Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 5 35-5, 1997, Pages

  Uchida, Atsuo ^a   Yamada, Tamaki ^a   Hayakawa, Tomihiro ^a   Hoshino, Makoto ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Bile acid; Indomethacin; Intestine

Indexed keywords

TAUROCHENODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BILE SECRETION; CELL PROTECTION; DRUG EFFECT; ENTERITIS; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030969846     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.5.g1249     Document Type: Article

References (31)

1. Attili, A. F., M. Angelico, A. Cantafora, A. Alvaro, and L. Capocaccia. Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids. Med. Hypotheses 19: 57-68, 1985.
2. Bjarnason, I., G. Zenelli, T. Smith, P. Prouse, P. Williams, P. Smethurst, G. Delacey, M. J. Grumpel, and A. J. Levi. Nonsteroidal anti-inflammatory drug-induced intestinal inflammation in humans. Gastroenterology 93: 480-489, 1987.
3. Brodie, D. A., P. G. Cook, B. J. Bauer, and G. E. Dagle. Indomethacin-induced intestinal lesions in the rat. Toxicol. Appl. Pharmacol. 17: 615-624, 1970.
4. Cahill, C. J., J. A. Pain, and M. E. Bailey. Bile salts, endotoxin and renal function in obstructive jaundice. Surg. Gynecol. Obstet. 165: 519-522, 1990.
5. Calmus, Y., J. Guechot, P. Podevin, M. T. Bonnefis, J. Giboudeau, and R. Poupon. Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis-α production by monocytes. Hepatology 16: 719-723, 1992.
6. Calmus, Y., B. Weill, Y. Ozier, C. Chereau, D. Houssin, and R. Poupon. Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse. Gastroenterology 103: 617-621, 1992.
7. Chretien, Y., R. Poupon, M. F. Gherardt, O. Chazouilleres, D. Labbe, A. Myara, and F. Trivin. Bile acid glycine and taurine conjugates in serum of patients with primary biliary cirrhosis: effect of ursodeoxycholic acid treatment. Gut 30: 1110-1115, 1989.
8. Coleman, R. Bile salts and biliary lipids. Biochem. Soc. Trans. 15, Suppl.: 68S-80S, 1987.
9. Deitch, E. A., K. Sittig, M. Li, R. Berg, and R. D. Specian. Obstructive jaundice promotes bacterial translocation from the gut. Am. J. Surg. 159: 79-84, 1987.
10. Floch, M. H., H. J. Binder, B. Filburn, and W. Gershengoren. The effect of bile acids on intestinal microflora. Am. J. Clin. Nutr. 25: 1418-1426, 1972.
11. Grisham, M. B., J. N. Benoit, and D. N. Granger. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol. 186: 729-741, 1990.
12. Hayakawa, T., H. Hachiya, K. Katagiri, M. Hoshino, N. Yoshioka, Y. Kawamura, A. Takeshima, H. Ohnishi, M. Miyaji, and T. Takeuchi. Effect of bile acid on cholestasis induced by 17α-ethinyl estradiol. Acta Hepatol. Jpn. 28: 1354-1360, 1987.
13. Heuman, D. M. Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions. J. Lipid Res. 30: 719-730, 1989.
14. Heuman, D. M., W. M. Pandak, P. B. Hylemon, and Z. R. Viahcevic. Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 14: 920-926, 1991.
15. Katagiri, K., T. Nakai, M. Hoshino, T. Hayakawa, H. Ohnishi, Y. Okayama, T. Yamada, T. Ohiwa, M. Miyaji, and T. Takeuchi. Tauro-β-muricholate preserves choleresis and prevents taurocholate-induced cholestasis in colchicine-treated rat liver. Gastroenterology 102: 1660-1667, 1992.
16. Kent, T. H., R. M. Cardelli, and F. W. Stamler. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am. J. Pathol. 54: 237-245, 1969.
17. Kitani, K., S. Kanai, Y. Sato, and M. Ohta. Tauro-α-muricholate is as effective as tauro-β-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. Hepatology 19: 1007-1012, 1994.
18. Kullmann, F., V. Gross, J. Ruschoff, H. Arndt, W. Benda, A. Winkler, V. Mohrenfels, and J. Scholmerich. Beneficial effect of ursodeoxycholic acid on experimental ileitis in the rat (Abstract). Gastroenterology 106: A716, 1994.
19. Masclee, A., A. Tangerman, A. Van Schaik, E. W. Van Der Hoek, and J. H. M. Van Tongeren. Unconjugated serum bile acids as a marker of small intestinal bacterial overgrowth. Eur. J. Clin. Invest. 19: 384-389, 1989.
20. Michie, H. R., K. R. Manogue, and D. R. Spriggs. Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 318: 1481-1486, 1988.
21. Ohiwa, T., K. Katagiri, M. Hoshino, T. Hayakawa, and T. Nakai. Tauroursodeoxycholate and tauro-β-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. Hepatology 17: 470-476, 1993.
22. Okuyama, S., N. Kokubun, S. Higashidate, D. Uemura, and Y. Hirata. A new analytical method for individual bile acids using high performance liquid chromatography and immobilized 3 alpha-hydroxysteroid dehydrogenase in column form. Chem. Lett. 1443-1446, 1979.
23. Ota, S., H. Tsukahara, A. Terano, Y. Hata, H. Hiraishi, H. Mutoh, and T. Sugimoto. Protective effect of tauroursodeoxycholate against chenodeoxycholate-induced damage to cultured rabbit gastric cells. Dig. Dis. Sci. 36: 409-416, 1991.
24. Pain, J. A. Endotoxemia and Reticuloendothelial Function in Obstructive Jaundice (MS thesis). London: Univ. of London, 1986.
25. Podda, M., C. Ghezzi, P. M. Battezzati, A. Crosignani, M. Zuin, and A. Roda. Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 98: 1044-1050, 1990.
26. Robert, A., and T. Asano. Resistance of germ free rats to indomethacin-induced intestinal lesions. Prostaglandins 14: 333-341, 1977.
27. Runkel, N. S., F. G. Moody, G. S. Smith, L. F. Rodriguez, M. T. LaRocco, and T. A. Miller. The role of the gut in the development of sepsis in acute pancreatitis. J. Surg. Res. 51: 18-23, 1991.
28. Sartor, R. B. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106: 533-539, 1994.
29. Sung, J. Y., E. A. Shaffer, K. Lam, I. Rususka, and J. W. Costerton. Hydrophobic bile salt inhibits bacterial adhesion on biliary stent material. Dig. Dis. Sci. 39: 999-1006, 1994.
30. Yamada, T., E. A. Deitch, R. D. Specian, M. A. Perry, R. B. Sartor, and M. B. Grisham. Mechanisms of acute and chronic intestinal injury induced by indomethacin. Inflammation 17: 641-662, 1993.
31. Yamada, T., M. Hoshino, T. Hayakawa, Y. Kamiya, H. Ohhara, K. Mizuno, H. Yamada, T. Nakazawa, T. Inagaki, A. Uchida, M. Miyaji, and T. Takeuchi. Bile secretion in rats with indomethacin-induced intestinal inflammation. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G804-G812, 1996.