메뉴 건너뛰기




Volumn 42, Issue 7, 2015, Pages 802-817

Systematic review: Bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; COLESTYRAMINE; INDOMETACIN; NABUMETONE; NONSTEROID ANTIINFLAMMATORY AGENT; VITAMIN D;

EID: 84940787936     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.13333     Document Type: Article
Times cited : (113)

References (176)
  • 1
    • 84905053368 scopus 로고    scopus 로고
    • Bile acid chemistry, biology, and therapeutics during the last 80 years: Historical aspects
    • Hofmann AF, Hagey LR,. Bile acid chemistry, biology, and therapeutics during the last 80 years: historical aspects. J. Lipid Res. 2014; 55: 1553-95.
    • (2014) J. Lipid Res. , vol.55 , pp. 1553-1595
    • Hofmann, A.F.1    Hagey, L.R.2
  • 2
    • 66349134159 scopus 로고    scopus 로고
    • Fifty years of advances in bile acid synthesis and metabolism
    • Russell DW,. Fifty years of advances in bile acid synthesis and metabolism. J Lipid Res 2009; 50 (Suppl.): S120-5.
    • (2009) J Lipid Res , vol.50 , pp. S120-S125
    • Russell, D.W.1
  • 3
    • 7544221726 scopus 로고    scopus 로고
    • Detoxification of lithocholic acid, a toxic bile acid: Relevance to drug hepatotoxicity
    • Oct.
    • Hofmann AF,. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev 2004 Oct; 36: 703-22.
    • (2004) Drug Metab Rev , vol.36 , pp. 703-722
    • Hofmann, A.F.1
  • 4
    • 84862579001 scopus 로고    scopus 로고
    • Role of CAR and PXR in xenobiotic sensing and metabolism
    • Jul.
    • Wang Y-M, Ong SS, Chai SC, et al,. Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opin Drug Metab Toxicol 2012 Jul; 8: 803-17.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 803-817
    • Wang, Y.-M.1    Ong, S.S.2    Chai, S.C.3
  • 5
    • 0033591297 scopus 로고    scopus 로고
    • Identification of a nuclear receptor for bile acids
    • Makishima M, Okamoto AY, Repa JJ, et al,. Identification of a nuclear receptor for bile acids. Science 1999; 284: 1362-5.
    • (1999) Science , vol.284 , pp. 1362-1365
    • Makishima, M.1    Okamoto, A.Y.2    Repa, J.J.3
  • 6
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: Natural ligands for an orphan nuclear receptor
    • Parks DJ, Blanchard SG, Bledsoe RK, et al,. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999; 284: 1365-8.
    • (1999) Science , vol.284 , pp. 1365-1368
    • Parks, D.J.1    Blanchard, S.G.2    Bledsoe, R.K.3
  • 7
    • 84859528536 scopus 로고    scopus 로고
    • Physiology of FGF15/19
    • Jones SA,. Physiology of FGF15/19. Adv Exp Med Biol 2012; 728: 171-82.
    • (2012) Adv Exp Med Biol , vol.728 , pp. 171-182
    • Jones, S.A.1
  • 8
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon JM, Kang D-J, Hylemon PB,. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006; 47: 241-59.
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.-J.2    Hylemon, P.B.3
  • 9
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin SI, Wahlström A, Felin J, et al,. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013; 17: 225-35.
    • (2013) Cell Metab , vol.17 , pp. 225-235
    • Sayin, S.I.1    Wahlström, A.2    Felin, J.3
  • 10
    • 66149115985 scopus 로고    scopus 로고
    • Bile acids: Trying to understand their chemistry and biology with the hope of helping patients
    • Hofmann AF,. Bile acids: trying to understand their chemistry and biology with the hope of helping patients. Hepatology 2009; 49: 1403-18.
    • (2009) Hepatology , vol.49 , pp. 1403-1418
    • Hofmann, A.F.1
  • 12
    • 0014071178 scopus 로고
    • The syndrome of ileal disease and the broken enterohepatic circulation: Cholerheic enteropathy
    • Hofmann AF,. The syndrome of ileal disease and the broken enterohepatic circulation: cholerheic enteropathy. Gastroenterology 1967; 52: 752-7.
    • (1967) Gastroenterology , vol.52 , pp. 752-757
    • Hofmann, A.F.1
  • 13
    • 70349496807 scopus 로고    scopus 로고
    • A new mechanism for bile acid diarrhea: Defective feedback inhibition of bile acid biosynthesis
    • Walters JRF, Tasleem AM, Omer OS, et al,. A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. Clin Gastroenterol Hepatol 2009; 7: 1189-94.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 1189-1194
    • Walters, J.R.F.1    Tasleem, A.M.2    Omer, O.S.3
  • 14
    • 0014254324 scopus 로고
    • Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea
    • Meihoff WE, Kern F,. Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea. J Clin Invest 1968; 47: 261-7.
    • (1968) J Clin Invest , vol.47 , pp. 261-267
    • Meihoff, W.E.1    Kern, F.2
  • 15
    • 0017662307 scopus 로고
    • Bile acid studies in uncomplicated Crohn's disease
    • Vantrappen G, Ghoos Y, Rutgeerts P, et al,. Bile acid studies in uncomplicated Crohn's disease. Gut 1977; 18: 730-5.
    • (1977) Gut , vol.18 , pp. 730-735
    • Vantrappen, G.1    Ghoos, Y.2    Rutgeerts, P.3
  • 16
    • 0019964977 scopus 로고
    • Bile acid absorption kinetics in Crohn's disease on elemental diet after oral administration of a stable-isotope tracer with chenodeoxycholic-11, 12-d2 acid
    • Nishida T, Miwa H, Yamamoto M, et al,. Bile acid absorption kinetics in Crohn's disease on elemental diet after oral administration of a stable-isotope tracer with chenodeoxycholic-11, 12-d2 acid. Gut 1982; 23: 751-7.
    • (1982) Gut , vol.23 , pp. 751-757
    • Nishida, T.1    Miwa, H.2    Yamamoto, M.3
  • 17
    • 0020657975 scopus 로고
    • Evaluation of ileal function using 23-selena-25-homotaurocholate, a-gamma-labeled conjugated bile acid. Initial clinical assessment
    • Nyhlin H, Merrick MV, Eastwood MA, et al,. Evaluation of ileal function using 23-selena-25-homotaurocholate, a-gamma-labeled conjugated bile acid. Initial clinical assessment. Gastroenterology 1983; 84: 63-8.
    • (1983) Gastroenterology , vol.84 , pp. 63-68
    • Nyhlin, H.1    Merrick, M.V.2    Eastwood, M.A.3
  • 18
    • 0027977042 scopus 로고
    • Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT
    • Nyhlin H, Merrick MV, Eastwood MA,. Bile acid malabsorption in Crohn's disease and indications for its assessment using SeHCAT. Gut 1994; 35: 90-3.
    • (1994) Gut , vol.35 , pp. 90-93
    • Nyhlin, H.1    Merrick, M.V.2    Eastwood, M.A.3
  • 19
    • 0022356476 scopus 로고
    • Studies on biliary and fecal bile acids in Crohn's disease (The 1st report)-Comparison of non-resected cases and resected ones
    • Konno Y, Hiwatashi N, Kumagai Y, et al,. Studies on biliary and fecal bile acids in Crohn's disease (The 1st report)-Comparison of non-resected cases and resected ones. Nihon Shokakibyo Gakkai Zasshi 1985; 82: 2742-51.
    • (1985) Nihon Shokakibyo Gakkai Zasshi , vol.82 , pp. 2742-2751
    • Konno, Y.1    Hiwatashi, N.2    Kumagai, Y.3
  • 20
    • 0036892294 scopus 로고    scopus 로고
    • Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation
    • Chen F, Ma L, Sartor RB, et al,. Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Gastroenterology 2002; 123: 2005-16.
    • (2002) Gastroenterology , vol.123 , pp. 2005-2016
    • Chen, F.1    Ma, L.2    Sartor, R.B.3
  • 21
    • 33746477130 scopus 로고    scopus 로고
    • C-Fos is a critical mediator of inammatory-mediated repression of the apical sodium-dependent bile acid transporter
    • Neimark E, Chen F, Li X, et al,. c-Fos is a critical mediator of inammatory-mediated repression of the apical sodium-dependent bile acid transporter. Gastroenterology 2006; 131: 554-67.
    • (2006) Gastroenterology , vol.131 , pp. 554-567
    • Neimark, E.1    Chen, F.2    Li, X.3
  • 22
    • 0018611535 scopus 로고
    • Bile acid studies in patients with Crohn's colitis
    • Rutgeerts P, Ghoos Y, Vantrappen G,. Bile acid studies in patients with Crohn's colitis. Gut 1979; 20: 1072-7.
