High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-Fli1 inhibition

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Awad, Ola ^a,c   Yustein, Jason T ^a,d   Shah, Preeti ^a   Gul, Naheed ^a   Katuri, Varalakshmi ^a   O'Neill, Alison ^b   Kong, Yali ^b   Brown, Milton L ^b   Toretsky, Jeffrey A ^b   Loeb, David M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c Suez Canal University Faculty of Medicine   (Egypt)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETOPOSIDE; UNCLASSIFIED DRUG; VERAPAMIL; YK 4 279; CALCIUM CHANNEL BLOCKING AGENT; EWS FLI1 FUSION PROTEIN; EWS-FLI1 FUSION PROTEIN; INTERLEUKIN 2 RECEPTOR GAMMA; ONCOPROTEIN; TRANSCRIPTION FACTOR FLI 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RESISTANCE; CANCER STEM CELL; CELL POPULATION; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVITY; EWING SARCOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECT; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; MULTICELLULAR SPHEROID; NONOBESE DIABETIC MOUSE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOMA; TUMOR CELL LINE; XENOGRAFT;

MUS;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM CHANNEL BLOCKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; NEOPLASTIC STEM CELLS; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEIN C-FLI-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, EWING'S; SARCOMA, EXPERIMENTAL; SPHEROIDS, CELLULAR; TRANSPLANTATION, HETEROLOGOUS; VERAPAMIL;

EID: 78649728590     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013943     Document Type: Article

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