메뉴 건너뛰기




Volumn 55, Issue 1, 2014, Pages 12-19

Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis

Author keywords

Inflammatory bowel diseases; Intestinal epithelium; Pregnane X receptor; Rifaximin; Wound healing

Indexed keywords

INFLAMMATORY BOWEL DISEASES; INTESTINAL EPITHELIUM; PREGNANE X RECEPTOR; RIFAXIMIN; WOUND HEALING;

EID: 84893871549     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.01.007     Document Type: Article
Times cited : (78)

References (37)
  • 1
    • 30944443377 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    • DOI 10.1038/labinvest.3700373, PII 3700373
    • S.A. Blair, S.V. Kane, D.R. Clayburgh, and J.R. Turner Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Laboratory investigation J. Tech. Methods Pathol. 86 2006 191 201 (Pubitemid 43117598)
    • (2006) Laboratory Investigation , vol.86 , Issue.2 , pp. 191-201
    • Blair, S.A.1    Kane, S.V.2    Clayburgh, D.R.3    Turner, J.R.4
  • 2
    • 80054932995 scopus 로고    scopus 로고
    • Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells
    • L.S. Chaturvedi, H.M. Marsh, and M.D. Basson Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells Am. J. Physiol. Cell Physiol. 301 2011 C1224 C1238
    • (2011) Am. J. Physiol. Cell Physiol. , vol.301
    • Chaturvedi, L.S.1    Marsh, H.M.2    Basson, M.D.3
  • 3
    • 77957236383 scopus 로고    scopus 로고
    • Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X receptor activation
    • J. Cheng, Y.M. Shah, X. Ma, X. Pang, T. Tanaka, T. Kodama, K.W. Krausz, and F.J. Gonzalez Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation J. Pharmacol. Exp. Ther. 335 2010 32 41
    • (2010) J. Pharmacol. Exp. Ther. , vol.335 , pp. 32-41
    • Cheng, J.1    Shah, Y.M.2    Ma, X.3    Pang, X.4    Tanaka, T.5    Kodama, T.6    Krausz, K.W.7    Gonzalez, F.J.8
  • 4
    • 84861862615 scopus 로고    scopus 로고
    • Pregnane X receptor as a target for treatment of inflammatory bowel disorders
    • J. Cheng, Y.M. Shah, and F.J. Gonzalez Pregnane X receptor as a target for treatment of inflammatory bowel disorders Trends Pharmacol. Sci. 33 2012 323 330
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 323-330
    • Cheng, J.1    Shah, Y.M.2    Gonzalez, F.J.3
  • 5
    • 0033870127 scopus 로고    scopus 로고
    • Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity
    • N. Diaz-Granados, K. Howe, J. Lu, and D.M. McKay Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity Am. J. Pathol. 156 2000 2169 2177 (Pubitemid 30641783)
    • (2000) American Journal of Pathology , vol.156 , Issue.6 , pp. 2169-2177
    • Diaz-Granados, N.1    Howe, K.2    Lu, J.3    McKay, D.M.4
  • 6
    • 84878028859 scopus 로고    scopus 로고
    • Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-kappaB signaling pathway
    • W. Dou, J. Zhang, E. Zhang, A. Sun, L. Ding, G. Chou, Z. Wang, and S. Mani Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-kappaB signaling pathway J. Pharmacol. Exp. Ther. 345 2013 473 482
    • (2013) J. Pharmacol. Exp. Ther. , vol.345 , pp. 473-482
    • Dou, W.1    Zhang, J.2    Zhang, E.3    Sun, A.4    Ding, L.5    Chou, G.6    Wang, Z.7    Mani, S.8
  • 8
    • 7244257577 scopus 로고    scopus 로고
    • Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling
    • DOI 10.1074/jbc.M406253200
    • M.R. Frey, A. Golovin, and D.B. Polk Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling J. Biol. Chem. 279 2004 44513 44521 (Pubitemid 39430858)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.43 , pp. 44513-44521
