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Volumn 17, Issue 1, 2015, Pages

On the predictive utility of animal models of osteoarthritis

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COLECALCIFEROL; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DOXYCYCLINE; DULOXETINE; FATTY ACID AMIDASE INHIBITOR; LICOFELONE; MATRIX METALLOPROTEINASE INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PLACEBO; PROSTAGLANDIN SYNTHASE INHIBITOR; RISEDRONIC ACID; SALCATONIN; SD 6010; STRONTIUM RANELATE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID; ANTIRHEUMATIC AGENT;

EID: 84941568248     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0747-6     Document Type: Review
Times cited : (117)

References (175)
  • 1
    • 0037447488 scopus 로고    scopus 로고
    • Translation of highly promising basic science research into clinical applications
    • Contopoulos-Ioannidis DG, Ntzani E, Ioannidis JP. Translation of highly promising basic science research into clinical applications. Am J Med. 2003;114:477-84.
    • (2003) Am J Med. , vol.114 , pp. 477-484
    • Contopoulos-Ioannidis, D.G.1    Ntzani, E.2    Ioannidis, J.P.3
  • 3
    • 82255179546 scopus 로고    scopus 로고
    • Drug development in the light of translational science: shine or shade?
    • Wehling M. Drug development in the light of translational science: shine or shade? Drug Discov Today. 2011;16:1076-83.
    • (2011) Drug Discov Today. , vol.16 , pp. 1076-1083
    • Wehling, M.1
  • 4
    • 84901706695 scopus 로고    scopus 로고
    • Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
    • Pound P, Bracken MB. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ. 2014;348:g3387.
    • (2014) BMJ. , vol.348 , pp. g3387
    • Pound, P.1    Bracken, M.B.2
  • 5
    • 67650069258 scopus 로고    scopus 로고
    • Assessing the translatability of drug projects: what needs to be scored to predict success?
    • Wehling M. Assessing the translatability of drug projects: what needs to be scored to predict success? Nat Rev Drug Discov. 2009;8:541-6.
    • (2009) Nat Rev Drug Discov. , vol.8 , pp. 541-546
    • Wehling, M.1
  • 6
    • 77956651943 scopus 로고    scopus 로고
    • The translatability of animal models for clinical development: biomarkers and disease models
    • Wendler A, Wehling M. The translatability of animal models for clinical development: biomarkers and disease models. Curr Opin Pharmacol. 2010;10:601-6.
    • (2010) Curr Opin Pharmacol. , vol.10 , pp. 601-606
    • Wendler, A.1    Wehling, M.2
  • 7
    • 84857708998 scopus 로고    scopus 로고
    • Translatability scoring in drug development: eight case studies
    • Wendler A, Wehling M. Translatability scoring in drug development: eight case studies. J Transl Med. 2012;10:39.
    • (2012) J Transl Med. , vol.10 , pp. 39
    • Wendler, A.1    Wehling, M.2
  • 8
    • 84901946024 scopus 로고    scopus 로고
    • Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
    • Cook D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G, et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nat Rev Drug Discov. 2014;13:419-31.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 419-431
    • Cook, D.1    Brown, D.2    Alexander, R.3    March, R.4    Morgan, P.5    Satterthwaite, G.6
  • 10
    • 84941588620 scopus 로고    scopus 로고
    • EMEA: Guideline On Clinical Investigation Of Medicinal Products Used In The Treatment Of Osteoarthritis. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003443.pdf .
  • 11
    • 62849097457 scopus 로고    scopus 로고
    • Imaging the painful osteoarthritic knee joint: what have we learned?
    • Wenham CY, Conaghan PG. Imaging the painful osteoarthritic knee joint: what have we learned? Nat Clin Pract Rheumatol. 2009;5:149-58.
    • (2009) Nat Clin Pract Rheumatol. , vol.5 , pp. 149-158
    • Wenham, C.Y.1    Conaghan, P.G.2
  • 14
    • 82155163808 scopus 로고    scopus 로고
    • Osteoarthritis subpopulations and implications for clinical trial design
    • Bierma-Zeinstra SM, Verhagen AP. Osteoarthritis subpopulations and implications for clinical trial design. Arthritis Res Ther. 2011;13:213.
    • (2011) Arthritis Res Ther. , vol.13 , pp. 213
    • Bierma-Zeinstra, S.M.1    Verhagen, A.P.2
  • 15
    • 84873411377 scopus 로고    scopus 로고
    • Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies
    • Conaghan PG. Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies. Nat Rev Rheumatol. 2013;9:68-70.
    • (2013) Nat Rev Rheumatol. , vol.9 , pp. 68-70
    • Conaghan, P.G.1
  • 16
    • 70349378297 scopus 로고    scopus 로고
    • Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics
    • Herrero-Beaumont G, Roman-Blas JA, Castaneda S, Jimenez SA. Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics. Semin Arthritis Rheum. 2009;39:71-80.
    • (2009) Semin Arthritis Rheum. , vol.39 , pp. 71-80
    • Herrero-Beaumont, G.1    Roman-Blas, J.A.2    Castaneda, S.3    Jimenez, S.A.4
  • 17
    • 77949879605 scopus 로고    scopus 로고
    • Is osteoarthritis a heterogeneous disease that can be stratified into subsets?
    • Driban JB, Sitler MR, Barbe MF, Balasubramanian E. Is osteoarthritis a heterogeneous disease that can be stratified into subsets? Clin Rheumatol. 2010;29:123-31.
    • (2010) Clin Rheumatol. , vol.29 , pp. 123-131
    • Driban, J.B.1    Sitler, M.R.2    Barbe, M.F.3    Balasubramanian, E.4
  • 18
    • 77949678912 scopus 로고    scopus 로고
    • The anatomical basis for a novel classification of osteoarthritis and allied disorders
    • McGonagle D, Tan AL, Carey J, Benjamin M. The anatomical basis for a novel classification of osteoarthritis and allied disorders. J Anat. 2010;216:279-91.
    • (2010) J Anat. , vol.216 , pp. 279-291
    • McGonagle, D.1    Tan, A.L.2    Carey, J.3    Benjamin, M.4
  • 19
    • 79959341732 scopus 로고    scopus 로고
    • Osteoarthritis: an update with relevance for clinical practice
    • Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:2115-26.
    • (2011) Lancet. , vol.377 , pp. 2115-2126
    • Bijlsma, J.W.1    Berenbaum, F.2    Lafeber, F.P.3
  • 20
    • 80055099774 scopus 로고    scopus 로고
    • Identification of phenotypes with different clinical outcomes in knee osteoarthritis: data from the Osteoarthritis Initiative
    • Knoop J, van der Leeden M, Thorstensson CA, Roorda LD, Lems WF, Knol DL, et al. Identification of phenotypes with different clinical outcomes in knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2011;63:1535-42.
    • (2011) Arthritis Care Res (Hoboken) , vol.63 , pp. 1535-1542
    • Knoop, J.1    Leeden, M.2    Thorstensson, C.A.3    Roorda, L.D.4    Lems, W.F.5    Knol, D.L.6
  • 21
    • 84858624231 scopus 로고    scopus 로고
    • What constitutes an 'animal model of osteoarthritis' - the need for consensus?
