Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

European Journal of Pain (United Kingdom)

Volumn 18, Issue 5, 2014, Pages 680-690

  Yang, P Y ^a   Tang, C C ^b   Chang, Y C ^c   Huang, S Y ^c   Hsieh, S P ^d   Fan, S S ^d   Lee, H P ^d   Lin, S C ^d   Chen, W F ^e   Wen, Z H ^c   Jean, Y H ^d  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d PINGTUNG CHRISTIAN HOSPITAL   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; PHOSPHORUS; TIBOLONE; ANALGESIC AGENT; PREGNANE DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ALKALINE PHOSPHATASE BLOOD LEVEL; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE METABOLISM; CALCIUM BLOOD LEVEL; CARTILAGE; CARTILAGE DEGENERATION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; NOCICEPTIVE PAIN; NONHUMAN; OSTEOARTHRITIS; OSTEOPOROSIS; OVARIECTOMY; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RAT; SYNOVITIS; SYNOVIUM; WEIGHT BEARING; ANIMAL; ANIMAL BEHAVIOR; ANTERIOR CRUCIATE LIGAMENT; BONE; DRUG EFFECTS; JOINT; METABOLISM; PATHOLOGY; PSYCHOLOGY; WISTAR RAT;

ANALGESICS; ANIMALS; ANTERIOR CRUCIATE LIGAMENT; BEHAVIOR, ANIMAL; BONE AND BONES; FEMALE; JOINTS; NOCICEPTIVE PAIN; NORPREGNENES; OSTEOARTHRITIS; OVARIECTOMY; RATS; RATS, WISTAR; SELECTIVE ESTROGEN RECEPTOR MODULATORS; WEIGHT-BEARING;

EID: 84899008185     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2013.00406.x     Document Type: Article

References (54)