    • Frey, M.R.1    Golovin, A.2    Brent Polk, D.3
  • 12
    • 79953327694 scopus 로고    scopus 로고
    • Looking beyond symptom relief: Evolution of mucosal healing in inflammatory bowel disease
    • M. Iacucci, and S. Ghosh Looking beyond symptom relief: evolution of mucosal healing in inflammatory bowel disease Ther. Adv. Gastroenterol. 4 2011 129 143
    • (2011) Ther. Adv. Gastroenterol. , vol.4 , pp. 129-143
    • Iacucci, M.1    Ghosh, S.2
  • 13
    • 79955799724 scopus 로고    scopus 로고
    • Wound healing of intestinal epithelial cells
    • M. Iizuka, and S. Konno Wound healing of intestinal epithelial cells World J. Gastroenterol.: WJG 17 2011 2161 2171
    • (2011) World J. Gastroenterol.: WJG , vol.17 , pp. 2161-2171
    • Iizuka, M.1    Konno, S.2
  • 14
    • 39349091818 scopus 로고    scopus 로고
    • Molecular mechanisms of cytochrome P450 induction: Potential for drug-drug interactions
    • DOI 10.2174/138920307783018668
    • S. Jana, and J. Paliwal Molecular mechanisms of cytochrome p450 induction: potential for drug-drug interactions Curr. Protein Pept. Sci. 8 2007 619 628 (Pubitemid 351266993)
    • (2007) Current Protein and Peptide Science , vol.8 , Issue.6 , pp. 619-628
    • Jana, S.1    Paliwal, J.2
  • 15
    • 33646349207 scopus 로고    scopus 로고
    • Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes
    • DOI 10.1002/jcp.20626
    • T. Karrasch, K.A. Steinbrecher, B. Allard, A.S. Baldwin, and C. Jobin Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes J. Cell. Physiol. 207 2006 809 815 (Pubitemid 43668246)
    • (2006) Journal of Cellular Physiology , vol.207 , Issue.3 , pp. 809-815
    • Karrasch, T.1    Steinbrecher, K.A.2    Allard, B.3    Baldwin, A.S.4    Jobin, C.5
  • 16
    • 79956027719 scopus 로고    scopus 로고
    • EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation
    • S. Kenchegowda, N.G. Bazan, and H.E. Bazan EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation Invest. Ophthalmol. Vis. Sci. 52 2011 2240 2249
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 2240-2249
    • Kenchegowda, S.1    Bazan, N.G.2    Bazan, H.E.3
  • 17
    • 79952784286 scopus 로고    scopus 로고
    • Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration
    • S. Kodama, and M. Negishi Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration J. Biol. Chem. 286 2011 3570 3578
    • (2011) J. Biol. Chem. , vol.286 , pp. 3570-3578
    • Kodama, S.1    Negishi, M.2
  • 18
    • 3242735503 scopus 로고    scopus 로고
    • Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes
    • DOI 10.1053/j.gastro.2004.04.019, PII S0016508504007140
    • T. Langmann, C. Moehle, R. Mauerer, M. Scharl, G. Liebisch, A. Zahn, W. Stremmel, and G. Schmitz Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes Gastroenterology 127 2004 26 40 (Pubitemid 38962271)
    • (2004) Gastroenterology , vol.127 , Issue.1 , pp. 26-40
    • Langmann, T.1    Moehle, C.2    Mauerer, R.3    Scharl, M.4    Liebisch, G.5    Zahn, A.6    Stremmel, W.7    Schmitz, G.8
  • 22
    • 80052052440 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells
    • A. Mencarelli, B. Renga, G. Palladino, D. Claudio, P. Ricci, E. Distrutti, M. Barbanti, F. Baldelli, and S. Fiorucci Inhibition of NF-kappaB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells Eur. J. Pharmacol. 668 2011 317 324
    • (2011) Eur. J. Pharmacol. , vol.668 , pp. 317-324
    • Mencarelli, A.1    Renga, B.2    Palladino, G.3    Claudio, D.4    Ricci, P.5    Distrutti, E.6    Barbanti, M.7    Baldelli, F.8    Fiorucci, S.9
