-
1
-
-
80052720863
-
TGR5: a novel target for weight maintenance and glucose metabolism
-
Chen X., Lou G., Meng Z., Huang W. TGR5: a novel target for weight maintenance and glucose metabolism. Experimental Diabetes Research 2011, 2011:853501.
-
(2011)
Experimental Diabetes Research
, vol.2011
, pp. 853501
-
-
Chen, X.1
Lou, G.2
Meng, Z.3
Huang, W.4
-
2
-
-
79959497278
-
TGR5 sequence variation in primary sclerosing cholangitis
-
Hov J.R., Keitel V., Schrumpf E., Häussinger D., Karlsen T.H. TGR5 sequence variation in primary sclerosing cholangitis. Digestive Diseases 2011, 29:78-84.
-
(2011)
Digestive Diseases
, vol.29
, pp. 78-84
-
-
Hov, J.R.1
Keitel, V.2
Schrumpf, E.3
Häussinger, D.4
Karlsen, T.H.5
-
3
-
-
79956088562
-
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
-
Pols T.W.H., Noriega L.G., Nomura M., Auwerx J., Schoonjans K. The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. Journal of Hepatology 2011, 54:1263-1272.
-
(2011)
Journal of Hepatology
, vol.54
, pp. 1263-1272
-
-
Pols, T.W.H.1
Noriega, L.G.2
Nomura, M.3
Auwerx, J.4
Schoonjans, K.5
-
4
-
-
77949425951
-
TGR5 as a therapeutic target for treating obesity
-
Zhong M. TGR5 as a therapeutic target for treating obesity. Current Topics in Medicinal Chemistry 2010, 10:386-396.
-
(2010)
Current Topics in Medicinal Chemistry
, vol.10
, pp. 386-396
-
-
Zhong, M.1
-
5
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H., Chen J., Hollister K., Sowers L.C., Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Molecular Cell 1999, 3:543-553.
-
(1999)
Molecular Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
6
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
Lefebvre P., Cariou B., Lien F., Kuipers F., Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiological Reviews 2009, 89:147-191.
-
(2009)
Physiological Reviews
, vol.89
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
7
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000, 102:731-744.
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
Gonzalez, F.J.6
-
10
-
-
33748757234
-
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
-
Vassileva G., Golovko A., Markowitz L., et al. Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochemical Journal 2006, 398:423-430.
-
(2006)
Biochemical Journal
, vol.398
, pp. 423-430
-
-
Vassileva, G.1
Golovko, A.2
Markowitz, L.3
-
11
-
-
71949113667
-
Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
-
Müssig K., Staiger H., Machicao F., et al. Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus. Metabolism - Clinical and Experimental 2009, 58:1809-1811.
-
(2009)
Metabolism - Clinical and Experimental
, vol.58
, pp. 1809-1811
-
-
Müssig, K.1
Staiger, H.2
Machicao, F.3
-
12
-
-
84895524732
-
-
Gene Symbol Report | HUGO Gene Nomenclature Committee. Available at.
-
Gene Symbol Report | HUGO Gene Nomenclature Committee. Available at. http://www.genenames.org/data/hgnc_data.php%3Fhgnc_id=19680.
-
-
-
-
13
-
-
0024387211
-
Bile acids inhibit endotoxin-induced release of tumor necrosis factor by monocytes: an in vitro study
-
Greve J.W., Gouma D.J., Buurman W.A. Bile acids inhibit endotoxin-induced release of tumor necrosis factor by monocytes: an in vitro study. Hepatology 1989, 10:454-458.
-
(1989)
Hepatology
, vol.10
, pp. 454-458
-
-
Greve, J.W.1
Gouma, D.J.2
Buurman, W.A.3
-
14
-
-
0026657890
-
Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes
-
Calmus Y., Guechot J., Podevin P., Bonnefis M.T., Giboudeau J., Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. Hepatology 1992, 16:719-723.
-
(1992)
Hepatology
, vol.16
, pp. 719-723
-
-
Calmus, Y.1
Guechot, J.2
Podevin, P.3
Bonnefis, M.T.4
Giboudeau, J.5
Poupon, R.6
-
15
-
-
77957877682
-
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
-
e12403
-
Hov J.R., Keitel V., Laerdahl J.K., et al. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS ONE 2010, 5:e12403.