    • (1979) Gut , vol.20 , pp. 1072-1077
    • Rutgeerts, P.1    Ghoos, Y.2    Vantrappen, G.3
  • 23
    • 0025748776 scopus 로고
    • Effects of ileal resection on biliary lipids and bile acid composition in patients with Crohn's disease
    • Lapidus A, Einarsson K,. Effects of ileal resection on biliary lipids and bile acid composition in patients with Crohn's disease. Gut 1991; 32: 1488-91.
    • (1991) Gut , vol.32 , pp. 1488-1491
    • Lapidus, A.1    Einarsson, K.2
  • 24
    • 0344511817 scopus 로고    scopus 로고
    • Bile composition in inflammatory bowel disease: Ileal disease and colectomy, but not colitis, induce lithogenic bile
    • Pereira SP, Bain IM, Kumar D, et al,. Bile composition in inflammatory bowel disease: ileal disease and colectomy, but not colitis, induce lithogenic bile. Aliment Pharmacol Ther 2003; 17: 923-33.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 923-933
    • Pereira, S.P.1    Bain, I.M.2    Kumar, D.3
  • 25
    • 0015928132 scopus 로고
    • Role of the colon in ileal-resection diarrhoea
    • Cummings JH, James WP, Wiggins HS,. Role of the colon in ileal-resection diarrhoea. Lancet 1973; 1: 344-7.
    • (1973) Lancet , vol.1 , pp. 344-347
    • Cummings, J.H.1    James, W.P.2    Wiggins, H.S.3
  • 26
    • 0020035543 scopus 로고
    • Kinetics of primary bile acids in patients with non-operated Crohn's disease
    • Rutgeerts P, Ghoos Y, Vantrappen G,. Kinetics of primary bile acids in patients with non-operated Crohn's disease. Eur J Clin Invest 1982; 12: 135-43.
    • (1982) Eur J Clin Invest , vol.12 , pp. 135-143
    • Rutgeerts, P.1    Ghoos, Y.2    Vantrappen, G.3
  • 27
    • 84874110821 scopus 로고    scopus 로고
    • Shotgun cholanomics of ileal fluid
    • Chen Y, Ogundare M, Williams CM, et al,. Shotgun cholanomics of ileal fluid. Biochimie 2013; 95: 461-3.
    • (2013) Biochimie , vol.95 , pp. 461-463
    • Chen, Y.1    Ogundare, M.2    Williams, C.M.3
  • 28
    • 0019817482 scopus 로고
    • Ileal dysfunction in Crohn's disease assessed by the postprandial serum bile acid response
    • Suchy FS, Balistreri WF,. Ileal dysfunction in Crohn's disease assessed by the postprandial serum bile acid response. Gut 1981; 22: 948-52.
    • (1981) Gut , vol.22 , pp. 948-952
    • Suchy, F.S.1    Balistreri, W.F.2
  • 29
    • 0020041147 scopus 로고
    • Postprandial serum bile acids in resected and non-resected patients with Crohn's disease
    • Heuman R, Sjödahl R, Tobiasson P, et al,. Postprandial serum bile acids in resected and non-resected patients with Crohn's disease. Scand J Gastroenterol 1982; 17: 137-40.
    • (1982) Scand J Gastroenterol , vol.17 , pp. 137-140
    • Heuman, R.1    Sjödahl, R.2    Tobiasson, P.3
  • 30
    • 0020522149 scopus 로고
    • Fasting and postprandial serum concentrations of glycine- and taurine-conjugated bile acids in Crohn's disease
    • Linnet K, Mertz Nielsen A,. Fasting and postprandial serum concentrations of glycine- and taurine-conjugated bile acids in Crohn's disease. Scand J Gastroenterol 1983; 18: 433-8.
    • (1983) Scand J Gastroenterol , vol.18 , pp. 433-438
    • Linnet, K.1    Mertz Nielsen, A.2
  • 31
    • 0029072674 scopus 로고
    • Bile acid absorption from ileoanal pouches using enema scintigraphy
    • Bain IM, Mostafa AB, Harding LK, et al,. Bile acid absorption from ileoanal pouches using enema scintigraphy. Br J Surg 1995; 82: 614-7.
    • (1995) Br J Surg , vol.82 , pp. 614-617
    • Bain, I.M.1    Mostafa, A.B.2    Harding, L.K.3
  • 32
    • 58149229449 scopus 로고    scopus 로고
    • Medical management of patients with ileal pouch anal anastomosis after restorative procto-colectomy
    • Johnson MW, Das P, Dewar DH, et al,. Medical management of patients with ileal pouch anal anastomosis after restorative procto-colectomy. Eur J Gastroenterol Hepatol 2009; 21: 9-17.
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , pp. 9-17
    • Johnson, M.W.1    Das, P.2    Dewar, D.H.3
  • 33
    • 0033406847 scopus 로고    scopus 로고
    • Ursodeoxycholic acid has no influence on function after restorative proctocolectomy in ulcerative colitis
    • Tan HT, Morton D, Bain IM, et al,. Ursodeoxycholic acid has no influence on function after restorative proctocolectomy in ulcerative colitis. Aliment Pharmacol Ther 1999; 13: 1593-6.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1593-1596
    • Tan, H.T.1    Morton, D.2    Bain, I.M.3
  • 34
    • 0022408161 scopus 로고
    • Studies on biliary and fecal bile acids in Crohn's disease (the 2nd report)-The effect of ED treatment on bile acid metabolism
    • Konno Y, Hiwatashi N, Kumagai Y, et al,. Studies on biliary and fecal bile acids in Crohn's disease (the 2nd report)-The effect of ED treatment on bile acid metabolism. Nihon Shokakibyo Gakkai Zasshi. 1985; 12: 2889-95.
    • (1985) Nihon Shokakibyo Gakkai Zasshi. , vol.12 , pp. 2889-2895
    • Konno, Y.1    Hiwatashi, N.2    Kumagai, Y.3
  • 35
    • 67651244689 scopus 로고    scopus 로고
    • Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease
    • Gnewuch C, Liebisch G, Langmann T, et al,. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. WJG 2009; 15: 3134-41.
    • (2009) WJG , vol.15 , pp. 3134-3141
    • Gnewuch, C.1    Liebisch, G.2    Langmann, T.3
  • 36
    • 84874651768 scopus 로고    scopus 로고
    • Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
    • Duboc H, Rajca S, Rainteau D, et al,. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 2013; 62: 531-9.
    • (2013) Gut , vol.62 , pp. 531-539
    • Duboc, H.1    Rajca, S.2    Rainteau, D.3
  • 37
    • 84901506886 scopus 로고    scopus 로고
    • Surface area of the digestive tract - Revisited
    • Helander HF, Fandriks L,. Surface area of the digestive tract-revisited. Scand J Gastroenterol 2014; 49: 681-9.
    • (2014) Scand J Gastroenterol , vol.49 , pp. 681-689
    • Helander, H.F.1    Fandriks, L.2
  • 39
    • 84882797836 scopus 로고    scopus 로고
    • Intestinal permeability defects: Is it time to treat?
    • Elsevier Inc.
    • Odenwald MA, Turner JR,. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol. Elsevier Inc 2013; 11: 1075-83.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1075-1083
    • Odenwald, M.A.1    Turner, J.R.2
  • 40
    • 0014245999 scopus 로고
    • Destruction of the gastric mucosal barrier by detergents and urea
    • Davenport HW,. Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterology 1968; 54: 175-81.
    • (1968) Gastroenterology , vol.54 , pp. 175-181
    • Davenport, H.W.1
  • 41
    • 0014819386 scopus 로고
    • Experimental gastric ulcers in the rat: The separate and combined effects of vagotomy and bile-duct implantation into the stomach
    • Kirk RM,. Experimental gastric ulcers in the rat: the separate and combined effects of vagotomy and bile-duct implantation into the stomach. Br J Surg 1970; 57: 521-4.
    • (1970) Br J Surg , vol.57 , pp. 521-524
    • Kirk, R.M.1
  • 42
    • 0015110792 scopus 로고
    • Bile damage to the gastric mucosal barrier: The influence of pH and bile acid concentration
    • Black RB, Hole D, Rhodes J,. Bile damage to the gastric mucosal barrier: the influence of pH and bile acid concentration. Gastroenterology 1971; 61: 178-84.
    • (1971) Gastroenterology , vol.61 , pp. 178-184
    • Black, R.B.1    Hole, D.2    Rhodes, J.3
  • 43
    • 0015165169 scopus 로고
    • A controlled clinical trial of cholestyramine in the treatment of gastric ulcer
    • Black RB, Rhodes J, Davies GT, et al,. A controlled clinical trial of cholestyramine in the treatment of gastric ulcer. Gastroenterology 1971; 61: 821-5.
