The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Cipriani, Sabrina ^a   Mencarelli, Andrea ^a   Chini, Maria Giovanna ^b   Distrutti, Eleonora ^c   Renga, Barbara ^a   Bifulco, Giuseppe ^b   Baldelli, Franco ^a   Donini, Annibale ^a   Fiorucci, Stefano ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CIPROFLOXACIN; CYCLIC AMP; GAP JUNCTION PROTEIN; OLEANOLIC ACID; TOLL LIKE RECEPTOR 4; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZONULIN 1; CHOLERA TOXIN; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, MOUSE; LIGAND; ZONULIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ISOLATION; CELL JUNCTION; CELL STRUCTURE; CELLULAR DISTRIBUTION; COLITIS; CONTROLLED STUDY; CROHN DISEASE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; FLOW CYTOMETRY; G PROTEIN COUPLED BILE ACID RECEPTOR 1 GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; INTESTINE MUCOSA PERMEABILITY; MALE; MOLECULAR DOCKING; MUCOUS CELL; NONHUMAN; RECEPTOR GENE; SCREENING TEST; WILD TYPE; ANIMAL; CHEMICALLY INDUCED DISORDER; IMMUNITY; IMMUNOLOGY; INTESTINE MUCOSA; MOUSE; MOUSE MUTANT; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; TIGHT JUNCTION;

MUS; RODENTIA;

ANIMALS; CHOLERA TOXIN; CIPROFLOXACIN; COLITIS; IMMUNITY; INTESTINAL MUCOSA; LIGANDS; MICE; MICE, KNOCKOUT; PERMEABILITY; RECEPTORS, G-PROTEIN-COUPLED; TIGHT JUNCTIONS;

EID: 80055090450     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025637     Document Type: Article

References (29)

1. Fiorucci S, Cipriani S, Baldelli F, Mencarelli A, (2010) Bile acid-activated receptors in the treatment of dyslipidemia and related disorders. Prog Lipid Res 49: 171-85.
2. Fiorucci S, Cipriani S, Mencarelli A, Renga B, Distrutti E, et al. (2010) Counter-regulatory role of bile acid activated receptors in immunity and inflammation. Curr Mol Med 10: 579-95.
3. Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, et al. (2002) Identification of membrane-type receptor for bile acids (M-BAR). Biochem Bophys Res Commun 298: 714-719.
4. Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, et al. (2003) A G protein-coupled receptor responsive to bile acids. J Biol Chem 278: 9435-9440.
5. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, et al. (2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439: 484-489.
6. Poole DP, Godfrey C, Cattaruzza F, Cottrell GS, Kirkland JG, et al. (2010) Expression and function of the bile acid receptor GP-BAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil 22: 814-25.
7. Katsuma S, Hirasawa A, Tsujimoto G, (2005) Bile acids promote glucagon like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophis Res Comm 329: 386-390.
8. Keitel V, Donner M, Winandy S, Kubitz R, Häussinger D, (2008) Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem Biophys Res Commun 372: 78-84.
9. Vassileva G, Golovko A, Markowitz L, Abbondanzo SJ, Zeng M, et al. (2006) Targeted deletion of GP-BAR1 protects mice from cholesterol gallstone formation. Biochem J 398: 423-30.
10. Wang Q, Fang CH, Hasselgren PO, (2001) Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. J Physiol Regl Integr Comp Physiol 281: R1013-23.
11. Fiorucci S, Mencarelli A, Palazzetti B, Sprague AG, Distrutti E, et al. (2002) Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Immunity 17: 769-80.
12. Santucci L, Wallace J, Mencarelli A, Farneti S, Morelli A, et al. (2005) Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis. Gastroenterology 128: 1243-57.
13. Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S, (2009) The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 183: 6251-61.
14. Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, et al. (2010) Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS One 20105: 1-13.
15. Sato H, Genet C, Strehle A, Thomas C, Lobstein A, et al. (2007) Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem Biophys Res Commun 362: 793-8.
16. Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, et al. (2009) AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry 30: 2785-2791.
17. Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, et al. (2008) Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem 51: 1831-1841.
18. Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, et al. (2007) Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6, 23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. J Med Chem 50: 4265-4268.
19. Marti-Renom MA, Stuart A, Fiser A, Sánchez R, Melo F, et al. (2000) Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct 29: 291-325.
20. Sali A, Blundell TL, (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234: 779-815.
21. Laskowski RA, Moss DS, Thornton JM, (1993) Main-chain bond lengths and bond angles in protein structures. J Mol Biol 231: 1049-67.
22. Drucker DJ, Jin T, Asa SL, Young TA, Brubaker PL, (1994) Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Mol Endocrinol 8: 1646-55.
23. Raimondi F, Santoro P, Barone MV, Pappacoda S, Barretta ML, et al. (2008) Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. Am J Physiol 294: G906-13.
24. Hughes R, Kurth MJ, McGilligan V, McGlynn H, Rowland I, (2008) Effect of colonic bacterial metabolites on Caco-2 cell paracellular permeability in vitro. Nutr Cancer 60: 259-66.
25. Fiorucci S, Mencarelli A, Palladino G, Cipriani S, (2009) Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci 30: 570-80.
26. Juillerat P, Pittet V, Felley C, Mottet C, Froehlich F, et al. (2007) Drug safety in Crohn's disease therapy. Digestion 76: 161-8.
27. Parker HE, Wallis K, le Roux CW, Wong KY, Reimann F, et al. (2011) Molecular mechanisms underlying bile acid stimulated glucagon-like peptide-1 secretion. Br J Pharmacol doi:10.1111/j.1476-5381.2011.01561.x.
28. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A, (2003) Macrophage polarization: tumor associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. TRENDS Immunology 23: 549-555.
29. Khan KJ, Ullman TA, Ford AC, Abreu MT, Abadir A, et al. (2011) Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol 106: 661-73.