-
(2010)
PLoS ONE
, vol.5
-
-
Hov, J.R.1
Keitel, V.2
Laerdahl, J.K.3
-
16
-
-
33751066787
-
Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
-
Maruyama T., Tanaka K., Suzuki J., et al. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. Journal of Endocrinology 2006, 191:197-205.
-
(2006)
Journal of Endocrinology
, vol.191
, pp. 197-205
-
-
Maruyama, T.1
Tanaka, K.2
Suzuki, J.3
-
17
-
-
78649386642
-
The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
-
Keitel V., Görg B., Bidmon H.J., et al. The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia 2010, 58:1794-1805.
-
(2010)
Glia
, vol.58
, pp. 1794-1805
-
-
Keitel, V.1
Görg, B.2
Bidmon, H.J.3
-
18
-
-
84875848761
-
The TGR5 receptor mediates bile acid-induced itch and analgesia
-
Alemi F., Kwon E., Poole D.P., et al. The TGR5 receptor mediates bile acid-induced itch and analgesia. Journal of Clinical Investigation 2013, 123:1513-1530.
-
(2013)
Journal of Clinical Investigation
, vol.123
, pp. 1513-1530
-
-
Alemi, F.1
Kwon, E.2
Poole, D.P.3
-
19
-
-
77953352917
-
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
-
e227-228
-
Poole D.P., Godfrey C., Cattaruzza F., et al. Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterology and Motility 2010, 22:814-825. e227-228.
-
(2010)
Neurogastroenterology and Motility
, vol.22
, pp. 814-825
-
-
Poole, D.P.1
Godfrey, C.2
Cattaruzza, F.3
-
20
-
-
0020658831
-
The importance of the enteric nervous system for the bile-salt-induced secretion in the small intestine of the rat
-
Karlström L., Cassuto J., Jodal M., Lundgren O. The importance of the enteric nervous system for the bile-salt-induced secretion in the small intestine of the rat. Scandinavian Journal of Gastroenterology 1983, 18:117-123.
-
(1983)
Scandinavian Journal of Gastroenterology
, vol.18
, pp. 117-123
-
-
Karlström, L.1
Cassuto, J.2
Jodal, M.3
Lundgren, O.4
-
21
-
-
0022648261
-
Involvement of the enteric nervous system in the intestinal secretion induced by sodium deoxycholate and sodium ricinoleate
-
Karlström L., Cassuto J., Jodal M., Lundgren O. Involvement of the enteric nervous system in the intestinal secretion induced by sodium deoxycholate and sodium ricinoleate. Scandinavian Journal of Gastroenterology 1986, 21:331-340.
-
(1986)
Scandinavian Journal of Gastroenterology
, vol.21
, pp. 331-340
-
-
Karlström, L.1
Cassuto, J.2
Jodal, M.3
Lundgren, O.4
-
22
-
-
33947383769
-
The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
-
Keitel V., Reinehr R., Gatsios P., et al. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 2007, 45:695-704.
-
(2007)
Hepatology
, vol.45
, pp. 695-704
-
-
Keitel, V.1
Reinehr, R.2
Gatsios, P.3
-
23
-
-
77954569180
-
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
-
Keitel V., Ullmer C., Häussinger D. The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biological Chemistry 2010, 391:785-789.
-
(2010)
Biological Chemistry
, vol.391
, pp. 785-789
-
-
Keitel, V.1
Ullmer, C.2
Häussinger, D.3
-
25
-
-
44649092024
-
Expression and function of the bile acid receptor TGR5 in Kupffer cells
-
Keitel V., Donner M., Winandy S., Kubitz R., Häussinger D. Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochemical and Biophysical Research Communications 2008, 372:78-84.
-
(2008)
Biochemical and Biophysical Research Communications
, vol.372
, pp. 78-84
-
-
Keitel, V.1
Donner, M.2
Winandy, S.3
Kubitz, R.4
Häussinger, D.5
-
27
-
-
73249142867
-
Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
-
Pellicciari R., Gioiello A., Macchiarulo A., et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Journal of Medicinal Chemistry 2009, 52:7958-7961.