    • Little CB, Zaki S. What constitutes an 'animal model of osteoarthritis' - the need for consensus? Osteoarthritis Cartilage. 2012;20:261-7.
    • (2012) Osteoarthritis Cartilage. , vol.20 , pp. 261-267
    • Little, C.B.1    Zaki, S.2
  • 22
    • 84881189186 scopus 로고    scopus 로고
    • Post-traumatic osteoarthritis: from mouse models to clinical trials
    • Little CB, Hunter DJ. Post-traumatic osteoarthritis: from mouse models to clinical trials. Nat Rev Rheumatol. 2013;9:485-97.
    • (2013) Nat Rev Rheumatol. , vol.9 , pp. 485-497
    • Little, C.B.1    Hunter, D.J.2
  • 23
    • 84858962777 scopus 로고    scopus 로고
    • Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
    • van Lent PL, Blom AB, Schelbergen RF, Sloetjes A, Lafeber FP, Lems WF, et al. Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum. 2012;64:1466-76.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1466-1476
    • Lent, P.L.1    Blom, A.B.2    Schelbergen, R.F.3    Sloetjes, A.4    Lafeber, F.P.5    Lems, W.F.6
  • 24
    • 84954239011 scopus 로고    scopus 로고
    • Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis
    • Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, et al. Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis. Ann Rheum Dis. 2014; doi: 10.1136/annrheumdis-2014-205480 .
    • (2014) Ann Rheum Dis
    • Schelbergen, R.F.1    de Munter, W.2    van den Bosch, M.H.3    Lafeber, F.P.4    Sloetjes, A.5    Vogl, T.6
  • 25
    • 80052333632 scopus 로고    scopus 로고
    • Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice
    • Ryu JH, Yang S, Shin Y, Rhee J, Chun CH, Chun JS. Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum. 2011;63:2732-43.
    • (2011) Arthritis Rheum. , vol.63 , pp. 2732-2743
    • Ryu, J.H.1    Yang, S.2    Shin, Y.3    Rhee, J.4    Chun, C.H.5    Chun, J.S.6
  • 27
    • 84871226206 scopus 로고    scopus 로고
    • Aging processes and the development of osteoarthritis
    • Loeser RF. Aging processes and the development of osteoarthritis. Curr Opin Rheumatol. 2013;25:108-13.
    • (2013) Curr Opin Rheumatol. , vol.25 , pp. 108-113
    • Loeser, R.F.1
  • 28
    • 34548566958 scopus 로고    scopus 로고
    • The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
    • Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 2007;15:1061-9.
    • (2007) Osteoarthritis Cartilage. , vol.15 , pp. 1061-1069
    • Glasson, S.S.1    Blanchet, T.J.2    Morris, E.A.3
  • 29
    • 84857742047 scopus 로고    scopus 로고
    • Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
    • Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. 2012;64:705-17.
    • (2012) Arthritis Rheum. , vol.64 , pp. 705-717
    • Loeser, R.F.1    Olex, A.L.2    McNulty, M.A.3    Carlson, C.S.4    Callahan, M.F.5    Ferguson, C.M.6
  • 32
    • 84871233297 scopus 로고    scopus 로고
    • Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation
    • Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis. 2012;2:17470.
    • (2012) Pathobiol Aging Age Relat Dis , vol.2 , pp. 17470
    • Issa, R.I.1    Griffin, T.M.2
  • 34
    • 84866174268 scopus 로고    scopus 로고
    • Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice
    • Gierman LM, van der Ham F, Koudijs A, Wielinga PY, Kleemann R, Kooistra T, et al. Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice. Arthritis Rheum. 2012;64:1172-81.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1172-1181
    • Gierman, L.M.1    Ham, F.2    Koudijs, A.3    Wielinga, P.Y.4    Kleemann, R.5    Kooistra, T.6
  • 35
    • 84876087523 scopus 로고    scopus 로고
    • Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: pivotal role of the IPFP as a cytokine fountain
    • Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, et al. Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: pivotal role of the IPFP as a cytokine fountain. PLoS One. 2013;8, e60706.
    • (2013) PLoS One , vol.8
    • Iwata, M.1    Ochi, H.2    Hara, Y.3    Tagawa, M.4    Koga, D.5    Okawa, A.6
  • 36
    • 84898769338 scopus 로고    scopus 로고
    • Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE * 3Leiden.CETP mice - a translational model for atherosclerosis
    • Gierman LM, Kuhnast S, Koudijs A, Pieterman EJ, Kloppenburg M, van Osch GJ, et al. Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE * 3Leiden.CETP mice - a translational model for atherosclerosis. Ann Rheum Dis. 2014;73:921-7.
    • (2014) Ann Rheum Dis , vol.73 , pp. 921-927
    • Gierman, L.M.1    Kuhnast, S.2    Koudijs, A.3    Pieterman, E.J.4    Kloppenburg, M.5    Osch, G.J.6
  • 37
    • 82755190435 scopus 로고    scopus 로고
    • High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    • Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ. High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther. 2011;13:R198.
    • (2011) Arthritis Res Ther. , vol.13 , pp. R198
    • Mooney, R.A.1    Sampson, E.R.2    Lerea, J.3    Rosier, R.N.4    Zuscik, M.J.5
  • 38
  • 39
    • 84872084088 scopus 로고    scopus 로고
    • Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
    • O'Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis. 2013;72:300-4.
    • (2013) Ann Rheum Dis. , vol.72 , pp. 300-304
    • O'Conor, C.J.1    Griffin, T.M.2    Liedtke, W.3    Guilak, F.4
  • 40
    • 78651417411 scopus 로고    scopus 로고
    • Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    • Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, et al. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther. 2010;12:R130.
    • (2010) Arthritis Res Ther. , vol.12 , pp. R130
    • Griffin, T.M.1    Fermor, B.2    Huebner, J.L.3    Kraus, V.B.4    Rodriguiz, R.M.5    Wetsel, W.C.6
  • 41
    • 77954920924 scopus 로고    scopus 로고
    • Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model
    • van der Kraan PM. Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model. Arthritis Res Ther. 2010;12:130.
    • (2010) Arthritis Res Ther. , vol.12 , pp. 130
    • Kraan, P.M.1
  • 42
    • 79952253318 scopus 로고    scopus 로고
    • Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
    • Yudoh K, Karasawa R. Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). Aging (Albany NY). 2010;2:990-8.
    • (2010) Aging (Albany NY). , vol.2 , pp. 990-998
    • Yudoh, K.1    Karasawa, R.2
  • 46
    • 84856368496 scopus 로고    scopus 로고
    • Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise
    • Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum. 2012;64:443-53.
    • (2012) Arthritis Rheum. , vol.64 , pp. 443-453
    • Griffin, T.M.1    Huebner, J.L.2    Kraus, V.B.3    Yan, Z.4    Guilak, F.5
  • 47
    • 84884619722 scopus 로고    scopus 로고
    • Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
    • Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310:1263-73.
    • (2013) JAMA. , vol.310 , pp. 1263-1273
    • Messier, S.P.1    Mihalko, S.L.2    Legault, C.3    Miller, G.D.4    Nicklas, B.J.5    DeVita, P.6
  • 48
    • 12144281641 scopus 로고    scopus 로고
    • Weight loss: the treatment of choice for knee osteoarthritis? A randomized trial
    • Christensen R, Astrup A, Bliddal H. Weight loss: the treatment of choice for knee osteoarthritis? A randomized trial. Osteoarthritis Cartilage. 2005;13:20-7.