    • (1971) Gastroenterology , vol.61 , pp. 821-825
    • Black, R.B.1    Rhodes, J.2    Davies, G.T.3
  • 44
    • 0016762001 scopus 로고
    • Failure of cholestyramine to prevent bile-salt injury to mouse gastric-mucosa
    • Eastwood GL,. Failure of cholestyramine to prevent bile-salt injury to mouse gastric-mucosa. Gastroenterology 1975; 68: 1466-72.
    • (1975) Gastroenterology , vol.68 , pp. 1466-1472
    • Eastwood, G.L.1
  • 45
    • 0023587793 scopus 로고
    • Healthy controls have as much bile reflux as gastric ulcer patients
    • Schindlbeck NE, Heinrich C, Stellaard F, et al,. Healthy controls have as much bile reflux as gastric ulcer patients. Gut 1987; 28: 1577-83.
    • (1987) Gut , vol.28 , pp. 1577-1583
    • Schindlbeck, N.E.1    Heinrich, C.2    Stellaard, F.3
  • 46
    • 50249180215 scopus 로고    scopus 로고
    • Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
    • Hofmann AF, Hagey LR,. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 2008; 65: 2461-83.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2461-2483
    • Hofmann, A.F.1    Hagey, L.R.2
  • 47
    • 0022263639 scopus 로고
    • Bile salt damage of egg phosphatidylcholine liposomes
    • O'Connor CJ, Wallace RG, Iwamoto K, et al,. Bile salt damage of egg phosphatidylcholine liposomes. Biochim Biophys Acta 1985; 817: 95-102.
    • (1985) Biochim Biophys Acta , vol.817 , pp. 95-102
    • O'Connor, C.J.1    Wallace, R.G.2    Iwamoto, K.3
  • 48
    • 0021178162 scopus 로고
    • Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties-studies on isolated hepatocytes and lipid membrane vesicles
    • Schölmerich J, Becher MS, Schmidt K, et al,. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties-studies on isolated hepatocytes and lipid membrane vesicles. Hepatology 1984; 4: 661-6.
    • (1984) Hepatology , vol.4 , pp. 661-666
    • Schölmerich, J.1    Becher, M.S.2    Schmidt, K.3
  • 49
    • 0035061980 scopus 로고    scopus 로고
    • Hydrophilic and hydrophobic bile acids exhibit different cytotoxicities through cytolysis, interleukin-8 synthesis and apoptosis in the intestinal epithelial cell lines. IEC-6 and Caco-2 cells
    • Araki Y, Fujiyama Y, Andoh A, et al,. Hydrophilic and hydrophobic bile acids exhibit different cytotoxicities through cytolysis, interleukin-8 synthesis and apoptosis in the intestinal epithelial cell lines. IEC-6 and Caco-2 cells. Scand J Gastroenterol 2001; 36: 533-9.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 533-539
    • Araki, Y.1    Fujiyama, Y.2    Andoh, A.3
  • 50
    • 0013879314 scopus 로고
    • The effect of bile salts on oxygen consumption, oxidative phosphorylation and ATP-ase activity of mucosal homogenates from rat jejunum and ileum
    • Faust RG, Wu SL,. The effect of bile salts on oxygen consumption, oxidative phosphorylation and ATP-ase activity of mucosal homogenates from rat jejunum and ileum. J Cell Physiol 1966; 67: 149-57.
    • (1966) J Cell Physiol , vol.67 , pp. 149-157
    • Faust, R.G.1    Wu, S.L.2
  • 51
    • 0025358102 scopus 로고
    • Bile salt-induced increases in duodenal brush-border membrane proton permeability, fluidity, and fragility
    • Zhao DL, Hirst BH,. Bile salt-induced increases in duodenal brush-border membrane proton permeability, fluidity, and fragility. Dig Dis Sci 1990; 35: 589-95.
    • (1990) Dig Dis Sci , vol.35 , pp. 589-595
    • Zhao, D.L.1    Hirst, B.H.2
  • 52
    • 0025569602 scopus 로고
    • Comparison of bile salt perturbation of duodenal and jejunal isolated brush-border membranes
    • Zhao DL, Hirst BH,. Comparison of bile salt perturbation of duodenal and jejunal isolated brush-border membranes. Digestion 1990; 47: 200-7.
    • (1990) Digestion , vol.47 , pp. 200-207
    • Zhao, D.L.1    Hirst, B.H.2
  • 53
    • 0031446552 scopus 로고    scopus 로고
    • Ileal pouch dialysate is cytotoxic to epithelial cell lines, but not to CaCo-2 monolayers
    • Merrett MN, Owen RW, Jewell DP,. Ileal pouch dialysate is cytotoxic to epithelial cell lines, but not to CaCo-2 monolayers. Eur J Gastroenterol Hepatol 1997; 9: 1219-26.
    • (1997) Eur J Gastroenterol Hepatol , vol.9 , pp. 1219-1226
    • Merrett, M.N.1    Owen, R.W.2    Jewell, D.P.3
  • 54
    • 0025306996 scopus 로고
    • Bile acids reversible effects on small intestinal permeability. An in vitro study in the rabbit
    • Fasano A, Budillon G, Guandalini S, et al,. Bile acids reversible effects on small intestinal permeability. An in vitro study in the rabbit. Dig Dis Sci 1990; 35: 801-8.
    • (1990) Dig Dis Sci , vol.35 , pp. 801-808
    • Fasano, A.1    Budillon, G.2    Guandalini, S.3
  • 55
    • 42049106193 scopus 로고    scopus 로고
    • Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation
    • Raimondi F, Santoro P, Barone MV, et al,. Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. Am J Physiol Gastrointest Liver Physiol 2008; 294: G906-13.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G906-G913
    • Raimondi, F.1    Santoro, P.2    Barone, M.V.3
  • 56
    • 59449111141 scopus 로고    scopus 로고
    • Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions
    • Lugo-Martínez V-H, Petit CS, Fouquet S, et al,. Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions. Am J Physiol Gastrointest Liver Physiol 2009; 296: G235-44.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G235-G244
    • Lugo-Martínez, V.-H.1    Petit, C.S.2    Fouquet, S.3
  • 57
    • 0037483705 scopus 로고    scopus 로고
    • Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis
    • Sinha A, Nightingale J, West KP, et al,. Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis. N Engl J Med 2003; 349: 350-7.
    • (2003) N Engl J Med , vol.349 , pp. 350-357
    • Sinha, A.1    Nightingale, J.2    West, K.P.3
  • 58
    • 0035366705 scopus 로고    scopus 로고
    • Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells
    • Powell AA, LaRue JM, Batta AK, et al,. Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells. Biochem J 2001; 356 (Pt 2): 481-6.
    • (2001) Biochem J , vol.356 , pp. 481-486
    • Powell, A.A.1    LaRue, J.M.2    Batta, A.K.3
  • 59
    • 0030061978 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid protects in vitro models of human colonic cancer cells from cytotoxic effects of hydrophobic bile acids
    • Shekels LL, Beste JE, Ho SB,. Tauroursodeoxycholic acid protects in vitro models of human colonic cancer cells from cytotoxic effects of hydrophobic bile acids. J Lab Clin Med 1996; 127: 57-66.
    • (1996) J Lab Clin Med , vol.127 , pp. 57-66
    • Shekels, L.L.1    Beste, J.E.2    Ho, S.B.3
  • 60
    • 84876294967 scopus 로고    scopus 로고
    • Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
    • Kakiyama G, Pandak WM, Gillevet PM, et al,. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol 2013; 58: 949-55.
    • (2013) J Hepatol , vol.58 , pp. 949-955
    • Kakiyama, G.1    Pandak, W.M.2    Gillevet, P.M.3
  • 62
    • 79951836666 scopus 로고    scopus 로고
    • Characterization of bacteria in biopsies of colon and stools by high throughput sequencing of the V2 region of bacterial 16S rRNA gene in human. Falciani F, editor
    • Momozawa Y, Deffontaine V, Louis E, et al,. Characterization of bacteria in biopsies of colon and stools by high throughput sequencing of the V2 region of bacterial 16S rRNA gene in human. Falciani F, editor. PLoS ONE 2011; 6: e16952.
    • (2011) PLoS ONE , vol.6 , pp. e16952
    • Momozawa, Y.1    Deffontaine, V.2    Louis, E.3
  • 63
    • 84896092821 scopus 로고    scopus 로고
    • The treatment-naive microbiome in new-onset Crohn's disease
    • Gevers D, Kugathasan S, Denson LA, et al,. The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe 2014; 15: 382-92.
