메뉴 건너뛰기




Volumn 46, Issue 4, 2014, Pages 302-312

The bile acid TGR5 membrane receptor: From basic research to clinical application

Author keywords

Bile acids; Diabetes; Inflammation; Motility; TGR5 receptor

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; BILE ACID TGR5 MEMBRANE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 84895520482     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2013.10.021     Document Type: Review
Times cited : (358)

References (93)
  • 1
    • 80052720863 scopus 로고    scopus 로고
    • TGR5: a novel target for weight maintenance and glucose metabolism
    • Chen X., Lou G., Meng Z., Huang W. TGR5: a novel target for weight maintenance and glucose metabolism. Experimental Diabetes Research 2011, 2011:853501.
    • (2011) Experimental Diabetes Research , vol.2011 , pp. 853501
    • Chen, X.1    Lou, G.2    Meng, Z.3    Huang, W.4
  • 3
    • 79956088562 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
    • Pols T.W.H., Noriega L.G., Nomura M., Auwerx J., Schoonjans K. The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. Journal of Hepatology 2011, 54:1263-1272.
    • (2011) Journal of Hepatology , vol.54 , pp. 1263-1272
    • Pols, T.W.H.1    Noriega, L.G.2    Nomura, M.3    Auwerx, J.4    Schoonjans, K.5
  • 4
    • 77949425951 scopus 로고    scopus 로고
    • TGR5 as a therapeutic target for treating obesity
    • Zhong M. TGR5 as a therapeutic target for treating obesity. Current Topics in Medicinal Chemistry 2010, 10:386-396.
    • (2010) Current Topics in Medicinal Chemistry , vol.10 , pp. 386-396
    • Zhong, M.1
  • 5
  • 7
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000, 102:731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 9
  • 10
    • 33748757234 scopus 로고    scopus 로고
    • Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
    • Vassileva G., Golovko A., Markowitz L., et al. Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochemical Journal 2006, 398:423-430.
    • (2006) Biochemical Journal , vol.398 , pp. 423-430
    • Vassileva, G.1    Golovko, A.2    Markowitz, L.3
  • 11
    • 71949113667 scopus 로고    scopus 로고
    • Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
    • Müssig K., Staiger H., Machicao F., et al. Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus. Metabolism - Clinical and Experimental 2009, 58:1809-1811.
    • (2009) Metabolism - Clinical and Experimental , vol.58 , pp. 1809-1811
    • Müssig, K.1    Staiger, H.2    Machicao, F.3
  • 12
    • 84895524732 scopus 로고    scopus 로고
    • Gene Symbol Report | HUGO Gene Nomenclature Committee. Available at.
    • Gene Symbol Report | HUGO Gene Nomenclature Committee. Available at. http://www.genenames.org/data/hgnc_data.php%3Fhgnc_id=19680.
  • 13
    • 0024387211 scopus 로고
    • Bile acids inhibit endotoxin-induced release of tumor necrosis factor by monocytes: an in vitro study
    • Greve J.W., Gouma D.J., Buurman W.A. Bile acids inhibit endotoxin-induced release of tumor necrosis factor by monocytes: an in vitro study. Hepatology 1989, 10:454-458.
    • (1989) Hepatology , vol.10 , pp. 454-458
    • Greve, J.W.1    Gouma, D.J.2    Buurman, W.A.3
  • 14
    • 0026657890 scopus 로고
    • Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes
    • Calmus Y., Guechot J., Podevin P., Bonnefis M.T., Giboudeau J., Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. Hepatology 1992, 16:719-723.
    • (1992) Hepatology , vol.16 , pp. 719-723
    • Calmus, Y.1    Guechot, J.2    Podevin, P.3    Bonnefis, M.T.4    Giboudeau, J.5    Poupon, R.6
  • 15
    • 77957877682 scopus 로고    scopus 로고
    • Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
    • e12403
    • Hov J.R., Keitel V., Laerdahl J.K., et al. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS ONE 2010, 5:e12403.