    • (2005) Osteoarthritis Cartilage. , vol.13 , pp. 20-27
    • Christensen, R.1    Astrup, A.2    Bliddal, H.3
  • 49
    • 84871758696 scopus 로고    scopus 로고
    • Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: a cohort study
    • Riddle DL, Stratford PW. Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: a cohort study. Arthritis Care Res (Hoboken). 2013;65:15-22.
    • (2013) Arthritis Care Res (Hoboken) , vol.65 , pp. 15-22
    • Riddle, D.L.1    Stratford, P.W.2
  • 50
    • 70449721151 scopus 로고    scopus 로고
    • A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog
    • Marshall W, Bockstahler B, Hulse D, Carmichael S. A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog. Vet Comp Orthop Traumatol. 2009;22:339-45.
    • (2009) Vet Comp Orthop Traumatol. , vol.22 , pp. 339-345
    • Marshall, W.1    Bockstahler, B.2    Hulse, D.3    Carmichael, S.4
  • 55
    • 84856590600 scopus 로고    scopus 로고
    • Differential age-related bone architecture changes between female and male STR/Ort mice
    • Uchida K, Urabe K, Naruse K, Kozai Y, Onuma K, Mikuni-Takagaki Y, et al. Differential age-related bone architecture changes between female and male STR/Ort mice. Exp Anim. 2012;61:59-66.
    • (2012) Exp Anim. , vol.61 , pp. 59-66
    • Uchida, K.1    Urabe, K.2    Naruse, K.3    Kozai, Y.4    Onuma, K.5    Mikuni-Takagaki, Y.6
  • 56
    • 77956937521 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig
    • Kraus VB, Huebner JL, DeGroot J, Bendele A. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig. Osteoarthritis Cartilage. 2010;18:S35-52.
    • (2010) Osteoarthritis Cartilage. , vol.18 , pp. S35-52
    • Kraus, V.B.1    Huebner, J.L.2    DeGroot, J.3    Bendele, A.4
  • 57
  • 59
    • 77950022936 scopus 로고    scopus 로고
    • ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization
    • Malfait AM, Ritchie J, Gil AS, Austin JS, Hartke J, Qin W, et al. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010;18:572-80.
    • (2010) Osteoarthritis Cartilage. , vol.18 , pp. 572-580
    • Malfait, A.M.1    Ritchie, J.2    Gil, A.S.3    Austin, J.S.4    Hartke, J.5    Qin, W.6
  • 60
    • 77955675653 scopus 로고    scopus 로고
    • The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats
    • Chang TK, Huang CH, Chen HC, Cheng CK. The influence of long-term treadmill exercise on bone mass and articular cartilage in ovariectomized rats. BMC Musculoskelet Disord. 2010;11:185.
    • (2010) BMC Musculoskelet Disord. , vol.11 , pp. 185
    • Chang, T.K.1    Huang, C.H.2    Chen, H.C.3    Cheng, C.K.4
  • 61
    • 84863258919 scopus 로고    scopus 로고
    • Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism
    • Funck-Brentano T, Lin H, Hay E, Ah Kioon MD, Schiltz C, Hannouche D, et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS One. 2012;7, e33543.
    • (2012) PLoS One. , vol.7
    • Funck-Brentano, T.1    Lin, H.2    Hay, E.3    Ah Kioon, M.D.4    Schiltz, C.5    Hannouche, D.6
  • 62
    • 84872814281 scopus 로고    scopus 로고
    • Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats
    • Zhu S, Chen K, Lan Y, Zhang N, Jiang R, Hu J. Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone. 2013;53:340-9.
    • (2013) Bone. , vol.53 , pp. 340-349
    • Zhu, S.1    Chen, K.2    Lan, Y.3    Zhang, N.4    Jiang, R.5    Hu, J.6
  • 63
    • 84899008185 scopus 로고    scopus 로고
    • Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour
    • Yang PY, Tang CC, Chang YC, Huang SY, Hsieh SP, Fan SS, et al. Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour. Eur J Pain. 2014;18:680-90.
    • (2014) Eur J Pain. , vol.18 , pp. 680-690
    • Yang, P.Y.1    Tang, C.C.2    Chang, Y.C.3    Huang, S.Y.4    Hsieh, S.P.5    Fan, S.S.6
  • 64
    • 84920982714 scopus 로고    scopus 로고
    • Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats
    • Cui Z, Xu C, Li X, Song J, Yu B. Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats. Bone. 2015;74C:37-47.
    • (2015) Bone. , vol.74C , pp. 37-47
    • Cui, Z.1    Xu, C.2    Li, X.3    Song, J.4    Yu, B.5
  • 68
    • 1642576125 scopus 로고    scopus 로고
    • In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate
    • Morenko BJ, Bove SE, Chen L, Guzman RE, Juneau P, Bocan TM, et al. In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate. Contemp Top Lab Anim Sci. 2004;43:39-43.
    • (2004) Contemp Top Lab Anim Sci. , vol.43 , pp. 39-43
    • Morenko, B.J.1    Bove, S.E.2    Chen, L.3    Guzman, R.E.4    Juneau, P.5    Bocan, T.M.6
  • 69
    • 84884165424 scopus 로고    scopus 로고
    • Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort
    • Mohan G, Perilli E, Parkinson IH, Humphries JM, Fazzalari NL, Kuliwaba JS. Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort. Osteoarthritis Cartilage. 2013;21:1595-604.
    • (2013) Osteoarthritis Cartilage. , vol.21 , pp. 1595-1604
    • Mohan, G.1    Perilli, E.2    Parkinson, I.H.3    Humphries, J.M.4    Fazzalari, N.L.5    Kuliwaba, J.S.6
  • 70
    • 84863681565 scopus 로고    scopus 로고
    • Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model
    • Yu DG, Yu B, Mao YQ, Zhao X, Wang XQ, Ding HF, et al. Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model. Acta Pharmacol Sin. 2012;33:924-34.
    • (2012) Acta Pharmacol Sin. , vol.33 , pp. 924-934
    • Yu, D.G.1    Yu, B.2    Mao, Y.Q.3    Zhao, X.4    Wang, X.Q.5    Ding, H.F.6
  • 71
    • 77955438432 scopus 로고    scopus 로고
    • Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling
    • Kadri A, Funck-Brentano T, Lin H, Ea HK, Hannouche D, Marty C, et al. Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling. Ann Rheum Dis. 2010;69:1533-8.
    • (2010) Ann Rheum Dis. , vol.69 , pp. 1533-1538
    • Kadri, A.1    Funck-Brentano, T.2    Lin, H.3    Ea, H.K.4    Hannouche, D.5    Marty, C.6
  • 72
    • 84903759857 scopus 로고    scopus 로고
    • Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model
    • Iijima H, Aoyama T, Ito A, Tajino J, Nagai M, Zhang X, et al. Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model. Osteoarthritis Cartilage. 2014;22:1036-43.
    • (2014) Osteoarthritis Cartilage. , vol.22 , pp. 1036-1043
    • Iijima, H.1    Aoyama, T.2    Ito, A.3    Tajino, J.4    Nagai, M.5    Zhang, X.6
  • 73
    • 84905561631 scopus 로고    scopus 로고
    • Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels
    • Schelbergen RF, van Dalen S, ter Huurne M, Roth J, Vogl T, Noel D, et al. Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels. Osteoarthritis Cartilage. 2014;22:1158-66.