    • (2014) Cell Host Microbe , vol.15 , pp. 382-392
    • Gevers, D.1    Kugathasan, S.2    Denson, L.A.3
  • 64
    • 78650099360 scopus 로고    scopus 로고
    • Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    • Frank DN, Robertson CE, Hamm CM, et al,. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 2011; 17: 179-84.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 179-184
    • Frank, D.N.1    Robertson, C.E.2    Hamm, C.M.3
  • 65
    • 84866549438 scopus 로고    scopus 로고
    • Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    • Morgan XC, Tickle TL, Sokol H, et al,. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 2012; 13: R79.
    • (2012) Genome Biol , vol.13 , pp. R79
    • Morgan, X.C.1    Tickle, T.L.2    Sokol, H.3
  • 66
    • 84881477044 scopus 로고    scopus 로고
    • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
    • Atarashi K, Tanoue T, Oshima K, et al,. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 2014; 500: 232-6.
    • (2014) Nature , vol.500 , pp. 232-236
    • Atarashi, K.1    Tanoue, T.2    Oshima, K.3
  • 67
    • 67649703525 scopus 로고    scopus 로고
    • Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa
    • Llopis M, Antolin M, Carol M, et al,. Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa. Inflamm Bowel Dis 2009; 15: 275-83.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 275-283
    • Llopis, M.1    Antolin, M.2    Carol, M.3
  • 68
    • 4143069158 scopus 로고    scopus 로고
    • High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease
    • Darfeuille-Michaud A, Boudeau J, Bulois P, et al,. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 2004; 127: 412-21.
    • (2004) Gastroenterology , vol.127 , pp. 412-421
    • Darfeuille-Michaud, A.1    Boudeau, J.2    Bulois, P.3
  • 69
    • 0034873344 scopus 로고    scopus 로고
    • Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death
    • Glasser AL, Boudeau J, Barnich N, et al,. Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death. Infect Immun 2001; 69: 5529-37.
    • (2001) Infect Immun , vol.69 , pp. 5529-5537
    • Glasser, A.L.1    Boudeau, J.2    Barnich, N.3
  • 70
    • 34047252362 scopus 로고    scopus 로고
    • Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro
    • Meconi S, Vercellone A, Levillain F, et al,. Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro. Cell Microbiol 2007; 9: 1252-61.
    • (2007) Cell Microbiol , vol.9 , pp. 1252-1261
    • Meconi, S.1    Vercellone, A.2    Levillain, F.3
  • 71
    • 70449653428 scopus 로고    scopus 로고
    • Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response
    • Hase K, Kawano K, Nochi T, et al,. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature 2009; 462: 226-30.
    • (2009) Nature , vol.462 , pp. 226-230
    • Hase, K.1    Kawano, K.2    Nochi, T.3
  • 72
    • 0029948461 scopus 로고    scopus 로고
    • Pathogenesis of aphthoid ulcers in Crohn's disease: Correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry
    • Fujimura Y, Kamoi R, Iida M,. Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry. Gut 1996; 38: 724-32.
    • (1996) Gut , vol.38 , pp. 724-732
    • Fujimura, Y.1    Kamoi, R.2    Iida, M.3
  • 73
    • 79952230127 scopus 로고    scopus 로고
    • Crohn disease-associated adherent-invasive E. Coli bacteria target mouse and human Peyer's patches via long polar fimbriae
    • Chassaing B, Rolhion N, de Vallée A, et al,. Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J Clin Invest 2011; 121: 966-75.
    • (2011) J Clin Invest , vol.121 , pp. 966-975
    • Chassaing, B.1    Rolhion, N.2    De Vallée, A.3
  • 74
    • 84897964236 scopus 로고    scopus 로고
    • Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer
    • Prorok-Hamon M, Friswell MK, Alswied A, et al,. Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer. Gut 2014; 63: 761-70.
    • (2014) Gut , vol.63 , pp. 761-770
    • Prorok-Hamon, M.1    Friswell, M.K.2    Alswied, A.3
  • 75
    • 84873207351 scopus 로고    scopus 로고
    • Bile salts induce long polar fimbriae expression favouring Crohn's disease-associated adherent-invasive Escherichia coli interaction with Peyer's patches
    • Chassaing B, Etienne-Mesmin L, Bonnet R, et al,. Bile salts induce long polar fimbriae expression favouring Crohn's disease-associated adherent-invasive Escherichia coli interaction with Peyer's patches. Environ Microbiol 2013; 15: 355-71.
    • (2013) Environ Microbiol , vol.15 , pp. 355-371
    • Chassaing, B.1    Etienne-Mesmin, L.2    Bonnet, R.3
  • 76
    • 79952777720 scopus 로고    scopus 로고
    • Low levels of bile acids increase bacterial uptake in colonic biopsies from patients with collagenous colitis in remission
    • Münch A, Soderholm JD, Öst Å, et al,. Low levels of bile acids increase bacterial uptake in colonic biopsies from patients with collagenous colitis in remission. Aliment Pharmacol Ther 2011; 33: 954-60.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 954-960
    • Münch, A.1    Soderholm, J.D.2    Öst, A.3
  • 77
    • 35148837743 scopus 로고    scopus 로고
    • Dihydroxy bile acids increase mucosal permeability and bacterial uptake in human colon biopsies
    • Münch A, Ström M, Söderholm JD,. Dihydroxy bile acids increase mucosal permeability and bacterial uptake in human colon biopsies. Scand J Gastroenterol 2007; 42: 1167-74.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 1167-1174
    • Münch, A.1    Ström, M.2    Söderholm, J.D.3
  • 78
    • 84863436944 scopus 로고    scopus 로고
    • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
    • Devkota S, Wang Y, Musch MW, et al,. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 2012; 487: 104-8.
    • (2012) Nature , vol.487 , pp. 104-108
    • Devkota, S.1    Wang, Y.2    Musch, M.W.3
  • 79
    • 0023193899 scopus 로고
    • Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans
    • Bjarnason I, Zanelli G, Smith T, et al,. Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans. Gastroenterology 1987; 93: 480-9.
    • (1987) Gastroenterology , vol.93 , pp. 480-489
    • Bjarnason, I.1    Zanelli, G.2    Smith, T.3
  • 80
    • 0024369143 scopus 로고
    • Intestinal permeability, non-steroidal anti-inflammatory drug enteropathy and inflammatory bowel disease: An overview
    • Bjarnason I, Peters TJ,. Intestinal permeability, non-steroidal anti-inflammatory drug enteropathy and inflammatory bowel disease: an overview. Gut 1989; 30: 22-8.
    • (1989) Gut , vol.30 , pp. 22-28
    • Bjarnason, I.1    Peters, T.J.2
  • 81
    • 0029127778 scopus 로고
    • Experimental-models of inflammatory bowel-disease
    • Elson CO, Sartor RB, Tennyson GS, et al,. Experimental-models of inflammatory bowel-disease. Gastroenterology 1995; 109: 1344-67.
    • (1995) Gastroenterology , vol.109 , pp. 1344-1367
    • Elson, C.O.1    Sartor, R.B.2    Tennyson, G.S.3
  • 82
    • 9844219743 scopus 로고    scopus 로고
    • Mitochondrial damage: A possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine
    • Somasundaram S, Rafi S, Hayllar J, et al,. Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine. Gut 1997; 41: 344-53.
    • (1997) Gut , vol.41 , pp. 344-353
    • Somasundaram, S.1    Rafi, S.2    Hayllar, J.3
  • 83
    • 0036083196 scopus 로고    scopus 로고
    • COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice
    • Sigthorsson G, Simpson RJ, Walley M, et al,. COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology 2002; 122: 1913-23.
    • (2002) Gastroenterology , vol.122 , pp. 1913-1923
    • Sigthorsson, G.1    Simpson, R.J.2    Walley, M.3
  • 84
    • 0028945016 scopus 로고
    • The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: A review and a hypothesis
    • Somasundaram S, Hayllar H, Rafi S, et al,. The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis. Scand J Gastroenterol 1995; 30: 289-99.
    • (1995) Scand J Gastroenterol , vol.30 , pp. 289-299
    • Somasundaram, S.1    Hayllar, H.2    Rafi, S.3
  • 85
    • 0025308163 scopus 로고
    • Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved
    • Beck WS, Schneider HT, Dietzel K, et al,. Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved. Arch Toxicol 1990; 64: 210-7.
