메뉴 건너뛰기




Volumn 72, Issue 18, 2015, Pages 3411-3424

Cancer stem cells: A potential target for cancer therapy

Author keywords

Cancer initiating cell; Self renewal; Tumor metastasis; Tumorigenesis

Indexed keywords

H RAS PROTEIN; INTERLEUKIN 4; INTERLEUKIN 6; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; PYRUVATE DEHYDROGENASE; RAS PROTEIN; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC AGENT;

EID: 84940467163     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1920-4     Document Type: Review
Times cited : (54)

References (177)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 1:CAS:528:DC%2BC3MXjsFeqtrk%3D 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84863021947 scopus 로고    scopus 로고
    • Periostin: A bridge between cancer stem cells and their metastatic niche
    • 1:CAS:528:DC%2BC38XhvFaqs7w%3D 22305559
    • Wang Z, Ouyang G (2012) Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell 10:111-112
    • (2012) Cell Stem Cell , vol.10 , pp. 111-112
    • Wang, Z.1    Ouyang, G.2
  • 4
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • 1:CAS:528:DyaK2sXkt1GrtLY%3D 9212098
    • Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3:730-737
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 10
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • 17122772
    • O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106-110
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 12
    • 79960006754 scopus 로고    scopus 로고
    • CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation
    • 1:CAS:528:DC%2BC3MXosFagu7c%3D 21726833
    • Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO (2011) CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell 9:50-63
    • (2011) Cell Stem Cell , vol.9 , pp. 50-63
    • Lee, T.K.1    Castilho, A.2    Cheung, V.C.3    Tang, K.H.4    Ma, S.5    Ng, I.O.6
  • 16
    • 0035877989 scopus 로고    scopus 로고
    • Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34(+)CD38(-) progenitor cells from patients with acute myeloid leukemia
    • 1:CAS:528:DC%2BD3MXksVOqsb0%3D 11389030
    • Feuring-Buske M, Hogge DE (2001) Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34(+)CD38(-) progenitor cells from patients with acute myeloid leukemia. Blood 97:3882-3889
    • (2001) Blood , vol.97 , pp. 3882-3889
    • Feuring-Buske, M.1    Hogge, D.E.2
  • 17
    • 0031821457 scopus 로고    scopus 로고
    • Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis
    • 1:CAS:528:DC%2BD3cXisFOhsL0%3D 9711908
    • Escribano L, Ocqueteau M, Almeida J, Orfao A, San Miguel JF (1998) Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis. Leuk Lymphoma 30:459-466
    • (1998) Leuk Lymphoma , vol.30 , pp. 459-466
    • Escribano, L.1    Ocqueteau, M.2    Almeida, J.3    Orfao, A.4    San Miguel, J.F.5
  • 23
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • 2553722 1:CAS:528:DC%2BD1cXmsFKmuro%3D 18519691
    • Zhang S, Balch C, Chan MW, Lai HC, Matei D, Schilder JM, Yan PS, Huang TH, Nephew KP (2008) Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68:4311-4320
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3    Lai, H.C.4    Matei, D.5    Schilder, J.M.6    Yan, P.S.7    Huang, T.H.8    Nephew, K.P.9
  • 27
    • 78751623400 scopus 로고    scopus 로고
    • Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-kappaB signalling
    • 3105310 21245843
    • Rajasekhar VK, Studer L, Gerald W, Socci ND, Scher HI (2011) Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-kappaB signalling. Nat Commun 2:162
    • (2011) Nat Commun , vol.2 , pp. 162
    • Rajasekhar, V.K.1    Studer, L.2    Gerald, W.3    Socci, N.D.4    Scher, H.I.5
  • 31
    • 77953170540 scopus 로고    scopus 로고
    • CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance
    • 3139225 1:CAS:528:DC%2BC3cXmslWgtLs%3D 20460510
    • Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, Iwakuma T (2010) CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 70:4602-4612