    • (2014) Osteoarthritis Cartilage. , vol.22 , pp. 1158-1166
    • Schelbergen, R.F.1    Dalen, S.2    Huurne, M.3    Roth, J.4    Vogl, T.5    Noel, D.6
  • 74
    • 84882680194 scopus 로고    scopus 로고
    • Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis
    • Mapp PI, Sagar DR, Ashraf S, Burston JJ, Suri S, Chapman V, et al. Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. Osteoarthritis Cartilage. 2013;21:1336-45.
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 1336-1345
    • Mapp, P.I.1    Sagar, D.R.2    Ashraf, S.3    Burston, J.J.4    Suri, S.5    Chapman, V.6
  • 75
    • 0034080616 scopus 로고    scopus 로고
    • Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee
    • Hannan MT, Felson DT, Pincus T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol. 2000;27:1513-7.
    • (2000) J Rheumatol. , vol.27 , pp. 1513-1517
    • Hannan, M.T.1    Felson, D.T.2    Pincus, T.3
  • 77
    • 84863825071 scopus 로고    scopus 로고
    • Zoledronic acid reduces knee pain and bone marrow lesions over 1year: a randomised controlled trial
    • Laslett LL, Dore DA, Quinn SJ, Boon P, Ryan E, Winzenberg TM, et al. Zoledronic acid reduces knee pain and bone marrow lesions over 1year: a randomised controlled trial. Ann Rheum Dis. 2012;71:1322-8.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1322-1328
    • Laslett, L.L.1    Dore, D.A.2    Quinn, S.J.3    Boon, P.4    Ryan, E.5    Winzenberg, T.M.6
  • 78
    • 84891746316 scopus 로고    scopus 로고
    • Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial
    • Reginster JY. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial. Ann Rheum Dis. 2014;73, e8.
    • (2014) Ann Rheum Dis. , vol.73
    • Reginster, J.Y.1
  • 79
    • 84904888189 scopus 로고    scopus 로고
    • Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis
    • Bruyere O, Reginster JY, Bellamy N, Chapurlat R, Richette P, Cooper C. Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. Rheumatology (Oxford). 2014;53:1457-64.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1457-1464
    • Bruyere, O.1    Reginster, J.Y.2    Bellamy, N.3    Chapurlat, R.4    Richette, P.5    Cooper, C.6
  • 80
    • 79953674495 scopus 로고    scopus 로고
    • Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging
    • Zhang Y, Nevitt M, Niu J, Lewis C, Torner J, Guermazi A, et al. Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging. Arthritis Rheum. 2011;63:691-9.
    • (2011) Arthritis Rheum. , vol.63 , pp. 691-699
    • Zhang, Y.1    Nevitt, M.2    Niu, J.3    Lewis, C.4    Torner, J.5    Guermazi, A.6
  • 81
    • 0029680070 scopus 로고    scopus 로고
    • Changes in synovial membrane and joint effusion volumes after intraarticular methylprednisolone. Quantitative assessment of inflammatory and destructive changes in arthritis by MRI
    • Ostergaard M, Stoltenberg M, Gideon P, Sorensen K, Henriksen O, Lorenzen I. Changes in synovial membrane and joint effusion volumes after intraarticular methylprednisolone. Quantitative assessment of inflammatory and destructive changes in arthritis by MRI. J Rheumatol. 1996;23:1151-61.
    • (1996) J Rheumatol , vol.23 , pp. 1151-1161
    • Ostergaard, M.1    Stoltenberg, M.2    Gideon, P.3    Sorensen, K.4    Henriksen, O.5    Lorenzen, I.6
  • 82
    • 84908181244 scopus 로고    scopus 로고
    • The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis
    • Wenham CY, Balamoody S, Grainger AJ, Hensor EM, Draycott S, Hodgson R, et al. The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis. Osteoarthritis Cartilage. 2014;22:1614-8.
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. 1614-1618
    • Wenham, C.Y.1    Balamoody, S.2    Grainger, A.J.3    Hensor, E.M.4    Draycott, S.5    Hodgson, R.6
  • 84
    • 15844413814 scopus 로고    scopus 로고
    • Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
    • Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005;434:644-8.
    • (2005) Nature. , vol.434 , pp. 644-648
    • Glasson, S.S.1    Askew, R.2    Sheppard, B.3    Carito, B.4    Blanchet, T.5    Ma, H.L.6
  • 85
    • 73249137617 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
    • Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum. 2009;60:3723-33.
    • (2009) Arthritis Rheum. , vol.60 , pp. 3723-3733
    • Little, C.B.1    Barai, A.2    Burkhardt, D.3    Smith, S.M.4    Fosang, A.J.5    Werb, Z.6
  • 86
    • 84924931349 scopus 로고    scopus 로고
    • The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone
    • Takebe K, Farooq Rai M, Schmidt E, Sandell L. The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone. Osteoarthritis Cartilage. 2015;23:454-61.
    • (2015) Osteoarthritis Cartilage. , vol.23 , pp. 454-461
    • Takebe, K.1    Farooq Rai, M.2    Schmidt, E.3    Sandell, L.4
  • 89
    • 78650980774 scopus 로고    scopus 로고
    • Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis
    • Roos EM, Herzog W, Block JA, Bennell KL. Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis. Nat Rev Rheumatol. 2011;7:57-63.
    • (2011) Nat Rev Rheumatol. , vol.7 , pp. 57-63
    • Roos, E.M.1    Herzog, W.2    Block, J.A.3    Bennell, K.L.4
  • 90
    • 84908260701 scopus 로고    scopus 로고
    • Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee
    • Egloff C, Sawatsky A, Leonard T, Hart DA, Valderrabano V, Herzog W. Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage. 2014;22:1886-93.
    • (2014) Osteoarthritis Cartilage. , vol.22 , pp. 1886-1893
    • Egloff, C.1    Sawatsky, A.2    Leonard, T.3    Hart, D.A.4    Valderrabano, V.5    Herzog, W.6
  • 91
    • 79959277624 scopus 로고    scopus 로고
    • Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model
    • Moreau M, Rialland P, Pelletier JP, Martel-Pelletier J, Lajeunesse D, Boileau C, et al. Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis Res Ther. 2011;13:R98.
    • (2011) Arthritis Res Ther. , vol.13 , pp. R98
    • Moreau, M.1    Rialland, P.2    Pelletier, J.P.3    Martel-Pelletier, J.4    Lajeunesse, D.5    Boileau, C.6
  • 93
    • 84903896382 scopus 로고    scopus 로고
    • Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis
    • Sagar DR, Ashraf S, Xu L, Burston JJ, Menhinick MR, Poulter CL, et al. Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis. Ann Rheum Dis. 2014;73:1558-65.
    • (2014) Ann Rheum Dis. , vol.73 , pp. 1558-1565
    • Sagar, D.R.1    Ashraf, S.2    Xu, L.3    Burston, J.J.4    Menhinick, M.R.5    Poulter, C.L.6
  • 94
    • 84863433008 scopus 로고    scopus 로고
    • Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis
    • Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012;8:390-8.
