Targeting the K-Ras - JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation

Oncotarget

Volumn 5, Issue 13, 2014, Pages 5100-5112

  Okada, Masashi ^a   Shibuya, Keita ^a,b,c   Sato, Atsushi ^a   Seino, Shizuka ^a,b,c   Suzuki, Shuhei ^a   Seino, Manabu ^a   Kitanaka, Chifumi ^a,b,c  

^a YAMAGATA UNIVERSITY   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

Author keywords

Cancer initiating cell; Pancreatic ductal adenocarcinoma (PDAC); Tumorigenicity; Xenograft analysis

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; K RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; CD133 ANTIGEN; GLYCOPROTEIN; KRAS PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 9; ONCOPROTEIN; PEPTIDE; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CANCER STEM LIKE CELL; CANCER THERAPY; CELL RENEWAL; CONTROLLED STUDY; DEPLETION; DOWN REGULATION; DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; GENE MUTATION; GENE SILENCING; HEALTH STATUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; SIGNAL TRANSDUCTION; TREATMENT DURATION; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; METABOLISM; NUDE MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTHRACENES; ANTIGENS, CD; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; IMMUNOBLOTTING; MALE; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PEPTIDES; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84905039972     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2087     Document Type: Article

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