Adult hippocampal neurogenesis, aging and neurodegenerative diseases: Possible strategies to prevent cognitive impairment

Current Topics in Medicinal Chemistry

Volumn 15, Issue 21, 2015, Pages 2175-2192

  Vivar, Carmen ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Adult neurogenesis; Aging; Alzheimer s disease; Curcumin; Exercise; Flavanols; Hippocampus; Huntington s disease; Omega 3 fatty acids

Indexed keywords

CURCUMIN; FLAVANOL DERIVATIVE; OMEGA 3 FATTY ACID; FLAVONOL DERIVATIVE;

AGING; ALZHEIMER DISEASE; ARTICLE; BEHAVIOR; COGNITIVE DEFECT; DEGENERATIVE DISEASE; EXERCISE; HIPPOCAMPUS; HUMAN; HUNTINGTON CHOREA; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHYSICAL ACTIVITY; ANIMAL; COGNITION DISORDERS; CYTOLOGY; DRUG EFFECTS; LIFESTYLE; NEURODEGENERATIVE DISEASES; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGING; ALZHEIMER DISEASE; ANIMALS; COGNITION DISORDERS; CURCUMIN; EXERCISE; FATTY ACIDS, OMEGA-3; FLAVONOLS; HIPPOCAMPUS; HUMANS; HUNTINGTON DISEASE; LIFE STYLE; NEURODEGENERATIVE DISEASES; NEUROGENESIS;

EID: 84939833114     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026615666150610141524     Document Type: Article

References (191)

1. [1] Altman, J.; Das, G.D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J. Comp. Neurol., 1965, 124, 319-335.
2. [2] Eriksson, P.S.; Perfilieva, E.; Bjork-Eriksson, T.; Alborn, A.M.; Nordborg, C.; Peterson, D.A.; Gage, F.H. Neurogenesis in the adult human hippocampus. Nat. Med, 1998, 11, 1313-1317.
3. [3] Gould, E.; Reeves, A.J.; Graziano, M.S.; Gross, C.G. Neurogenesis in the neocortex of adult primates. Science, 1999, 286 (5439), 548-552.
4. [4] Spalding, K.L.; Bergmann, O.; Alkass, K.; Bernard, S.; Salehpour, M.; Huttner, H.B.; Bostrom, E.; Westerlund, I.; Vial, C.; Buchholz, B.A.; Possnert, G.; Mash, D.C.; Druid, H.; Frisen, J. Dynamics of hippocampal neurogenesis in adult humans. Cell, 2013, 153(6), 1219-1227.
5. [5] Ernst, A.; Bernard, S.; Salehpour, M.; Perl, S.; Tisdale, J.; Possnert, G.; Druid, H.; Frisen, J. Neurogenesis in the striatum of the adult human brain. Cell, 2014 156(5), 1072-1083.
6. [6] Ming, G. L.; Song, H. Adult neurogenesis in the mammalian brain: Significant answers and significant questions. Neuron, 2011, 70, 687-702.
7. [7] Bergmann, O.; Liebl, J.; Bernard, S.; Alkass, K.; Yeung, M.S.; Steier, P.; Kutschera, W.; Johnson, L.; Landen, M.; Druid, H.; Spalding, K.L.; Frisen, J. The age of olfactory bulb neurons in humans. Neuron, 2012, 74(4), 634-639.
8. [8] Wang, C.; You, Y.; Qi, D.; Zhou, X.; Wang, L.; Wei, S.; Zhang, Z.; Huang, W.; Liu, Z.; Liu, F.; Ma, L.; Yang, Z. Human and monkey striatal interneurons are derived from the medial ganglionic emi nence but not from the adult subventricular zone. J. Neurosci., 2014, 54(33), 10906-10923.
9. [9] Lie, D.C.; Song, H.; Colamarino, S.A.; Ming GL; Gage, F.H. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu. Rev. Pharmacol. Toxicol., 2004, 44, 399-421.
10. [10] Scoville, W.B.; Milner, B. Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiatry, 1957, 20(1), 11-21.
11. [11] Zhao, C.; Deng, W.; Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell, 2008, 132, 645-660.
12. [12] Vivar, C.; Potter, M.C.; Choi, J.; Lee, J.Y.; Stringer, T.P.; Calla-way, E.M.; Gage, F.H.; Suh, H.; van Praag, H. Monosynaptic inputs to new neurons in the dentate gyrus. Nat. Commun., 2012, 3, 1107.
13. [13] Vivar, C.; van Praag, H. Functional circuits of new neurons in the dentate gyrus. Front. Neural Circuits, 2013 7, 15.
14. [14] Schmidt-Hieber, C.; Jonas, P.; Bischofberger, J. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature, 2004, 429(6988), 184-187.
15. [15] Esposito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J. and Schinder, A. F. Neuronal differentiation in the adult hippocampus recapitulates embryonic development. J. Neurosci, 2005, 25, 10074-10086.
16. [16] Ge, S.; Yang, C.H.; Hsu, K.S.; Ming, G.L.; Song, H. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron, 2007, 54(4), 559-566.
