Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug

Microbiology and Immunology

Volumn 40, Issue 8, 1996, Pages 553-560

  Uejima, Motoo ^a,b   Kinouchi, Takemi ^a   Kataoka, Keiko ^a   Hiraoka, Isao ^b   Ohnishi, Yoshinari ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Ileal ulcer; Intestinal bacteria; Nonsteroidal antiinflammatory drug

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ANTIBIOTIC AGENT; BACITRACIN; NEOMYCIN; NONSTEROID ANTIINFLAMMATORY AGENT; STREPTOMYCIN SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; BACTEROIDES; COLONY FORMING UNIT; CONTROLLED STUDY; ESCHERICHIA COLI; EUBACTERIUM; INTESTINE FLORA; INTESTINE ULCER; KLEBSIELLA; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS BIFIDUS; MALE; NONHUMAN; PROTEUS; RAT; STREPTOCOCCUS THERMOPHILUS; ULCER PERFORATION; ULCEROGENESIS;

ANIMALIA; BACTERIA (MICROORGANISMS); BACTEROIDES; BIFIDOBACTERIUM ADOLESCENTIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM BREVE; ESCHERICHIA COLI; EUBACTERIUM LIMOSUM; KLEBSIELLA; LACTOBACILLUS ACIDOPHILUS; NEGIBACTERIA; POSIBACTERIA; RATTUS NORVEGICUS; STREPTOCOCCUS THERMOPHILUS;

EID: 0029787769     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.1996.tb01108.x     Document Type: Article

References (36)