    • (2010) PLoS ONE , vol.5
    • Hov, J.R.1    Keitel, V.2    Laerdahl, J.K.3
  • 16
    • 33751066787 scopus 로고    scopus 로고
    • Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
    • Maruyama T., Tanaka K., Suzuki J., et al. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. Journal of Endocrinology 2006, 191:197-205.
    • (2006) Journal of Endocrinology , vol.191 , pp. 197-205
    • Maruyama, T.1    Tanaka, K.2    Suzuki, J.3
  • 17
    • 78649386642 scopus 로고    scopus 로고
    • The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
    • Keitel V., Görg B., Bidmon H.J., et al. The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia 2010, 58:1794-1805.
    • (2010) Glia , vol.58 , pp. 1794-1805
    • Keitel, V.1    Görg, B.2    Bidmon, H.J.3
  • 18
    • 84875848761 scopus 로고    scopus 로고
    • The TGR5 receptor mediates bile acid-induced itch and analgesia
    • Alemi F., Kwon E., Poole D.P., et al. The TGR5 receptor mediates bile acid-induced itch and analgesia. Journal of Clinical Investigation 2013, 123:1513-1530.
    • (2013) Journal of Clinical Investigation , vol.123 , pp. 1513-1530
    • Alemi, F.1    Kwon, E.2    Poole, D.P.3
  • 19
    • 77953352917 scopus 로고    scopus 로고
    • Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    • e227-228
    • Poole D.P., Godfrey C., Cattaruzza F., et al. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterology and Motility 2010, 22:814-825. e227-228.
    • (2010) Neurogastroenterology and Motility , vol.22 , pp. 814-825
    • Poole, D.P.1    Godfrey, C.2    Cattaruzza, F.3
  • 20
    • 0020658831 scopus 로고
    • The importance of the enteric nervous system for the bile-salt-induced secretion in the small intestine of the rat
    • Karlström L., Cassuto J., Jodal M., Lundgren O. The importance of the enteric nervous system for the bile-salt-induced secretion in the small intestine of the rat. Scandinavian Journal of Gastroenterology 1983, 18:117-123.
    • (1983) Scandinavian Journal of Gastroenterology , vol.18 , pp. 117-123
    • Karlström, L.1    Cassuto, J.2    Jodal, M.3    Lundgren, O.4
  • 21
    • 0022648261 scopus 로고
    • Involvement of the enteric nervous system in the intestinal secretion induced by sodium deoxycholate and sodium ricinoleate
    • Karlström L., Cassuto J., Jodal M., Lundgren O. Involvement of the enteric nervous system in the intestinal secretion induced by sodium deoxycholate and sodium ricinoleate. Scandinavian Journal of Gastroenterology 1986, 21:331-340.
    • (1986) Scandinavian Journal of Gastroenterology , vol.21 , pp. 331-340
    • Karlström, L.1    Cassuto, J.2    Jodal, M.3    Lundgren, O.4
  • 22
    • 33947383769 scopus 로고    scopus 로고
    • The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
    • Keitel V., Reinehr R., Gatsios P., et al. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 2007, 45:695-704.
    • (2007) Hepatology , vol.45 , pp. 695-704
    • Keitel, V.1    Reinehr, R.2    Gatsios, P.3
  • 23
    • 77954569180 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
    • Keitel V., Ullmer C., Häussinger D. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biological Chemistry 2010, 391:785-789.
    • (2010) Biological Chemistry , vol.391 , pp. 785-789
    • Keitel, V.1    Ullmer, C.2    Häussinger, D.3
  • 27
    • 73249142867 scopus 로고    scopus 로고
    • Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
    • Pellicciari R., Gioiello A., Macchiarulo A., et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Journal of Medicinal Chemistry 2009, 52:7958-7961.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 7958-7961
    • Pellicciari, R.1    Gioiello, A.2    Macchiarulo, A.3
  • 29
    • 77957242451 scopus 로고    scopus 로고
    • Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist
    • Rizzo G., Passeri D., De Franco F., et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist. Molecular Pharmacology 2010, 78:617-630.