  • 25
    • 84864396725 scopus 로고    scopus 로고
    • Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases
    • W.A. Rose 2nd, K. Sakamoto, and C.A. Leifer Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases BMC Immunol. 13 2012 41
    • (2012) BMC Immunol. , vol.13 , pp. 41
    • Rose II, W.A.1    Sakamoto, K.2    Leifer, C.A.3
  • 26
    • 84866058423 scopus 로고    scopus 로고
    • TLR9 is important for protection against intestinal damage and for intestinal repair
    • W.A. Rose 2nd, K. Sakamoto, and C.A. Leifer TLR9 is important for protection against intestinal damage and for intestinal repair Sci. Rep. 2 2012 574
    • (2012) Sci. Rep. , vol.2 , pp. 574
    • Rose II, W.A.1    Sakamoto, K.2    Leifer, C.A.3
  • 27
    • 20044371666 scopus 로고    scopus 로고
    • The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics
    • DOI 10.1007/s10565-005-0085-6
    • Y. Sambuy, I. De Angelis, G. Ranaldi, M.L. Scarino, A. Stammati, and F. Zucco The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics Cell Biol. Toxicol. 21 2005 1 26 (Pubitemid 40767684)
    • (2005) Cell Biology and Toxicology , vol.21 , Issue.1 , pp. 1-26
    • Sambuy, Y.1    De Angelis, I.2    Ranaldi, G.3    Scarino, M.L.4    Stammati, A.5    Zucco, F.6
  • 28
    • 34147170945 scopus 로고    scopus 로고
    • Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression
    • Y.M. Shah, X. Ma, K. Morimura, I. Kim, and F.J. Gonzalez Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression Am. J. Phys. Gastrointestinal Liver Phys. 292 2007 G1114 G1122
    • (2007) Am. J. Phys. Gastrointestinal Liver Phys. , vol.292
    • Shah, Y.M.1    Ma, X.2    Morimura, K.3    Kim, I.4    Gonzalez, F.J.5
  • 29
    • 84872704227 scopus 로고    scopus 로고
    • Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver
    • J.L. Staudinger, S. Woody, M. Sun, and W. Cui Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver Drug Metab. Rev. 45 2013 48 59
    • (2013) Drug Metab. Rev. , vol.45 , pp. 48-59
    • Staudinger, J.L.1    Woody, S.2    Sun, M.3    Cui, W.4
  • 31
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • J.R. Turner Intestinal mucosal barrier function in health and disease Nat. Rev. Immunol. 9 2009 799 809
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 33
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • DOI 10.1038/nature06005, PII NATURE06005
    • R.J. Xavier, and D.K. Podolsky Unravelling the pathogenesis of inflammatory bowel disease Nature 448 2007 427 434 (Pubitemid 47123518)
    • (2007) Nature , vol.448 , Issue.7152 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 34
    • 79961011027 scopus 로고    scopus 로고
    • Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution
    • T. Yamaoka, M.R. Frey, R.S. Dise, J.K. Bernard, and D.B. Polk Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution Am. J. Phys. Gastrointestinal Liver Phys. 301 2011 G368 G376
    • (2011) Am. J. Phys. Gastrointestinal Liver Phys. , vol.301
    • Yamaoka, T.1    Frey, M.R.2    Dise, R.S.3    Bernard, J.K.4    Polk, D.B.5
  • 36
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • DOI 10.1136/gut.2006.094375
    • S. Zeissig, N. Burgel, D. Gunzel, J. Richter, J. Mankertz, U. Wahnschaffe, A.J. Kroesen, M. Zeitz, M. Fromm, and J.D. Schulzke Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease Gut 56 2007 61 72 (Pubitemid 46044890)
    • (2007) Gut , vol.56 , Issue.1 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.-D.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.