17. [17] Treves, A.; Tashiro, A.; Witter, M.E.; Moser, E.I. What is the mammalian dentate gyrus good for? Neuroscience, 2008, 154, 1155-1172.
18. [18] Deng, W.; Aimone, J.B.; Gage, F.H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat. Rev. Neurosci., 2010, 11(5), 339-350.
19. [19] Aimone, J.B.; Li, Y.; Lee, S.W.; Clemenson, G.D.; Deng, W.; Gage, F.H. Regulation and function of adult neurogenesis: from genes to cognition. Physiol. Rev., 2014, 94(4), 991-1026.
20. [20] Christian, K.M.; Song, H.; Ming, G.L. Functions and dysfunctions of adult hippocampal neurogenesis. Annu. Rev. Neurosci., 2014, 37, 243-262.
21. [21] van Praag H,; Christie, B.R,; Sejnowski, T.J.; Gage, F.H. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U. S. A., 1999a, 96(23), 13427-13431.
22. [22] Stangl, D.; Thuret, S. Impact of diet on adult hippocampal neuro-genesis. Genes Nutr, 2009, 4(4), 271-282.
23. [23] Creer, D.J.; Romberg, C.; Saksida, L.M.; van Praag, H.; Bussey, T.J. Running enhances spatial pattern separation in mice. Proc. Natl. Acad. Sci. U. S. A., 2010, 107, 2367-2372.
24. [24] Sahay, A.; Scobie, K.N.; Hill, A.S.; O’Carroll, C.M.; Kheirbek, M.A.; Burghardt, N.S.; Fenton, A.A.; Dranovsky, A.; Hen, R. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature, 2011 472(7344), 466-470.
25. [25] Shors, T.J.; Miesegaes, G.; Beylin, A.; Zhao, M.; Rydel, T.; Gould, E. Neurogenesis in the adult is involved in the formation of trace memories. Nature, 2001, 410(6826), 372-376.
26. [26] Snyder, J.S.; Hong, N.S.; McDonald, R.J.; Wojtowicz, J.M. A role for adult neurogenesis in spatial long-term memory. Neuroscience, 2005, 130(4), 843-852.
27. [27] Saxe, M.D.; Battaglia, F.; Wang, J.W.; Malleret, G.; David, D.J.; Monckton, J.E.; Garcia, A.D.; Sofroniew, M.V.; Kandel, E.R.; Santarelli, L.; Hen, R.; Drew, M.R. Ablation of hippocampal neuro-genesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Natl. Acad. Sci. U.S. A, 2006, 103(46), 17501-17506.
28. [28] Drapeau, E.; Mayo, W.; Aurousseau, C.; Le Moal, M.; Piazza, P.V.; Abrous, D.N. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc. Natl. Acad. Sci. U. S. A, 2003, 100(24), 14385-14390.
29. [29] Clelland, C.D.; Choi, M.; Romberg, C.; Clemenson, G.D. Jr.; Fragniere, A.; Tyers, P.; Jessberger, S.; Saksida, L.M.; Barker, R.A.; Gage, F.H.; Bussey, T.J. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science, 2009, 325(5937), 210-213.
30. [30] Ko, H.G.; Jang, D.J.; Son, J.; Kwak, C.; Choi, J.H.; Ji, Y.H.; Lee, Y.S.; Son, H.; Kaang, B.K. Effect of ablated hippocampal neuro-genesis on the formation and extinction of contextual fear memory. Mol. Brain, 2009, 2, 1.
31. [31] Tronel, S.; Fabre, A.; Charrier, V.; Oliet, S.H.; Gage, F.H.; Abrous, D.N. Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A, 2010, 707(17), 7963-7968.
32. [32] Nakashiba, T.; Cushman, J. D.; Pelkey, K. A.; Renaudineau, S.; Buhl, D. L.; McHugh, T. J.; Rodriguez Barrera, V.; Chittajallu, R.; Iwamoto, K. S.; McBain, C. J.; Fanselow, M. S.; Tonegawa, S. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell, 2012, 149, 188201.
33. [33] Treves, A.; Rolls, E.T. Computational analysis of the role of the hippocampus in memory. Hippocampus, 1994, 4, 374-391.
34. [34] Lazarov, O.; Mattson, M.P.; Peterson, D.A.; Pimplikar, S.W.; van Praag, H. When neurogenesis encounters aging and disease. Trends Neurosci., 2010, 55(12), 569-579.
35. [35] Ransome, M.I.; Renoir, T.; Hannan, A.J. Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington’s Disease. Neural Plasticity, 2012, 874387, 7.
36. [36] Small, S.A.; Tsai, W.Y.; De La Paz, R.; Mayeux, R.; Stern, Y. Imaging hippocampal function across the human life span: is memory decline normal or not? Ann. Neurol, 2002, 51(3), 290-295.
37. [37] Small, S.A.; Schobel, S.A.; Buxton, R.B.; Witter, M.P.; Barnes, C.A. A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nat. Rev. Neurosci., 2011, 12(10), 585-601.