    • (1990) Arch Toxicol , vol.64 , pp. 210-217
    • Beck, W.S.1    Schneider, H.T.2    Dietzel, K.3
  • 86
    • 0016711377 scopus 로고
    • Enterohepatic circulation of indomethacin and its role in intestinal irritation
    • Duggan DE, Hooke KF, Noll RM, et al,. Enterohepatic circulation of indomethacin and its role in intestinal irritation. Biochem Pharmacol 1975; 24: 1749-54.
    • (1975) Biochem Pharmacol , vol.24 , pp. 1749-1754
    • Duggan, D.E.1    Hooke, K.F.2    Noll, R.M.3
  • 87
    • 0014877725 scopus 로고
    • Indomethacin-induced intestinal lesions in the rat
    • Brodie DA, Cook PG, Bauer BJ, et al,. Indomethacin-induced intestinal lesions in the rat. Toxicol Appl Pharmacol 1970; 17: 615-24.
    • (1970) Toxicol Appl Pharmacol , vol.17 , pp. 615-624
    • Brodie, D.A.1    Cook, P.G.2    Bauer, B.J.3
  • 88
    • 0014800670 scopus 로고
    • Relationship of enterohepatic cycle to ulcerogenesis in rat small bowel with flufenamic acid
    • Wax J, Clinger WA, Varner P, et al,. Relationship of enterohepatic cycle to ulcerogenesis in rat small bowel with flufenamic acid. Gastroenterology 1970; 58: 772-80.
    • (1970) Gastroenterology , vol.58 , pp. 772-780
    • Wax, J.1    Clinger, W.A.2    Varner, P.3
  • 89
    • 0020068310 scopus 로고
    • Role of food in gastrointestinal ulceration produced by indomethacin in the rat
    • Satoh H, Guth PH, Grossman MI,. Role of food in gastrointestinal ulceration produced by indomethacin in the rat. Gastroenterology 1982; 83 (1 Pt 2): 210-5.
    • (1982) Gastroenterology , vol.83 , Issue.1 , pp. 210-215
    • Satoh, H.1    Guth, P.H.2    Grossman, M.I.3
  • 90
    • 84859109335 scopus 로고    scopus 로고
    • NSAIDs: Take with food or after fasting?
    • Rainsford KD, Bjarnason I,. NSAIDs: take with food or after fasting? J Pharm Pharmacol 2012; 64: 465-9.
    • (2012) J Pharm Pharmacol , vol.64 , pp. 465-469
    • Rainsford, K.D.1    Bjarnason, I.2
  • 91
    • 77951447882 scopus 로고    scopus 로고
    • Effect of indomethacin on bile acid-phospholipid interactions: Implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs
    • Zhou Y, Dial EJ, Doyen R, et al,. Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs. Am J Physiol Gastrointest Liver Physiol 2010; 298: G722-31.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G722-G731
    • Zhou, Y.1    Dial, E.J.2    Doyen, R.3
  • 92
    • 5044219927 scopus 로고    scopus 로고
    • Ursodeoxycholic acid ameliorates experimental ileitis counteracting intestinal barrier dysfunction and oxidative stress
    • Bernardes-Silva CF, Damião AOMC, Sipahi AM, et al,. Ursodeoxycholic acid ameliorates experimental ileitis counteracting intestinal barrier dysfunction and oxidative stress. Dig Dis Sci 2004; 49: 1569-74.
    • (2004) Dig Dis Sci , vol.49 , pp. 1569-1574
    • Bernardes-Silva, C.F.1    Damião, A.2    Sipahi, A.M.3
  • 93
    • 0030969846 scopus 로고    scopus 로고
    • Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation
    • Uchida A, Yamada T, Hayakawa T, et al,. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol 1997; 272 (5 Pt 1): G1249-57.
    • (1997) Am J Physiol , vol.272 , Issue.5 , pp. G1249-G1257
    • Uchida, A.1    Yamada, T.2    Hayakawa, T.3
  • 94
    • 0031760270 scopus 로고    scopus 로고
    • Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats
    • Seitz S, Boelsterli UA,. Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats. Gastroenterology 1998; 115: 1476-82.
    • (1998) Gastroenterology , vol.115 , pp. 1476-1482
    • Seitz, S.1    Boelsterli, U.A.2
  • 95
    • 0014468568 scopus 로고
    • Small intestinal ulcers and intestinal flora in rats given indomethacin
    • Kent TH, Cardelli RM, Stamler FW,. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol 1969; 54: 237-49.
    • (1969) Am J Pathol , vol.54 , pp. 237-249
    • Kent, T.H.1    Cardelli, R.M.2    Stamler, F.W.3
  • 96
    • 0029787769 scopus 로고    scopus 로고
    • Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug
    • Uejima M, Kinouchi T, Kataoka K, et al,. Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug. Microbiol Immunol 1996; 40: 553-60.
    • (1996) Microbiol Immunol , vol.40 , pp. 553-560
    • Uejima, M.1    Kinouchi, T.2    Kataoka, K.3
  • 97
    • 0026785849 scopus 로고
    • Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy
    • Bjarnason I, Hayllar J, Smethurst P, et al,. Metronidazole reduces intestinal inflammation and blood loss in non-steroidal anti-inflammatory drug induced enteropathy. Gut 1992; 33: 1204-8.
    • (1992) Gut , vol.33 , pp. 1204-1208
    • Bjarnason, I.1    Hayllar, J.2    Smethurst, P.3
  • 98
    • 0018844685 scopus 로고
    • Binding of Clostridium difficile cytotoxin and vancomycin by anion-exchange resins
    • Taylor NS, Bartlett JG,. Binding of Clostridium difficile cytotoxin and vancomycin by anion-exchange resins. J Infect Dis 1980; 141: 92-7.
    • (1980) J Infect Dis , vol.141 , pp. 92-97
    • Taylor, N.S.1    Bartlett, J.G.2
  • 99
    • 0017147477 scopus 로고
    • Endotoxin, bile-salts and renal-function in obstructive-jaundice
    • Bailey ME,. Endotoxin, bile-salts and renal-function in obstructive-jaundice. Br J Surg 1976; 63: 774-8.
    • (1976) Br J Surg , vol.63 , pp. 774-778
    • Bailey, M.E.1
  • 100
    • 0017086423 scopus 로고
    • Endotoxaemia and renal failure in cirrhosis and obstructive jaundice
    • Wilkinson SP, Moodie H, Stamatakis JD, et al,. Endotoxaemia and renal failure in cirrhosis and obstructive jaundice. Br Med J 1976; 2: 1415-8.
    • (1976) Br Med J , vol.2 , pp. 1415-1418
    • Wilkinson, S.P.1    Moodie, H.2    Stamatakis, J.D.3
  • 101
    • 0014588959 scopus 로고
    • Effect of bile acids on intestinal absorption of endotoxin in rats
    • Kocsar LT, Bertok L, Varteres V,. Effect of bile acids on intestinal absorption of endotoxin in rats. J Bacteriol 1969; 100: 220-7.
    • (1969) J Bacteriol , vol.100 , pp. 220-227
    • Kocsar, L.T.1    Bertok, L.2    Varteres, V.3
  • 102
    • 0014031965 scopus 로고
    • Physical aspects of reversible inactivation of endotoxin
    • Rudbach JA, Anacker RL, Haskins WT, et al,. Physical aspects of reversible inactivation of endotoxin. Ann N Y Acad Sci 1966; 133: 629-43.
    • (1966) Ann N y Acad Sci , vol.133 , pp. 629-643
    • Rudbach, J.A.1    Anacker, R.L.2    Haskins, W.T.3
  • 103
    • 0024079670 scopus 로고
    • Prevention of endotoxaemia in obstructive jaundice-a comparative study of bile salts
    • Pain JA, Bailey ME,. Prevention of endotoxaemia in obstructive jaundice-a comparative study of bile salts. HPB Surg 1988; 1: 21-7.
    • (1988) HPB Surg , vol.1 , pp. 21-27
    • Pain, J.A.1    Bailey, M.E.2
  • 104
    • 0025907275 scopus 로고
    • Prevention of postoperative renal dysfunction in patients with obstructive jaundice: A multicentre study of bile salts and lactulose
    • Pain JA, Cahill CJ, Gilbert JM, et al,. Prevention of postoperative renal dysfunction in patients with obstructive jaundice: a multicentre study of bile salts and lactulose. Br J Surg 1991; 78: 467-9.
    • (1991) Br J Surg , vol.78 , pp. 467-469
    • Pain, J.A.1    Cahill, C.J.2    Gilbert, J.M.3
  • 105
    • 0015111189 scopus 로고
    • Bile acid inhibition of the intestinal microflora-a function for simple bile acids?
    • Floch MH, Gershengoren W, Elliott S, et al,. Bile acid inhibition of the intestinal microflora-a function for simple bile acids? Gastroenterology 1971; 61: 228-33.
