Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

Osteoarthritis and Cartilage

Volumn 21, Issue 11, 2013, Pages 1807-1810

  Chiusaroli, R ^a   Visentini, M ^b   Galimberti, C ^a   Casseler, C ^b   Mennuni, L ^a   Covaceuszach, S ^b   Lanza, M ^a   Ugolini, G ^b   Caselli, G ^a   Rovati, L C ^a   Visintin, M ^b  

^a Rotta Research Laboratorium   (Italy)

^b Edificio Q1   (Italy)

Author keywords

ADAMTS5; Animal model; Monoclonal antibody; Osteoarthritis; STR ort mouse

Indexed keywords

AGGRECANASE 2; CRB 0017; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, MOUSE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE; CONTROLLED STUDY; DISEASE COURSE; DRUG PROTEIN BINDING; HISTOLOGY; IN VIVO STUDY; KNEE; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; DRUG ADMINISTRATION; DRUG SCREENING; IMMUNOLOGY; INBRED MOUSE STRAIN; INTRAARTICULAR DRUG ADMINISTRATION; PATHOLOGY; PROCEDURES;

ADAM PROTEINS; ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, EXPERIMENTAL; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; INJECTIONS, INTRA-ARTICULAR; MALE; MICE; MICE, INBRED STRAINS; OSTEOARTHRITIS; RECOMBINANT PROTEINS;

EID: 84884975754     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.08.015     Document Type: Article

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