.2
Fahmi, H.3
Lajeunesse, D.4
Blesius, A.5
Maillet, J.6
-
153
-
-
84874606888
-
Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model
-
Yu DG, Ding HF, Mao YQ, Liu M, Yu B, Zhao X, et al. Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model. Acta Pharmacol Sin. 2013;34:393-402.
-
(2013)
Acta Pharmacol Sin.
, vol.34
, pp. 393-402
-
-
Yu, D.G.1
Ding, H.F.2
Mao, Y.Q.3
Liu, M.4
Yu, B.5
Zhao, X.6
-
154
-
-
84872080405
-
A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
-
le Graverand MP H, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD, et al. A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis. 2013;72:187-95.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 187-195
-
-
Graverand MP, H.1
Clemmer, R.S.2
Redifer, P.3
Brunell, R.M.4
Hayes, C.W.5
Brandt, K.D.6
-
155
-
-
0031864605
-
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase
-
Pelletier JP, Jovanovic D, Fernandes JC, Manning P, Connor JR, Currie MG, et al. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum. 1998;41:1275-86.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1275-1286
-
-
Pelletier, J.P.1
Jovanovic, D.2
Fernandes, J.C.3
Manning, P.4
Connor, J.R.5
Currie, M.G.6
-
156
-
-
0033166769
-
Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor
-
Pelletier JP, Jovanovic D, Fernandes JC, Manning P, Connor JR, Currie MG, et al. Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor. Osteoarthritis Cartilage. 1999;7:416-8.
-
(1999)
Osteoarthritis Cartilage
, vol.7
, pp. 416-418
-
-
Pelletier, J.P.1
Jovanovic, D.2
Fernandes, J.C.3
Manning, P.4
Connor, J.R.5
Currie, M.G.6
-
158
-
-
84941551269
-
Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain
-
Connor J, Rogers K, Sunyer T, Hellio Le Graverand-Gastineau MP, Manning PT. Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain. Osteoarthritis Cartilage. 2012;20:S64-5.
-
(2012)
Osteoarthritis Cartilage
, vol.20
, pp. S64-S65
-
-
Connor, J.1
Rogers, K.2
Sunyer, T.3
Hellio Le Graverand-Gastineau, M.P.4
Manning, P.T.5
-
159
-
-
84872070090
-
Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial
-
McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155-62.
-
(2013)
JAMA.
, vol.309
, pp. 155-162
-
-
McAlindon, T.1
LaValley, M.2
Schneider, E.3
Nuite, M.4
Lee, J.Y.5
Price, L.L.6
-
160
-
-
84869074282
-
Effects of vitamin D supplementation during the induction and progression of osteoarthritis in a rat model
-
Castillo EC, Hernandez-Cueto MA, Vega-Lopez MA, Lavalle C, Kouri JB, Ortiz-Navarrete V. Effects of vitamin D supplementation during the induction and progression of osteoarthritis in a rat model. Evid Based Complement Alternat Med. 2012;2012:156563.
-
(2012)
Evid Based Complement Alternat Med.
, vol.2012
, pp. 156563
-
-
Castillo, E.C.1
Hernandez-Cueto, M.A.2
Vega-Lopez, M.A.3
Lavalle, C.4
Kouri, J.B.5
Ortiz-Navarrete, V.6
-
161
-
-
0036023020
-
Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3
-
Jefferies D, Farquharson C, Thomson J, Smith W, Seawright E, McCormack H, et al. Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3. Vet Res. 2002;33:383-96.
-
(2002)
Vet Res
, vol.33
, pp. 383-396
-
-
Jefferies, D.1
Farquharson, C.2
Thomson, J.3
Smith, W.4
Seawright, E.5
McCormack, H.6
-
162
-
-
67449128722
-
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
-
Raynauld JP, Martel-Pelletier J, Bias P, Laufer S, Haraoui B, Choquette D, et al. Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI. Ann Rheum Dis. 2009;68:938-47.
-
(2009)
Ann Rheum Dis.
, vol.68
, pp. 938-947
-
-
Raynauld, J.P.1
Martel-Pelletier, J.2
Bias, P.3
Laufer, S.4
Haraoui, B.5
Choquette, D.6
-
163
-
-
33744771340
-
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity
-
Moreau M, Boileau C, Martel-Pelletier J, Brunet J, Laufer S, Pelletier JP. Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. J Rheumatol. 2006;33:1176-83.
-
(2006)
J Rheumatol.
, vol.33
, pp. 1176-1183
-
-
Moreau, M.1
Boileau, C.2
Martel-Pelletier, J.3
Brunet, J.4
Laufer, S.5
Pelletier, J.P.6
-
164
-
-
84883697009
-
No effect of risedronate on articular cartilage damage in the Dunkin Hartley guinea pig model of osteoarthritis
-
Thomsen JS, Straarup TS, Danielsen CC, Oxlund H, Brüel A. No effect of risedronate on articular cartilage damage in the Dunkin Hartley guinea pig model of osteoarthritis. Scand J Rheumatol. 2013;42:408-16.
-
(2013)
Scand J Rheumatol.