-
(2009)
Journal of Medicinal Chemistry
, vol.52
, pp. 7958-7961
-
-
Pellicciari, R.1
Gioiello, A.2
Macchiarulo, A.3
-
28
-
-
84869755410
-
Patented TGR5 modulators: a review (2006 - present)
-
Gioiello A., Rosatelli E., Nuti R., et al. Patented TGR5 modulators: a review (2006 - present). Expert Opinion on Therapeutic Patent 2012, 22(12):1399-1414.
-
(2012)
Expert Opinion on Therapeutic Patent
, vol.22
, Issue.12
, pp. 1399-1414
-
-
Gioiello, A.1
Rosatelli, E.2
Nuti, R.3
-
29
-
-
77957242451
-
Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist
-
Rizzo G., Passeri D., De Franco F., et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist. Molecular Pharmacology 2010, 78:617-630.
-
(2010)
Molecular Pharmacology
, vol.78
, pp. 617-630
-
-
Rizzo, G.1
Passeri, D.2
De Franco, F.3
-
30
-
-
75449105670
-
Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists
-
Budzik B.W., Evans K.A., Wisnoski D.D., et al. Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists. Bioorganic and Medicinal Chemistry Letters 2010, 20:1363-1367.
-
(2010)
Bioorganic and Medicinal Chemistry Letters
, vol.20
, pp. 1363-1367
-
-
Budzik, B.W.1
Evans, K.A.2
Wisnoski, D.D.3
-
31
-
-
73249134773
-
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists
-
Evans K.A., Budzik B.W., Ross S.A., et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. Journal of Medicinal Chemistry 2009, 52:7962-7965.
-
(2009)
Journal of Medicinal Chemistry
, vol.52
, pp. 7962-7965
-
-
Evans, K.A.1
Budzik, B.W.2
Ross, S.A.3
-
32
-
-
77957581107
-
Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5
-
Herbert M.R., Siegel D.L., Staszewski L., et al. Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorganic and Medicinal Chemistry Letters 2010, 20:5718-5721.
-
(2010)
Bioorganic and Medicinal Chemistry Letters
, vol.20
, pp. 5718-5721
-
-
Herbert, M.R.1
Siegel, D.L.2
Staszewski, L.3
-
33
-
-
80055090450
-
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
-
Cipriani S., Mencarelli A., Chini M.G., et al. The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 2011, 6:e25637.
-
(2011)
PLoS ONE
, vol.6
-
-
Cipriani, S.1
Mencarelli, A.2
Chini, M.G.3
-
34
-
-
84867886430
-
Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells
-
Kumar D.P., Rajagopal S., Mahavadi S., et al. Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Biochemical and Biophysical Research Communications 2012, 427:600-605.
-
(2012)
Biochemical and Biophysical Research Communications
, vol.427
, pp. 600-605
-
-
Kumar, D.P.1
Rajagopal, S.2
Mahavadi, S.3
-
35
-
-
77956276608
-
Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels
-
Lavoie B., Balemba O.B., Godfrey C., et al. Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. Journal of Physiology (London) 2010, 588(Pt 17):3295-3305.
-
(2010)
Journal of Physiology (London)
, vol.588
, Issue.PART 17
, pp. 3295-3305
-
-
Lavoie, B.1
Balemba, O.B.2
Godfrey, C.3
-
36
-
-
77952562273
-
Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
-
Vassileva G., Hu W., Hoos L., et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. Journal of Endocrinology 2010, 205:225-232.
-
(2010)
Journal of Endocrinology
, vol.205
, pp. 225-232
-
-
Vassileva, G.1
Hu, W.2
Hoos, L.3
-
37
-
-
82955168360
-
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
-
Pols T.W.H., Nomura M., Harach T., et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metabolism 2011, 14:747-757.
-
(2011)
Cell Metabolism
, vol.14
, pp. 747-757
-
-
Pols, T.W.H.1
Nomura, M.2
Harach, T.3
-
38
-
-
80053308007
-
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice
-
Wang Y.-D., Chen W.-D., Yu D., Forman B.M., Huang W. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology 2011, 54:1421-1432.
-
(2011)
Hepatology
, vol.54
, pp. 1421-1432
-
-
Wang, Y.-D.1
Chen, W.-D.2
Yu, D.3
Forman, B.M.4
Huang, W.5
-
39
-
-
84860253913
-
Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
-
Ichikawa R., Takayama T., Yoneno K., et al. Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 2012, 136:153-162.