    • (2010) Molecular Pharmacology , vol.78 , pp. 617-630
    • Rizzo, G.1    Passeri, D.2    De Franco, F.3
  • 30
    • 75449105670 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists
    • Budzik B.W., Evans K.A., Wisnoski D.D., et al. Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists. Bioorganic and Medicinal Chemistry Letters 2010, 20:1363-1367.
    • (2010) Bioorganic and Medicinal Chemistry Letters , vol.20 , pp. 1363-1367
    • Budzik, B.W.1    Evans, K.A.2    Wisnoski, D.D.3
  • 31
    • 73249134773 scopus 로고    scopus 로고
    • Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists
    • Evans K.A., Budzik B.W., Ross S.A., et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. Journal of Medicinal Chemistry 2009, 52:7962-7965.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 7962-7965
    • Evans, K.A.1    Budzik, B.W.2    Ross, S.A.3
  • 32
    • 77957581107 scopus 로고    scopus 로고
    • Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5
    • Herbert M.R., Siegel D.L., Staszewski L., et al. Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorganic and Medicinal Chemistry Letters 2010, 20:5718-5721.
    • (2010) Bioorganic and Medicinal Chemistry Letters , vol.20 , pp. 5718-5721
    • Herbert, M.R.1    Siegel, D.L.2    Staszewski, L.3
  • 33
    • 80055090450 scopus 로고    scopus 로고
    • The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
    • Cipriani S., Mencarelli A., Chini M.G., et al. The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 2011, 6:e25637.
    • (2011) PLoS ONE , vol.6
    • Cipriani, S.1    Mencarelli, A.2    Chini, M.G.3
  • 34
    • 84867886430 scopus 로고    scopus 로고
    • Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells
    • Kumar D.P., Rajagopal S., Mahavadi S., et al. Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Biochemical and Biophysical Research Communications 2012, 427:600-605.
    • (2012) Biochemical and Biophysical Research Communications , vol.427 , pp. 600-605
    • Kumar, D.P.1    Rajagopal, S.2    Mahavadi, S.3
  • 35
    • 77956276608 scopus 로고    scopus 로고
    • Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels
    • Lavoie B., Balemba O.B., Godfrey C., et al. Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. Journal of Physiology (London) 2010, 588(Pt 17):3295-3305.
    • (2010) Journal of Physiology (London) , vol.588 , Issue.PART 17 , pp. 3295-3305
    • Lavoie, B.1    Balemba, O.B.2    Godfrey, C.3
  • 36
    • 77952562273 scopus 로고    scopus 로고
    • Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
    • Vassileva G., Hu W., Hoos L., et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. Journal of Endocrinology 2010, 205:225-232.
    • (2010) Journal of Endocrinology , vol.205 , pp. 225-232
    • Vassileva, G.1    Hu, W.2    Hoos, L.3
  • 37
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • Pols T.W.H., Nomura M., Harach T., et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metabolism 2011, 14:747-757.
    • (2011) Cell Metabolism , vol.14 , pp. 747-757
    • Pols, T.W.H.1    Nomura, M.2    Harach, T.3
  • 38
    • 80053308007 scopus 로고    scopus 로고
    • The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice
    • Wang Y.-D., Chen W.-D., Yu D., Forman B.M., Huang W. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology 2011, 54:1421-1432.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.-D.1    Chen, W.-D.2    Yu, D.3    Forman, B.M.4    Huang, W.5
  • 39
    • 84860253913 scopus 로고    scopus 로고
    • Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
    • Ichikawa R., Takayama T., Yoneno K., et al. Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 2012, 136:153-162.
    • (2012) Immunology , vol.136 , pp. 153-162
    • Ichikawa, R.1    Takayama, T.2    Yoneno, K.3
  • 42
    • 70349255713 scopus 로고    scopus 로고
    • The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
    • Keitel V., Cupisti K., Ullmer C., Knoefel W.T., Kubitz R., Häussinger D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009, 50:861-870.
