Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells

Biochemical and Biophysical Research Communications

Volumn 417, Issue 1, 2012, Pages 17-22

  Soeda, Junpei ^a   Morgan, Maelle ^a   McKee, Chad ^a   Mouralidarane, Angelina ^a   Lin, ChingI ^a   Roskams, Tania ^b   Oben, Jude A ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Acetylcholine receptors; Cigarette smoke; Fibrosis; Liver disease; Nicotine

Indexed keywords

BUNGAROTOXIN RECEPTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA2; MECAMYLAMINE; MESSENGER RNA; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA1; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA6; NICOTINIC RECEPTOR BETA1; NICOTINIC RECEPTOR BETA2; NICOTINIC RECEPTOR BETA4; NICOTINIC RECEPTOR DELTA; NICOTINIC RECEPTOR EPSILON; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; CELL PROLIFERATION; CONTROLLED STUDY; FIBROGENESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; WESTERN BLOTTING;

CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; GENE EXPRESSION; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MECAMYLAMINE; NICOTINE; NICOTINIC ANTAGONISTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE C; RECEPTORS, NICOTINIC; SMOKING; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84855760014     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.151     Document Type: Article

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