Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

Arthritis and Rheumatism

Volumn 64, Issue 5, 2012, Pages 1466-1476

  Van Lent, Peter L E M ^a   Blom, Arjen B ^a   Schelbergen, Rik F P ^a   Slöetjes, Annet ^a   Lafeber, Floris P J G ^b   Lems, Willem F ^c   Cats, Hans ^d   Vogl, Thomas ^e   Roth, Johannes ^e   Van Den Berg, Wim B ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d SINT MAARTENSKLINIEK   (Netherlands)

^e UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN A; CALGRANULIN B; COLLAGENASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOLOCALIZATION; JOINT BIOPSY; JOINT DESTRUCTION; KNEE OSTEOARTHRITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIUM;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CALGRANULIN A; CALGRANULIN B; CHEMOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; MALE; MICE; MICE, INBRED C57BL; OSTEOARTHRITIS, KNEE; PROSPECTIVE STUDIES; STIFLE; SYNOVIAL MEMBRANE;

EID: 84858962777     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34315     Document Type: Article

References (51)

1. Goldring MB, Goldring SR,. Osteoarthritis. J Cell Physiol 2007; 213: 626-34.
2. Blom AB, van der Kraan PM, van den Berg WB,. Cytokine targeting in osteoarthritis. Curr Drug Targets 2007; 8: 283-92.
3. Van den Berg WB,. Lessons from animal models of osteoarthritis. Curr Rheumatol Rep 2008; 10: 26-9.
4. Cawston TE, Young DA,. Proteinases involved in matrix turnover during cartilage and bone breakdown. Cell Tissue Res 2010; 339: 221-35.
5. Krasnokutsky S, Attur M, Palmer G, Samuels J, Abramson SB,. Current concepts in the pathogenesis of osteoarthritis. Osteoarthritis Cartilage 2008; 16: S1-3.
6. Abramson SB, Attur M,. Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther 2009; 11: 227.
7. Sellam J, Berenbaum F,. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010; 6: 625-35.
8. Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M,. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritisâresults of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 2005; 13: 361-7.
9. Mazieres B, Garnero P, Gueguen A, Abbal M, Berdah L, Lequesne M, et al. Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis: the ECHODIAH cohort. Ann Rheum Dis 2006; 65: 354-9.
10. Roemer FW, Guermazi A, Hunter DJ, Niu J, Zhang Y, Englund M, et al. The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies. Osteoarthritis Cartilage 2009; 17: 748-53.
11. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B,. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005; 64: 1263-7.
12. Blom AB, van Lent PL, Libregts S, Holthuysen AE, van der Kraan PM, et al. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. Arthritis Rheum 2007; 56: 147-57.
13. Bondeson J, Blom AB, Wainwright S, Hughes C, Caterson B, van den Berg WB,. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis [review]. Arthritis Rheum 2010; 62: 647-57.
14. Heizmann CW, Fritz G, Schafer BW,. S100 proteins: structure, functions and pathology. Front Biosci 2002; 7: 1356-68.
15. Foell D, Wittkowski H, Roth J,. Mechanisms of disease: a 'DAMP' view of inflammatory arthritis. Nat Clin Pract Rheumatol 2007; 3: 382-90.
16. Vogl T, Ludwig S, Goebeler M, Strey A, Thorey IS, Reichelt R, et al. MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood 2004; 104: 4260-8.
17. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007; 13: 1042-9.
18. Ehrchen JM, Sunderkotter C, Foell D, Vogl T, Roth J,. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 2009; 86: 557-66.
19. Chen YS, Yan W, Geczy CL, Brown MA, Thomas R,. Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis. Arthritis Res Ther 2009; 11: R39.
20. Hammer HB, Odegard S, Syversen SW, Landewe R, van der Heijde D, Uhlig T, et al. Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis. Ann Rheum Dis 2010; 69: 150-4.
21. Van Lent PL, Grevers L, Blom AB, Sloetjes A, Mort JS, Vogl T, et al. Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis. Ann Rheum Dis 2008; 67: 1750-8.
22. Zreiqat H, Belluoccio D, Smith MM, Wilson R, Rowley LA, Jones K, et al. S100A8 and S100A9 in experimental osteoarthritis. Arthritis Res Ther 2010; 12: R16.
23. Van Lent PL, Grevers LC, Blom AB, Arntz OJ, van de Loo FA, van der Kraan P, et al. Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis. Arthritis Rheum 2008; 58: 3776-87.
24. Manitz MP, Horst B, Seeliger S, Strey A, Skryabin BV, Gunzer M, et al. Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol 2003; 23: 1034-43.