38. [38] Erickson, C.A., Barnes, C.A. The neurobiology of memory changes in normal aging. Exp. Gerontol., 2003, 38(2), 61-69.
39. [39] Driscoll I, Sutherland RJ. The aging hippocampus: navigating between rat and human experiments. Rev. Neurosci., 2005, 16(2), 87-121.
40. [40] Patrylo, P.R.; Williamson, A. The effects of aging on dentate circuitry and function. Prog. Brain Res., 2007, 163, 679-696.
41. [41] Hara, Y.; Rapp, P.R.; Morrison, J.H. Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr), 2012, 34(5), 1051-1073.
42. [42] Dorszewska, J. Cell biology of normal brain aging: synaptic plasticity-cell death. Aging Clin. Exp. Res., 2013, 25(1), 25-34.
43. [43] Vijg, J.; Suh, Y. Genome instability and aging. Annu. Rev. Physiol., 2013, 75, 645-668.
44. [44] Kuhn, H.G.; Dickinson-Anson, H.; Gage, F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci., 1996, 16(6), 2027-2033.
45. [45] Lichtenwalner, R.J.; Forbes, M.E.; Bennett, S.A.; Lynch, C.D.; Sonntag, W.E.; Riddle, D.R. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience, 2001, 107(4), 603-613.
46. [46] Rao, M.S.; Hattiangady, B.; Shetty, A.K. The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus. Aging Cell, 2006, 5(6), 545-558.
47. [47] Knoth, R.; Singec, I.; Ditter, M.; Pantazis, G.; Capetian, P.; Meyer, R.P.; Horvat, V.; Volk, B.; Kempermann, G. Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS One, 2010, 5(1), e8809.
48. [48] Lee, S.W.; Clemenson, G.D.; Gage, F.H. New neurons in an aged brain. Behav. Brain Res., 2012, 227(2), 497-507.
49. [49] McDonald, H.Y.; Wojtowicz, J.M. Dynamics of neurogenesis in the dentate gyrus of adult rats. Neurosci. Lett., 2005, 385(1), 70-75.
50. [50] Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., Gage, F.H. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development, 2003, 130, 391-399.
51. [51] Bizon, J.L.; Gallagher, M. Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. Eur. J. Neurosci., 2003, 18(1), 215-219.
52. [52] Bizon, J.L.; Lee, H.J.; Gallagher, M. Neurogenesis in a rat model of age-related cognitive decline. Aging Cell, 2004, 3(4), 227-234.
53. [53] Pereira, A.C.; Huddleston, D.E.; Brickman, A.M.; Sosunov, A.A.; Hen, R.; McKhann, G.M.; Sloan, R.; Gage, F.H.; Brown, T.R.; Small, S.A. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. U. S. A, 2007, 104(13), 5638-5643.
54. [54] Erickson, K.I.; Prakash, R.S.; Voss, M.W.; Chaddock, L.; Heo, S.; McLaren, M.; Pence, B.D.; Martin, S.A.; Vieira, V.J.; Woods, J.A.; McAuley, E.; Kramer, A.F. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J. Neurosci., 2010, 30(15), 5368-5375.
55. [55] Erickson, K.I.; Voss, M.W.; Prakash, R.S.; Basak, C.; Szabo, A.; Chaddock, L.; Kim, J.S.; Heo, S.; Alves, H.; White, S.M.; Wo-jcicki, T.R.; Mailey, E.; Vieira, V.J.; Martin, S.A.; Pence, B.D.; Woods, J.A.; McAuley, E.; Kramer, A.F. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U. S. A, 2011, 108(7), 3017-3022.
56. [56] Sierra, A.; Encinas, J.M.; Maletic-Savatic, M. Adult human neuro-genesis: from microscopy to magnetic resonance imaging. Front. Neurosci., 2011, 5, 47.
57. [57] Ho, N.F.; Hooker, J.M.; Sahay, A.; Holt, D.J.; Roffman, J.L. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol. Psychiatry, 2013, 18(4), 404-416.
58. [58] Voss, M.W.; Vivar, C.; Kramer, A.F.; van Praag H. Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn. Sci., 2013, 17(10), 525-544.
59. [59] Maass, A.; Düzel, S.; Goerke, M.; Becke, A.; Sobieray, U.; Neumann, K.; Lövden, M.; Lindenberger, U.; Bäckman, L.; Braun-Dullaeus, R.; Ahrens, D.; Heinze, H.J.; Müller, N.G.; Düzel, E. Vascular hippocampal plasticity after aerobic exercise in older adults. Mol. Psychiatry, 2014, Oct 14.
60. [60] Selkoe, D.J. Preventing Alzheimer’s disease. Science, 2012, 337(6101), 1488-1492.
61. [61] Davis, S.; Laroche, S. What can rodent models tell us about cognitive decline in Alzheimer’s disease? Mol Neurobiol., 2003, 27(3), 249-276.