    • (2010) Cancer Res , vol.70 , pp. 4602-4612
    • Adhikari, A.S.1    Agarwal, N.2    Wood, B.M.3    Porretta, C.4    Ruiz, B.5    Pochampally, R.R.6    Iwakuma, T.7
  • 33
    • 84874627380 scopus 로고    scopus 로고
    • + subpopulation of the SW982 human synovial sarcoma cell line exhibits cancer stem-like characteristics
    • 1:CAS:528:DC%2BC3sXmt1emtLY%3D 23416969
    • + subpopulation of the SW982 human synovial sarcoma cell line exhibits cancer stem-like characteristics. Int J Oncol 42:1399-1407
    • (2013) Int J Oncol , vol.42 , pp. 1399-1407
    • Liu, A.1    Feng, B.2    Gu, W.3    Cheng, X.4    Tong, T.5    Zhang, H.6    Hu, Y.7
  • 35
    • 78649728590 scopus 로고    scopus 로고
    • High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition
    • 2978678 21085683
    • Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM (2010) High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. PLoS ONE 5:e13943
    • (2010) PLoS ONE , vol.5 , pp. e13943
    • Awad, O.1    Yustein, J.T.2    Shah, P.3    Gul, N.4    Katuri, V.5    O'Neill, A.6    Kong, Y.7    Brown, M.L.8    Toretsky, J.A.9    Loeb, D.M.10
  • 38
    • 70350660817 scopus 로고    scopus 로고
    • Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation
    • 1:CAS:528:DC%2BD1MXht1ynurbO 19808959
    • Hide T, Takezaki T, Nakatani Y, Nakamura H, Kuratsu J, Kondo T (2009) Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res 69:7953-7959
    • (2009) Cancer Res , vol.69 , pp. 7953-7959
    • Hide, T.1    Takezaki, T.2    Nakatani, Y.3    Nakamura, H.4    Kuratsu, J.5    Kondo, T.6
  • 39
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • 1:CAS:528:DC%2BC38XhtFCgsrzM 22854777
    • Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C (2012) Defining the mode of tumour growth by clonal analysis. Nature 488:527-530
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1    Beck, B.2    Caauwe, A.3    Simons, B.D.4    Blanpain, C.5
  • 44
    • 84879940905 scopus 로고    scopus 로고
    • Tumor angiogenesis: A new source of pericytes
    • 1:CAS:528:DC%2BC3sXhtVOrsbvN 23845244
    • Liu AY, Ouyang G (2013) Tumor angiogenesis: a new source of pericytes. Curr Biol 23:R565-R568
    • (2013) Curr Biol , vol.23 , pp. R565-R568
    • Liu, A.Y.1    Ouyang, G.2
  • 45
    • 34250315214 scopus 로고    scopus 로고
    • Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo
    • 1:CAS:528:DC%2BD2sXltl2gsL8%3D 17510410
    • Gu G, Yuan J, Wills M, Kasper S (2007) Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res 67:4807-4815
    • (2007) Cancer Res , vol.67 , pp. 4807-4815
    • Gu, G.1    Yuan, J.2    Wills, M.3    Kasper, S.4
  • 46
    • 84884774935 scopus 로고    scopus 로고
    • Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors
    • 1:CAS:528:DC%2BC3sXhsVCqsL7N 23867471
    • Ashley N, Yeung TM, Bodmer WF (2013) Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors. Cancer Res 73:5798-5809
    • (2013) Cancer Res , vol.73 , pp. 5798-5809
    • Ashley, N.1    Yeung, T.M.2    Bodmer, W.F.3
  • 48
    • 84870329341 scopus 로고    scopus 로고
    • Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis
    • 1:CAS:528:DC%2BC38XhsFymu73L 23017941
    • Lin SP, Lee YT, Yang SH, Miller SA, Chiou SH, Hung MC, Hung SC (2013) Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis. Cancer Lett 328:226-234
    • (2013) Cancer Lett , vol.328 , pp. 226-234
    • Lin, S.P.1    Lee, Y.T.2    Yang, S.H.3    Miller, S.A.4    Chiou, S.H.5    Hung, M.C.6    Hung, S.C.7
  • 50
    • 34547702285 scopus 로고    scopus 로고
    • Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine
    • 1:CAS:528:DC%2BD2sXhtVSnsrvF 18371349
    • Demidov ON, Timofeev O, Lwin HN, Kek C, Appella E, Bulavin DV (2007) Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. Cell Stem Cell 1:180-190
    • (2007) Cell Stem Cell , vol.1 , pp. 180-190
