Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover

Osteoarthritis and Cartilage

Volumn 19, Issue 4, 2011, Pages 466-473

  Nielsen, R H ^a   Bay Jensen, A C ^a   Byrjalsen, I ^a   Karsdal, M A ^a  

^a NORDIC BIOSCIENCE A S   (Denmark)

Author keywords

Cartilage pathology; Meniscectomy; OARSI score; Oral salmon calcitonin; Osteoarthritis; Ovariectomy; Rat model

Indexed keywords

8 (N 2 HYDROXY 5 CHLOROBENZOYL)AMINOCAPRYLIC ACID; OCTANOIC ACID; SALCATONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE INJURY; BONE PLATE; BONE TURNOVER; CARTILAGE; CONTROLLED STUDY; FEMALE; MENISCECTOMY; NONHUMAN; OSTEOARTHRITIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; THICKNESS;

ADMINISTRATION, ORAL; ANIMALS; BONE DENSITY CONSERVATION AGENTS; CALCITONIN; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; FEMALE; OSTEOARTHRITIS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 79952819173     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2011.01.008     Document Type: Article

References (32)

1. Manicourt D.H., Altman R.D., Williams J.M., Devogelaer J.P., Druetz-Van Egeren A., Lenz M.E., et al. Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions. Arthritis Rheum 1999, 42:1159-1167.
2. Stoop R., Buma P., van der Kraan P.M., Hollander A.P., Billinghurst R.C., Meijers T.H., et al. Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats. Osteoarthritis Cartilage 2001, 9:308-315.
3. Hayami T., Pickarski M., Wesolowski G.A., McLane J., Bone A., Destefano J., et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum 2004, 50:1193-1206.
4. Hoegh-Andersen P., Tanko L.B., Andersen T.L., Lundberg C.V., Mo J.A., Heegaard A.M., et al. Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application. Arthritis Res Ther 2004, 6:R169-R180.
5. Ham K.D., Loeser R.F., Lindgren B.R., Carlson C.S. Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum 2002, 46:1956-1964.
6. Calvo E., Castaneda S., Largo R., Fernandez-Valle M.E., Rodriguez-Salvanes F., Herrero-Beaumont G. Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits. Osteoarthritis Cartilage 2007, 15:69-77.
7. Ma H.L., Blanchet T.J., Peluso D., Hopkins B., Morris E.A., Glasson S.S. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 2007, 15:695-700.
8. Gerwin N., Bendele A.M., Glasson S., Carlson C.S. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat. Osteoarthritis Cartilage 2010, 18(Suppl 3):S24-S34.
9. Cranney A., Tugwell P., Zytaruk N., Robinson V., Weaver B., Shea B., et al. Meta-analyses of therapies for postmenopausal osteoporosis. VI. Meta-analysis of calcitonin for the treatment of postmenopausal osteoporosis. Endocr Rev 2002, 23:540-551.
10. Chambers T.J., Moore A. The sensitivity of isolated osteoclasts to morphological transformation by calcitonin. J Clin Endocrinol Metab 1983, 57:819-824.
11. Suzuki H., Nakamura I., Takahashi N., Ikuhara T., Matsuzaki K., Isogai Y., et al. Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Endocrinology 1996, 137:4685-4690.
12. Shyu J.F., Shih C., Tseng C.Y., Lin C.H., Sun D.T., Liu H.T., et al. Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities. Bone 2007, 40:1329-1342.
13. Sorensen M.G., Henriksen K., Schaller S., Henriksen D.B., Nielsen F.C., Dziegiel M.H., et al. Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood. J Bone Miner Metab 2007, 25:36-45.
14. Sondergaard B.C., Wulf H., Henriksen K., Schaller S., Oestergaard S., Qvist P., et al. Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes. Osteoarthritis Cartilage 2006, 14:759-768.
15. Sondergaard B.C., Oestergaard S., Christiansen C., Tanko L.B., Karsdal M.A. The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum 2007, 56:2674-2678.
16. Behets C., Williams J.M., Chappard D., Devogelaer J.P., Manicourt D.H. Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency. J Bone Miner Res 2004, 19:1821-1826.
17. El Hajjaji H., Williams J.M., Devogelaer J.P., Lenz M.E., Thonar E.J., Manicourt D.H. Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis. Osteoarthritis Cartilage 2004, 12:904-911.
18. Karsdal M.A., Byrjalsen I., Riis B.J., Christiansen C. Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin. BMC Clin Pharmacol 2008, 8:12.
19. Karsdal M.A., Byrjalsen I., Riis B.J., Christiansen C. Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of Salmon Calcitonin. BMC Clin Pharmacol 2008, 8:5.
20. Karsdal M.A., Byrjalsen I., Henriksen K., Riis B.J., Lau E.M., Arnold M., et al. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study. Osteoarthritis Cartilage 2010, 18:150-159.
21. Malkov D., Angelo R., Wang H.Z., Flanders E., Tang H., Gomez-Orellana I. Oral delivery of insulin with the eligen technology: mechanistic studies. Curr Drug Deliv 2005, 2:191-197.
22. Oestergaard S., Sondergaard B.C., Hoegh-Andersen P., Henriksen K., Qvist P., Christiansen C., et al. Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation. Arthritis Rheum 2006, 54:2441-2451.
23. Mouritzen U., Christgau S., Lehmann H.J., Tanko L.B., Christiansen C. Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 2003, 62:332-336.
24. Oliveria S.A., Felson D.T., Reed J.I., Cirillo P.A., Walker A.M. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum 1995, 38:1134-1141.
25. Cauley J.A., Kwoh C.K., Egeland G., Nevitt M.C., Cooperstein L., Rohay J., et al. Serum sex hormones and severity of osteoarthritis of the hand. J Rheumatol 1993, 20:1170-1175.
26. Spector T.D., Perry L.A., Jubb R.W. Endogenous sex steroid levels in women with generalised osteoarthritis. Clin Rheumatol 1991, 10:316-319.
27. Sowers M.F., Hochberg M., Crabbe J.P., Muhich A., Crutchfield M., Updike S. Association of bone mineral density and sex hormone levels with osteoarthritis of the hand and knee in premenopausal women. Am J Epidemiol 1996, 143:38-47.
28. Ham K.D., Carlson C.S. Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys. J Bone Miner Res 2004, 19:823-829.
29. Manicourt D.H., Azria M., Mindeholm L., Thonar E.J., Devogelaer J.P. Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. Arthritis Rheum 2006, 54:3205-3211.
30. Franchimont P., Bassleer C., Henrotin Y., Gysen P., Bassleer R. Effects of human and salmon calcitonin on human articular chondrocytes cultivated in clusters. J Clin Endocrinol Metab 1989, 69:259-266.
31. Badurski J.E., Schwamm W., Popko J., Zimnoch L., Rogowski F., Pawlica J. Chondroprotective action of salmon calcitonin in experimental arthropathies. Calcif Tissue Int 1991, 49:27-34.
32. Bagger Y.Z., Tanko L.B., Alexandersen P., Karsdal M.A., Olson M., Mindeholm L., et al. Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis. Bone 2005, 37:425-430.