, vol.42
, pp. 408-416
-
-
Thomsen, J.S.1
Straarup, T.S.2
Danielsen, C.C.3
Oxlund, H.4
Brüel, A.5
-
165
-
-
84900809898
-
Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis
-
Permuy M, Guede D, López-Peña M, Muñoz F, González-Cantalapiedra A, Caeiro JR. Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis. BMC Vet Res. 2014;10:97.
-
(2014)
BMC Vet Res.
, vol.10
, pp. 97
-
-
Permuy, M.1
Guede, D.2
López-Peña, M.3
Muñoz, F.4
González-Cantalapiedra, A.5
Caeiro, J.R.6
-
166
-
-
27744441326
-
Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]
-
Spector TD, Conaghan PG, Buckland-Wright JC, Garnero P, Cline GA, Beary JF, et al. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res Ther. 2005;7:R625-33.
-
(2005)
Arthritis Res Ther.
, vol.7
, pp. R625-R633
-
-
Spector, T.D.1
Conaghan, P.G.2
Buckland-Wright, J.C.3
Garnero, P.4
Cline, G.A.5
Beary, J.F.6
-
167
-
-
33750961447
-
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study
-
Bingham 3rd CO, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, et al. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum. 2006;54:3494-507.
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 3494-3507
-
-
Bingham, C.O.1
Buckland-Wright, J.C.2
Garnero, P.3
Cohen, S.B.4
Dougados, M.5
Adami, S.6
-
168
-
-
33846655848
-
A 2yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients
-
Buckland-Wright JC, Messent EA, Bingham 3rd CO, Ward RJ, Tonkin C. A 2yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology (Oxford). 2007;46:257-64.
-
(2007)
Rheumatology (Oxford)
, vol.46
, pp. 257-264
-
-
Buckland-Wright, J.C.1
Messent, E.A.2
Bingham, C.O.3
Ward, R.J.4
Tonkin, C.5
-
169
-
-
36849020581
-
Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study
-
Krzeski P, Buckland-Wright C, Bálint G, Cline GA, Stoner K, Lyon R, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9:R109.
-
(2007)
Arthritis Res Ther.
, vol.9
, pp. R109
-
-
Krzeski, P.1
Buckland-Wright, C.2
Bálint, G.3
Cline, G.A.4
Stoner, K.5
Lyon, R.6
-
170
-
-
0035161142
-
Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors
-
Janusz MJ, Hookfin EB, Heitmeyer SA, Woessner JF, Freemont AJ, Hoyland JA, et al. Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. Osteoarthritis Cartilage. 2001;9:751-60.
-
(2001)
Osteoarthritis Cartilage.
, vol.9
, pp. 751-760
-
-
Janusz, M.J.1
Hookfin, E.B.2
Heitmeyer, S.A.3
Woessner, J.F.4
Freemont, A.J.5
Hoyland, J.A.6
-
171
-
-
0031654554
-
Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis
-
Brewster M, Lewis EJ, Wilson KL, Greenham AK, Bottomley KM. Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis. Arthritis Rheum. 1998;41:1639-44.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1639-1644
-
-
Brewster, M.1
Lewis, E.J.2
Wilson, K.L.3
Greenham, A.K.4
Bottomley, K.M.5
-
172
-
-
22244469120
-
Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial
-
Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005;52:2015-25.
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 2015-2025
-
-
Brandt, K.D.1
Mazzuca, S.A.2
Katz, B.P.3
Lane, K.A.4
Buckwalter, K.A.5
Yocum, D.E.6
-
173
-
-
0026804664
-
Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline
-
Yu LP, Smith Jr GN, Brandt KD, Myers SL, O'Connor BL, Brandt DA. Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum. 1992;35:1150-9.
-
(1992)
Arthritis Rheum.
, vol.35
, pp. 1150-1159
-
-
Yu, L.P.1
Smith, G.N.2
Brandt, K.D.3
Myers, S.L.4
O'Connor, B.L.5
Brandt, D.A.6
-
174
-
-
62749141216
-
Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig
-
Bowyer J, Heapy CG, Flannelly JK, Waterton JC, Maciewicz RA. Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig. Int J Exp Pathol. 2009;90:174-81.
-
(2009)
Int J Exp Pathol.
, vol.90
, pp. 174-181
-
-
Bowyer, J.1
Heapy, C.G.2
Flannelly, J.K.3
Waterton, J.C.4
Maciewicz, R.A.5
-
175
-
-
84941588622
-
Effects of disease-modifying osteoarthritis drugs in an in-vivo animal model [abstract]. Las Vegas, NV
-
Poster Presentation
-
Silva JA, Fanning PJ, O'Connell SL, Mason-Savas A, Walcott M, Hays P, et al. Effects of disease-modifying osteoarthritis drugs in an in-vivo animal model [abstract]. Las Vegas, NV: Orthopedic Research Society Annual Meeting; 2009. Poster Presentation.
-
(2009)
Orthopedic Research Society Annual Meeting
-
-
Silva, J.A.1
Fanning, P.J.2
O'Connell, S.L.3
Mason-Savas, A.4
Walcott, M.5
Hays, P.6
|