    • Demidov, O.N.1    Timofeev, O.2    Lwin, H.N.3    Kek, C.4    Appella, E.5    Bulavin, D.V.6
  • 51
    • 33746218202 scopus 로고    scopus 로고
    • Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death
    • 2423216 1:CAS:528:DC%2BD28XntVWksrk%3D 16501599
    • Liu L, Andrews LG, Tollefsbol TO (2006) Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death. Oncogene 25:4370-4375
    • (2006) Oncogene , vol.25 , pp. 4370-4375
    • Liu, L.1    Andrews, L.G.2    Tollefsbol, T.O.3
  • 52
    • 78651066526 scopus 로고    scopus 로고
    • Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord blood-derived mesenchymal stem cells in glioma therapy
    • 20945331
    • Kim SM, Oh JH, Park SA, Ryu CH, Lim JY, Kim DS, Chang JW, Oh W, Jeun SS (2010) Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord blood-derived mesenchymal stem cells in glioma therapy. Stem Cells 28:2217-2228
    • (2010) Stem Cells , vol.28 , pp. 2217-2228
    • Kim, S.M.1    Oh, J.H.2    Park, S.A.3    Ryu, C.H.4    Lim, J.Y.5    Kim, D.S.6    Chang, J.W.7    Oh, W.8    Jeun, S.S.9
  • 55
    • 84884235663 scopus 로고    scopus 로고
    • Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells
    • 3776833 1:CAS:528:DC%2BC3sXhsFekt73P 24058587
    • Wang YC, Chao TK, Chang CC, Yo YT, Yu MH, Lai HC (2013) Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells. PLoS ONE 8:e74538
    • (2013) PLoS ONE , vol.8 , pp. e74538
    • Wang, Y.C.1    Chao, T.K.2    Chang, C.C.3    Yo, Y.T.4    Yu, M.H.5    Lai, H.C.6
  • 56
    • 0035908492 scopus 로고    scopus 로고
    • Heterogeneity of angiogenic activity in a human liposarcoma: A proposed mechanism for "no take" of human tumors in mice
    • 1:STN:280:DC%2BD3MvgvVWmsQ%3D%3D 11459868
    • Achilles EG, Fernandez A, Allred EN, Kisker O, Udagawa T, Beecken WD, Flynn E, Folkman J (2001) Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice. J Natl Cancer Inst 93:1075-1081
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1075-1081
    • Achilles, E.G.1    Fernandez, A.2    Allred, E.N.3    Kisker, O.4    Udagawa, T.5    Beecken, W.D.6    Flynn, E.7    Folkman, J.8
  • 57
    • 79960960417 scopus 로고    scopus 로고
    • Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche
    • 1:CAS:528:DC%2BC3MXpsVOgsL8%3D 21670082
    • Grange C, Tapparo M, Collino F, Vitillo L, Damasco C, Deregibus MC, Tetta C, Bussolati B, Camussi G (2011) Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res 71:5346-5356
    • (2011) Cancer Res , vol.71 , pp. 5346-5356
    • Grange, C.1    Tapparo, M.2    Collino, F.3    Vitillo, L.4    Damasco, C.5    Deregibus, M.C.6    Tetta, C.7    Bussolati, B.8    Camussi, G.9
  • 59
    • 70349747011 scopus 로고    scopus 로고
    • Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1
    • 3409689 1:CAS:528:DC%2BD1MXhtFaku73J 19738068
    • Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, Hoffman RM, Kerbel RS (2009) Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res 69:7243-7251
    • (2009) Cancer Res , vol.69 , pp. 7243-7251
    • Folkins, C.1    Shaked, Y.2    Man, S.3    Tang, T.4    Lee, C.R.5    Zhu, Z.6    Hoffman, R.M.7    Kerbel, R.S.8
  • 62
    • 45749143564 scopus 로고    scopus 로고
    • Precancerous stem cells can serve as tumor vasculogenic progenitors
    • 2242848 18286204
    • Shen R, Ye Y, Chen L, Yan Q, Barsky SH, Gao JX (2008) Precancerous stem cells can serve as tumor vasculogenic progenitors. PLoS ONE 3:e1652
    • (2008) PLoS ONE , vol.3 , pp. e1652
    • Shen, R.1    Ye, Y.2    Chen, L.3    Yan, Q.4    Barsky, S.H.5    Gao, J.X.6
  • 63
    • 84862777489 scopus 로고    scopus 로고
    • CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    • 1:CAS:528:DC%2BC38Xislaiu7c%3D 21994122
    • Tang KH, Ma S, Lee TK, Chan YP, Kwan PS, Tong CM, Ng IO, Man K, To KF, Lai PB, Lo CM, Guan XY, Chan KW (2012) CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. Hepatology 55:807-820
