Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague-Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

Inhalation Toxicology

Volumn 27, Issue 9, 2015, Pages 405-431

  Phillips, Blaine ^a   Esposito, Marco ^a   Verbeeck, Jan ^a   Boué, Stéphanie ^a   Iskandar, Anita ^a   Vuillaume, Gregory ^a   Leroy, Patrice ^a   Krishnan, Subash ^a   Kogel, Ulrike ^a   Utan, Aneli ^a   Schlage, Walter K ^a   Bera, Monali ^a   Veljkovic, Emilija ^a   Hoeng, Julia ^a   Peitsch, Manuel C ^a   Vanscheeuwijck, Patrick ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

Author keywords

Nicotine; pyruvic acid; sub chronic inhalation; systems toxicology

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CHOLESTEROL; CHOLESTEROL ESTER; CYTOCHROME P450 1A1; GLUCOSE; GLYCOGEN; LIPID; NICOTINE; PHOSPHOLIPID; PYRUVIC ACID; SPHINGOLIPID; TRIACYLGLYCEROL; AEROSOL; ANTIOXIDANT; BIOLOGICAL MARKER; DRUG COMBINATION; NICOTINE GUM; NICOTINIC AGENT;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; FATTY ACID METABOLISM; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; INHALATION; LARYNX; LIPID BLOOD LEVEL; LIPIDOMICS; LIVER WEIGHT; LYMPHOCYTE COUNT; MALE; NEUTROPHIL COUNT; NONHUMAN; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; SPRAGUE DAWLEY RAT; TOXICITY TESTING; TRANSCRIPTOMICS; UPREGULATION; WEIGHT GAIN; ANIMAL; BLOOD; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GERMFREE ANIMAL; INHALATIONAL DRUG ADMINISTRATION; LIPID METABOLISM; LIVER; METABOLISM; ORGAN SIZE; RANDOMIZATION;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANTIOXIDANTS; BIOMARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEMALE; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIVER; MALE; NICOTINE; NICOTINIC AGONISTS; ORGAN SIZE; PYRUVIC ACID; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SPECIFIC PATHOGEN-FREE ORGANISMS; TOBACCO USE CESSATION PRODUCTS; TOXICITY TESTS, SUBCHRONIC; WEIGHT GAIN;

EID: 84941170902     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2015.1046000     Document Type: Article

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