-
(2012)
Immunology
, vol.136
, pp. 153-162
-
-
Ichikawa, R.1
Takayama, T.2
Yoneno, K.3
-
42
-
-
70349255713
-
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
-
Keitel V., Cupisti K., Ullmer C., Knoefel W.T., Kubitz R., Häussinger D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009, 50:861-870.
-
(2009)
Hepatology
, vol.50
, pp. 861-870
-
-
Keitel, V.1
Cupisti, K.2
Ullmer, C.3
Knoefel, W.T.4
Kubitz, R.5
Häussinger, D.6
-
43
-
-
84884982788
-
The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice
-
Péan N., Doignon I., Garcin I., et al. The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. Hepatology 2013, 58(4):1451-1460.
-
(2013)
Hepatology
, vol.58
, Issue.4
, pp. 1451-1460
-
-
Péan, N.1
Doignon, I.2
Garcin, I.3
-
45
-
-
79957663467
-
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
-
Li T., Holmstrom S.R., Kir S., et al. The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Molecular Endocrinology 2011, 25:1066-1071.
-
(2011)
Molecular Endocrinology
, vol.25
, pp. 1066-1071
-
-
Li, T.1
Holmstrom, S.R.2
Kir, S.3
-
46
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
Watanabe M., Houten S.M., Mataki C., et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006, 439:484-489.
-
(2006)
Nature
, vol.439
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
-
47
-
-
69149083245
-
TGR5-mediated bile acid sensing controls glucose homeostasis
-
Thomas C., Gioiello A., Noriega L., et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metabolism 2009, 10:167-177.
-
(2009)
Cell Metabolism
, vol.10
, pp. 167-177
-
-
Thomas, C.1
Gioiello, A.2
Noriega, L.3
-
48
-
-
79959525960
-
The bile acid membrane receptor TGR5: a valuable metabolic target
-
Pols T.W.H., Noriega L.G., Nomura M., Auwerx J., Schoonjans K. The bile acid membrane receptor TGR5: a valuable metabolic target. Digestive Diseases 2011, 29:37-44.
-
(2011)
Digestive Diseases
, vol.29
, pp. 37-44
-
-
Pols, T.W.H.1
Noriega, L.G.2
Nomura, M.3
Auwerx, J.4
Schoonjans, K.5
-
49
-
-
84864861866
-
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
-
Porez G., Prawitt J., Gross B., Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. Journal of Lipid Research 2012, 53:1723-1737.
-
(2012)
Journal of Lipid Research
, vol.53
, pp. 1723-1737
-
-
Porez, G.1
Prawitt, J.2
Gross, B.3
Staels, B.4
-
52
-
-
34047212040
-
Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver
-
Marzioni M., Ueno Y., Glaser S., et al. Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver. Liver International 2007, 27:558-568.
-
(2007)
Liver International
, vol.27
, pp. 558-568
-
-
Marzioni, M.1
Ueno, Y.2
Glaser, S.3
-
54
-
-
0347361545
-
Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95
-
Reinehr R., Häussinger D. Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95. Gastroenterology 2004, 126:249-262.
-
(2004)
Gastroenterology
, vol.126
, pp. 249-262
-
-
Reinehr, R.1
Häussinger, D.2
-
55
-
-
69249141789
-
Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis
-
Sommerfeld A., Reinehr R., Häussinger D. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. Journal of Biological Chemistry 2009, 284:22173-22183.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 22173-22183
-
-
Sommerfeld, A.1
Reinehr, R.2
Häussinger, D.3
-
56
-
-
33846345695
-
Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells
-
Yasuda H., Hirata S., Inoue K., Mashima H., Ohnishi H., Yoshiba M. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. Biochemical and Biophysical Research Communications 2007, 354:154-159.
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, pp. 154-159
-
-
Yasuda, H.1
Hirata, S.2
Inoue, K.3
Mashima, H.4
Ohnishi, H.5
Yoshiba, M.6
-
57
-
-
84878936197
-
The deficiency of G-protein-coupled bile acid receptor gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis
-
Chen W.-D., Yu D., Forman B.M., Huang W., Wang Y.-D. The deficiency of G-protein-coupled bile acid receptor gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis. Hepatology 2012.