    • (2009) Hepatology , vol.50 , pp. 861-870
    • Keitel, V.1    Cupisti, K.2    Ullmer, C.3    Knoefel, W.T.4    Kubitz, R.5    Häussinger, D.6
  • 43
    • 84884982788 scopus 로고    scopus 로고
    • The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice
    • Péan N., Doignon I., Garcin I., et al. The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. Hepatology 2013, 58(4):1451-1460.
    • (2013) Hepatology , vol.58 , Issue.4 , pp. 1451-1460
    • Péan, N.1    Doignon, I.2    Garcin, I.3
  • 45
    • 79957663467 scopus 로고    scopus 로고
    • The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
    • Li T., Holmstrom S.R., Kir S., et al. The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Molecular Endocrinology 2011, 25:1066-1071.
    • (2011) Molecular Endocrinology , vol.25 , pp. 1066-1071
    • Li, T.1    Holmstrom, S.R.2    Kir, S.3
  • 46
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M., Houten S.M., Mataki C., et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006, 439:484-489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3
  • 47
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C., Gioiello A., Noriega L., et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metabolism 2009, 10:167-177.
    • (2009) Cell Metabolism , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 49
    • 84864861866 scopus 로고    scopus 로고
    • Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
    • Porez G., Prawitt J., Gross B., Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. Journal of Lipid Research 2012, 53:1723-1737.
    • (2012) Journal of Lipid Research , vol.53 , pp. 1723-1737
    • Porez, G.1    Prawitt, J.2    Gross, B.3    Staels, B.4
  • 52
    • 34047212040 scopus 로고    scopus 로고
    • Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver
    • Marzioni M., Ueno Y., Glaser S., et al. Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver. Liver International 2007, 27:558-568.
    • (2007) Liver International , vol.27 , pp. 558-568
    • Marzioni, M.1    Ueno, Y.2    Glaser, S.3
  • 54
    • 0347361545 scopus 로고    scopus 로고
    • Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95
    • Reinehr R., Häussinger D. Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95. Gastroenterology 2004, 126:249-262.
    • (2004) Gastroenterology , vol.126 , pp. 249-262
    • Reinehr, R.1    Häussinger, D.2
  • 55
    • 69249141789 scopus 로고    scopus 로고
    • Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis
    • Sommerfeld A., Reinehr R., Häussinger D. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. Journal of Biological Chemistry 2009, 284:22173-22183.
    • (2009) Journal of Biological Chemistry , vol.284 , pp. 22173-22183
    • Sommerfeld, A.1    Reinehr, R.2    Häussinger, D.3
  • 56
    • 33846345695 scopus 로고    scopus 로고
    • Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells
    • Yasuda H., Hirata S., Inoue K., Mashima H., Ohnishi H., Yoshiba M. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. Biochemical and Biophysical Research Communications 2007, 354:154-159.
    • (2007) Biochemical and Biophysical Research Communications , vol.354 , pp. 154-159
    • Yasuda, H.1    Hirata, S.2    Inoue, K.3    Mashima, H.4    Ohnishi, H.5    Yoshiba, M.6
  • 57
    • 84878936197 scopus 로고    scopus 로고
    • The deficiency of G-protein-coupled bile acid receptor gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis
    • Chen W.-D., Yu D., Forman B.M., Huang W., Wang Y.-D. The deficiency of G-protein-coupled bile acid receptor gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis. Hepatology 2012.
    • (2012) Hepatology
    • Chen, W.-D.1    Yu, D.2    Forman, B.M.3    Huang, W.4    Wang, Y.-D.5
  • 58
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G., Yu G.-Y., Temkin V., et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cells 2010, 17:286-297.
    • (2010) Cancer Cells , vol.17 , pp. 286-297
    • He, G.1    Yu, G.-Y.2    Temkin, V.3
  • 59
    • 84895544205 scopus 로고    scopus 로고
    • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
    • Alemi F., Poole D.P., Chiu J., et al. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 2012.
    • (2012) Gastroenterology
    • Alemi, F.1    Poole, D.P.2    Chiu, J.3
  • 61
    • 84861682490 scopus 로고    scopus 로고
    • TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
    • Harach T., Pols T.W.H., Nomura M., et al. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Science Reporter 2012, 2:430.