1. Allison, M.C., Howatson, A.G., Torrance, C.J., Lee, F.D., and Russell, R.I. 1992. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 327: 749-754.
2. Beck, W.S., Schneider, H.T., Dietzel, K., Nuernberg, B., and Brune, K. 1990. Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Arch. Toxicol. 64: 210-217.
3. Bjarnason, I., Hayllar, J., Macpherson, A.J., and Russell, A.S. 1993. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104: 1832-1847.
4. Bjarnason, I., and Macpherson, A. 1989. The changing gastrointestinal side effect profile of non-steroidal anti-inflammatory drugs. Scand. J. Gastroenterol, 24: 56-64.
5. Committee for Regulation of the Sterility Test for Germ-Free Animals in Japanese Experimental Animal Research Association. 1972. The methods for the sterility for germ-free animals. Jpn. Exp. Anim. Res. Assoc. 21: 35-38.
6. Deakin, M. 1988. Small bowel perforation associated with an excessive dose of slow release diclofenac sodium. Br. Med. J. 297: 488-489.
7. Dong, Q., Kinouchi, T., Kunitomo, K., Kataoka, K., Matin, M.A., Akimoto, S., Komi, N., and Ohnishi, Y. 1993. Mutagenicity of the bile of dogs with an experimental model of an anomalous arrangement of the pancreaticobiliary duct. Carcinogenesis 14: 743-747.
8. Drasar, B.S. 1988. The bacterial flora of intestine, p. 23-38. In Rawland, I.R. (ed), Role of the gut flora in toxicity and cancer, Academic Press, London.
9. Duggan, D.E., Hooke, K.F., Noll, R.M., and Kwan, K.C. 1975. Enterohepatic circulation of indomethacin and its role in intestinal irritation. Biochem. Pharmac. 25: 1749-1754.
10. Evangelista, S., Ciappi, R., Ortolani, C., Barzanti, A., and Meli, A. 1985. Further studies on the mechanism of fat-free diet (FFD)-protection against indomethacin-induced intestinal ulcers in the rats. Proc. Soc. Exp. Biol. Med. 179: 113-115.
11. Gans, K.R., Galbraith, W., Roman, R.J., Haber, S.B., Kerr, J.S., Schmidt, W.K., Smith, C., Hewes, W.E., and Ackerman, N.R. 1990. Anti-inflammatory and safety profile of DUP 697, a novel orally effective prostaglandin synthesis inhibitor. J. Pharmacol. Exp. Ther. 254: 180-187.
12. Gerkens, J.F., Shand, D.G., Flexner, C., Nies, A., Oates, J.A., and Data, J.L. 1977. Effect of indomethacin and aspirin on gastric blood flow and acid secretion. J. Pharmacol. Exp. Ther. 203: 646-652.
13. Graham, D.Y. 1990. The relationship between nonsteroidal anti-inflammatory drug use and peptic ulcer disease. Gastroenterol. Clin. North Am. 19: 171-182.
14. Hamilton, J.D., Dyer, N.H., Dawson, A.M., O'Grady, F.W., Vince, A., Fenton, J.C.B., and Mollin, D.L. 1970. Assessment and significance of bacterial overgrowth in the small bowel. Quart. J. Med. 39: 265-285.
15. Kent, T.H., Cardelli, R.M., and Stamler, F.W. 1969. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am. J. Pathol. 54: 237-249.
16. Kent, T.H., Osborne, J.W., and Wende, C.M. 1968. Intestinal flora in whole-body and intestinal X-irradiated rats. Radiat. Res. 35: 635-651.
17. Kinouchi, T, Kataoka, K., Miyanishi, K., Akimoto, S., and Ohnishi, Y. 1993. Biological activities of the intestinal microflora in mice treated with antibiotics or untreated and the effects of the microflora on absorption and metabolic activation of orally administered glutathione conjugates of K-region epoxides of 1-nitropyrene. Carcinogenesis 14: 869-874.
18. Kinouchi, T., Nishifuji, K., and Ohnishi, Y. 1990. Biliary excretion of glutathione conjugates of 4,5-epoxy-4,5-dihydro-1-nitropyrene and 9,10-epoxy-9,10-dihydro-l-nitropyrene in rats administered 1-nitropyrene orally and their further metabolism in the intestinal tract. Carcinogenesis 11:1381-1387.
19. Kinouchi, T., and Ohnishi, Y. 1986. Metabolic activation of 1-nitropyrene and 1,6-dinitropyrene by nitroreductases from Bacteroides fragilis and distribution of nitroreductase activity in rats. Microbiol. Immunol. 30: 979-992.
20. Kyuki, K. 1980. Study on small intestinal lesions induced by nonsteroidal anti-inflammatory drugs. I. Effect of single administration of various nonsteroidal anti-inflammatory drugs and influence of fasting or bile-duct ligation on it in rats. Ann. Proc. Gifu Med. Univ. 28: 141-151.
21. Langman, M.J.S. 1989. Epidemiological evidence on the association between peptic ulceration and antiinflammatory drug use. Gastroenterology 96: 640-646.
22. Langman, M.J.S., Morgan, L., and Worrall, A. 1985. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. Br. Med. J. 290: 347-349.
23. Pemberton, R.E., and Strand, L.J. 1979. A review of upper-gastrointestinal effects of newer the nonsteroidal antiinflammatory agents. Dig. Dis. Sci. 24: 53-62.
24. Rainsford, K.D. 1982. An analysis of gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species. Rheumatol. Int. 2: 1-10.
25. Robert, A. 1977. Prostaglandins and the digestive system, p. 225-266. In Ramwell, P.W. (ed), The prostaglandins, Vol. 3, Plenum Press, New York.
26. Robert, A., and Asano, T. 1977. Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins 14: 333-341.
27. Sato, H., Guth, P.H., and Grossman, M.I. 1982. Role of food in gastrointestinal ulceration produced by indomethacin in the rats. Gastroenterology 83: 210-215.
28. Saverymuttu, S.H., Thomas, A., Grundy, A., and Maxwell, J.D. 1986. Ileal stricturing after long-term indomethacin treatment. Prostaglandins Med. 62: 967-968.
29. Stierlin, H., and Faigle, J.W. 1979. Biotransformation of diclofenac sodium (Voltaren) in animals and in man. II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile. Xenobiotica 9: 611-621.
30. Srurges, H.F., and Krone, C.L 1973. Ulceration and stricture of the jejunum in a patient on long-term indomethacin therapy. Am. J. Gastroenterol. 59: 162-169.
31. Sugiyama, K., Bamba, T., Nakajo, S., and Hosoda, S. 1991. A study on the mechanism of indomethacin induced intestinal ulcer - from a viewpoint of unstirred water layer - Jpn. J. Gastroenterol. 88: 2636-2643.
32. Sun, D.C.H., Roth, S.H., Mitchell, C.S., and Euglund, D.W. 1974. Upper gastrointestinal disease in rheumatoid arthritis. Am. J. Dig. Dis. 19: 405-410.
33. Tannock, G.W., and Savage, D.C. 1974. Influences of dietary and environmental stress on microbial populations in the murine gastrointestinal tract. Infect. Immun. 9: 591-598.
34. Vince, A., Dawson, A.M., Park, N., and O'Grady, F. 1973. Ammonia production by intestinal bacteria. Gut 14: 171-177.
35. Yamada, T., Deitch, E., Specian, R.D., Perry, M.A., Sartor, R.B., and Grisham, M.B. 1993. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 17: 641-662.
36. Yoshikawa, T., Naito, Y., Kishi, A., Tomii, T., Kaneko, T., Iinuma, S., Ichikawa, H., Yasuda, M., Takahashi, S., and Kondo, M. 1993. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 34: 732-737.