Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: Doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig

International Journal of Experimental Pathology

Volumn 90, Issue 2, 2009, Pages 174-181

  Bowyer, Jonathan ^a   Heapy, Chris G ^a   Flannelly, Joanne K ^a   Waterton, John C ^a   MacIewicz, Rose A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Cartilage volume; Doxycycline; Guinea pig; Magnetic resonance imaging; Matrix metalloproteinases; Osteoarthritis

Indexed keywords

COLLAGENASE 3; DOXYCYCLINE; GELATINASE B; INTERSTITIAL COLLAGENASE; MERCURY DERIVATIVE; NEUTROPHIL COLLAGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG EFFECT; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GUINEA PIG; IMAGE ANALYSIS; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DEGRADATION; TIBIA; TREATMENT DURATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; MAGNETIC RESONANCE IMAGING; MALE; MATRIX METALLOPROTEINASES; OSTEOARTHRITIS; TIBIA;

EID: 62749141216     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2008.00634.x     Document Type: Article

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