-
(2012)
Hepatology
-
-
Chen, W.-D.1
Yu, D.2
Forman, B.M.3
Huang, W.4
Wang, Y.-D.5
-
58
-
-
74549217325
-
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
-
He G., Yu G.-Y., Temkin V., et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cells 2010, 17:286-297.
-
(2010)
Cancer Cells
, vol.17
, pp. 286-297
-
-
He, G.1
Yu, G.-Y.2
Temkin, V.3
-
59
-
-
84895544205
-
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
-
Alemi F., Poole D.P., Chiu J., et al. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 2012.
-
(2012)
Gastroenterology
-
-
Alemi, F.1
Poole, D.P.2
Chiu, J.3
-
61
-
-
84861682490
-
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
-
Harach T., Pols T.W.H., Nomura M., et al. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Science Reporter 2012, 2:430.
-
(2012)
Science Reporter
, vol.2
, pp. 430
-
-
Harach, T.1
Pols, T.W.H.2
Nomura, M.3
-
63
-
-
84876326720
-
Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans
-
Wu T., Bound M.J., Standfield S.D., et al. Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans. Diabetes, Obesity and Metabolism 2013, 15:474-477.
-
(2013)
Diabetes, Obesity and Metabolism
, vol.15
, pp. 474-477
-
-
Wu, T.1
Bound, M.J.2
Standfield, S.D.3
-
64
-
-
84879103477
-
Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
-
Kida T., Tsubosaka Y., Hori M., et al. Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2013, 33(7):1663-1669.
-
(2013)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.33
, Issue.7
, pp. 1663-1669
-
-
Kida, T.1
Tsubosaka, Y.2
Hori, M.3
-
65
-
-
67650566600
-
Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice
-
Hartman H.B., Gardell S.J., Petucci C.J., Wang S., Krueger J.A., Evans M.J. Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice. Journal of Lipid Research 2009, 50:1090-1100.
-
(2009)
Journal of Lipid Research
, vol.50
, pp. 1090-1100
-
-
Hartman, H.B.1
Gardell, S.J.2
Petucci, C.J.3
Wang, S.4
Krueger, J.A.5
Evans, M.J.6
-
66
-
-
78149439749
-
The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
-
e13238
-
Mencarelli A., Cipriani S., Renga B., et al. The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. PLoS ONE 2010, 5:e13238.
-
(2010)
PLoS ONE
, vol.5
-
-
Mencarelli, A.1
Cipriani, S.2
Renga, B.3
-
67
-
-
84870526387
-
Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor?
-
Duboc H., Aelion H., Rainteau D., et al. Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor?. Hepatology 2012, 56(6):2426.
-
(2012)
Hepatology
, vol.56
, Issue.6
, pp. 2426
-
-
Duboc, H.1
Aelion, H.2
Rainteau, D.3
-
68
-
-
84876896348
-
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
-
McMahan R.H., Wang X.X., Cheng L.L., et al. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. Journal of Biological Chemistry 2013, 288:11761-11770.
-
(2013)
Journal of Biological Chemistry
, vol.288
, pp. 11761-11770
-
-
McMahan, R.H.1
Wang, X.X.2
Cheng, L.L.3
-
69
-
-
33751526705
-
Peliosis hepatis: microscopic and macroscopic type, time pattern, and correlation with liver cell apoptosis in a model of toxic liver injury
-
Tzirogiannis K.N., Papadimas G.K., Kondyli V.G., et al. Peliosis hepatis: microscopic and macroscopic type, time pattern, and correlation with liver cell apoptosis in a model of toxic liver injury. Digestive Diseases and Sciences 2006, 51:1998-2006.
-
(2006)
Digestive Diseases and Sciences
, vol.51
, pp. 1998-2006
-
-
Tzirogiannis, K.N.1
Papadimas, G.K.2
Kondyli, V.G.3
-
70
-
-
79955965170
-
Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension
-
Hartleb M., Gutkowski K., Milkiewicz P. Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension. World Journal of Gastroenterology 2011, 17:1400-1409.
