Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model

Osteoarthritis and Cartilage

Volumn 22, Issue 7, 2014, Pages 1036-1043

  Iijima, H ^a   Aoyama, T ^a   Ito, A ^a   Tajino, J ^a   Nagai, M ^a   Zhang, X ^a   Yamaguchi, S ^a   Akiyama, H ^b   Kuroki, H ^a  

^a KYOTO UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Cartilage covered by menisci; Cartilage degeneration; Destabilization of medial meniscus; Subchondral bone defects

Indexed keywords

COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 4C; COLLAGENASE 3; UNCLASSIFIED DRUG; VASCULOTROPIN; COLLAGENASE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE DEFECT; CARTILAGE DEGENERATION; CONTROLLED STUDY; DESTABILIZATION OF THE MEDIAL MENISCUS MODEL; DISEASE MODEL; ENCHONDRAL OSSIFICATION; HISTOPATHOLOGY; IMAGING SYSTEM; IMMUNOHISTOCHEMISTRY; INFANT; KNEE FUNCTION; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OARSI SCORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT MODEL; SCORING SYSTEM; THICKNESS; TISSUE SECTION; ANIMAL; CARTILAGE CELL; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; RADIOGRAPHY; TIME; WISTAR RAT;

ANIMALS; CHONDROCYTES; COLLAGEN TYPE II; COLLAGEN TYPE III; COLLAGEN TYPE IV; COLLAGENASES; DISEASE MODELS, ANIMAL; MALE; MATRIX METALLOPROTEINASE 13; MENISCI, TIBIAL; OSTEOARTHRITIS; RATS; RATS, WISTAR; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; X-RAY MICROTOMOGRAPHY;

EID: 84903759857     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.05.009     Document Type: Article

References (43)