    • (2012) Nat Rev Rheumatol. , vol.8 , pp. 390-398
    • Mapp, P.I.1    Walsh, D.A.2
  • 95
    • 52449097838 scopus 로고    scopus 로고
    • Imaging of experimental osteoarthritis in small animal models
    • Piscaer TM, van Osch GJ, Verhaar JA, Weinans H. Imaging of experimental osteoarthritis in small animal models. Biorheology. 2008;45:355-64.
    • (2008) Biorheology. , vol.45 , pp. 355-364
    • Piscaer, T.M.1    Osch, G.J.2    Verhaar, J.A.3    Weinans, H.4
  • 98
    • 84908070606 scopus 로고    scopus 로고
    • Identifying and treating preclinical and early osteoarthritis
    • Felson DT, Hodgson R. Identifying and treating preclinical and early osteoarthritis. Rheum Dis Clin North Am. 2014;40:699-710.
    • (2014) Rheum Dis Clin North Am. , vol.40 , pp. 699-710
    • Felson, D.T.1    Hodgson, R.2
  • 99
    • 84901617622 scopus 로고    scopus 로고
    • Biomarkers for osteoarthritis: current position and steps towards further validation
    • Hunter DJ, Nevitt M, Losina E, Kraus V. Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol. 2014;28:61-71.
    • (2014) Best Pract Res Clin Rheumatol. , vol.28 , pp. 61-71
    • Hunter, D.J.1    Nevitt, M.2    Losina, E.3    Kraus, V.4
  • 101
    • 84872088054 scopus 로고    scopus 로고
    • Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis
    • Kamm JL, Frisbie DD, McIlwraith CW, Orr KE. Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis. Am J Vet Res. 2013;74:115-21.
    • (2013) Am J Vet Res. , vol.74 , pp. 115-121
    • Kamm, J.L.1    Frisbie, D.D.2    McIlwraith, C.W.3    Orr, K.E.4
  • 102
    • 84864580172 scopus 로고    scopus 로고
    • 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep
    • Maher AD, Coles C, White J, Bateman JF, Fuller ES, Burkhardt D, et al. 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. J Proteome Res. 2012;11:4261-8.
    • (2012) J Proteome Res. , vol.11 , pp. 4261-4268
    • Maher, A.D.1    Coles, C.2    White, J.3    Bateman, J.F.4    Fuller, E.S.5    Burkhardt, D.6
  • 103
    • 84912022490 scopus 로고    scopus 로고
    • Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis
    • Mickiewicz B, Heard BJ, Chau JK, Chung M, Hart DA, Shrive NG, et al. Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis. J Orthop Res. 2015;33:71-7.
    • (2015) J Orthop Res. , vol.33 , pp. 71-77
    • Mickiewicz, B.1    Heard, B.J.2    Chau, J.K.3    Chung, M.4    Hart, D.A.5    Shrive, N.G.6
  • 104
    • 76849084506 scopus 로고    scopus 로고
    • Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model
    • Allen KD, Adams SB, Setton LA. Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. Tissue Eng Part B Rev. 2010;16:81-92.
    • (2010) Tissue Eng Part B Rev. , vol.16 , pp. 81-92
    • Allen, K.D.1    Adams, S.B.2    Setton, L.A.3
  • 105
    • 84882574568 scopus 로고    scopus 로고
    • Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model
    • Ruan MZ, Patel RM, Dawson BC, Jiang MM, Lee BH. Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model. Osteoarthritis Cartilage. 2013;21:1355-64.
    • (2013) Osteoarthritis Cartilage. , vol.21 , pp. 1355-1364
    • Ruan, M.Z.1    Patel, R.M.2    Dawson, B.C.3    Jiang, M.M.4    Lee, B.H.5
  • 106
    • 84912017984 scopus 로고    scopus 로고
    • Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis
    • Arendt-Nielsen L, Eskehave TN, Egsgaard LL, Petersen KK, Graven-Nielsen T, Hoeck HC, et al. Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis. Arthritis Rheumatol. 2014;66:3317-26.
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 3317-3326
    • Arendt-Nielsen, L.1    Eskehave, T.N.2    Egsgaard, L.L.3    Petersen, K.K.4    Graven-Nielsen, T.5    Hoeck, H.C.6
  • 107
    • 84896300321 scopus 로고    scopus 로고
    • In vivo luminescence imaging of NF-kappaB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis
    • Bowles RD, Mata BA, Bell RD, Mwangi TK, Huebner JL, Kraus VB, et al. In vivo luminescence imaging of NF-kappaB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis. Arthritis Rheumatol. 2014;66:637-46.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 637-646
    • Bowles, R.D.1    Mata, B.A.2    Bell, R.D.3    Mwangi, T.K.4    Huebner, J.L.5    Kraus, V.B.6
  • 109
    • 20944436579 scopus 로고    scopus 로고
    • Osteoarthritis development in novel experimental mouse models induced by knee joint instability
    • Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage. 2005;13:632-41.
    • (2005) Osteoarthritis Cartilage. , vol.13 , pp. 632-641
    • Kamekura, S.1    Hoshi, K.2    Shimoaka, T.3    Chung, U.4    Chikuda, H.5    Yamada, T.6
  • 110
    • 77956875415 scopus 로고    scopus 로고
    • Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis
    • McDougall JJ, Schuelert N, Bowyer J. Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis. Osteoarthritis Cartilage. 2010;18:1355-7.
    • (2010) Osteoarthritis Cartilage. , vol.18 , pp. 1355-1357
    • McDougall, J.J.1    Schuelert, N.2    Bowyer, J.3
  • 111
    • 84858280968 scopus 로고    scopus 로고
    • Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs
    • Taniguchi S, Ryu J, Seki M, Sumino T, Tokuhashi Y, Esumi M. Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs. J Orthop Res. 2012;30:673-8.
    • (2012) J Orthop Res. , vol.30 , pp. 673-678
    • Taniguchi, S.1    Ryu, J.2    Seki, M.3    Sumino, T.4    Tokuhashi, Y.5    Esumi, M.6
  • 113
    • 84884975754 scopus 로고    scopus 로고
    • Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis
    • Chiusaroli R, Visentini M, Galimberti C, Casseler C, Mennuni L, Covaceuszach S, et al. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage. 2013;21:1807-10.
    • (2013) Osteoarthritis Cartilage. , vol.21 , pp. 1807-1810
    • Chiusaroli, R.1    Visentini, M.2    Galimberti, C.3    Casseler, C.4    Mennuni, L.5    Covaceuszach, S.6
  • 114
    • 33747101281 scopus 로고    scopus 로고
    • Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis
    • Quasnichka HL, Anderson-MacKenzie JM, Bailey AJ. Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis. Biorheology. 2006;43:389-97.
    • (2006) Biorheology. , vol.43 , pp. 389-397
    • Quasnichka, H.L.1    Anderson-MacKenzie, J.M.2    Bailey, A.J.3
  • 115
    • 35348827545 scopus 로고    scopus 로고
    • Role of subchondral bone in osteoarthritis development: a comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis
    • Muraoka T, Hagino H, Okano T, Enokida M, Teshima R. Role of subchondral bone in osteoarthritis development: a comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis. Arthritis Rheum. 2007;56:3366-74.