62. [62] Mattson, M.P. Pathways towards and away from Alzheimer’s disease. Nature, 2004, 430(7000), 631-639.
63. [63] Lazarov, O.; Marr, R.A. Neurogenesis and Alzheimer’s disease: at the crossroads. Exp. Neurol., 2010, 223(2), 267-281.
64. [64] Lazarov, O.; Marr, R.A. Of mice and men: neurogenesis, cognition and Alzheimer’s disease. Front. Aging Neurosci., 2013, 5, 43.
65. [65] Marlatt, M.W.; Lucassen, P.J. Neurogenesis and Alzheimer’s disease: Biology and pathophysiology in mice and men. Curr. Alzheimer Res., 2010, 7(2), 113-125.
66. [66] Mu, Y.; Gage, F.H. Adult hippocampal neurogenesis and its role in Alzheimer’s disease. Mol. Neurodegener., 2011, 6, 85.
67. [67] Bryan, K.J.; Lee, H.; Perry, G.; Smith, M.A.; Casadesus, G. Trans-genic Mouse Models of Alzheimer’s Disease: Behavioral Testing and Considerations. In: Buccafusco JJ, editor. Methods of Behavior Analysis in Neuroscience. 2nd edition. Boca Raton (FL): CRC Press; 2009. Chapter 1.
68. [68] Wang, R.; Dineley, K.T.; Sweatt, J.D.; Zheng, H. Presenilin 1 familial Alzheimer’s disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience, 2004, 126, 305-312.
69. [69] Wen, P.H.; Hof, P.R.; Chen, X.; Gluck, K.; Austin, G.; Younkin, S.G.; Younkin, L.H.; DeGasperi, R.; Gama Sosa, M.A.; Robakis, N.K.; Haroutunian, V.; Elder, G.A. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp. Neurol., 2004, 188(2), 224-237.
70. [70] Rodriguez, J.J.; Jones, V.C.; Tabuchi, M.; Allan, S.M.; Knight, E.M.; LaFerla, F.M.; Oddo, S.; Verkhratsky, A. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease. PLoS One, 2008, 3(8), e2935.
71. [71] Jin, K.; Galvan, V.; Xie, L.; Mao, X.O.; Gorostiza, O.F.; Bredesen DE.; Greenberg, D.A. Enhanced neurogenesis in Alzheimer’s disease transgenic (PDGF-APPSw, Ind) mice. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 13363-13367.
72. [72] Lopez-Toledano, M.A.; Shelanski, M.L. Increased neurogenesis in young transgenic mice overexpressing human APP (Sw, Ind). J. Alzheimers Dis., 2007, 12, 229-240.
73. [73] Yu, Y.; He, J.; Zhang, Y.; Luo, H.; Zhu, S.; Yang, Y.; Zhao, T.; Wu, J.; Huang, Y.; Kong, J.; Tan, Q.; Li, X.M. Increased hippo-campal neurogenesis in the progressive stage of Alzheimer’s disease phenotype in an APP/PS1 double transgenic mouse model. Hippocampus, 2009, 19 (12), 1247-1253.
74. [74] Van Hoesen, G.W.; Augustinack, J. C.; Dierking, J.; Redman, S. J.; Thangavel, R. The parahippocampal gyrus in Alzheimer’s disease. Clinical and preclinical neuroanatomical correlates. Ann. NY Acad. Sci., 2000, 911, 254-274.
75. [75] Shetty, A.K.; Turner, D.A. Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. J. Comp. Neurol., 1998, 394, 252-269.
76. [76] Shi, L.; Argenta, A.E.; Winseck, A.K.; Brunso-Bechtold, J.K. Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats. J. Comp. Neurol., 2004, 478 (3), 282-291.
77. [77] Stranahan, A.M.; Mattson, M.P. Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer’s disease. Neural Plast., 2010, 2010, 108-190.
78. [78] Schliebs, R.; Arendt, T. The cholinergic system in aging and neuronal degeneration. Behav. Brain Res., 2011, 221(2), 555-563.
79. [79] HDCRG. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. The Huntington’s Disease Collaborative Research Group. Cell, 1993, 72, 971-983.
80. [80] Kremer, B.; Goldberg, P.; Andrew, S.E.; Theilmann, J.; Telenius, H.; Zeisler, J.; Squitieri, F.; Lin, B.; Bassett, A.; Almqvist, E.; Bird, T.D.; Hayden, M.R. A worldwide study of the Huntington’s disease mutation. The sensitivity and specificity of measuring CAG repeats. N. Engl. J. Med. Line, 1994, 30, 1401-1406.
81. [81] Vonsattel, J.P.; DiFiglia, M. Huntington disease. J. Neuropathol. Exp. Neurol., 1998, 57, 369-384.
82. [82] Novak, M.J.U.; Tabrizi, S.J. Huntington’s disease: clinical presentation and treatment. Int. Rev. Neurobiol., 2011, 98, 297-323.