-
(2011)
World Journal of Gastroenterology
, vol.17
, pp. 1400-1409
-
-
Hartleb, M.1
Gutkowski, K.2
Milkiewicz, P.3
-
71
-
-
34247547012
-
Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
-
Reinehr R., Görg B., Becker S., et al. Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices. Glia 2007, 55:758-771.
-
(2007)
Glia
, vol.55
, pp. 758-771
-
-
Reinehr, R.1
Görg, B.2
Becker, S.3
-
72
-
-
49649103144
-
Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo
-
Görg B., Qvartskhava N., Keitel V., et al. Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo. Hepatology 2008, 48:567-579.
-
(2008)
Hepatology
, vol.48
, pp. 567-579
-
-
Görg, B.1
Qvartskhava, N.2
Keitel, V.3
-
73
-
-
75149187435
-
Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1
-
Perides G., Laukkarinen J.M., Vassileva G., Steer M.L. Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1. Gastroenterology 2010, 138:715-725.
-
(2010)
Gastroenterology
, vol.138
, pp. 715-725
-
-
Perides, G.1
Laukkarinen, J.M.2
Vassileva, G.3
Steer, M.L.4
-
74
-
-
77249164222
-
Genome-wide association analysis in primary sclerosing cholangitis
-
Karlsen T.H., Franke A., Melum E., et al. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010, 138:1102-1111.
-
(2010)
Gastroenterology
, vol.138
, pp. 1102-1111
-
-
Karlsen, T.H.1
Franke, A.2
Melum, E.3
-
75
-
-
10844282782
-
PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis
-
Loftus E.V., Harewood G.C., Loftus C.G., et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut 2005, 54:91-96.
-
(2005)
Gut
, vol.54
, pp. 91-96
-
-
Loftus, E.V.1
Harewood, G.C.2
Loftus, C.G.3
-
76
-
-
84876041065
-
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
-
Yoneno K., Hisamatsu T., Shimamura K., et al. TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology 2013, 139:19-29.
-
(2013)
Immunology
, vol.139
, pp. 19-29
-
-
Yoneno, K.1
Hisamatsu, T.2
Shimamura, K.3
-
77
-
-
84867828617
-
Peripheral mechanisms in irritable bowel syndrome
-
Camilleri M. Peripheral mechanisms in irritable bowel syndrome. New England Journal of Medicine 2012, 367:1626-1635.
-
(2012)
New England Journal of Medicine
, vol.367
, pp. 1626-1635
-
-
Camilleri, M.1
-
78
-
-
76349097992
-
Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort
-
Manabe N., Wong B.S., Camilleri M., Burton D., McKinzie S., Zinsmeister A.R. Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterology and Motility 2010, 22:293-382.
-
(2010)
Neurogastroenterology and Motility
, vol.22
, pp. 293-382
-
-
Manabe, N.1
Wong, B.S.2
Camilleri, M.3
Burton, D.4
McKinzie, S.5
Zinsmeister, A.R.6
-
79
-
-
47749148828
-
Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome
-
Sabate J.-M., Veyrac M., Mion F., et al. Relationship between rectal sensitivity, symptoms intensity and quality of life in patients with irritable bowel syndrome. Alimentary Pharmacology and Therapeutics 2008, 28:484-490.
-
(2008)
Alimentary Pharmacology and Therapeutics
, vol.28
, pp. 484-490
-
-
Sabate, J.-M.1
Veyrac, M.2
Mion, F.3
-
80
-
-
4644295600
-
Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome
-
Coffin B., Bouhassira D., Sabaté J.-M., Barbe L., Jian R. Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome. Gut 2004, 53:1465-1470.
-
(2004)
Gut
, vol.53
, pp. 1465-1470
-
-
Coffin, B.1
Bouhassira, D.2
Sabaté, J.-M.3
Barbe, L.4
Jian, R.5
-
81
-
-
80053909415
-
Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders
-
e458
-
Camilleri M., Vazquez-Roque M.I., Carlson P., Burton D., Wong B.S., Zinsmeister A.R. Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders. Neurogastroenterology and Motility 2011, 23:995-999. e458.