    • (1971) Gastroenterology , vol.61 , pp. 228-233
    • Floch, M.H.1    Gershengoren, W.2    Elliott, S.3
  • 106
    • 0016760238 scopus 로고
    • In vivo effect of bile salts and cholestyramine on intestinal anaerobic bacteria
    • Williams RC, Showalter R, Kern F,. In vivo effect of bile salts and cholestyramine on intestinal anaerobic bacteria. Gastroenterology 1975; 69: 483-91.
    • (1975) Gastroenterology , vol.69 , pp. 483-491
    • Williams, R.C.1    Showalter, R.2    Kern, F.3
  • 107
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T, Moschetta A, Lee Y-K, et al,. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci USA 2006; 103: 3920-5.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.-K.3
  • 108
    • 0020084325 scopus 로고
    • Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium-difficile
    • Wilson KH, Kennedy MJ, Fekety FR,. Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium-difficile. J Clin Microbiol 1982; 15: 443-6.
    • (1982) J Clin Microbiol , vol.15 , pp. 443-446
    • Wilson, K.H.1    Kennedy, M.J.2    Fekety, F.R.3
  • 109
    • 41549142775 scopus 로고    scopus 로고
    • Bile salts and glycine as cogerminants for Clostridium difficile spores
    • Sorg JA, Sonenshein AL,. Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol 2008; 190: 2505-12.
    • (2008) J Bacteriol , vol.190 , pp. 2505-2512
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 110
    • 67649391053 scopus 로고    scopus 로고
    • Clostridium difficile infection: New developments in epidemiology and pathogenesis
    • Rupnik M, Wilcox MH, Gerding DN,. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 2009; 7: 526-36.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 526-536
    • Rupnik, M.1    Wilcox, M.H.2    Gerding, D.N.3
  • 111
    • 63449096364 scopus 로고    scopus 로고
    • Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination
    • Sorg JA, Sonenshein AL,. Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol 2009; 191: 1115-7.
    • (2009) J Bacteriol , vol.191 , pp. 1115-1117
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 112
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie CG, Bucci V, Stein RR, et al,. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 2015; 517: 205-8.
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1    Bucci, V.2    Stein, R.R.3
  • 113
    • 0030069928 scopus 로고    scopus 로고
    • Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines
    • Shekels LL, Lyftogt CT, Ho SB,. Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Int J Biochem Cell Biol 1996; 28: 193-201.
    • (1996) Int J Biochem Cell Biol , vol.28 , pp. 193-201
    • Shekels, L.L.1    Lyftogt, C.T.2    Ho, S.B.3
  • 114
    • 0642303141 scopus 로고    scopus 로고
    • Bile salts regulate intestinal epithelial cell migration by nuclear factor-κB-induced expression of transforming growth factor-β
    • Strauch ED, Yamaguchi J, Bass BL, et al,. Bile salts regulate intestinal epithelial cell migration by nuclear factor-κB-induced expression of transforming growth factor-β. J Am Coll Surg 2003; 197: 974-84.
    • (2003) J Am Coll Surg , vol.197 , pp. 974-984
    • Strauch, E.D.1    Yamaguchi, J.2    Bass, B.L.3
  • 115
    • 2142765892 scopus 로고    scopus 로고
    • Bile salts affect epithelial restitution
    • Riegler FM, Consentini EP,. Bile salts affect epithelial restitution. J Am Coll Surg 2004; 198: 855.
    • (2004) J Am Coll Surg , vol.198 , pp. 855
    • Riegler, F.M.1    Consentini, E.P.2
  • 116
    • 0031751777 scopus 로고    scopus 로고
    • Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
    • Martinez JD, Stratagoules ED, LaRue JM, et al,. Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr Cancer 1998; 31: 111-8.
    • (1998) Nutr Cancer , vol.31 , pp. 111-118
    • Martinez, J.D.1    Stratagoules, E.D.2    LaRue, J.M.3
  • 117
    • 1642438260 scopus 로고    scopus 로고
    • Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression
    • Yamaguchi J, Toledo A, Bass BL, et al,. Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression. Surgery 2004; 135: 215-21.
    • (2004) Surgery , vol.135 , pp. 215-221
    • Yamaguchi, J.1    Toledo, A.2    Bass, B.L.3
  • 118
    • 0030891456 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid on the inflammatory activity of indomethacin-induced intestinal inflammation in rats
    • Kullmann F, Gross V, Rüschoff J, et al,. Effect of ursodeoxycholic acid on the inflammatory activity of indomethacin-induced intestinal inflammation in rats. Z Gastroenterol 1997; 35: 171-8.
    • (1997) Z Gastroenterol , vol.35 , pp. 171-178
    • Kullmann, F.1    Gross, V.2    Rüschoff, J.3
  • 119
    • 84872855413 scopus 로고    scopus 로고
    • Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice
    • Cipriani S, Mencarelli A, Bruno A, et al,. Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice. Br J Pharmacol 2013; 168: 225-37.
    • (2013) Br J Pharmacol , vol.168 , pp. 225-237
    • Cipriani, S.1    Mencarelli, A.2    Bruno, A.3
  • 120
    • 26844568431 scopus 로고    scopus 로고
    • Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs
    • Fiorucci S, Antonelli E, Distrutti E, et al,. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology 2005; 129: 1210-24.
    • (2005) Gastroenterology , vol.129 , pp. 1210-1224
    • Fiorucci, S.1    Antonelli, E.2    Distrutti, E.3
  • 121
    • 81855228908 scopus 로고    scopus 로고
    • Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice
    • Fiorucci S, Mencarelli A, Cipriani S, et al,. Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice. Br J Pharmacol 2011; 164: 1929-38.
    • (2011) Br J Pharmacol , vol.164 , pp. 1929-1938
    • Fiorucci, S.1    Mencarelli, A.2    Cipriani, S.3
  • 122
    • 80055090450 scopus 로고    scopus 로고
    • The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. Ryffel B, editor
    • Cipriani S, Mencarelli A, Chini MG, et al,. The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. Ryffel B, editor. PLoS ONE 2011; 6: e25637.
    • (2011) PLoS ONE , vol.6 , pp. e25637
    • Cipriani, S.1    Mencarelli, A.2    Chini, M.G.3
  • 123
    • 38349108166 scopus 로고    scopus 로고
    • Novel role of the Vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier
    • Kong J, Zhang Z, Musch MW, et al,. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol 2008; 294: G208-16.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G208-G216
    • Kong, J.1    Zhang, Z.2    Musch, M.W.3
  • 124
    • 0037123667 scopus 로고    scopus 로고
    • Vitamin D receptor as an intestinal bile acid sensor
    • Makishima M, Lu TT, Xie W, et al,. Vitamin D receptor as an intestinal bile acid sensor. Science 2002; 296: 1313-6.
    • (2002) Science , vol.296 , pp. 1313-1316
    • Makishima, M.1    Lu, T.T.2    Xie, W.3
  • 125
    • 58549118947 scopus 로고    scopus 로고
    • Failure of T cell homing, reduced CD4/CD8 alpha alpha intraepithelial lymphocytes, and inflammation in the gut of Vitamin D receptor KO mice
    • Yu S, Bruce D, Froicu M, et al,. Failure of T cell homing, reduced CD4/CD8 alpha alpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc Natl Acad Sci USA 2008; 105: 20834-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20834-20839
    • Yu, S.1    Bruce, D.2    Froicu, M.3
  • 126
    • 84883503073 scopus 로고    scopus 로고
    • Intestinal epithelial Vitamin D receptor signaling inhibits experimental colitis
    • Liu W, Chen Y, Golan MA, et al,. Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest 2013; 123: 3983-96.
    • (2013) J Clin Invest , vol.123 , pp. 3983-3996
    • Liu, W.1    Chen, Y.2    Golan, M.A.3
  • 127
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • Vavassori P, Mencarelli A, Renga B, et al,. The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 2009; 183 (10): 6251-61.
    • (2009) J Immunol , vol.183 , Issue.10 , pp. 6251-6261
    • Vavassori, P.1    Mencarelli, A.2    Renga, B.3
  • 128
    • 84872852300 scopus 로고    scopus 로고
    • The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation. Boone DL, editor
    • Renga B, Mencarelli A, Cipriani S, et al,. The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation. Boone DL, editor. PLoS ONE 2013; 8: e54472.
    • (2013) PLoS ONE , vol.8 , pp. e54472
    • Renga, B.1    Mencarelli, A.2    Cipriani, S.3
  • 129
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee J, Mo J-H, Katakura K, et al,. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol 2006; 8: 1327-36.