    • (2012) Hepatology , vol.55 , pp. 807-820
    • Tang, K.H.1    Ma, S.2    Lee, T.K.3    Chan, Y.P.4    Kwan, P.S.5    Tong, C.M.6    Ng, I.O.7    Man, K.8    To, K.F.9    Lai, P.B.10    Lo, C.M.11    Guan, X.Y.12    Chan, K.W.13
  • 65
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • 1:CAS:528:DC%2BC3MXhtF2ht7fL 21925313
    • Potente M, Gerhardt H, Carmeliet P (2011) Basic and therapeutic aspects of angiogenesis. Cell 146:873-887
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 68
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • 1:CAS:528:DC%2BC3MXhsFyqtbbE 21740232
    • Nieto MA (2011) The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 27:347-376
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 70
    • 81855182066 scopus 로고    scopus 로고
    • Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal
    • 1:CAS:528:DC%2BC3MXmsVGmtbs%3D 21602879
    • Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G (2011) Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene 30:4707-4720
    • (2011) Oncogene , vol.30 , pp. 4707-4720
    • Fang, X.1    Cai, Y.2    Liu, J.3    Wang, Z.4    Wu, Q.5    Zhang, Z.6    Yang, C.J.7    Yuan, L.8    Ouyang, G.9
  • 72
    • 84903768676 scopus 로고    scopus 로고
    • Tackling the cancer stem cells - What challenges do they pose?
    • 4234172 1:CAS:528:DC%2BC2cXhtVOisbzI 24981363
    • Pattabiraman DR, Weinberg RA (2014) Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov 13:497-512
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 497-512
    • Pattabiraman, D.R.1    Weinberg, R.A.2
  • 76
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • 3522773 1:CAS:528:DC%2BC38XhslKqsLjL 23201165
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J (2012) Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22:725-736
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 79
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • 1:CAS:528:DC%2BD2sXhtFagu7vN 18371365
    • Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313-323
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 80
    • 84866640259 scopus 로고    scopus 로고
    • + ovarian cancer stem-like cells via NF-kappaB-mediated MMP-9 upregulation
    • 1:CAS:528:DC%2BC38XhsF2nt7%2FM 22887854
    • + ovarian cancer stem-like cells via NF-kappaB-mediated MMP-9 upregulation. Stem Cells 30:2309-2319
    • (2012) Stem Cells , vol.30 , pp. 2309-2319
    • Long, H.1
  • 81
    • 34547095240 scopus 로고    scopus 로고
    • Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma
    • 1:CAS:528:DC%2BD2sXntlWrt7Y%3D 17332509
    • Shiras A, Chettiar ST, Shepal V, Rajendran G, Prasad GR, Shastry P (2007) Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma. Stem Cells 25:1478-1489
    • (2007) Stem Cells , vol.25 , pp. 1478-1489
    • Shiras, A.1    Chettiar, S.T.2    Shepal, V.3    Rajendran, G.4    Prasad, G.R.5    Shastry, P.6
  • 82
    • 0036280235 scopus 로고    scopus 로고
    • Bcr-Abl variants: Biological and clinical aspects
    • 1:CAS:528:DC%2BD38XksVShtL8%3D 12191565
    • Advani AS, Pendergast AM (2002) Bcr-Abl variants: biological and clinical aspects. Leuk Res 26:713-720
    • (2002) Leuk Res , vol.26 , pp. 713-720
    • Advani, A.S.1    Pendergast, A.M.2
  • 84
    • 84898420078 scopus 로고    scopus 로고
    • A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression
    • 4012341 1:CAS:528:DC%2BC2cXls1emsrs%3D 24703906
    • Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M (2014) A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell 25:415-427
    • (2014) Cancer Cell , vol.25 , pp. 415-427
    • Yamazaki, H.1    Suzuki, M.2    Otsuki, A.3    Shimizu, R.4    Bresnick, E.H.5    Engel, J.D.6    Yamamoto, M.7
  • 92
    • 77951192102 scopus 로고    scopus 로고
    • Stem-like cancer cells are inducible by increasing genomic instability in cancer cells
    • 2836097 1:CAS:528:DC%2BC3cXhs1aksbs%3D 20007324