83. [83] Sathasivam, K.; Hobbs, C.; Mangiarini, L.; Mahal, A.; Turmaine, M.; Doherty, P.; Davies, S.W.; Bates, G.P. Transgenic models of Huntington’s disease. Philos Trans. R. Soc. Lond. B. Biol. Sci., 1999, 354 (1386), 963-969.
84. [84] Slow, E.J.; van Raamsdonk, J.; Rogers, D.; Coleman, S.H.; Graham, R.K.; Deng, Y.; Oh, R.; Bissada, N.; Hossain, S.M.; Yang, Y.Z.; Li, X.J.; Simpson, E.M.; Gutekunst, C.A.; Leavitt, B.R.; Hayden, M.R. Selective striatal neuronal loss in a YAC128 mouse modelof Huntington disease. Hum. Mol. Genet., 2003, 12, 1555-1567.
85. [85] Southwell, A.L.; Warby, S.C.; Carroll, J.B.; Doty, C.N.; Skotte, N.H.; Zhang, W.; Villanueva, E.B.; Kovalik, V.; Xie, Y.; Pouladi, M.A.; Collins, J.A.; Yang, X.W.; Franciosi, S.; Hayden, M.R. A fully humanized transgenic mouse model of Huntington disease. Hum. Mol. Genet., 2013, 22(1), 18-34.
86. [86] Schilling, G.; Becher, M.W.; Sharp, A.H.; Jinnah, H.A.; Duan, K.; Kotzuk, J.A.; Slunt, H.H.; Ratovitski, T.; Cooper, J.K.; Jenkins, N.A.; Copeland, N.G.; Price, D.L.; Ross, C.A.; Borchelt, D.R. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum. Mol. Genet., 1999, 8, 397-407.
87. [87] Murphy, K.P.S.J. Carter, R. J.; Lione L.A.; Mangiarini, L.; Mahal, A.; Bates, G.P.; Dunnett, S.B.; Morton, A.J. Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington’s disease mutation. Neuroscience, 2000, 20(13), 5115-5123.
88. [88] Van Raamsdonk, J.M.; Pearson, J.; Slow, E.J.; Hossain, S.M.; Leavitt, B.R.; Hayden, M.R. Cognitive dysfunction precedes neu-ropathology and motor abnormalities in the YAC128 mouse model of Huntington’s disease. J. Neurosci., 2005, 25, 4169-4180.
89. [89] Nithianantharajah, J.; Barkus, C.; Murphy, M.; Hannan, A.J. Geneenvironment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington’s disease transgenic mice. Neurobiol. Dis., 2008, 29(3), 490-504.
90. [90] Zagrebelsky, M.; Holz, A.; Dechant, G.; Barde, Y.A.; Bonhoeffer, T.; Korte, M. The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J. Neurosci. 2005, 25(43), 9989-9999.
91. [91] Brito, V.; Giralt, A.; Enriquez-Barreto, L.; Puigdellivol, M.; Suelves, N.; Zamora-Moratalla, A.; Ballesteros, J.J.; Martin, E.D.; Dominguez-Iturza, N.; Morales, M.; Alberch J.; Gines, S. Neu-rotrophin receptor p75(NTR) mediates Huntington’s disease-associated synaptic and memory dysfunction. J. Clin. Invest., 2014, 124(10), 4411-4428.
92. [92] Gil, J.M.; Leist, M.; Popovic, N.; Brundin, P.; Petersen, A. Asialo-erythropoietin is not effective in the R6/2 line of Huntington’sdisease mice. BMC Neurosci., 2004, 5, 1-10.
93. [93] Gil, J.M.; Mohapel, P.; Araüjo, I.M.; Popovic, N.; Li, J.Y.; Brundin, P.; Petersen, A. Reduced hippocampal neurogenesis in R6/2 transgenic Huntington’s disease mice. Neurobiol Dis., 2005, 20(3), 744-751.
94. [94] Lazic, S.E.; Grote, H.; Armstrong, R.J.; Blakemore, C.; Hannan, A.J.; van Dellen, A.; Barker, R.A. Decreased hippocampal cell pro-liferationin R6/1 Huntington’s mice. NeuroReport, 2004, 15, 811-813.
95. [95] Lazic, S.E.; Grote, H.E.; Blakemore, C.; Hannan, A.J.; van Dellen, A.; Phillips, W.; Barker, R.A. Neurogenesis in the R6/1 transgenic mouse model of Huntington’s disease: effects of environmental enrichment. Eur. J. Neurosci., 2006, 23, 1829-1838.
96. [96] Simpson, J.M.; Gil-Mohapel, J.; Pouladi, M.A.; Ghilan, M.; Xie, Y.; Hayden, M.R.; Christie, B.R. Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease. Neurobiol. Dis., 2011, 41, 249-260.
97. [97] Booth, F.W.; Roberts, C.K.; Laye, M.J. Lack of exercise is a major cause of chronic diseases. Compr. Physiol., 2012, 2(2), 1143-1211.
98. [98] van Praag, H.; Kempermann, G.; Gage, F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci., 1999b, 2, 266-270.
99. [99] van Praag, H.; Shubert, T.; Zhao, C.; Gage, F.H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci., 2005, 25(38), 8680-8685.