25. Van der Kraan PM, Vitters EL, van Beuningen HM, van de Putte LB, van den Berg WB,. Degenerative knee joint lesions in mice after a single intra-articular collagenase injection: a new model of osteoarthritis. J Exp Pathol 1990; 71: 19-31.
26. Ma HL, Blanchet TJ, Peluso D, Hopkins B, Morris EA, Glasson SS,. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 2007; 15: 695-700.
27. Geurts J, Vermeij EA, Pohlers D, Arntz OJ, Kinne RW, van den Berg WB, et al. A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts. Ann Rheum Dis 2011; 70: 1311-9.
28. Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006; 14: 13-29.
29. Van Meurs JB, van Lent PL, Joosten LA, van der Kraan PM, van den Berg WB,. Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: kinetics of stromelysin and IL-1 mRNA levels during arthritis. Rheumatol Int 1997; 16: 197-205.
30. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29: 1039-49.
31. Wesseling J, Dekker J, van den Berg WB, Bierma-Zeinstra SM, Boers M, Cats HA, et al. CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative. Ann Rheum Dis 2009; 68: 1413-9.
32. Wulffraat NM, Haas PJ, Frosch M, De Kleer IM, Vogl T, Brinkman DM, et al. Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation. Ann Rheum Dis 2003; 62: 236-41.
33. Pessler F, Dai L, Diaz-Torne C, Gomez-Vaquero C, Paessler ME, Zheng DH, et al. The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis. Ann Rheum Dis 2008; 67: 1184-7.
34. Passey RJ, Williams E, Lichanska AM, Wells C, Hu S, Geczy CL, et al. A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol 1999; 163: 2209-16.
35. Viemann D, Strey A, Janning A, Jurk K, Klimmek K, Vogl T, et al. Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 2005; 105: 2955-62.
36. Van Lent PL, Blom AB, van der Kraan P, Holthuysen AE, Vitters E, van Rooijen N, et al. Crucial role of synovial lining macrophages in the promotion of transforming growth factor β-mediated osteophyte formation. Arthritis Rheum 2004; 50: 103-11.
37. Loeser RF,. Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide [editorial]. Arthritis Rheum 2006; 54: 1357-60.
38. Vankemmelbeke MN, Holen I, Wilson AG, Ilic MZ, Handley CJ, Kelner GS, et al. Expression and activity of ADAMTS-5 in synovium. Eur J Biochem 2001; 268: 1259-68.
39. Tetlow LC, Adlam DJ, Woolley DE,. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001; 44: 585-94.
40. Wu W, Billinghurst RC, Pidoux I, Antoniou J, Zukor D, Tanzer M, et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 2002; 46: 2087-94.
41. Dinarello CA,. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011; 117: 3720-32.
42. Zhen EY, Brittain IJ, Laska DA, Mitchell PG, Sumer EU, Karsdal MA, et al. Characterization of metalloprotease cleavage products of human articular cartilage. Arthritis Rheum 2008; 58: 2420-31.
43. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via Toll-like and P2X receptors. J Biol Chem 2009; 284: 24035-48.
44. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 2005; 115: 2223-33.
45. Van Lent PL, van den Berg WB, Schalkwijk J, van de Putte LB, van den Bersselaar L,. The impact of protein size and charge on its retention in articular cartilage. J Rheumatol 1987; 14: 798-805.
46. Schelbergen RF, Blom AB, van den Bosch MH, Sloetjes A, Abdollahi-Roodsaz S, Schreurs BW, et al. Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4. Arthritis Rheum 2012; 64: 1477-8.
47. Van Meurs J, van Lent P, Holthuysen A, Lambrou D, Bayne E, Singer I, et al. Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction. J Immunol 1999; 163: 5633-9.
48. Van Lent PL, Grevers LC, Schelbergen R, Blom A, Geurts J, Sloetjes A, et al. S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via Toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis. Arthritis Rheum 2010; 62: 3353-64.
49. Gebhardt C, Riehl A, Durchdewald M, Nemeth J, Furstenberger G, Muller-Decker K, et al. RAGE signaling sustains inflammation and promotes tumor development. J Exp Med 2008; 205: 275-85.
50. Turovskaya O, Foell D, Sinha P, Vogl T, Newlin R, Nayak J, et al. RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis 2008; 29: 2035-43.
51. Sunahori K, Yamamura M, Yamana J, Takasugi K, Kawashima M, Yamamoto H, et al. The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor κB and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther 2006; 8: R69.