    • Liang Y, Zhong Z, Huang Y, Deng W, Cao J, Tsao G, Liu Q, Pei D, Kang T, Zeng YX (2010) Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. J Biol Chem 285:4931-4940
    • (2010) J Biol Chem , vol.285 , pp. 4931-4940
    • Liang, Y.1    Zhong, Z.2    Huang, Y.3    Deng, W.4    Cao, J.5    Tsao, G.6    Liu, Q.7    Pei, D.8    Kang, T.9    Zeng, Y.X.10
  • 93
    • 77954983149 scopus 로고    scopus 로고
    • Tumor-initiating and -propagating cells: Cells that we would like to identify and control
    • 2907577 1:CAS:528:DC%2BC3cXovFGrt78%3D 20651980
    • Tysnes BB (2010) Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia 12:506-515
    • (2010) Neoplasia , vol.12 , pp. 506-515
    • Tysnes, B.B.1
  • 94
    • 34347323902 scopus 로고    scopus 로고
    • Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: A meta-analysis
    • 17617273
    • Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM (2007) Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370:59-67
    • (2007) Lancet , vol.370 , pp. 59-67
    • Grulich, A.E.1    Van Leeuwen, M.T.2    Falster, M.O.3    Vajdic, C.M.4
  • 96
    • 78049279685 scopus 로고    scopus 로고
    • Spheres derived from the human SK-RC-42 renal cell carcinoma cell line are enriched in cancer stem cells
    • 1:CAS:528:DC%2BC3cXhtlKhs7vK 20846785
    • Zhong Y, Guan K, Guo S, Zhou C, Wang D, Ma W, Zhang Y, Li C, Zhang S (2010) Spheres derived from the human SK-RC-42 renal cell carcinoma cell line are enriched in cancer stem cells. Cancer Lett 299:150-160
    • (2010) Cancer Lett , vol.299 , pp. 150-160
    • Zhong, Y.1    Guan, K.2    Guo, S.3    Zhou, C.4    Wang, D.5    Ma, W.6    Zhang, Y.7    Li, C.8    Zhang, S.9
  • 100
    • 57749090255 scopus 로고    scopus 로고
    • Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
    • 2491345 1:CAS:528:DC%2BD1cXhsV2itL%2FM 19074896
    • Hahn MA, Hahn T, Lee DH, Esworthy RS, Kim BW, Riggs AD, Chu FF, Pfeifer GP (2008) Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res 68:10280-10289
    • (2008) Cancer Res , vol.68 , pp. 10280-10289
    • Hahn, M.A.1    Hahn, T.2    Lee, D.H.3    Esworthy, R.S.4    Kim, B.W.5    Riggs, A.D.6    Chu, F.F.7    Pfeifer, G.P.8
  • 102
    • 55549131565 scopus 로고    scopus 로고
    • Inflammation as the primary aetiological agent of human prostate cancer: A stem cell connection?
    • 1:CAS:528:DC%2BD1cXhtl2hsLbM 18655194
    • Maitland NJ, Collins AT (2008) Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection? J Cell Biochem 105:931-939
    • (2008) J Cell Biochem , vol.105 , pp. 931-939
    • Maitland, N.J.1    Collins, A.T.2
  • 104
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • 2783826 1:CAS:528:DC%2BD1MXhsFylsbbM 19878981
    • Iliopoulos D, Hirsch HA, Struhl K (2009) An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139:693-706
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 107
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • 2849637 1:CAS:528:DC%2BD1MXmtVKlsbg%3D 19460998
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 109
    • 40749099894 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a phosphotyrosine-binding protein
    • 1:CAS:528:DC%2BD1cXjt1Gnu7k%3D 18337815
    • Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (2008) Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452:181-186
    • (2008) Nature , vol.452 , pp. 181-186
    • Christofk, H.R.1    Vander Heiden, M.G.2    Wu, N.3    Asara, J.M.4    Cantley, L.C.5
  • 115
    • 84866950193 scopus 로고    scopus 로고
    • Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
    • 3460464 1:CAS:528:DC%2BC38XhsVarsLbM 22782899
    • Morfouace M, Lalier L, Bahut M, Bonnamain V, Naveilhan P, Guette C, Oliver L, Gueguen N, Reynier P, Vallette FM (2012) Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. J Biol Chem 287:33664-33674
    • (2012) J Biol Chem , vol.287 , pp. 33664-33674
