Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study

Annals of the Rheumatic Diseases

Volumn 71, Issue 5, 2012, Pages 642-647

  Clockaerts, S ^a,b   Van Osch, G J V M ^a   Bastiaansen Jenniskens, Y M ^a   Verhaar, J A N ^a   Van Glabbeek, F ^b   Van Meurs, J B ^a   Kerkhof, H J M ^a,c   Hofman, A ^a,c   Stricker, B H Ch ^a,d   Bierma Zeinstra, S M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c Netherlands Genomics Initiative   (Netherlands)

^d Inspectorate of Health Care   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; SIMVASTATIN;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFECT; DRUG USE; FEMALE; FOLLOW UP; HIP OSTEOARTHRITIS; HUMAN; HYPERCHOLESTEROLEMIA; INCIDENCE; JOINT RADIOGRAPHY; KELLGREN AND LAWRENCE SCORE; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; NETHERLANDS; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM;

COHORT STUDIES; DATABASES, FACTUAL; DISEASE PROGRESSION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; PROSPECTIVE STUDIES;

EID: 84859494190     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2011-200092     Document Type: Article

References (42)

1. Brooks PM. The burden of musculoskeletal disease - a global perspective. Clin Rheumatol 2006;25:778-81. (Pubitemid 44473138)
2. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull WHO 2003;81:646-56. (Pubitemid 37254686)
3. Goldring SR. Role of bone in osteoarthritis pathogenesis. Med Clin North Am 2009;93:25-35; xv.
4. Goldring SR, Goldring MB. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 2004;427(Suppl):S27-36. (Pubitemid 39362798)
5. Hunter DJ, Felson DT. Osteoarthritis. BMJ 2006;332:639-42. (Pubitemid 44365719)
6. Conaghan PG, Vanharanta H, Dieppe PA. Is progressive osteoarthritis an atheromatous vascular disease? Ann Rheum Dis 2005;64:1539-41. (Pubitemid 41532034)
7. Davies-Tuck ML, Hanna F, Davis SR, et al. Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study. Arthritis Res Ther 2009;11:R181.
8. Masuko K, Murata M, Suematsu N, et al. A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation. Clin Exp Rheumatol 2009;27:347-53.
9. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthr Cartil 2008;16:137-62. (Pubitemid 351222155)
10. Lazzerini PE, Capecchi PL, Selvi E, et al. Statins and the joint: multiple targets for a global protection? Semin Arthritis Rheum 2011;40:430-46.
11. Bauer DC. HMG CoA reductase inhibitors and the skeleton: a comprehensive review. Osteoporos Int 2003;14:273-82. (Pubitemid 40824242)
12. Clockaerts S, Bierma-Zeinstra SM. Comment on: statins and the joint: multiple target for a global protection? Semin Arthritis Rheum 2011;40:588.
13. Nissen SE, Tuzcu EM, Schoenhagen P, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 2005;352:29-38. (Pubitemid 40075678)
14. Akasaki Y, Matsuda S, Nakayama K, et al. Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation. Osteoarthr Cartil 2009;17:235-43.
15. Ghosh P, Cheras PA. Vascular mechanisms in osteoarthritis. Best Pract Res Clin Rheumatol 2001;15:693-709. (Pubitemid 34092509)
16. Wu YS, Hu YY, Yang RF, et al. The matrix metalloproteinases as pharmacological target in osteoarthritis: statins may be of therapeutic benefit. Med Hypotheses 2007;69:557-9. (Pubitemid 47043272)
17. Hofman A, Breteler MM, van Duijn CM, et al. The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol 2009;24:553-72.
18. World Health Organization. Anatomical Therapeutic Classification (ATC) Index: including defined daily doses (DDD) for plain substances. Geneva: WHO, 1992.
19. Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol 2005;19:117-25. (Pubitemid 40204354)
20. Kellgren JH, Jeffrey MR, Ball J. The Epidemiology of Chronic Rheumatism. Atlas of Standard Radiographs of Arthritis. Oxford: Blackwell Scientific Publications 1963.
21. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957;16:494-502.
22. Reijman M, Hazes JM, Pols HA, et al. Validity and reliability of three definitions of hip osteoarthritis: cross sectional and longitudinal approach. Ann Rheum Dis 2004;63:1427-33. (Pubitemid 39433946)
23. Schiphof D, Boers M, Bierma-Zeinstra SM. Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis. Ann Rheum Dis 2008;67:1034-6. (Pubitemid 351956670)
24. Spector TD, Hart DJ, Byrne J, et al. Definition of osteoarthritis of the knee for epidemiological studies. Ann Rheum Dis 1993;52:790-4. (Pubitemid 23328690)
25. Auleley GR, Giraudeau B, Dougados M, et al. Radiographic assessment of hip osteoarthritis progression: impact of reading procedures for longitudinal studies. Ann Rheum Dis 2000;59:422-7. (Pubitemid 30395598)
26. Reijman M, Hazes JM, Koes BW, et al. Validity, reliability, and applicability of seven definitions of hip osteoarthritis used in epidemiological studies: a systematic appraisal. Ann Rheum Dis 2004;63:226-32. (Pubitemid 38250661)
27. Brouwer GM, van Tol AW, Bergink AP, et al. Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum 2007;56:1204-11. (Pubitemid 46608645)
28. Zhang Y, Niu J, Felson DT, et al. Methodologic challenges in studying risk factors for progression of knee osteoarthritis. Arthritis Care Res (Hoboken) 2010;62:1527-32.
29. Clockaerts S, Bastiaansen-Jenniskens YM, Runhaar J, et al. The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review. Osteoarthr Cartil 2010;18:876-82.
30. Runhaar J, Koes BW, Bierma-Zeinstra SM. Obesity and biomechanics of every day movements; a systematic review. Osteoarthritis Cartilage 2009;17(Suppl 1):S91.
31. Reijman M, Pols HA, Bergink AP, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 2007;66:158-62. (Pubitemid 46226047)
32. Grotle M, Hagen KB, Natvig B, et al. Obesity and osteoarthritis in knee, hip and/ or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord 2008;9:132.
33. Bierma-Zeinstra SM, Koes BW. Risk factors and prognostic factors of hip and knee osteoarthritis. Nat Clin Pract Rheumatol 2007;3:78-85.
34. Beattie MS, Lane NE, Hung YY, et al. Association of statin use and development and progression of hip osteoarthritis in elderly women. J Rheumatol 2005;32:106-10. (Pubitemid 40092600)
35. Chodick G, Amital H, Shalem Y, et al. Persistence with statins and onset of rheumatoid arthritis: a population-based cohort study. PLoS Med 2010;7:e1000336.
36. Mazzuca SA, Brandt KD, Buckwalter KA. Detection of radiographic joint space narrowing in subjects with knee osteoarthritis: longitudinal comparison of the metatarsophalangeal and semiflexed anteroposterior views. Arthritis Rheum 2003;48:385-90. (Pubitemid 36278006)
37. Abe M, Matsuda M, Kobayashi H, et al. Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages. Arterioscler Thromb Vasc Biol 2008;28:871-7. (Pubitemid 351544101)
38. Dollery CM, McEwan JR, Henney AM. Matrix metalloproteinases and cardiovascular disease. Circ Res 1995;77:863-8.
39. Nissen SE. Effect of intensive lipid lowering on progression of coronary atherosclerosis: evidence for an early benefit from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial. Am J Cardiol 2005;96:61F-8F. (Pubitemid 41207735)
40. Palmer G, Chobaz V, Talabot-Ayer D, et al. Assessment of the efficacy of different statins in murine collagen-induced arthritis. Arthritis Rheum 2004;50:4051-9. (Pubitemid 39643955)
41. Schoofs MW, Sturkenboom MC, van der Klift M, et al. HMG-CoA reductase inhibitors and the risk of vertebral fracture. J Bone Miner Res 2004;19:1525-30. (Pubitemid 41094355)
42. Dahaghin S, Bierma-Zeinstra SM, Koes BW, et al. Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study. Ann Rheum Dis 2007;66:916-20. (Pubitemid 46999793)