1. Albertazzi, P., Di Micco, R., Zanardi, E., (1998). Tibolone: A review. Maturitas 30, 295-305.
2. Badger, A.M., Blake, S.M., Dodds, R.A., Griswold, D.E., Swift, B.A., Rieman, D.J., Stroup, G.B., Hoffman, S.J., Gowen, M., (1999). Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis. J Pharmacol Exp Ther 291, 1380-1386.
3. Bajaj, P., Baja, P., Graven-Nielsen, T., Arendt-Nielsen, L., (2001). Osteoarthritis and its association with muscle hyperalgesia: An experimental controlled study. Pain 93, 107-114.
4. Bonnelye, E., Reboul, P., Duval, N., Cardelli, M., Aubin, J.E., (2011). Estrogen receptor-related receptor α regulation by interleukin-1β in prostaglandin E(2)- and cAMP-dependent pathways in osteoarthritic chondrocytes. Arthritis Rheum 63, 2374-2384.
5. Calvo, E., Castaneda, S., Largo, R., Fernandez-Valle, M.E., Rodriguez-Salvanes, F., Herrero-Beaumont, G., (2007). Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits. Osteoarthritis Cartilage 15, 69-77.
6. Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M., Yaksh, T.L., (1994). Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53, 55-63.
7. Claassen, H., Steffen, R., Hassenpflug, J., Varoga, D., Wruck, C.J., Brandenburg, L.O., Pufe, T., (2010). 17β-estradiol reduces expression of MMP-1, -3, and -13 in human primary articular chondrocytes from female patients cultured in a three dimensional alginate system. Cell Tissue Res 342, 283-293.
8. Dalle Carbonare, L., Valenti, M.T., Zanatta, M., Donatelli, L., Lo Cascio, V., (2009). Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis. Arthritis Rheum 60, 3356-3365.
9. de Gooyer, M.E., Deckers, G.H., Schoonen, W.G., Verheul, H.A., Kloosterboer, H.J., (2003). Receptor profiling and endocrine interactions of tibolone. Steroids 68, 21-30.
10. de Gooyer, M.E., Kleyn, G.T., Smits, K.C., Ederveen, A.G., Verheul, H.A., Kloosterboer, H.J., (2001). Tibolone: A compound with tissue specific inhibitory effects on sulfatase. Mol Cell Endocrinol 183, 55-62.
11. Ederveen, A.G.H., Spanjers, C.P.M., Quaijtaal, J.H.M., Kloosterboer, H.J., (2001). Effect of 16 months of treatment with tibolone on bone mass, turnover, and biomechanical quality in mature ovariectomized rats. J Bone Miner Res 16, 1674-1681.
12. Egarter, C., Sator, M., Huber, J., (2003). Effects of tibolone on cell adhesion molecules in postmenopausal women. Menopause 10, 218-221.
13. Elders, M.J., (2000). The increasing impact of arthritis on public health. J Rheumatol Suppl 60, 6-8.
14. Erb, A., Brenner, H., Günther, K.P., Stürmer, T., (2000). Hormone replacement therapy and patterns of osteoarthritis: Baseline data from the Ulm Osteoarthritis Study. Ann Rheum Dis 59, 105-109.
15. Fenkci, V., Yilmazer, M., Fenkci, S., (2003). Effects of short-time (3 months) tibolone treatment on bone turnover in postmenopausal women. Arch Gynecol Obstet 268, 85-87.
16. Fernandes, J.C., Martel-Pelletier, J., Otterness, I.G., Lopez-Anaya, A., Mineau, F., Tardif, G., Pelletier, J.P., (1995). Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis. Arthritis Rheum 38, 1290-1303.
17. Fernihough, J., Gentry, C., Malcangio, M., Fox, A., Rediske, J., Pellas, T., Kidd, B., Bevan, S., Winter, J., (2004). Pain related behaviour in two models of osteoarthritic in the rat knee. Pain 112, 83-93.
18. Ganesan, K., Balachandran, C., Manohar, B.M., Puvanakrishnan, R., (2008). Comparative studies on the interplay of testosterone, estrogen and progesterone in collagen induced arthritis in rats. Bone 43, 758-765.
19. Genazzani, A.R., Petraglia, F., Facchinetti, F., Genazzani, A.D., Bergamaschi, M., Grasso, A., Volpe, A., (1987). Effects of Org OD 14 on pituitary and peripheral beta-endorphin in castrated rats and post-menopausal women. Maturitas 1, 35-48.
20. Genazzani, A.R., Petraglia, F., Facchinetti, F., Grasso, A., Alessandrini, G., Volpe, A., (1988). Steroid replacement treatment increases beta-endorphin and beta-lipotropin plasma levels in postmenopausal women. Gynecol Obstet Invest 26, 153-159.
21. Ham, K.D., Loeser, R.F., Lindgren, B.R., Carlson, C.S., (2002). Effects of longterm estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum 46, 1956-1964.
22. Hudelmaier, M., Glaser, C., Hohe, J., Englmeier, K.H., Reiser, M., Putz, R., Eckstein, F., Eckstein, F., (2001). Age-related changes in the morphology and deformational behavior of knee joint cartilage. Arthritis Rheum 11, 2556-2561.
23. Jean, Y.H., Wen, Z.H., Chang, Y.C., Hsieh, S.P., Lin, J.D., Tang, C.C., Chen, W.F., Chou, A.K., Wong, C.S., (2008). Increase in excitatory amino acid concentration and transporters expression in osteoarthritic knees of anterior cruciate ligament transected rabbits. Osteoarthritis Cartilage 16, 1442-1449.
24. Jean, Y.H., Wen, Z.H., Chang, Y.C., Hsieh, S.P., Tang, C.C., Wang, Y.H., Wong, C.S., (2007). Intra-articular injection of cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transection knee in rats: Role of excitatory amino acids. Osteoarthritis Cartilage 15, 638-645.
25. Karsdal, M.A., Byrjalsen, I., Leeming, D.J., Christiansen, C., (2008). Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation. BMC Musculoskelet Disord 9, 153-160.
26. Kasugai, Y., Ikegami, A., Matsuo, K., Ohashi, M., Sukamoto, T., Hosoi, T., Ouchi, Y., Orimo, H., (1998). Effects of tibolone (Org OD14) treatment for 3 months on ovariectomy-induced osteopenia in 8-month-old rats on a low-calcium diet: Preventive testing for 3 months. Bone 22, 119-124.
27. Kloosterbor, H.J., (2001). Tibolone: A steroid with tissue specific mode of action. J Steroid Biochem Mol Biol 76, 231-238.