    • Morfouace, M.1    Lalier, L.2    Bahut, M.3    Bonnamain, V.4    Naveilhan, P.5    Guette, C.6    Oliver, L.7    Gueguen, N.8    Reynier, P.9    Vallette, F.M.10
  • 116
    • 84883501150 scopus 로고    scopus 로고
    • HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • 3754249 1:CAS:528:DC%2BC3sXhsVenu7bJ 23999440
    • Semenza GL (2013) HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest 123:3664-3671
    • (2013) J Clin Invest , vol.123 , pp. 3664-3671
    • Semenza, G.L.1
  • 118
    • 84928194762 scopus 로고    scopus 로고
    • Glioblastoma stem-like cells: At the root of tumor recurrence and a therapeutic target
    • 10.1093/carcin/bgu243 25504149
    • Jackson M, Hassiotou F, Nowak A (2015) Glioblastoma stem-like cells: at the root of tumor recurrence and a therapeutic target. Carcinogenesis. doi: 10.1093/carcin/bgu243
    • (2015) Carcinogenesis
    • Jackson, M.1    Hassiotou, F.2    Nowak, A.3
  • 119
    • 0034456656 scopus 로고    scopus 로고
    • Multidrug resistance transporters and modulation
    • 1:CAS:528:DC%2BD3cXmvVCgsLw%3D 10975553
    • Tan B, Piwnica-Worms D, Ratner L (2000) Multidrug resistance transporters and modulation. Curr Opin Oncol 12:450-458
    • (2000) Curr Opin Oncol , vol.12 , pp. 450-458
    • Tan, B.1    Piwnica-Worms, D.2    Ratner, L.3
  • 120
    • 33645514001 scopus 로고    scopus 로고
    • A side order of stem cells: The SP phenotype
    • 16449630
    • Challen GA, Little MH (2006) A side order of stem cells: the SP phenotype. Stem Cells 24:3-12
    • (2006) Stem Cells , vol.24 , pp. 3-12
    • Challen, G.A.1    Little, M.H.2
  • 123
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • 1:CAS:528:DC%2BD28Xht1OntbzP 17051156
    • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6    Dewhirst, M.W.7    Bigner, D.D.8    Rich, J.N.9
  • 124
    • 84873449363 scopus 로고    scopus 로고
    • MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells
    • 1:CAS:528:DC%2BC3sXhvV2ktro%3D 23269272
    • Wang WJ, Wu SP, Liu JB, Shi YS, Huang X, Zhang QB, Yao KT (2013) MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res 73:1219-1231
    • (2013) Cancer Res , vol.73 , pp. 1219-1231
    • Wang, W.J.1    Wu, S.P.2    Liu, J.B.3    Shi, Y.S.4    Huang, X.5    Zhang, Q.B.6    Yao, K.T.7
  • 125
    • 40749150740 scopus 로고    scopus 로고
    • + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • 1:CAS:528:DC%2BD1cXjtFOnsbw%3D 17891174
    • + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 27:1749-1758
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 127
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • 3427400 1:CAS:528:DC%2BC38XhtFChu7rO 22854781
    • Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488:522-526
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 132
    • 45549091414 scopus 로고    scopus 로고
    • Prostate cancer stem cells: A new target for therapy
    • 18539965
    • Maitland NJ, Collins AT (2008) Prostate cancer stem cells: a new target for therapy. J Clin Oncol 26:2862-2870
    • (2008) J Clin Oncol , vol.26 , pp. 2862-2870
    • Maitland, N.J.1    Collins, A.T.2
  • 133
    • 84921816801 scopus 로고    scopus 로고
    • Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells
    • 4359246 25528771
    • Shibuya K, Okada M, Suzuki S, Seino M, Seino S, Takeda H, Kitanaka C (2015) Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells. Oncotarget 6:651-661
    • (2015) Oncotarget , vol.6 , pp. 651-661
    • Shibuya, K.1    Okada, M.2    Suzuki, S.3    Seino, M.4    Seino, S.5    Takeda, H.6    Kitanaka, C.7
  • 135
    • 84917691199 scopus 로고    scopus 로고
    • Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas
    • 1:CAS:528:DC%2BC2cXitVOht73L 25320014
    • Sun S, Liu S, Duan SZ, Zhang L, Zhou H, Hu Y, Zhou X, Shi C, Zhou R, Zhang Z (2014) Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas. Cancer Res 74:7546-7559
    • (2014) Cancer Res , vol.74 , pp. 7546-7559