    • (2007) Arthritis Rheum. , vol.56 , pp. 3366-3374
    • Muraoka, T.1    Hagino, H.2    Okano, T.3    Enokida, M.4    Teshima, R.5
  • 116
    • 80053420330 scopus 로고    scopus 로고
    • Relationship between articular cartilage damage and subchondral bone properties and meniscal ossification in the Dunkin Hartley guinea pig model of osteoarthritis
    • Thomsen JS, Straarup TS, Danielsen CC, Oxlund H, Bruel A. Relationship between articular cartilage damage and subchondral bone properties and meniscal ossification in the Dunkin Hartley guinea pig model of osteoarthritis. Scand J Rheumatol. 2011;40:391-9.
    • (2011) Scand J Rheumatol. , vol.40 , pp. 391-399
    • Thomsen, J.S.1    Straarup, T.S.2    Danielsen, C.C.3    Oxlund, H.4    Bruel, A.5
  • 117
    • 84874961072 scopus 로고    scopus 로고
    • Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis
    • Wang T, Wen CY, Yan CH, Lu WW, Chiu KY. Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis. Osteoarthritis Cartilage. 2013;21:574-81.
    • (2013) Osteoarthritis Cartilage. , vol.21 , pp. 574-581
    • Wang, T.1    Wen, C.Y.2    Yan, C.H.3    Lu, W.W.4    Chiu, K.Y.5
  • 118
    • 84869076212 scopus 로고    scopus 로고
    • Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis
    • Poulet B, Ulici V, Stone TC, Pead M, Gburcik V, Constantinou E, et al. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis Rheum. 2012;64:3256-66.
    • (2012) Arthritis Rheum. , vol.64 , pp. 3256-3266
    • Poulet, B.1    Ulici, V.2    Stone, T.C.3    Pead, M.4    Gburcik, V.5    Constantinou, E.6
  • 119
    • 84880987097 scopus 로고    scopus 로고
    • Increase of circulating CD11b(+)Gr1(+) cells and recruitment into the synovium in osteoarthritic mice with hyperlipidemia
    • Uchida K, Naruse K, Satoh M, Onuma K, Ueno M, Takano S, et al. Increase of circulating CD11b(+)Gr1(+) cells and recruitment into the synovium in osteoarthritic mice with hyperlipidemia. Exp Anim. 2013;62:255-65.
    • (2013) Exp Anim. , vol.62 , pp. 255-265
    • Uchida, K.1    Naruse, K.2    Satoh, M.3    Onuma, K.4    Ueno, M.5    Takano, S.6
  • 120
    • 84868121444 scopus 로고    scopus 로고
    • Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis
    • ter Huurne M, Schelbergen R, Blattes R, Blom A, de Munter W, Grevers LC, et al. Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis Rheum. 2012;64:3604-13.
    • (2012) Arthritis Rheum. , vol.64 , pp. 3604-3613
    • Huurne, M.1    Schelbergen, R.2    Blattes, R.3    Blom, A.4    Munter, W.5    Grevers, L.C.6
  • 121
    • 84875950652 scopus 로고    scopus 로고
    • A novel disease-modifying osteoarthritis drug candidate targeting Runx1
    • Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013;72:748-53.
    • (2013) Ann Rheum Dis. , vol.72 , pp. 748-753
    • Yano, F.1    Hojo, H.2    Ohba, S.3    Fukai, A.4    Hosaka, Y.5    Ikeda, T.6
  • 122
    • 0037975559 scopus 로고    scopus 로고
    • Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats
    • Renkiewicz R, Qiu L, Lesch C, Sun X, Devalaraja R, Cody T, et al. Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats. Arthritis Rheum. 2003;48:1742-9.
    • (2003) Arthritis Rheum. , vol.48 , pp. 1742-1749
    • Renkiewicz, R.1    Qiu, L.2    Lesch, C.3    Sun, X.4    Devalaraja, R.5    Cody, T.6
  • 124
    • 84869186227 scopus 로고    scopus 로고
    • Control of arthritis pain with anti-nerve-growth factor: risk and benefit
    • Seidel MF, Lane NE. Control of arthritis pain with anti-nerve-growth factor: risk and benefit. Curr Rheumatol Rep. 2012;14:583-8.
    • (2012) Curr Rheumatol Rep. , vol.14 , pp. 583-588
    • Seidel, M.F.1    Lane, N.E.2
  • 125
    • 84901415559 scopus 로고    scopus 로고
    • Distinguishing between exploratory and confirmatory preclinical research will improve translation
    • Kimmelman J, Mogil JS, Dirnagl U. Distinguishing between exploratory and confirmatory preclinical research will improve translation. PLoS Biol. 2014;12, e1001863.
    • (2014) PLoS Biol. , vol.12
    • Kimmelman, J.1    Mogil, J.S.2    Dirnagl, U.3
  • 126
    • 78651430475 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee
    • Chappell AS, Desaiah D, Liu-Seifert H, Zhang S, Skljarevski V, Belenkov Y, et al. A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee. Pain Pract. 2011;11:33-41.
    • (2011) Pain Pract , vol.11 , pp. 33-41
    • Chappell, A.S.1    Desaiah, D.2    Liu-Seifert, H.3    Zhang, S.4    Skljarevski, V.5    Belenkov, Y.6
  • 128
    • 84902061999 scopus 로고    scopus 로고
    • Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis
    • Ishikawa G, Nagakura Y, Takeshita N, Shimizu Y. Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis. Eur J Pharmacol. 2014;738:111-7.
    • (2014) Eur J Pharmacol. , vol.738 , pp. 111-117
    • Ishikawa, G.1    Nagakura, Y.2    Takeshita, N.3    Shimizu, Y.4
  • 129
    • 79954616674 scopus 로고    scopus 로고
    • Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis
    • Schuelert N, Johnson MP, Oskins JL, Jassal K, Chambers MG, McDougall JJ. Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. Pain. 2011;152:975-81.
    • (2011) Pain. , vol.152 , pp. 975-981
    • Schuelert, N.1    Johnson, M.P.2    Oskins, J.L.3    Jassal, K.4    Chambers, M.G.5    McDougall, J.J.6
  • 130
    • 84864577250 scopus 로고    scopus 로고
    • An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee
    • Huggins JP, Smart TS, Langman S, Taylor L, Young T. An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee. Pain. 2012;153:1837-46.
    • (2012) Pain. , vol.153 , pp. 1837-1846
    • Huggins, J.P.1    Smart, T.S.2    Langman, S.3    Taylor, L.4    Young, T.5
  • 131
    • 85027916656 scopus 로고    scopus 로고
    • Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis
    • Suokas AK, Sagar DR, Mapp PI, Chapman V, Walsh DA. Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis. Osteoarthritis Cartilage. 2014;22:1207-23.
    • (2014) Osteoarthritis Cartilage. , vol.22 , pp. 1207-1223
    • Suokas, A.K.1    Sagar, D.R.2    Mapp, P.I.3    Chapman, V.4    Walsh, D.A.5
  • 132
    • 84892372344 scopus 로고    scopus 로고
    • Animal models of human disease: challenges in enabling translation
    • McGonigle P, Ruggeri B. Animal models of human disease: challenges in enabling translation. Biochem Pharmacol. 2014;87:162-71.
    • (2014) Biochem Pharmacol. , vol.87 , pp. 162-171
    • McGonigle, P.1    Ruggeri, B.2
  • 134
    • 53049100118 scopus 로고    scopus 로고
    • Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards
    • Rice AS, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, Machin I, et al. Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain. 2008;139:243-7.