-
(2011)
Neurogastroenterology and Motility
, vol.23
, pp. 995-999
-
-
Camilleri, M.1
Vazquez-Roque, M.I.2
Carlson, P.3
Burton, D.4
Wong, B.S.5
Zinsmeister, A.R.6
-
82
-
-
79955839320
-
Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test
-
Gerova V.A., Stoynov S.G., Katsarov D.S., Svinarov D.A. Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test. World Journal of Gastroenterology 2011, 17:2211-2215.
-
(2011)
World Journal of Gastroenterology
, vol.17
, pp. 2211-2215
-
-
Gerova, V.A.1
Stoynov, S.G.2
Katsarov, D.S.3
Svinarov, D.A.4
-
83
-
-
82955233025
-
The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype
-
Bertiaux-Vandaële N., Youmba S.B., Belmonte L., et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. American Journal of Gastroenterology 2011, 106:2165-2173.
-
(2011)
American Journal of Gastroenterology
, vol.106
, pp. 2165-2173
-
-
Bertiaux-Vandaële, N.1
Youmba, S.B.2
Belmonte, L.3
-
85
-
-
0026240054
-
Bile acids and colorectal cancer: hypothesis
-
Hill M.J. Bile acids and colorectal cancer: hypothesis. European Journal of Cancer Prevention 1991, 1(Suppl. 2):69-74.
-
(1991)
European Journal of Cancer Prevention
, vol.1
, Issue.SUPPL. 2
, pp. 69-74
-
-
Hill, M.J.1
-
86
-
-
0017413089
-
Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps
-
Reddy B.S., Wynder E.L. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 1977, 39:2533-2539.
-
(1977)
Cancer
, vol.39
, pp. 2533-2539
-
-
Reddy, B.S.1
Wynder, E.L.2
-
87
-
-
0035451350
-
The role of bile acids in carcinogenesis
-
Debruyne P.R., Bruyneel E.A., Li X., Zimber A., Gespach C., Mareel M.M. The role of bile acids in carcinogenesis. Mutation Research 2001, 480-481:359-369.
-
(2001)
Mutation Research
, pp. 359-369
-
-
Debruyne, P.R.1
Bruyneel, E.A.2
Li, X.3
Zimber, A.4
Gespach, C.5
Mareel, M.M.6
-
88
-
-
80052739162
-
Carcinogenicity of deoxycholate, a secondary bile acid
-
Bernstein C., Holubec H., Bhattacharyya A.K., et al. Carcinogenicity of deoxycholate, a secondary bile acid. Archives of Toxicology 2011, 85:863-871.
-
(2011)
Archives of Toxicology
, vol.85
, pp. 863-871
-
-
Bernstein, C.1
Holubec, H.2
Bhattacharyya, A.K.3
-
89
-
-
84867742919
-
The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer
-
Kong Y., Bai P.S., Sun H., et al. The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer. International Journal of Biochemistry and Cell Biology 2012, 44(12):2321-2332.
-
(2012)
International Journal of Biochemistry and Cell Biology
, vol.44
, Issue.12
, pp. 2321-2332
-
-
Kong, Y.1
Bai, P.S.2
Sun, H.3
-
90
-
-
77149120776
-
Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
-
Hong J., Behar J., Wands J., et al. Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma. Gut 2010, 59:170-180.
-
(2010)
Gut
, vol.59
, pp. 170-180
-
-
Hong, J.1
Behar, J.2
Wands, J.3
-
91
-
-
0023705910
-
Stomach cancer after partial gastrectomy for benign ulcer disease
-
Lundegårdh G., Adami H.O., Helmick C., Zack M., Meirik O. Stomach cancer after partial gastrectomy for benign ulcer disease. New England Journal of Medicine 1988, 319:195-200.
-
(1988)
New England Journal of Medicine
, vol.319
, pp. 195-200
-
-
Lundegårdh, G.1
Adami, H.O.2
Helmick, C.3
Zack, M.4
Meirik, O.5
-
92
-
-
0027934666
-
Risk of cancer following partial gastrectomy for benign ulcer disease
-
Lundegårdh G., Adami H.O., Helmick C., Zack M. Risk of cancer following partial gastrectomy for benign ulcer disease. British Journal of Surgery 1994, 81:1164-1167.
-
(1994)
British Journal of Surgery
, vol.81
, pp. 1164-1167
-
-
Lundegårdh, G.1
Adami, H.O.2
Helmick, C.3
Zack, M.4
|