100. [100] Marlatt, M.W.; Potter, M.C.; Lucassen, P.J.; van Praag H. Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice. Dev. Neurobiol., 2012, 72(6), 943-952.
101. [101] Kobilo, T.; Liu, Q.R.; Gandhi, K.; Mughal, M.; Shaham, Y.; van Praag, H. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learn Mem., 2011, 18(9), 605-609.
102. [102] Vivar, C.; Peterson, B.; van Praag, H. Exercise modifies the neuronal network of newborn dentate granule cells. Program No. 395.13/A43. 2014 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2014. Online.
103. [103] Kramer, A.F.; Colcombe, S.J.; McAuley, E.; Eriksen, K.I.; Scalf, P.; Jerome, G.J.; Marquez, D.X.; Elavsky, S.; Webb, A.G. Enhancing brain and cognitive function of older adults through fitness training. J. Mol. Neurosci., 2003, 20(3), 213-221.
104. [104] Intlekofer, K.A.; Cotman, C.W. Exercise counteracts declining hippocampal function in aging and Alzheimer’s disease. Neurobiol. Dis., 2013, 57, 47-55.
105. [105] Erickson, K.I.; Prakash, R.S.; Voss, M.W.; Chaddock, L.; Hu, L.; Morris, K.S.; White, S.M.; Wöjcicki, T.R.;McAuley, E.; Kramer, A.F. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus, 2009, 19(10), 1030-1039.
106. [106] Palmer, T.D.; Willhoite, A.R.; Gage, F.H. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol., 2000, 425 (4), 479-494.
107. [107] Vivar, C.; Potter, M.C.; van Praag, H. All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis. Curr. Top. Behav. Neurosci., 2013, 15, 189-210.
108. [108] Um, H.S.; Kang, E.B.; Koo, J.H.; Kim, H.T.; Kim, E.J.; Yang, C.H.; An, G.Y.; Cho, I.H.; Cho, J.Y. Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer’s disease. Neurosci. Res., 2011, 69(2), 161-173.
109. [109] Leem, Y.H.; Lim, H.J.; Shim, S.B.; Cho, J.; Kim, B.S.; Han, P.L. Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. J. Neurosci. Res., 2009, 87(11), 2561-2570.
110. [110] Belarbi, K.; Burnouf, S.; Fernandez-Gomez, F.J.; Laurent, C.; Lestavel, S.; Figeac, M.; Sultan, A.; Troquier, L.; Leboucher, A.; Caillierez, R.; Grosjean, M.E.; Demeyer, D.; Obriot, H.; Brion, I.; Barbot, B.; Galas, M.C.; Staels, B.; Humez, S.; Sergeant, N.; Schraen-Maschke, S.; Muhr-Tailleux, A.; Hamdane, M.; Buée, L.; Blum, D. Beneficial effects of exercise in a transgenic mouse model of Alzheimer’s disease-like Tau pathology. Neurobiol. Dis., 2011, 43(2), 486-494.
111. [111] Adlard PA.; Perreau, V.M.; Pop, V.; Cotman, C.W. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer’s disease. J. Neurosci., 2005, 25(17), 4217-4221.
112. [112] Yuede, C.M.; Zimmerman, S.D.; Dong, H.; Kling, M.J.; Bero, A.W.; Holtzman, D.M.; Timson, B.F.; Csernansky, J.G. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer’s disease. Neurobiol. Dis., 2009, 35(3), 426-432.
113. [113] Nichol, K.E.; Poon, W.W.; Parachikova, A.I.; Cribbs, D.H.; Glabe, C.G.; Cotman, C.W. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J. Neuroinflammation, 2008, 5, 13.
114. [114] Nichol, K.; Deeny, S.P.; Seif, J.; Camaclang, K.; Cotman, C.W. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement., 2009, 5(4), 287-294.
115. [115] Walker, J.M.; Klakotskaia, D.; Ajit, D.; Weisman, G.A.; Wood, W.G.; Sun, G.Y.; Serfozo, P.; Simonyi, A.; Schachtman, T.R. Beneficial Effects of Dietary EGCG and Voluntary Exercise on Behavior in an Alzheimer’s Disease Mouse Model. J. Alzheimers Dis., 2015, 44(2), 561-572.
116. [116] Mirochnic, S.; Wolf, S.; Staufenbiel, M.; Kempermann, G. Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus, 2009, 19(10), 1008-1018.
117. [117] Rodriguez, J.J.; Noristani, H.N.; Olabarria, M.; Fletcher, J.; Somerville, T.D.; Yeh, C.Y.; Verkhratsky, A. Voluntary running and environmental enrichment restores impaired hippocampal neu-rogenesis in a triple transgenic mouse model of Alzheimer’s disease. Curr. Alzheimer Res., 2011, 8(7), 707-717.
118. [118] Marlatt, M.W.; Potter, M.C.; Bayer, T.A.; van Praag, H.; Lucassen, P.J. Prolonged running, not fluoxetine treatment, increases neuro-genesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer’s disease. Curr. Top. Behav. Neurosci., 2013, 15, 313-340.