    • (2006) Nat Cell Biol , vol.8 , pp. 1327-1336
    • Lee, J.1    Mo, J.-H.2    Katakura, K.3
  • 130
    • 79952535597 scopus 로고    scopus 로고
    • Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
    • Gadaleta RM, van Erpecum KJ, Oldenburg B, et al,. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011; 60: 463-72.
    • (2011) Gut , vol.60 , pp. 463-472
    • Gadaleta, R.M.1    Van Erpecum, K.J.2    Oldenburg, B.3
  • 131
    • 34147170945 scopus 로고    scopus 로고
    • Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF- B target gene expression
    • Shah YM, Ma X, Morimura K, et al,. Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF- B target gene expression. Am J Physiol Gastrointest Liver Physiol 2006; 292: G1114-22.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G1114-G1122
    • Shah, Y.M.1    Ma, X.2    Morimura, K.3
  • 132
    • 84893871549 scopus 로고    scopus 로고
    • Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
    • Terc J, Hansen A, Alston L, et al,. Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis. Eur J Pharm Sci 2014; 13: 12-9.
    • (2014) Eur J Pharm Sci , vol.13 , pp. 12-19
    • Terc, J.1    Hansen, A.2    Alston, L.3
  • 133
    • 77953352917 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    • Poole DP, Godfrey C, Cattaruzza F, et al,. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil 2010; 22: 814-e228.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 814-e228
    • Poole, D.P.1    Godfrey, C.2    Cattaruzza, F.3
  • 134
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • Pols TWH, Nomura M, Harach T, et al,. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 2011; 14: 747-57.
    • (2011) Cell Metab , vol.14 , pp. 747-757
    • Pols, T.W.H.1    Nomura, M.2    Harach, T.3
  • 135
    • 80053308007 scopus 로고    scopus 로고
    • The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice
    • Wang Y-D, Chen W-D, Yu D, et al,. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology 2011; 54: 1421-32.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.-D.1    Chen, W.-D.2    Yu, D.3
  • 136
    • 84876041065 scopus 로고    scopus 로고
    • TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
    • Yoneno K, Hisamatsu T, Shimamura K, et al,. TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology 2013; 139: 19-29.
    • (2013) Immunology , vol.139 , pp. 19-29
    • Yoneno, K.1    Hisamatsu, T.2    Shimamura, K.3
  • 137
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP,. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-69.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 138
    • 84888798215 scopus 로고    scopus 로고
    • Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages
    • Society for Leukocyte Biology.
    • Haselow K, Bode JG, Wammers M, et al,. Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages. J Leukoc Biol. Society for Leukocyte Biology. 2013; 94: 1253-64.
    • (2013) J Leukoc Biol , vol.94 , pp. 1253-1264
    • Haselow, K.1    Bode, J.G.2    Wammers, M.3
  • 139
    • 79958278121 scopus 로고    scopus 로고
    • Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine
    • Gadaleta RM, Oldenburg B, Willemsen ECL, et al,. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine. Biochim Biophys Acta 2011; 1812: 851-8.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 851-858
    • Gadaleta, R.M.1    Oldenburg, B.2    Willemsen, E.C.L.3
  • 140
    • 80051940457 scopus 로고    scopus 로고
    • Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease. Bereswill S, editor
    • Nijmeijer RM, Gadaleta RM, van Mil SWC, et al,. Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease. Bereswill S, editor. PLoS ONE 2011; 6: e23745.
    • (2011) PLoS ONE , vol.6 , pp. e23745
    • Nijmeijer, R.M.1    Gadaleta, R.M.2    Van Mil, S.W.C.3
  • 141
    • 84870023768 scopus 로고    scopus 로고
    • Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis. Makishima M, editor
    • van Schaik FDM, Gadaleta RM, Schaap FG, et al,. Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis. Makishima M, editor. PLoS ONE 2012; 7: e49706.
    • (2012) PLoS ONE , vol.7 , pp. e49706
    • Van Schaik, F.D.M.1    Gadaleta, R.M.2    Schaap, F.G.3
  • 142
    • 84907323014 scopus 로고    scopus 로고
    • PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis
    • Zhou X, Cao L, Jiang C, et al,. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun 2014; 5: 4573.
    • (2014) Nat Commun , vol.5 , pp. 4573
    • Zhou, X.1    Cao, L.2    Jiang, C.3
  • 143
    • 84915747794 scopus 로고    scopus 로고
    • The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid
    • Walters JRF, Johnston IM, Nolan JD, et al,. The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. Aliment Pharmacol Ther 2015; 41: 54-64.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 54-64
    • Walters, J.R.F.1    Johnston, I.M.2    Nolan, J.D.3
  • 144
    • 80051516622 scopus 로고    scopus 로고
    • Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease
    • Glas J, Seiderer J, Fischer D, et al,. Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease. Inflamm Bowel Dis 2011; 17: 1917-24.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1917-1924
    • Glas, J.1    Seiderer, J.2    Fischer, D.3
  • 145
    • 84865344897 scopus 로고    scopus 로고
    • Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease
    • Attinkara R, Mwinyi J, Truninger K, et al,. Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease. BMC Res Notes 2012; 5: 461.
    • (2012) BMC Res Notes , vol.5 , pp. 461
    • Attinkara, R.1    Mwinyi, J.2    Truninger, K.3
  • 146
    • 84873716082 scopus 로고    scopus 로고
    • Associations between Vitamin D receptor polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis
    • Xue L-N, Xu K-Q, Zhang W, et al,. Associations between vitamin D receptor polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis. Inflamm Bowel Dis 2013; 19: 54-60.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 54-60
    • Xue, L.-N.1    Xu, K.-Q.2    Zhang, W.3
  • 147
    • 68149099597 scopus 로고    scopus 로고
    • Metabolomics reveals metabolic biomarkers of Crohn's disease. Bereswill S, editor
    • Jansson J, Willing B, Lucio M, et al,. Metabolomics reveals metabolic biomarkers of Crohn's disease. Bereswill S, editor. PLoS ONE 2009; 4: e6386.
    • (2009) PLoS ONE , vol.4 , pp. e6386
    • Jansson, J.1    Willing, B.2    Lucio, M.3
  • 148
    • 0036209411 scopus 로고    scopus 로고
    • Crohn's disease clinical course and severity in obese patients
    • Blain A, Cattan S, Beaugerie L, et al,. Crohn's disease clinical course and severity in obese patients. Clin Nutr 2002; 21: 51-7.
    • (2002) Clin Nutr , vol.21 , pp. 51-57
    • Blain, A.1    Cattan, S.2    Beaugerie, L.3
  • 149
    • 80052726054 scopus 로고    scopus 로고
    • Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease
    • Long MD, Crandall WV, Leibowitz IH, et al,. Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease. Inflamm Bowel Dis 2011; 17: 2162-8.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 2162-2168
    • Long, M.D.1    Crandall, W.V.2    Leibowitz, I.H.3
  • 150
    • 1242269322 scopus 로고    scopus 로고
    • Bowel inflammation as measured by fecal calprotectin: A link between lifestyle factors and colorectal cancer risk
    • Poullis A, Foster R, Shetty A, et al,. Bowel inflammation as measured by fecal calprotectin: a link between lifestyle factors and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2004; 13: 279-84.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 279-284
    • Poullis, A.1    Foster, R.2    Shetty, A.3
  • 151
    • 84866604327 scopus 로고    scopus 로고
    • Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors
    • Teixeira TFS, Souza NCS, Chiarello PG, et al,. Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors. Clin Nutr 2012; 31: 735-40.
    • (2012) Clin Nutr , vol.31 , pp. 735-740
    • Teixeira, T.F.S.1    Souza, N.C.S.2    Chiarello, P.G.3
  • 152
    • 84862067310 scopus 로고    scopus 로고
    • Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. Federici M, editor
    • Moreno-Navarrete JM, Sabater M, Ortega F, et al,. Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. Federici M, editor. PLoS ONE 2012; 5: e37160.
    • (2012) PLoS ONE , vol.5 , pp. e37160
    • Moreno-Navarrete, J.M.1    Sabater, M.2    Ortega, F.3
  • 153
    • 34347229116 scopus 로고    scopus 로고
    • Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people
    • John BJ, Abulafi AM, Poullis A, et al,. Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people. Gut 2007; 56: 1034-5.
    • (2007) Gut , vol.56 , pp. 1034-1035
    • John, B.J.1    Abulafi, A.M.2    Poullis, A.3
  • 154
    • 84873714313 scopus 로고    scopus 로고
    • Faecal calprotectin levels before and after weight loss in obese and overweight subjects
    • Kant P, Fazakerley R, Hull MA,. Faecal calprotectin levels before and after weight loss in obese and overweight subjects. Int J Obes (Lond) 2013; 37: 317-9.