    • (2008) Pain. , vol.139 , pp. 243-247
    • Rice, A.S.1    Cimino-Brown, D.2    Eisenach, J.C.3    Kontinen, V.K.4    Lacroix-Fralish, M.L.5    Machin, I.6
  • 135
    • 84908207627 scopus 로고    scopus 로고
    • Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib may possess disease-modifying properties
    • Panahifar A, Jaremko JL, Tessier AG, Lambert RG, Maksymowych WP, Fallone BG, et al. Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib may possess disease-modifying properties. Osteoarthritis Cartilage. 2014;22:1639-50.
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. 1639-1650
    • Panahifar, A.1    Jaremko, J.L.2    Tessier, A.G.3    Lambert, R.G.4    Maksymowych, W.P.5    Fallone, B.G.6
  • 136
    • 84907424687 scopus 로고    scopus 로고
    • Minimal clinically important difference: defining what really matters to patients
    • McGlothlin AE, Lewis RJ. Minimal clinically important difference: defining what really matters to patients. JAMA. 2014;312:1342-3.
    • (2014) JAMA. , vol.312 , pp. 1342-1343
    • McGlothlin, A.E.1    Lewis, R.J.2
  • 137
    • 84908261004 scopus 로고    scopus 로고
    • How good is 'evidence' from clinical studies of drug effects and why might such evidence fail in the prediction of the clinical utility of drugs?
    • Naci H, Ioannidis JP. How good is 'evidence' from clinical studies of drug effects and why might such evidence fail in the prediction of the clinical utility of drugs? Annu Rev Pharmacol Toxicol. 2015;55:169-89.
    • (2015) Annu Rev Pharmacol Toxicol. , vol.55 , pp. 169-189
    • Naci, H.1    Ioannidis, J.P.2
  • 138
    • 84890157151 scopus 로고    scopus 로고
    • An industry perspective on the role and utility of animal models of pain in drug discovery
    • Whiteside GT, Pomonis JD, Kennedy JD. An industry perspective on the role and utility of animal models of pain in drug discovery. Neurosci Lett. 2013;557:65-72.
    • (2013) Neurosci Lett , vol.557 , pp. 65-72
    • Whiteside, G.T.1    Pomonis, J.D.2    Kennedy, J.D.3
  • 140
    • 84899895006 scopus 로고    scopus 로고
    • Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
    • Sena ES, Currie GL, McCann SK, Macleod MR, Howells DW. Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically. J Cereb Blood Flow Metab. 2014;34:737-42.
    • (2014) J Cereb Blood Flow Metab. , vol.34 , pp. 737-742
    • Sena, E.S.1    Currie, G.L.2    McCann, S.K.3    Macleod, M.R.4    Howells, D.W.5
  • 141
    • 84941588621 scopus 로고    scopus 로고
    • One Health Initiative
    • One Health Initiative. http://www.onehealthinitiative.com/index.php .
  • 143
    • 84928350430 scopus 로고    scopus 로고
    • Post-market safety warnings for drugs approved in Canada under the Notice of Compliance with conditions policy
    • Lexchin J. Post-market safety warnings for drugs approved in Canada under the Notice of Compliance with conditions policy. Br J Clin Pharmacol. 2015;79:847-59.
    • (2015) Br J Clin Pharmacol. , vol.79 , pp. 847-859
    • Lexchin, J.1
  • 144
    • 84900462132 scopus 로고    scopus 로고
    • How safe are new drugs? Market withdrawal of drugs approved in Canada between 1990 and 2009
    • Lexchin J. How safe are new drugs? Market withdrawal of drugs approved in Canada between 1990 and 2009. Open Med. 2014;28:e14-9.
    • (2014) Open Med. , vol.28 , pp. e14-e19
    • Lexchin, J.1
  • 146
    • 79952819173 scopus 로고    scopus 로고
    • Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover
    • Nielsen RH, Bay-Jensen AC, Byrjalsen I, Karsdal MA. Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover. Osteoarthritis Cartilage. 2011;19:466-73.
    • (2011) Osteoarthritis Cartilage. , vol.19 , pp. 466-473
    • Nielsen, R.H.1    Bay-Jensen, A.C.2    Byrjalsen, I.3    Karsdal, M.A.4
  • 147
    • 7744219600 scopus 로고    scopus 로고
    • Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis
    • El Hajjaji H, Williams JM, Devogelaer JP, Lenz ME, Thonar EJ, Manicourt DH. Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis. Osteoarthritis Cartilage. 2004;12:904-11.
    • (2004) Osteoarthritis Cartilage. , vol.12 , pp. 904-911
    • Hajjaji, H.1    Williams, J.M.2    Devogelaer, J.P.3    Lenz, M.E.4    Thonar, E.J.5    Manicourt, D.H.6
  • 148
    • 84855834663 scopus 로고    scopus 로고
    • Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus
    • Sondergaard BC, Catala-Lehnen P, Huebner AK, Bay-Jensen AC, Schinke T, Henriksen K, et al. Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus. Osteoarthritis Cartilage. 2012;20:136-43.
    • (2012) Osteoarthritis Cartilage. , vol.20 , pp. 136-143
    • Sondergaard, B.C.1    Catala-Lehnen, P.2    Huebner, A.K.3    Bay-Jensen, A.C.4    Schinke, T.5    Henriksen, K.6
  • 149
    • 84903455882 scopus 로고    scopus 로고
    • Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial
    • Lohmander LS, Hellot S, Dreher D, Krantz EF, Kruger DS, Guermazi A, et al. Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2014;66:1820-31.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1820-1831
    • Lohmander, L.S.1    Hellot, S.2    Dreher, D.3    Krantz, E.F.4    Kruger, D.S.5    Guermazi, A.6
  • 150
    • 20944443514 scopus 로고    scopus 로고
    • Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis
    • Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, et al. Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage. 2005;13:623-31.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 623-631
    • Moore, E.E.1    Bendele, A.M.2    Thompson, D.L.3    Littau, A.4    Waggie, K.S.5    Reardon, B.6
  • 151
    • 84872091677 scopus 로고    scopus 로고
    • Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
    • Reginster JY, Badurski J, Bellamy N, Bensen W, Chapurlat R, Chevalier X, et al. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis. 2013;72:179-86.
    • (2013) Ann Rheum Dis. , vol.72 , pp. 179-186
    • Reginster, J.Y.1    Badurski, J.2    Bellamy, N.3    Bensen, W.4    Chapurlat, R.5    Chevalier, X.6
  • 152
    • 84872070437 scopus 로고    scopus 로고
    • Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
    • Pelletier JP, Kapoor M, Fahmi H, Lajeunesse D, Blesius A, Maillet J, et al. Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium. Ann Rheum Dis. 2013;72:250-7.
    • (2013) Ann Rheum Dis , vol.72 , pp. 250-257
    • Pelletier, J.P.1    Kapoor, M.2    Fahmi, H.3    Lajeunesse, D.4    Blesius, A.5    Maillet, J.6
  • 153
    • 84874606888 scopus 로고    scopus 로고
    • Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model
    • Yu DG, Ding HF, Mao YQ, Liu M, Yu B, Zhao X, et al. Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model. Acta Pharmacol Sin. 2013;34:393-402.