    • Sun, S.1    Liu, S.2    Duan, S.Z.3    Zhang, L.4    Zhou, H.5    Hu, Y.6    Zhou, X.7    Shi, C.8    Zhou, R.9    Zhang, Z.10
  • 137
    • 84905039972 scopus 로고    scopus 로고
    • Targeting the K-Ras-JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation
    • 4148125 24947996
    • Okada M, Shibuya K, Sato A, Seino S, Suzuki S, Seino M, Kitanaka C (2014) Targeting the K-Ras-JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation. Oncotarget 5:5100-5112
    • (2014) Oncotarget , vol.5 , pp. 5100-5112
    • Okada, M.1    Shibuya, K.2    Sato, A.3    Seino, S.4    Suzuki, S.5    Seino, M.6    Kitanaka, C.7
  • 139
    • 84883423984 scopus 로고    scopus 로고
    • Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity
    • 3965360 23982413
    • Bhat-Nakshatri P, Goswami CP, Badve S, Sledge GW Jr, Nakshatri H (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3:2530
    • (2013) Sci Rep , vol.3 , pp. 2530
    • Bhat-Nakshatri, P.1    Goswami, C.P.2    Badve, S.3    Sledge, G.W.4    Nakshatri, H.5
  • 141
    • 84876395186 scopus 로고    scopus 로고
    • 1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit
    • 1:CAS:528:DC%2BC3sXmtV2mu74%3D 23597567
    • Zhao W, Wang L, Han H, Jin K, Lin N, Guo T, Chen Y, Cheng H, Lu F, Fang W, Wang Y, Xing B, Zhang Z (2013) 1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit. Cancer Cell 23:541-556
    • (2013) Cancer Cell , vol.23 , pp. 541-556
    • Zhao, W.1    Wang, L.2    Han, H.3    Jin, K.4    Lin, N.5    Guo, T.6    Chen, Y.7    Cheng, H.8    Lu, F.9    Fang, W.10    Wang, Y.11    Xing, B.12    Zhang, Z.13
  • 142
    • 84863216083 scopus 로고    scopus 로고
    • Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells
    • 3292889 22289880
    • Schlaak M, Schmidt P, Bangard C, Kurschat P, Mauch C, Abken H (2012) Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells. Oncotarget 3:22-30
    • (2012) Oncotarget , vol.3 , pp. 22-30
    • Schlaak, M.1    Schmidt, P.2    Bangard, C.3    Kurschat, P.4    Mauch, C.5    Abken, H.6
  • 145
    • 79953870540 scopus 로고    scopus 로고
    • Targeting HIF1α eliminates cancer stem cells in hematological malignancies
    • 3084595 1:CAS:528:DC%2BC3MXksFGns7w%3D 21474104
    • Wang Y, Liu Y, Malek SN, Zheng P, Liu Y (2011) Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8:399-411
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1    Liu, Y.2    Malek, S.N.3    Zheng, P.4    Liu, Y.5
  • 150
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • 1:CAS:528:DC%2BD1MXhsVCjs73E 19682730
    • Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, Lander ES (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138:645-659
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 156
    • 70350497349 scopus 로고    scopus 로고
    • Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors
    • 1:CAS:528:DC%2BD1MXhsFKltLvF 19896441
    • Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K (2009) Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell 5:504-514
    • (2009) Cell Stem Cell , vol.5 , pp. 504-514
    • Ikushima, H.1    Todo, T.2    Ino, Y.3    Takahashi, M.4    Miyazawa, K.5    Miyazono, K.6
  • 157
    • 38849142632 scopus 로고    scopus 로고
    • Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity
    • 18245488
    • Garcia-Hernandez Mde L, Gray A, Hubby B, Klinger OJ, Kast WM (2008) Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity. Cancer Res 68:861-869
    • (2008) Cancer Res , vol.68 , pp. 861-869
    • Garcia-Hernandez Mde, L.1    Gray, A.2    Hubby, B.3    Klinger, O.J.4    Kast, W.M.5
  • 158
    • 69249149701 scopus 로고    scopus 로고
    • Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens
    • 1:CAS:528:DC%2BD1MXht1Wqu7fO 19536809
    • Xu Q, Liu G, Yuan X, Xu M, Wang H, Ji J, Konda B, Black KL, Yu JS (2009) Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Stem Cells 27:1734-1740
    • (2009) Stem Cells , vol.27 , pp. 1734-1740
