Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet

Annals of the Rheumatic Diseases

Volumn 72, Issue 2, 2013, Pages 300-304

  O'Conor, Christopher J ^a,b   Griffin, Timothy M ^c   Liedtke, Wolfgang ^a   Guilak, Farshid ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VANILLOID RECEPTOR 4;

ADIPOGENESIS; ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW; CELL DIFFERENTIATION; CHONDROGENESIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; HISTOPATHOLOGY; KNEE OSTEOARTHRITIS; KNOCKOUT MOUSE; LIPID DIET; MALE; MESODERM; MOUSE; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN FUNCTION; STEM CELL; TISSUE METABOLISM; WEIGHT GAIN; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; DIET, HIGH-FAT; GENETIC PREDISPOSITION TO DISEASE; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, KNOCKOUT; OBESITY; OSTEOARTHRITIS, KNEE; TRPV CATION CHANNELS;

EID: 84872084088     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202272     Document Type: Article

References (31)

1. Teichtahl AJ, Wang Y, Wluka AE, et al. Obesity and knee osteoarthritis: new insights provided by body composition studies. Obesity (Silver Spring) 2008;16:232-40.
2. Felson DT, Anderson JJ, Naimark A, et al. Obesity and knee osteoarthritis. The Framingham Study. Ann of Intern Med 1988;109:18-24.
3. Runhaar J, Koes BW, Clockaerts S, et al. A systematic review on changed biomechanics of lower extremities in obese individuals: a possible role in development of osteoarthritis. Obes Rev 2011;12:1071-82.
4. Oliveria SA, Felson DT, Cirillo PA, et al. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 1999;10:161-6.
5. Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17:4-12.
6. Griffin TM, Fermor B, Huebner JL, et al. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther 2010;12:130.
7. Griffin TM, Guilak F. Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology 2008;45:387-98.
8. Liedtke W, Choe Y, Marti-Renom MA, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 2000;103:525-35.
9. Strotmann R, Harteneck C, Nunnenmacher K, et al. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Bio 2000;2:695-702.
10. Phan MN, Leddy HA, Votta BJ, et al. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum 2009;60:3028-37.
11. Rock MJ, Prenen J, Funari VA, et al. Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nature Genet 2008;40:999-1003.
12. Nilius B, Owsianik G. Channelopathies converge on TRPV4. Nature Genet 2010;42:98-100.
13. Clark AL, Votta BJ, Kumar S, et al. Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum 2010;62:2973-83.
14. Kochukov MY, McNearney TA, Yin H, et al. Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes. Mol Pain 2009;5:49.
15. Denadai-Souza A, Martin L, Vieira de Paula MA, et al. Role of transient receptor potential vanilloid 4 in joint inflammation. Arthritis Rheum 2011;64:1848-58.
16. Furman BD, Olson SA, Guilak F. The development of posttraumatic arthritis after articular fracture. J Orthop Trauma 2006;20:719-25.
17. Morikawa S, Mabuchi Y, Kubota Y, et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 2009;206:2483-96.
18. Diekman BO, Wu CL, Furman BD, et al. Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents post-traumatic arthritis. Cell Transplant Published Online First: 10 Aug 2012. doi:10.3727/096368912X653264.
19. Glasson S, Chambers M, Van Den Berg W, et al. The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010;18(Suppl 3):S17-23.
20. Kusudo T, Wang Z, Mizuno A, et al. TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J Appl Physiol 2012;112:1223-32.
21. Griffin TM, Huebner JL, Kraus VB, et al. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum 2012;64:443-53.
22. Kimura T, Okada A, Yatabe T, et al. RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage. Am J Pathol 2010;176:2858-67.
23. Dreier R. Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders. Arthritis Res Ther 2010;12:216.
24. Merz D, Liu R, Johnson K, et al. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol 2003;171:4406-15.
25. Zhu Z, Luo Z, Ma S, et al. TRP channels and their implications in metabolic diseases. Pflugers Arch 2011;461:211-23.
26. Masuyama R, Vriens J, Voets T, et al. TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab 2008;8:257-65.
27. Muramatsu S, Wakabayashi M, Ohno T, et al. Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation. J Biol Chem 2007;282:32158-67.
28. Levine JD, Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim Biophys Acta 2007;1772:989-1003.
29. Barlow C, Schroeder M, Lekstrom-Himes J, et al. Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments. Nucleic Acids Res 1997;25:2543-5.
30. Chen M, Lichtler AC, Sheu TJ, et al. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 2007;45:44-50.
31. Lau J, Minett MS, Zhao J, et al. Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. Mol Pain 2011;7:100.