    • (2013) Acta Pharmacol Sin. , vol.34 , pp. 393-402
    • Yu, D.G.1    Ding, H.F.2    Mao, Y.Q.3    Liu, M.4    Yu, B.5    Zhao, X.6
  • 154
    • 84872080405 scopus 로고    scopus 로고
    • A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
    • le Graverand MP H, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD, et al. A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis. 2013;72:187-95.
    • (2013) Ann Rheum Dis , vol.72 , pp. 187-195
    • Graverand MP, H.1    Clemmer, R.S.2    Redifer, P.3    Brunell, R.M.4    Hayes, C.W.5    Brandt, K.D.6
  • 155
    • 0031864605 scopus 로고    scopus 로고
    • Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase
    • Pelletier JP, Jovanovic D, Fernandes JC, Manning P, Connor JR, Currie MG, et al. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum. 1998;41:1275-86.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1275-1286
    • Pelletier, J.P.1    Jovanovic, D.2    Fernandes, J.C.3    Manning, P.4    Connor, J.R.5    Currie, M.G.6
  • 158
    • 84941551269 scopus 로고    scopus 로고
    • Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain
    • Connor J, Rogers K, Sunyer T, Hellio Le Graverand-Gastineau MP, Manning PT. Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain. Osteoarthritis Cartilage. 2012;20:S64-5.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. S64-S65
    • Connor, J.1    Rogers, K.2    Sunyer, T.3    Hellio Le Graverand-Gastineau, M.P.4    Manning, P.T.5
  • 159
    • 84872070090 scopus 로고    scopus 로고
    • Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial
    • McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155-62.
    • (2013) JAMA. , vol.309 , pp. 155-162
    • McAlindon, T.1    LaValley, M.2    Schneider, E.3    Nuite, M.4    Lee, J.Y.5    Price, L.L.6
  • 161
    • 0036023020 scopus 로고    scopus 로고
    • Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3
    • Jefferies D, Farquharson C, Thomson J, Smith W, Seawright E, McCormack H, et al. Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3. Vet Res. 2002;33:383-96.
    • (2002) Vet Res , vol.33 , pp. 383-396
    • Jefferies, D.1    Farquharson, C.2    Thomson, J.3    Smith, W.4    Seawright, E.5    McCormack, H.6
  • 162
    • 67449128722 scopus 로고    scopus 로고
    • Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
    • Raynauld JP, Martel-Pelletier J, Bias P, Laufer S, Haraoui B, Choquette D, et al. Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI. Ann Rheum Dis. 2009;68:938-47.
    • (2009) Ann Rheum Dis. , vol.68 , pp. 938-947
    • Raynauld, J.P.1    Martel-Pelletier, J.2    Bias, P.3    Laufer, S.4    Haraoui, B.5    Choquette, D.6
  • 163
    • 33744771340 scopus 로고    scopus 로고
    • Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity
    • Moreau M, Boileau C, Martel-Pelletier J, Brunet J, Laufer S, Pelletier JP. Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. J Rheumatol. 2006;33:1176-83.
    • (2006) J Rheumatol. , vol.33 , pp. 1176-1183
    • Moreau, M.1    Boileau, C.2    Martel-Pelletier, J.3    Brunet, J.4    Laufer, S.5    Pelletier, J.P.6
  • 164
    • 84883697009 scopus 로고    scopus 로고
    • No effect of risedronate on articular cartilage damage in the Dunkin Hartley guinea pig model of osteoarthritis
    • Thomsen JS, Straarup TS, Danielsen CC, Oxlund H, Brüel A. No effect of risedronate on articular cartilage damage in the Dunkin Hartley guinea pig model of osteoarthritis. Scand J Rheumatol. 2013;42:408-16.
    • (2013) Scand J Rheumatol. , vol.42 , pp. 408-416
    • Thomsen, J.S.1    Straarup, T.S.2    Danielsen, C.C.3    Oxlund, H.4    Brüel, A.5
  • 166
    • 27744441326 scopus 로고    scopus 로고
    • Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]
    • Spector TD, Conaghan PG, Buckland-Wright JC, Garnero P, Cline GA, Beary JF, et al. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res Ther. 2005;7:R625-33.
    • (2005) Arthritis Res Ther. , vol.7 , pp. R625-R633
    • Spector, T.D.1    Conaghan, P.G.2    Buckland-Wright, J.C.3    Garnero, P.4    Cline, G.A.5    Beary, J.F.6
  • 167
    • 33750961447 scopus 로고    scopus 로고
    • Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study
    • Bingham 3rd CO, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, et al. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum. 2006;54:3494-507.
    • (2006) Arthritis Rheum. , vol.54 , pp. 3494-3507
    • Bingham, C.O.1    Buckland-Wright, J.C.2    Garnero, P.3    Cohen, S.B.4    Dougados, M.5    Adami, S.6
  • 168
    • 33846655848 scopus 로고    scopus 로고
    • A 2yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients
    • Buckland-Wright JC, Messent EA, Bingham 3rd CO, Ward RJ, Tonkin C. A 2yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology (Oxford). 2007;46:257-64.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 257-264
    • Buckland-Wright, J.C.1    Messent, E.A.2    Bingham, C.O.3    Ward, R.J.4    Tonkin, C.5
  • 169
    • 36849020581 scopus 로고    scopus 로고
    • Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study
    • Krzeski P, Buckland-Wright C, Bálint G, Cline GA, Stoner K, Lyon R, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9:R109.
    • (2007) Arthritis Res Ther. , vol.9 , pp. R109
    • Krzeski, P.1    Buckland-Wright, C.2    Bálint, G.3    Cline, G.A.4    Stoner, K.5    Lyon, R.6
  • 171
    • 0031654554 scopus 로고    scopus 로고
    • Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis
    • Brewster M, Lewis EJ, Wilson KL, Greenham AK, Bottomley KM. Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis. Arthritis Rheum. 1998;41:1639-44.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1639-1644
    • Brewster, M.1    Lewis, E.J.2    Wilson, K.L.3    Greenham, A.K.4    Bottomley, K.M.5
  • 172
    • 22244469120 scopus 로고    scopus 로고
    • Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial
    • Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005;52:2015-25.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2015-2025
    • Brandt, K.D.1    Mazzuca, S.A.2    Katz, B.P.3    Lane, K.A.4    Buckwalter, K.A.5    Yocum, D.E.6
  • 173
    • 0026804664 scopus 로고
    • Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline
    • Yu LP, Smith Jr GN, Brandt KD, Myers SL, O'Connor BL, Brandt DA. Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline. Arthritis Rheum. 1992;35:1150-9.
    • (1992) Arthritis Rheum. , vol.35 , pp. 1150-1159
    • Yu, L.P.1    Smith, G.N.2    Brandt, K.D.3    Myers, S.L.4    O'Connor, B.L.5    Brandt, D.A.6
  • 174
    • 62749141216 scopus 로고    scopus 로고
    • Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig
    • Bowyer J, Heapy CG, Flannelly JK, Waterton JC, Maciewicz RA. Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig. Int J Exp Pathol. 2009;90:174-81.
    • (2009) Int J Exp Pathol. , vol.90 , pp. 174-181
    • Bowyer, J.1    Heapy, C.G.2    Flannelly, J.K.3    Waterton, J.C.4    Maciewicz, R.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.