28. Lee, C.H., Wen, C.H., Chang, Y.C., Huang, S.Y., Tang, C.C., Chen, W.F., Hsieh, S.P., Hsieh, C.S., Jean, Y.H., (2009). Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: Association with attenuation of N-methyl-D-aspartate(NMDA) receptor subunit 1 phosphorylation and apoptosis in rat chondrocytes. Osteoarthritis Cartilage 17, 1485-1493.
29. Levine, J.D., Reichling, D.B., (1999). Peripheral mechanisms of inflammatory pain. In Textbook of Pain, 4th edn, P.D. Wall, R. Melzack, eds. (Hong Kong: Churchill Livingstone) pp. 9-84.
30. Lohmander, L.S., Dalen, N., Englund, G., Hamalainen, M., Jensen, E.M., Karlsson, K., Odensten, M., Ryd, L., Sernbo, I., Suomalainen, O., Tegnander, A., (1996). Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: A randomized, double blind, placebo controlled multicentre trial. Ann Rheum Dis 55, 424-431.
31. Ma, H.L., Blanchet, T.J., Peluso, D., Hopkins, B., Morris, E.A., Glasson, S.S., (2007). Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 15, 69-77.
32. Maran, A., Shogren, K., Zhang, M., Yaszemski, M.J., Hefferan, T.E., Spelsberg, T.C., Kloosterboer, H.J., Turner, R.T., (2006). Effects of stable transfection of human fetal osteoblast cells with estrogen receptor-alpha on regulation of gene expression by tibolone. Bone 9, 523-529.
33. McCarthy, T.L., Hochberg, R.B., Labaree, D.C., Centrella, M., (2007). 3-Ketosteroid reductase activity and expression by fetal rat osteoblasts. J Biol Chem 282, 34003-34012.
34. McDougall, J.J., Watkins, L., Li, Z., (2006). Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis. Pain 123 (1-2), 98-105.
35. Modelska, K., Cummings, S., (2002). Tibolone for post-menopausal women: Systematic review of randomized trial. J Clin Endocrinol Metab 87, 16-23.
36. Mouritzen, U., Christgau, S., Lehmann, H.J., Tanko, L.B., Christiansen, C., (2003). Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: Influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 62, 332-336.
37. Oestergaard, S., Sondergaard, B.C., Hoegh-Anderson, P., Henriksen, K., Qvist, P., Christiansen, C., Tankõ, L.B., Karsdal, M.A., (2006). Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: Implications of the time of initiation. Arthritis Rheum 54, 2411-2451.
38. Oliveria, S.A., Felson, D.T., Klein, R.A., Reed, J.I., (1996). Walker AM: Estrogen replacement therapy and the development of osteoarthritis. Epidemiology 7, 415-419.
39. Pelletier, J.P., Martel-Pelletier, J., Abramson, S.B., (2001). Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets. Arthritis Rheum 44, 1237-1247.
40. Prelevic, G.M., Kwong, P., Byrne, D.J., Jagroop, I.A., Ginsburg, J., Mikhailidis, D.P., (2002). A cross-sectional study of the effects of hormone replacement therapy on the cardiovascular disease risk profile in healthy postmenopausal women. Fertil Steril 77, 945-951.
41. Pritzker, K.P., Gay, S., Jimenez, S.A., Ostergaard, K., Pelletier, J.P., Revell, P.A., Salter, D., van den Berg, W.B., (2006). Osteoarthritis cartilage histopathology: Grading and staging. Osteoarthritis Cartilage 14, 13-29.
42. Reginster, J.Y., Felsenberg, D., Boonen, S., Diez-Perez, A., Rizzoli, R., Brandi, M.L., Spector, T.D., Brixen, K., Goemaere, S., Cormier, C., Balogh, A., Delmas, P.D., Meunier, P.J., (2008). Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum 58, 1687-1695.
43. Rymer, J., Chapman, M.G., Fogelman, I., (1994). Effect of tibolone on postmenopausal bone loss. Osteoporos Int 4, 314-319.
44. Sarajari, S., Oblinger, M.M., (2010). Estrogen effects on pain sensitivity and neuropeptide expression in rat sensory neurons. Exp Neurol 224, 163-169.
45. Simoncini, T., Genazzani, A.R., (2000). Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells. Mol Cell Endocrinol 162 (1-2), 87-94.
46. Sniekers, Y.H., Weinans, H., van Osch, G.J., van Leeuwen, J.P., (2010). Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis. Arthritis Res Ther 12, R182.
47. Sondergaard, B.C., Ostergaard, S., Christiansen, C., Karsdal, M.A., (2007). The effect of oral calcitonin on cartilage turnover and surface erosion in the ovariectomized rat model. Arthritis Rheum 56, 2674-2678.
48. Sowers, M.R., McConnell, D., Jannausch, M., Buyuktur, A.G., Hochberg, M., Jamadar, D.A., (2006). Estradiol and its metabolites and their association with knee osteoarthritis. Arthritis Rheum 54, 2481-2487.
49. Teitelbaum, S.L., Seton, M.P., Saag, K.G., (2011). Should bisphosphonates be used for long-term treatment of glucocorticoid-induced osteoporosis. Arthritis Rheum 63, 325-328.
50. Vassalle, C., Cicinelli, E., Lello, S., Mercuri, A., Battaglia, D., Maffei, S., (2011). Effects of menopause and tibolone on different cardiovascular biomarkers in healthy women. Gynecol Endocrinol 27, 163-169.
51. Wen, Z.H., Tang, C.C., Chang, Y.C., Huang, S.Y., Hsieh, S.P., Lee, C.H., Huang, G.S., Ng, H.F., Neoh, C.A., Hsieh, C.S., Chen, W.F., Jean, Y.H., (2010). Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: Association with changes of mitogen-activated protein kinase in chondrocytes. Osteoarthritis Cartilage 18, 1192-1202.
52. Wu, A.H., Lu, Q.A., Todd, J., Moecks, J., Wians, F., (2009). Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: Implications for clinical practice. Clin Chem 55, 52-58.
53. Yoshimi, T., Kikuchi, T., Obara, T., Yamaguchi, T., Salcalcibara, Y., Itoh, H., Iwata, H., Miura, T., (1994). Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthritis induced by the resection of rabbit cruciate ligament. Clin Orthop Relat Res 298, 296-304.
54. Yoshitake, K., Yokota, K., Kasugai, Y., Kagawa, M., Sukamoto, T., Nakamura, T., (1999). Effects of 16 weeks of treatment with tibolone on bone mass and bone mechanical and histomorphometric indices in mature ovariectomized rats with established osteopenia on a low-calcium diet. Bone 25, 311-319.