    • (2012) Science Reporter , vol.2 , pp. 430
    • Harach, T.1    Pols, T.W.H.2    Nomura, M.3
  • 63
    • 84876326720 scopus 로고    scopus 로고
    • Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans
    • Wu T., Bound M.J., Standfield S.D., et al. Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans. Diabetes, Obesity and Metabolism 2013, 15:474-477.
    • (2013) Diabetes, Obesity and Metabolism , vol.15 , pp. 474-477
    • Wu, T.1    Bound, M.J.2    Standfield, S.D.3
  • 64
    • 84879103477 scopus 로고    scopus 로고
    • Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
    • Kida T., Tsubosaka Y., Hori M., et al. Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2013, 33(7):1663-1669.
    • (2013) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.33 , Issue.7 , pp. 1663-1669
    • Kida, T.1    Tsubosaka, Y.2    Hori, M.3
  • 65
  • 66
    • 78149439749 scopus 로고    scopus 로고
    • The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
    • e13238
    • Mencarelli A., Cipriani S., Renga B., et al. The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. PLoS ONE 2010, 5:e13238.
    • (2010) PLoS ONE , vol.5
    • Mencarelli, A.1    Cipriani, S.2    Renga, B.3
  • 67
    • 84870526387 scopus 로고    scopus 로고
    • Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor?
    • Duboc H., Aelion H., Rainteau D., et al. Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor?. Hepatology 2012, 56(6):2426.
    • (2012) Hepatology , vol.56 , Issue.6 , pp. 2426
    • Duboc, H.1    Aelion, H.2    Rainteau, D.3
  • 68
    • 84876896348 scopus 로고    scopus 로고
    • Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
    • McMahan R.H., Wang X.X., Cheng L.L., et al. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. Journal of Biological Chemistry 2013, 288:11761-11770.
    • (2013) Journal of Biological Chemistry , vol.288 , pp. 11761-11770
    • McMahan, R.H.1    Wang, X.X.2    Cheng, L.L.3
  • 69
    • 33751526705 scopus 로고    scopus 로고
    • Peliosis hepatis: microscopic and macroscopic type, time pattern, and correlation with liver cell apoptosis in a model of toxic liver injury
    • Tzirogiannis K.N., Papadimas G.K., Kondyli V.G., et al. Peliosis hepatis: microscopic and macroscopic type, time pattern, and correlation with liver cell apoptosis in a model of toxic liver injury. Digestive Diseases and Sciences 2006, 51:1998-2006.
    • (2006) Digestive Diseases and Sciences , vol.51 , pp. 1998-2006
    • Tzirogiannis, K.N.1    Papadimas, G.K.2    Kondyli, V.G.3
  • 70
    • 79955965170 scopus 로고    scopus 로고
    • Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension
    • Hartleb M., Gutkowski K., Milkiewicz P. Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension. World Journal of Gastroenterology 2011, 17:1400-1409.
    • (2011) World Journal of Gastroenterology , vol.17 , pp. 1400-1409
    • Hartleb, M.1    Gutkowski, K.2    Milkiewicz, P.3
  • 71
    • 34247547012 scopus 로고    scopus 로고
    • Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    • Reinehr R., Görg B., Becker S., et al. Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices. Glia 2007, 55:758-771.
    • (2007) Glia , vol.55 , pp. 758-771
    • Reinehr, R.1    Görg, B.2    Becker, S.3
  • 72
    • 49649103144 scopus 로고    scopus 로고
    • Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo
    • Görg B., Qvartskhava N., Keitel V., et al. Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo. Hepatology 2008, 48:567-579.
    • (2008) Hepatology , vol.48 , pp. 567-579
    • Görg, B.1    Qvartskhava, N.2    Keitel, V.3
  • 73
    • 75149187435 scopus 로고    scopus 로고
    • Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1
    • Perides G., Laukkarinen J.M., Vassileva G., Steer M.L. Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1. Gastroenterology 2010, 138:715-725.
