Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24

Carcinogenesis

Volumn 35, Issue 3, 2014, Pages 537-545

  Liu, Allan Yi ^a   Cai, Yao ^a   Mao, Yubin ^a   Lin, Yancheng ^a   Zheng, Hong ^a   Wu, Tiantian ^a   Huang, Yangmei ^a   Fang, Xiaoguang ^a,b   Lin, Shuyong ^a   Feng, Qingzhao ^c   Huang, Zhengjie ^c   Yang, Tianci ^a   Luo, Qi ^c   Ouyang, Gaoliang ^a  

^a XIAMEN UNIVERSITY   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

^c THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CD24 ANTIGEN; STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TWIST; TWIST2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL RENEWAL; COLONY FORMING UNIT; CONTROLLED STUDY; E BOX ELEMENT; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR GROWTH; UPREGULATION;

ANTIGENS, CD24; BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; DNA PRIMERS; EPITHELIAL-MESENCHYMAL TRANSITION; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; NEOPLASTIC STEM CELLS; POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; TWIST TRANSCRIPTION FACTOR;

EID: 84895790841     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt364     Document Type: Article

References (40)

1. Farazi,P.A. et al. (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer, 6, 674-687.
2. El-Serag,H.B. et al. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-2576.
3. Guégan,J.P. et al. (2013) MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells. Carcinogenesis, 34, 38-47.
4. Marquardt,J.U. et al. (2012) Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): an emerging field for advanced technologies. J. Hepatol., 56, 267-275.
5. Schwabe,R.F. et al. (2011) Targeting liver cancer: first steps toward a miRacle? Cancer Cell, 20, 698-699.
6. Gupta,P.B. et al. (2009) Cancer stem cells: mirage or reality? Nat. Med., 15, 1010-1012.
7. Ouyang,G. et al. (2010) Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells. Cell. Mol. Life Sci., 67, 2605-2618.
8. Wang,Z. et al. (2012) Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell, 10, 111-112.
9. Ma,S. et al. (2007) Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology, 132, 2542-2556.
10. Yang,Z.F. et al. (2008) Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell, 13, 153-166.
11. Yamashita,T. et al. (2009) EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology, 136, 1012-1024.
12. Lee,T.K. et al. (2011) CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell, 9, 50-63.
13. Xu,X.L. et al. (2010) The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. Carcinogenesis, 31, 167-174.
14. Rountree,C.B. et al. (2012) Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology, 55, 298-306.
15. Šošic,D. et al. (2003) Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell, 112, 169-180.
16. Ansieau,S. et al. (2010) TWISTing an embryonic transcription factor into an oncoprotein. Oncogene, 29, 3173-3184.
17. Franco,H.L. et al. (2011) Redundant or separate entities?-roles of Twist1 and Twist2 as molecular switches during gene transcription. Nucleic Acids Res., 39, 1177-1186.
18. Ansieau,S. et al. (2008) Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell, 14, 79-89.
19. Mani,S.A. et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704-715.
20. Vesuna,F. et al. (2009) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression. Neoplasia, 11, 1318-1328.
21. Morel,A.P. et al. (2012) EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLoS Genet., 8, e1002723.
22. Fang,X. et al. (2011) Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene, 30, 4707-4720.
23. Lee,T.K. et al. (2006) Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin. Cancer Res., 12, 5369-5376.
24. Sun,T. et al. (2010) Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology, 51, 545-556.
25. Zhao,X.L. et al. (2011) Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1. J. Cell. Mol. Med., 15, 691-700.
26. Rhodes,D.R. et al. (2007) Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia, 9, 166-180.
27. Wurmbach,E. et al. (2007) Genome-wide molecular profiles of HCVinduced dysplasia and hepatocellular carcinoma. Hepatology, 45, 938-947.
28. Gong,X.Q. et al. (2002) Dermo-1, a multifunctional basic helix-loophelix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. J. Biol. Chem., 277, 12310-12317.
29. Bao,S. et al. (2004) Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 5, 329-339.
30. Hanahan,D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
31. Thiery,J.P. et al. (2009) Epithelial-mesenchymal transitions in development and disease. Cell, 139, 871-890.
32. Yang,M.H. et al. (2010) Bmi1 is essential in Twist1-induced epithelialmesenchymal transition. Nat. Cell Biol., 12, 982-992.
33. Visvader,J.E. et al. (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer, 8, 755-768.
34. Liu,A.Y. et al. (2013) Tumor angiogenesis: a new source of pericytes. Curr. Biol., 23, R565-R568.
35. Morel,A.P. et al. (2008) Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One, 3, e2888.
36. Wang,X. et al. (2013) Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells. PLoS One, 8, e72962.
37. Kristiansen,G. et al. (2002) CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival. Am. J. Pathol., 161, 1215-1221.
38. Al-Hajj,M. et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA, 100, 3983-3988.
39. Yeung,T.M. et al. (2010) Cancer stem cells from colorectal cancer-derived cell lines. Proc. Natl. Acad. Sci. USA, 107, 3722-3727.
40. Bretz,N.P. et al. (2012) CD24 controls Src/STAT3 activity in human tumors. Cell. Mol. Life Sci., 69, 3863-3879.