Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells

Biochemical Journal

Volumn 356, Issue 2, 2001, Pages 481-486

  Powell, A A ^a   LaRue, J M ^a   Batta, A K ^a   Martinez, J D ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cellular uptake; Colon cancer; Deoxycholic acid; Signal transduction pathways; Ursodeoxycholic acid

Indexed keywords

ASSAYS; CELL CULTURE; CELL MEMBRANES; GLYCEROL; HYDROPHOBICITY; TUMORS;

APOPTOSIS;

BIOCHEMISTRY;

BILE ACID; BILE ACID CONJUGATE; CARBON 14; CHENODEOXYCHOLIC ACID; DEOXYCHOLIC ACID; GLYCINE; TAURINE; TRITIUM; URSODEOXYCHOLIC ACID;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL STRAIN HEPG2; CELL STRAIN HT29; CELL TRANSPORT; COLON CANCER; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; HYDROPHOBICITY; INCUBATION TIME; LIVER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; BILE ACIDS AND SALTS; CELL DIVISION; COLONIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

TRITIUM;

EID: 0035366705     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560481     Document Type: Article

References (24)

1. Role of bile metabolites in colon carcinogenesis. Animal models
2. Dietary fat and colon cancer: Animal model studies
3. Degradation of bile salts by human intestinal bacteria
4. Promoting effects of bile acids in colon carcinogenesis in germfree and conventional F344 rats
5. Effect of dietary deoxycholic acid and cholesterol on fecal steroid concentration and its impact on the colonic crypt cell proliferation in azoxymethane-treated rats
6. Protection against hydrophobic bile salt-induced cell membrane damage by liposomes and hydrophilic bile salts
7. Effects of different bile salts upon the composition and morphology of a liver plasma membrane preparation. Deoxycholate is more membrane damaging than cholate and its conjugates
8. Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties
9. Bile acid structure and intestinal absorption in the animal model
10. Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling
11. Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture
12. The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: Suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue
13. Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
14. Reversed-phase high-performance thin-layer chromatography of free and conjugated bile acids
15. Bile acid structure-activity relationship: Evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC
16. In vitro formation of DNA adducts with bile acids
17. Activation of protein kinase C alpha and delta by bile acids: Correlation with bile acid structure and diacylglycerol formation
18. Identification of a nuclear receptor for bile acids
19. Bile acids: Natural ligands for an orphan nuclear receptor
20. Characterization of bile salt-induced apoptosis in colon cancer cell lines
21. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes
22. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
23. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas