Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver

Alcohol

Volumn 47, Issue 5, 2013, Pages 353-357

  Lu, Yongke ^a   Ward, Stephen C ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Collagen; CYP2A5; Ethanol; Nicotine; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; COLLAGEN; COLLAGEN TYPE 1; CYTOCHROME P450 2A5; CYTOCHROME P450 2E1; FAT DROPLET; NICOTINE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INFLAMMATION; LIPID STORAGE; LIPOLYSIS; LIVER; LIVER FIBROSIS; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; STELLATE CELL; TRIACYLGLYCEROL BLOOD LEVEL;

ALANINE TRANSAMINASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COLLAGEN TYPE I; CYTOCHROME P-450 CYP2E1; DRUG SYNERGISM; ETHANOL; FATTY LIVER; HEPATIC STELLATE CELLS; INFLAMMATION; LIVER; MALE; MICE; MICROSOMES; NICOTINE; TRIGLYCERIDES;

MUS; NICOTIANA TABACUM;

EID: 84879788408     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2013.04.004     Document Type: Article

References (35)

1. Andersson K., Arner P. Cholinoceptor-mediated effects on glycerol output from human adipose tissue using in situ microdialysis. British Journal of Pharmacology 1995, 115:1155-1162.
2. Bailey S.M., Mantena S.K., Millender-Swain T., Cakir Y., Jhala N.C., Chhieng D., et al. Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease. Free Radical Biology and Medicine 2009, 46:928-938.
3. Chajek-Shaul T., Scherer G., Barash V., Shiloni E., Caine Y., Stein O., et al. Metabolic effects of nicotine on human adipose tissue in organ culture. Clinical Investigation 1994, 72:94-99.
4. Davis R., Rizwani W., Banerjee S., Kovacs M., Haura E., Coppola D., et al. Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One 2009, 4:e7524.
5. El-Sokkary G.H., Cuzzocrea S., Reiter R.J. Effect of chronic nicotine administration on the rat lung and liver: beneficial role of melatonin. Toxicology 2007, 239:60-67.
6. Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134:1655-1669.
7. Friedman T.C., Sinha-Hikim I., Parveen M., Najjar S.M., Liu Y., Mangubat M., et al. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology 2012, 153:5809-5820.
8. Hiramoto T., Chida Y., Sonoda J., Yoshihara K., Sudo N., Kubo C. The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine receptor. Gastroenterology 2008, 134:2122-2131.
9. Horning M.G., Williams E.A., Maling H.M., Brodie B.B. Depot fat as source of increased liver triglycerides after ethanol. Biochemical and Biophysical Research Communications 1960, 3:635-640.
10. Itier V., Bertrand D. Neuronal nicotinic receptors: from protein structure to function. FEBS Letters 2001, 504:118-125.
11. Jeong W.I., Osei-Hyiaman D., Park O., Liu J., Bátkai S., Mukhopadhyay P., et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metabolism 2008, 7:227-235.
12. Kershbaum A., Khorsandian R., Caplan R.F., Bellet S., Feinberg L.J. The role of catecholamines in the free fatty acid response to cigarette smoking. Circulation 1963, 28:52-57.
13. Le Lay S., Dugail I. Connecting lipid droplet biology and the metabolic syndrome. Progress in Lipid Research 2009, 48:191-195.
14. Lieber C.S. Metabolism of alcohol. Clinical Liver Disease 2005, 9:1-35.
15. Liu R.H., Mizuta M., Matsukura S. The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes. Journal of Pharmacology and Experimental Therapeutics 2004, 310:52-58.
16. Lu Y., Cederbaum A.I. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P4502E1 and 2A5. Hepatology 2006, 44:263-274.
17. Lu Y., Cederbaum A.I. CYP2E1 and oxidative liver injury by alcohol. Free Radical Biology and Medicine 2008, 46:723-738.
18. Lu Y., Wang X., Cederbaum A.I. Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole. American Journal of Physiology- Gastrointestinal and Liver Physiology 2005, 289:G308-G319.
19. Lu Y., Wu D., Wang X., Ward S.C., Cederbaum A.I. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radical Biology and Medicine 2010, 49:1406-1416.
20. Lu Y., Zhang X.H., Cederbaum A.I. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicological Sciences 2012, 128:427-438.
21. Lu Y., Zhuge J., Wang X., Bai J., Cederbaum A.I. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 2008, 47:1483-1494.
22. Lu Y., Zhuge J., Wu D., Cederbaum A.I. Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug Metabolism and Disposition 2011, 39:330-336.
23. Matta S.G., Balfour D.J., Benowitz N.L., Boyd R.T., Buccafusco J.J., Caggiula A.R., et al. Guidelines on nicotine dose selection for invivo research. Psychopharmacology 2007, 190:269-319.
24. Mineur Y.S., Abizaid A., Rao Y., Salas R., DiLeone R.J., Gündisch D., et al. Nicotine decreases food intake through activation of POMC neurons. Science 2011, 332:1330-1332.
25. Niemela O., Parkkila S., Juvonen R.O., Viitala K., Gelboin H.V., Pasanen M. Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. Journal of Hepatology 2000, 33:893-901.
26. Raunio H., Pokela N., Puhakainen K., Rahnasto M., Mauriala T., Auriola S., et al. Nicotine metabolism and urinary elimination in mouse: invitro and invivo. Xenobiotica 2008, 38:34-47.
27. Soeda J., Morgan M., McKee C., Mouralidarane A., Lin C., Roskams T., et al. Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells. Biochemical and Biophysical Research Communications 2012, 417:17-22.
28. Sellers E.M., Tyndale R.F., Fernandes L.C. Decreasing smoking behaviour and risk through CYP2A6 inhibition. Drug Discovery Today 2003, 8:487-493.
29. Su T., Ding X. Regulation of the cytochrome P450 2A genes. Toxicology and Applied Pharmacology 2004, 199:285-294.
30. Taysi S., Gumustekin K., Demircan B., Aktas O., Oztasan N., Akcay F., et al. Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver. Pharmaceutical Biology 2010, 48:488-493.
31. Thun M.J., Apicella L.F., Henley S.J. Smoking vs other risk factors as the cause of smoking-attributable deaths: confounding in the courtroom. Journal of the American Medical Association 2000, 284:706-712.
32. Vainio P.J., Tuominen R.K. Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes. Nicotine & Tobacco Research 2001, 3:177-182.
33. Wang J.H., Batey R.G., George J. Role of ethanol in the regulation of hepatic stellate cell function. World Journal of Gastroenterology 2006, 12:6926-6932.
34. Zein C.O., Beatty K., Post A.B., Logan L., Debanne S., McCullough A.J. Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: a cross validated retrospective assessment. Hepatology 2006, 44:1564-1571.
35. Zhong W., Zhao Y., Tang Y., Wei X., Shi X., Sun W., et al. Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. American Journal of Pathology 2012, 180:998-1007.