    • (2013) Int J Obes (Lond) , vol.37 , pp. 317-319
    • Kant, P.1    Fazakerley, R.2    Hull, M.A.3
  • 155
    • 79952201102 scopus 로고    scopus 로고
    • Relationship between severe obesity and gut inflammation in children: What's next?
    • Spagnuolo MI, Cicalese MP, Caiazzo MA, et al,. Relationship between severe obesity and gut inflammation in children: what's next? Ital J Pediatr 2010; 36: 66.
    • (2010) Ital J Pediatr , vol.36 , pp. 66
    • Spagnuolo, M.I.1    Cicalese, M.P.2    Caiazzo, M.A.3
  • 156
    • 84876209742 scopus 로고    scopus 로고
    • Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids
    • Kohli R, Bradley D, Setchell KD, et al,. Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J Clin Endocrinol Metab 2013; 98: E708-12.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E708-E712
    • Kohli, R.1    Bradley, D.2    Setchell, K.D.3
  • 157
    • 84885923467 scopus 로고    scopus 로고
    • Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery
    • Werling M, Vincent RP, Cross GF, et al,. Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery. Scand J Gastroenterol 2013; 48: 1257-64.
    • (2013) Scand J Gastroenterol , vol.48 , pp. 1257-1264
    • Werling, M.1    Vincent, R.P.2    Cross, G.F.3
  • 158
    • 84898051705 scopus 로고    scopus 로고
    • FXR is a molecular target for the effects of vertical sleeve gastrectomy
    • Ryan KK, Tremaroli V, Clemmensen C, et al,. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 2014; 509: 183-8.
    • (2014) Nature , vol.509 , pp. 183-188
    • Ryan, K.K.1    Tremaroli, V.2    Clemmensen, C.3
  • 159
    • 84927740816 scopus 로고    scopus 로고
    • Measures of obesity and risk of Crohn's disease and ulcerative colitis
    • Khalili H, Ananthakrishnan AN, Konijeti GG, et al,. Measures of obesity and risk of Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2015; 21: 361-8.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 361-368
    • Khalili, H.1    Ananthakrishnan, A.N.2    Konijeti, G.G.3
  • 160
    • 84885951276 scopus 로고    scopus 로고
    • Review article: Evidence-based dietary advice for patients with inflammatory bowel disease
    • Richman E, Rhodes JM,. Review article: evidence-based dietary advice for patients with inflammatory bowel disease. Aliment Pharmacol Ther 2013; 38: 1156-71.
    • (2013) Aliment Pharmacol Ther , vol.38 , pp. 1156-1171
    • Richman, E.1    Rhodes, J.M.2
  • 161
    • 84924301510 scopus 로고    scopus 로고
    • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
    • Chassaing B, Koren O, Goodrich JK, et al,. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 2015; 519: 92-6.
    • (2015) Nature , vol.519 , pp. 92-96
    • Chassaing, B.1    Koren, O.2    Goodrich, J.K.3
  • 162
    • 84889681706 scopus 로고    scopus 로고
    • Western diet induces dysbiosis with increased e coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
    • Martinez-Medina M, Denizot J, Dreux N, et al,. Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation. Gut 2013; 63: 116-24.
    • (2013) Gut , vol.63 , pp. 116-124
    • Martinez-Medina, M.1    Denizot, J.2    Dreux, N.3
  • 163
    • 84870800293 scopus 로고    scopus 로고
    • The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis
    • Joshi D, Bjarnason I, Belgaumkar A, et al,. The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis. Liver Int 2013; 33: 53-61.
    • (2013) Liver Int , vol.33 , pp. 53-61
    • Joshi, D.1    Bjarnason, I.2    Belgaumkar, A.3
  • 164
    • 85003053366 scopus 로고    scopus 로고
    • Cholestyramine treats primary sclerosing cholangitis associated inflammatory bowel disease
    • Pavlidis P, Heneghan MA, Hayee B,. Cholestyramine treats primary sclerosing cholangitis associated inflammatory bowel disease. J Crohns Colitis 2015; 9: 210.
    • (2015) J Crohns Colitis , vol.9 , pp. 210
    • Pavlidis, P.1    Heneghan, M.A.2    Hayee, B.3
  • 165
    • 84868344438 scopus 로고    scopus 로고
    • PSC, AIH and overlap syndrome in inflammatory bowel disease
    • Trivedi PJ, Chapman RW,. PSC, AIH and overlap syndrome in inflammatory bowel disease. Clin Res Hepatol Gastroenterol 2012; 36: 420-36.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 420-436
    • Trivedi, P.J.1    Chapman, R.W.2
  • 166
    • 13344287538 scopus 로고
    • The role of bile salts in diarrhoea of patients with ulcerative colitis
    • Miettinen TA,. The role of bile salts in diarrhoea of patients with ulcerative colitis. Gut 1971; 12: 632-5.
    • (1971) Gut , vol.12 , pp. 632-635
    • Miettinen, T.A.1
  • 167
    • 0346607187 scopus 로고    scopus 로고
    • Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
    • Jung D, Fantin AC, Scheurer U, et al,. Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut 2004; 53: 78-84.
    • (2004) Gut , vol.53 , pp. 78-84
    • Jung, D.1    Fantin, A.C.2    Scheurer, U.3
  • 168
    • 33845490017 scopus 로고    scopus 로고
    • Budesonide treatment is associated with increased bile acid absorption in collagenous colitis
    • Bajor A, Kilander A, Gälman C, et al,. Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. Aliment Pharmacol Ther 2006; 24: 1643-9.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 1643-1649
    • Bajor, A.1    Kilander, A.2    Gälman, C.3
  • 169
    • 84899508969 scopus 로고    scopus 로고
    • A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: Validation by GC-MS and LC-MS
    • Kakiyama G, Muto A, Takei H, et al,. A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS. J Lipid Res 2014; 55: 978-90.
    • (2014) J Lipid Res , vol.55 , pp. 978-990
    • Kakiyama, G.1    Muto, A.2    Takei, H.3
  • 170
    • 77957674664 scopus 로고    scopus 로고
    • Postprandial plasma bile acid responses in normal weight and obese subjects
    • Glicksman C, Pournaras DJ, Wright M, et al,. Postprandial plasma bile acid responses in normal weight and obese subjects. Ann Clin Biochem 2010; 47 (Pt 5): 482-4.
    • (2010) Ann Clin Biochem , vol.47 , pp. 482-484
    • Glicksman, C.1    Pournaras, D.J.2    Wright, M.3
  • 172
    • 84861862615 scopus 로고    scopus 로고
    • Pregnane X receptor as a target for treatment of inflammatory bowel disorders
    • Cheng J, Shah YM, Gonzalez FJ,. Pregnane X receptor as a target for treatment of inflammatory bowel disorders. Trends Pharmacol Sci 2012; 33: 323-30.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 323-330
    • Cheng, J.1    Shah, Y.M.2    Gonzalez, F.J.3
  • 173
    • 84895520482 scopus 로고    scopus 로고
    • The bile acid TGR5 membrane receptor: From basic research to clinical application
    • Duboc H, Taché Y, Hofmann AF,. The bile acid TGR5 membrane receptor: From basic research to clinical application. Dig Liver Dis 2014; 46: 302-12.
    • (2014) Dig Liver Dis , vol.46 , pp. 302-312
    • Duboc, H.1    Taché, Y.2    Hofmann, A.F.3
  • 174
    • 84910093083 scopus 로고    scopus 로고
    • Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease
    • Cantorna MT, McDaniel K, Bora S, et al,. Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. Exp Biol Med 2014; 239: 1524-30.
    • (2014) Exp Biol Med , vol.239 , pp. 1524-1530
    • Cantorna, M.T.1    McDaniel, K.2    Bora, S.3
  • 175
    • 15844403224 scopus 로고    scopus 로고
    • Biochemical epidemiology of gallbladder cancer
    • Strom BL, Soloway RD, Rios-Dalenz J, et al,. Biochemical epidemiology of gallbladder cancer. Hepatology 1996; 23: 1402-11.
    • (1996) Hepatology , vol.23 , pp. 1402-1411
    • Strom, B.L.1    Soloway, R.D.2    Rios-Dalenz, J.3
  • 176
    • 0032747621 scopus 로고    scopus 로고
    • Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas
    • de Kok TM, van Faassen A, Glinghammar B, et al,. Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas. Dig Dis Sci 1999; 44: 2218-25.
    • (1999) Dig Dis Sci , vol.44 , pp. 2218-2225
    • De Kok, T.M.1    Van Faassen, A.2    Glinghammar, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.