119. [119] Erickson, K.I.; Weinstein, A.M.; Lopez, O.L. Physical activity, brain plasticity, and Alzheimer’s disease. Arch. Med. Res., 2012, 43(8), 615-621.
120. [120] Heyn, P.; Abreu, B.C.; Ottenbacher, K.J. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch. Phys. Med. Rehabil., 2004, 85(10), 1694-1704.
121. [121] Lautenschlager, N.T.; Cox, K.L.; Flicker, L.; Foster, J.K.; van Bockxmeer, F.M.; Xiao, J.; Greenop, K.R.; Almeida, O.P. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA, 2008, 300 (9), 1027-1037.
122. [122] Baker, L.D.; Frank, L.L.; Foster-Schubert, K.; Green, P.S.; Wilkinson, C.W.; McTiernan, A.; Plymate, S.R.; Fishel, M.A.; Watson, G.S.; Cholerton, B.A.; Duncan, G.E.; Mehta, P.D.; Craft, S. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch. Neurol., 2010, 67(1), 71-79.
123. [123] Suzuki, T.; Shimada, H.; Makizako, H.; Doi, T.; Yoshida, D.; Tsutsumimoto, K.; Anan, Y.; Uemura, K.; Lee, S.; Park, H. Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial. BMC Neurol., 2012, 12, 128.
124. [124] Suzuki, T.; Shimada, H.; Makizako, H.; Doi, T.; Yoshida, D.; Ito, K.; Shimokata, H.; Washimi, Y.; Endo, H.; Kato, T. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One, 2013, 8(4), e61483.
125. [125] Pang, T.Y.; Stam, N.C.; Nithianantharajah, J.; Howard, M.L.; Han-nan, A.J. Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington’s disease transgenic mice. Neuroscience, 2006, 141(2), 569-584.
126. [126] Potter, M.C.; Yuan, C.; Ottenritter, C.; Mughal, M.; van Praag, H. Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington’s disease. PLoS Curr., 2010, 2, RRN1201.
127. [127] Kohl, Z.; Kandasamy, M.; Winner, B.; Aigner, R.; Gross, C.; Couillard-Despres, S.; Bogdahn, U.; Aigner, L.; Winkler, J. Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington’s disease. Brain Res., 2007, 25, 1155:24-33.
128. [128] Zajac, M.S.; Pang, T.Y.; Wong, N.; Weinrich, B.; Leang, L.S.; Craig, J.M.; Saffery, R.; Hannan, A.J. Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington’s disease mice. Hippocampus, 2010, 20, 621-636.
129. [129] Kosinski, C.M.; Schlangen, C.; Gellerich, F.N.; Gizatullina, Z.; Deschauer, M.; Schiefer, J.; Young, A.B.; Landwehrmeyer, G.B.; Toyka, K.V.; Sellhaus, B.; Lindenberg, K.S. Myopathy as a first symptom of Huntington’s disease in a Marathon runner. Mov. Disord, 2007, 22(11), 1637-1640.
130. [130] Morris, M.C.; Evans, D.A.; Bienias, J.L.; Tangney, C.C.; Bennett, D.A.; Wilson, R.S.; Aggarwal, N.; Schneider, J. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch. Neurol., 2003, 60(7), 940-946.
131. [131] Kalmijn, S.; van Boxtel, M.P.; Ocke, M.; Verschuren, W.M.; Kromhout, D.; Launer, L.J. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology, 2004, 62(2), 275-80.
132. [132] Huang, T.L.; Zandi, P.P.; Tucker, K.L.; Fitzpatrick, A.L.; Kuller, L.H.; Fried, L.P.; Burke, G.L.; Carlson, M.C. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology, 2005, 65(9), 1409-1414.
133. [133] van Gelder, B.M.; Tijhuis, M.; Kalmijn, S.; Kromhout, D. Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am. J. Clin. Nutr., 2007, 85, 1142-1147
134. [134] Cederholm, T.; Salem, N.; Palmblad, J. ω-3 fatty acids in the prevention of cognitive decline in humans. Adv. Nutr., 2013, 4(6), 672-676.
135. [135] Bauer, I.; Crewther, S.; Pipingas, A.; Sellick, L.; Crewther, D. Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. Hum. Psychopharmacol, 2014, 29(1), 8-18.
136. [136] Gömez-Pinilla, F. Brain foods: the effects of nutrients on brain function. Nat. Rev. Neurosci., 2008, 9(7), 568-578.
137. [137] Su, H.M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J. Nutr. Biochem., 2010, 21(5), 364-373.
138. [138] McGahon, B.M.; Martin, D.S.; Horrobin, D.F.; Lynch, M.A. Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. Neuroscience, 1999, 94(1), 305-314.
139. [139] Martin, D.S.; Spencer, P.; Horrobin, D.F.; Lynch, M.A. Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed. Prosta-glandins Leukot. Essent. Fatty Acids, 2002, 67(3), 121-130.