    • Xu, Q.1    Liu, G.2    Yuan, X.3    Xu, M.4    Wang, H.5    Ji, J.6    Konda, B.7    Black, K.L.8    Yu, J.S.9
  • 159
    • 58149357568 scopus 로고    scopus 로고
    • Monoclonal antibody CC188 binds a carbohydrate epitope expressed on the surface of both colorectal cancer stem cells and their differentiated progeny
    • 1:CAS:528:DC%2BD1cXhtlylurzJ 19010863
    • Xu M, Yuan Y, Xia Y, Achilefu S (2008) Monoclonal antibody CC188 binds a carbohydrate epitope expressed on the surface of both colorectal cancer stem cells and their differentiated progeny. Clin Cancer Res 14:7461-7469
    • (2008) Clin Cancer Res , vol.14 , pp. 7461-7469
    • Xu, M.1    Yuan, Y.2    Xia, Y.3    Achilefu, S.4
  • 160
    • 79952282655 scopus 로고    scopus 로고
    • Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells
    • 1:CAS:528:DC%2BC3cXhsVWmurnK 21076471
    • Majeti R (2011) Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells. Oncogene 30:1009-1019
    • (2011) Oncogene , vol.30 , pp. 1009-1019
    • Majeti, R.1
  • 161
    • 58049195459 scopus 로고    scopus 로고
    • Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population
    • 1:CAS:528:DC%2BD1MXhtFSktrc%3D 18802034
    • Steiniger SC, Coppinger JA, Krüger JA, Yates J 3rd, Janda KD (2008) Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. Stem Cells 26:3037-3046
    • (2008) Stem Cells , vol.26 , pp. 3037-3046
    • Steiniger, S.C.1    Coppinger, J.A.2    Krüger, J.A.3    Yates, J.4    Janda, K.D.5
  • 163
    • 84904409295 scopus 로고    scopus 로고
    • The zinc finger transcription factor ZFX Is required for maintaining the tumorigenic potential of glioblastoma stem cells
    • 4349564 1:CAS:528:DC%2BC2cXhs1Chs7%2FK 24831540
    • Fang X, Huang Z, Zhou W, Wu Q, Sloan AE, Ouyang G, McLendon RE, Yu JS, Rich JN, Bao S (2014) The zinc finger transcription factor ZFX Is required for maintaining the tumorigenic potential of glioblastoma stem cells. Stem Cells 32:2033-2047
    • (2014) Stem Cells , vol.32 , pp. 2033-2047
    • Fang, X.1    Huang, Z.2    Zhou, W.3    Wu, Q.4    Sloan, A.E.5    Ouyang, G.6    McLendon, R.E.7    Yu, J.S.8    Rich, J.N.9    Bao, S.10
  • 167
    • 66149180568 scopus 로고    scopus 로고
    • An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells
    • 1:CAS:528:DC%2BD1MXmtVKlsr8%3D 19447872
    • Lau CK, Yang ZF, Ho DW, Ng MN, Yeoh GC, Poon RT, Fan ST (2009) An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells. Clin Cancer Res 15:3462-3471
    • (2009) Clin Cancer Res , vol.15 , pp. 3462-3471
    • Lau, C.K.1    Yang, Z.F.2    Ho, D.W.3    Ng, M.N.4    Yeoh, G.C.5    Poon, R.T.6    Fan, S.T.7
  • 172
    • 84863686386 scopus 로고    scopus 로고
    • Metformin: An emerging new therapeutic option for targeting cancer stem cells and metastasis
    • 3373168 22701483
    • Rattan R, Ali Fehmi R, Munkarah A (2012) Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis. J Oncol 2012:928127
    • (2012) J Oncol , vol.2012 , pp. 928127
    • Rattan, R.1    Ali Fehmi, R.2    Munkarah, A.3
  • 173
    • 84862517728 scopus 로고    scopus 로고
    • Cancer stem cells: Current status and evolving complexities
    • 1:CAS:528:DC%2BC38XosFCitLc%3D 22704512
    • Visvader JE, Lindeman GJ (2012) Cancer stem cells: current status and evolving complexities. Cell Stem Cell 10:717-728
    • (2012) Cell Stem Cell , vol.10 , pp. 717-728
    • Visvader, J.E.1    Lindeman, G.J.2
  • 176
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • 1:CAS:528:DC%2BC3MXhtVKjsbrM 21854987
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES (2011) Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146:633-644
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 177
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • 1:CAS:528:DC%2BD2sXhsVKku73J 18059462
    • Gatenby RA, Gillies RJ (2008) A microenvironmental model of carcinogenesis. Nat Rev Cancer 8:56-61
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.