Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastoma

Stem Cells

Volumn 25, Issue 6, 2007, Pages 1478-1489

  Shiras, Anjali ^a   Chettiar T, Sivarajan ^a   Shepal, Varsha ^a   Rajendran, Ganeshkumar ^a   Rajendra Prasad, G ^a   Shastry, Padma ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Adult stem cell transformation; Cancer stem cells; Genomic instability; Glioblastoma; Neural stem cells; Spontaneous immortalization

Indexed keywords

CD133 ANTIGEN; NOTCH RECEPTOR; PROTEIN; PROTEIN HES; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CONTROLLED STUDY; DISEASE COURSE; GENE OVEREXPRESSION; GENOMIC INSTABILITY; GLIA CELL; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACRANIAL TUMOR; MOUSE; NEURAL STEM CELL; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; SENESCENCE; STATISTICAL SIGNIFICANCE;

ADULT STEM CELLS; ANIMALS; BRAIN NEOPLASMS; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENOMIC INSTABILITY; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; TELOMERASE; TUMOR CELLS, CULTURED; TUMOR STEM CELLS;

EID: 34547095240     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2006-0585     Document Type: Article

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