1. Muraki S., Oka H., Akune T., Mabuchi A., En-yo Y., Yoshida M., et al. Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis Cartilage 2009, 17:1137-1143.
2. Liu L., Ishijima M., Kaneko H., Futami I., Sadatsuki R., Hada S., et al. Disability for daily living is a predictor for joint replacement in patients with end-stage knee osteoarthritis. JBone Miner Metab 2013, 32:192-199.
3. Blagojevic M., Jinks C., Jeffery A., Jordan K.P. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage 2010, 18:24-33.
4. Andriacchi T.P., Koo S., Scanlan S.F. Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee. JBone Joint Surg Am 2009, 91(Suppl 1):95-101.
5. Messner K., Gao J. The menisci of the knee joint. Anatomical and functional characteristics, and a rationale for clinical treatment. JAnat 1998, 193:161-178.
6. Lee S.J., Aadalen K.J., Malaviya P., Lorenz E.P., Hayden J.K., Farr J., et al. Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee. Am J Sports Med 2006, 34:1334-1344.
7. Wang Y., Wluka A.E., Pelletier J.P., Martel-Pelletier J., Abram F., Ding C., et al. Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees. Rheumatology 2010, 49:997-1004.
8. Roos H., Lauren M., Adalberth T., Roos E.M., Jonsson K., Lohmander L.S. Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis Rheum 1998, 41:687-693.
9. McErlain D.D., Ulici V., Darling M., Gati J.S., Pitelka V., Beier F., et al. An invivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis. Arthritis Res Ther 2012, 14:R26.
10. Castaneda S., Roman-Blas J.A., Largo R., Herrero-Beaumont G. Subchondral bone as a key target for osteoarthritis treatment. Biochem Pharmacol 2012, 83:315-323.
11. Higuchi H., Kobayashi Y., Kobayashi A., Hatayama K., Kimura M. Histologic analysis of postmeniscectomy osteonecrosis. Am J Orthop 2013, 42:220-222.
12. Nakamura N., Horibe S., Nakamura S., Mitsuoka T. Subchondral microfracture of the knee without osteonecrosis after arthroscopic medial meniscectomy. Arthroscopy 2002, 18:538-541.
13. MacDessi S.J., Brophy R.H., Bullough P.G., Windsor R.E., Sculco T.P. Subchondral fracture following arthroscopic knee surgery. A series of eight cases. JBone Joint Surg Am 2008, 90:1007-1012.
14. Glasson S.S., Blanchet T.J., Morris E.A. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007, 15:1061-1069.
15. Loeser R.F., Olex A.L., McNulty M.A., Carlson C.S., Callahan M., Ferguson C., et al. Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. PLoS One 2013, 8:e54633.
16. Ruan M.Z., Dawson B., Jiang M.M., Gannon F., Heggeness M., Lee B.H. Quantitative imaging of murine osteoarthritic cartilage by phase-contrast micro-computed tomography. Arthritis Rheum 2013, 65:388-396.
17. Botter S.M., Glasson S.S., Hopkins B., Clockaerts S., Weinans H., van Leeuwen J.P., et al. ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes. Osteoarthritis Cartilage 2009, 17:636-645.
18. McErlain D.D., Appleton C.T., Litchfield R.B., Pitelka V., Henry J.L., Bernier S.M., et al. Study of subchondral bone adaptations in a rodent surgical model of OA using invivo micro-computed tomography. Osteoarthritis Cartilage 2008, 16:458-469.
19. Gu X.I., Palacio-Mancheno P.E., Leong D.J., Borisov Y.A., Williams E., Maldonado N., et al. High resolution micro arthrography of hard and soft tissues in a murine model. Osteoarthritis Cartilage 2012, 20:1011-1019.
20. Kenny C. Radial displacement of the medial meniscus and Fairbank's signs. Clin Orthop Relat Res 1997, 339:163-173.
21. Arunakul M., Tochigi Y., Goetz J.E., Diestelmeier B.W., Heiner A.D., Rudert J., et al. Replication of chronic abnormal cartilage loading by medial meniscus destabilization for modeling osteoarthritis in the rabbit knee invivo. JOrthop Res 2013, 31:1555-1560.
22. Thambyah A., Nather A., Goh J. Mechanical properties of articular cartilage covered by the meniscus. Osteoarthritis Cartilage 2006, 14:580-588.
23. Iijima H., Aoyama T., Ito A., Tajino J., Nagai M., Zhang X., et al. Immature articular cartilage and subchondral bone covered by menisci are potentially susceptive to mechanical load. BMC Musculoskelet Disord 2014, 15:101.
24. Yeow C.H., Lau S.T., Lee P.V., Goh J.C. Damage and degenerative changes in menisci-covered and exposed tibial osteochondral regions after simulated landing impact compression-a porcine study. JOrthop Res 2009, 27:1100-1108.
25. Bevill S.L., Briant P.L., Levenston M.E., Andriacchi T.P. Central and peripheral region tibial plateau chondrocytes respond differently to invitro dynamic compression. Osteoarthritis Cartilage 2009, 17:980-987.
26. Stoop R., Buma P., van der Kraan P.M., Hollander A.P., Clark Billinghurst R., Robin Poole A., et al. Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection. Arthritis Rheum 2000, 43:2121-2131.
27. Young A.A., McLennan S., Smith M.M., Smith S.M., Cake M.A., Read R.A., et al. Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther 2006, 8:R41.
28. Cake M.A., Read R.A., Corfield G., Daniel A., Burkhardt D., Smith M.M., et al. Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis Cartilage 2013, 21:226-236.
29. Gerwin N., Bendele A.M., Glasson S., Carlson C.S. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat. Osteoarthritis Cartilage 2010, 18:S24-S34.
30. Pritzker K.P., Gay S., Jimenez S.A., Ostergaard K., Pelletier J.P., Revell P.A., et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006, 14:13-29.
31. Cake M.A., Read R.A., Guillou B., Ghosh P. Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU). Osteoarthritis Cartilage 2000, 8:404-411.
32. Little C.B., Smith M.M., Cake M.A., Read R.A., Murphy M.J., Barry F.P. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis Cartilage 2010, 18:S80-S92.
33. Thote T., Lin A.S., Raji Y., Moran S., Stevens H.Y., Hart M., et al. Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration. Osteoarthritis Cartilage 2013, 21:1132-1141.
34. Botter S.M., van Osch G.J., Clockaerts S., Waarsing J.H., Weinans H., van Leeuwen J.P. Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an invivo microfocal computed tomography study. Arthritis Rheum 2011, 63:2690-2699.
35. Landells J.W. The bone cysts of osteoarthritis. JBone Joint Surg Br 1953, 35:643-649.
36. Pallante-Kichura A.L., Cory E., Bugbee W.D., Sah R.L. Bone cysts after osteochondral allograft repair of cartilage defects in goats suggest abnormal interaction between subchondral bone and overlying synovial joint tissues. Bone 2013, 57:259-268.
37. Guzman R.E., Evans M.G., Bove S., Morenko B., Kilgore K. Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol 2003, 31:619-624.
38. Shibakawa A., Yudoh K., Masuko-Hongo K., Kato T., Nishioka K., Nakamura H. The role of subchondral bone resorption pits in osteoarthritis: MMP production by cells derived from bone marrow. Osteoarthritis Cartilage 2005, 13:679-687.
39. Tanamas S.K., Wluka A.E., Pelletier J.P., Martel-Pelletier J., Abram F., Wang Y., et al. The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study. Arthritis Res Ther 2010, 12:R58.
40. Kaspiris A., Khaldi L., Grivas T.B., Vasiliadis E., Kouvaras I., Dagkas S., et al. Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: an immunohistochemical study. Orthop Traumatol Surg Res 2013, 99:523-529.
41. Wang M., Sampson E.R., Jin H., Li J., Ke Q.H., Im H.J., et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther 2013, 15:R5.
42. Arokoski J.P., Jurvelin J.S., Vaatainen U., Helminen H.J. Normal and pathological adaptations of articular cartilage to joint loading. Scand J Med Sci Sports 2000, 10:186-198.
43. Moskowitz R.W., Davis W., Sammarco J., Martens M., Baker J., Mayor M., et al. Experimentally induced degenerative joint lesions following partial meniscectomy in the rabbit. Arthritis Rheum 1973, 16:397-405.