Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Funck Brentano, Thomas ^a   Lin, Hilène ^a   Hay, Eric ^a   Ah Kioon, Marie Dominique ^a   Schiltz, Corinne ^a   Hannouche, Didier ^b   Nizard, Rémy ^b   Lioté, Frédéric ^a   Orcel, Philippe ^b   de Vernejoul, Marie Christine ^a   Cohen Solal, Martine Esther ^a  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; ESTRADIOL; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; PHOSPHATE BUFFERED SALINE; PROTEINASE; PROTEOGLYCAN; ADAM PROTEIN; ADAMTS5 PROTEIN, MOUSE; BISPHOSPHONIC ACID DERIVATIVE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE PLATE; BONE REMODELING; CARTILAGE; CATABOLISM; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; EXPLANT; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; JOINT INSTABILITY; MENISCECTOMY; METABOLIC REGULATION; MOUSE; NONHUMAN; OSTEOARTHRITIS; OSTEOCLAST; OSTEOLYSIS; OSTEOPENIA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SUPERNATANT; TISSUE CULTURE; ANIMAL; BONE; C57BL MOUSE; DRUG EFFECT; ENZYMOLOGY; KNEE MENISCUS; METABOLIC BONE DISEASE; METABOLISM; PATHOLOGY;

MUS;

ADAM PROTEINS; ANIMALS; BONE AND BONES; BONE DISEASES, METABOLIC; BONE RESORPTION; CARTILAGE; DIPHOSPHONATES; ESTRADIOL; FEMALE; HUMANS; MENISCI, TIBIAL; MICE; MICE, INBRED C57BL; OSTEOARTHRITIS; OSTEOPROTEGERIN; PROTECTIVE AGENTS;

EID: 84863258919     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033543     Document Type: Article

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