    • (2010) Gastroenterology , vol.138 , pp. 715-725
    • Perides, G.1    Laukkarinen, J.M.2    Vassileva, G.3    Steer, M.L.4
  • 74
    • 77249164222 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis
    • Karlsen T.H., Franke A., Melum E., et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010, 138:1102-1111.
    • (2010) Gastroenterology , vol.138 , pp. 1102-1111
    • Karlsen, T.H.1    Franke, A.2    Melum, E.3
  • 75
    • 10844282782 scopus 로고    scopus 로고
    • PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis
    • Loftus E.V., Harewood G.C., Loftus C.G., et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut 2005, 54:91-96.
    • (2005) Gut , vol.54 , pp. 91-96
    • Loftus, E.V.1    Harewood, G.C.2    Loftus, C.G.3
  • 76
    • 84876041065 scopus 로고    scopus 로고
    • TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
    • Yoneno K., Hisamatsu T., Shimamura K., et al. TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology 2013, 139:19-29.
    • (2013) Immunology , vol.139 , pp. 19-29
    • Yoneno, K.1    Hisamatsu, T.2    Shimamura, K.3
  • 77
    • 84867828617 scopus 로고    scopus 로고
    • Peripheral mechanisms in irritable bowel syndrome
    • Camilleri M. Peripheral mechanisms in irritable bowel syndrome. New England Journal of Medicine 2012, 367:1626-1635.
    • (2012) New England Journal of Medicine , vol.367 , pp. 1626-1635
    • Camilleri, M.1
  • 79
    • 47749148828 scopus 로고    scopus 로고
    • Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome
    • Sabate J.-M., Veyrac M., Mion F., et al. Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome. Alimentary Pharmacology and Therapeutics 2008, 28:484-490.
    • (2008) Alimentary Pharmacology and Therapeutics , vol.28 , pp. 484-490
    • Sabate, J.-M.1    Veyrac, M.2    Mion, F.3
  • 80
    • 4644295600 scopus 로고    scopus 로고
    • Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome
    • Coffin B., Bouhassira D., Sabaté J.-M., Barbe L., Jian R. Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome. Gut 2004, 53:1465-1470.
    • (2004) Gut , vol.53 , pp. 1465-1470
    • Coffin, B.1    Bouhassira, D.2    Sabaté, J.-M.3    Barbe, L.4    Jian, R.5
  • 83
    • 82955233025 scopus 로고    scopus 로고
    • The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype
    • Bertiaux-Vandaële N., Youmba S.B., Belmonte L., et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. American Journal of Gastroenterology 2011, 106:2165-2173.
    • (2011) American Journal of Gastroenterology , vol.106 , pp. 2165-2173
    • Bertiaux-Vandaële, N.1    Youmba, S.B.2    Belmonte, L.3
  • 85
    • 0026240054 scopus 로고
    • Bile acids and colorectal cancer: hypothesis
    • Hill M.J. Bile acids and colorectal cancer: hypothesis. European Journal of Cancer Prevention 1991, 1(Suppl. 2):69-74.
    • (1991) European Journal of Cancer Prevention , vol.1 , Issue.SUPPL. 2 , pp. 69-74
    • Hill, M.J.1
  • 86
    • 0017413089 scopus 로고
    • Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps
    • Reddy B.S., Wynder E.L. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 1977, 39:2533-2539.
    • (1977) Cancer , vol.39 , pp. 2533-2539
    • Reddy, B.S.1    Wynder, E.L.2
  • 89
    • 84867742919 scopus 로고    scopus 로고
    • The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer
    • Kong Y., Bai P.S., Sun H., et al. The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer. International Journal of Biochemistry and Cell Biology 2012, 44(12):2321-2332.
    • (2012) International Journal of Biochemistry and Cell Biology , vol.44 , Issue.12 , pp. 2321-2332
    • Kong, Y.1    Bai, P.S.2    Sun, H.3
  • 90
    • 77149120776 scopus 로고    scopus 로고
    • Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
    • Hong J., Behar J., Wands J., et al. Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma. Gut 2010, 59:170-180.
    • (2010) Gut , vol.59 , pp. 170-180
    • Hong, J.1    Behar, J.2    Wands, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.