140. [140] Gamoh, S.; Hashimoto, M.; Hossain, S.; Masumura, S. Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. Clin. Exp. Pharmacol. Physiol., 2001, 28(4), 266-270.
141. [141] Fedorova I; Salem, N.; Omega-3 fatty acids and rodent behavior. Prostaglandins Leukot. Essent. Fatty Acids., 2006, 75(5), 271-289.
142. [142] Kawakita, E.; Hashimoto, M.; Shido, O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience, 2006, 139(3), 991-997.
143. [143] Dyall, S.C.; Michael, G.J.; Michael-Titus, A.T. Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J. Neurosci. Res., 2010, 88(10), 2091-2102.
144. [144] Clifford, J.J.; Drago, J.; Natoli, A.L.; Wong, J.Y.; Kinsella, A.; Waddington, J.L.; Vaddadi, K.S. Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington’s disease. Neuroscience, 2002, 109, 81-88.
145. [145] Puri, B.K.; Bydder, G.M.; Counsell, S.J.; Corridan, B.J.; Richardson, A.J.; Hajnal, J.V.; Appel, C.; Mckee, H.M.; Vaddadi, K.S.; Horrobin, D.F. MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment. Neuroreport, 2002, 13(1):123-126.
146. [146] Puri, B.K.; Bydder, G.M.; Manku, M.S.; Clarke, A.; Waldman, A.D.; Beckmann, C.F. Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington’s disease. J. Int. Med. Res., 2008, 36(5), 896-905.
147. [147] Huntington Study Group TREND-HD Investigators. Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study. Arch. Neurol., 2008, 65 (12), 1582-1589.
148. [148] Puri, B.K.; Leavitt, B.R.; Hayden, M.R.; Ross, C.A.; Rosenblatt, A.; Greenamyre, J.T.; Hersch, S.; Vaddadi, K.S.; Sword, A.; Hor-robin, D.F.; Manku, M.; Murck, H. Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial. Neurology, 2005, 65(2), 286-292.
149. [149] Gupta, S.C.; Sung, B.; Kim, J.H.; Prasad, S.; Li, S.; Aggarwal, B.B. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol. Nutr. Food Res., 2013, 57(9), 1510-1528.
150. [150] Lim, G.P.; Chu, T.; Yang, F.; Beech, W.; Frautschy, S.A.; Cole, G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci., 2001, 21(21), 8370-8377.
151. [151] Frautschy, S.A.; Hu, W.; Kim, P.; Miller, S.A.; Chu, T.; Harris-White, M.E.; Cole, G.M. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol. Aging, 2001, 22(6), 993-1005.
152. [152] Yang, F.; Lim, G.P.; Begum, A.N.; Ubeda, O.J.; Simmons, M.R.; Ambegaokar, S.S.; Chen, P.P.; Kayed, R.; Glabe, C.G.; Frautschy, S.A.; Cole, G.M. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J. Biol. Chem., 2005, 280(7), 5892-5901.
153. [153] Kim, S.J.; Son, T.G.; Park, H.R.; Park, M.; Kim, M.S.; Kim, H.S.; Chung, H.Y.; Mattson, M.P.; Lee, J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J. Biol. Chem, 2008, 283(21), 14497-14505.
154. [154] Dong, S.; Zeng, Q.; Mitchell, E.S.; Xiu, J.; Duan, Y.; Li, C.; Ti- wari, J.K.; Hu, Y.; Cao, X.; Zhao, Z. Curcumin enhances neuro-genesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity. PLoS One, 2012, 7(2), e31211.
155. [155] Cheng, Y.F.; Guo, L.; Xie, Y.S.; Liu, Y.S.; Zhang, J.; Wu, Q.W.; Li, J.M. Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice. Neuro-chem. Res., 2013, 38(1), 98-107.
156. [156] Belviranli, M.; Okudan, N.; Atalik, K.E.; Öz, M. Curcumin improves spatial memory and decreases oxidative damage in aged female rats. Biogerontology, 2013, 14(2), 187-196.
157. [157] Wu, A.; Noble, E.E.; Tyagi, E.; Ying, Z.; Zhuang, Y.; Gomez-Pinilla, F. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. Biochim. Biophys. Acta, 2014, pii, S0925-4439(14) 00377-9.
158. [158] Ng, T.P.; Chiam, P.C.; Lee, T.; Chua, H.C.; Lim, L.; Kua, E.H. Curry consumption and cognitive function in the elderly. Am. J. Epidemiol., 2006, 164(9), 898-906.
159. [159] Brondino, N.; Re, S.; Boldrini, A.; Cuccomarino, A.; Lanati, N.; Barale, F.; Politi, P. Curcumin as a therapeutic agent in dementia: a mini systematic review of human studies. Scientific World J., 2014, 2014, 174-282.
160. [160] Kumar, P.; Padi, S.S.; Naidu, P.S.; Kumar, A. Possible neuropro-tective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. Methods Find Exp. Clin. Pharmacol,. 2007, 29(1), 19-25.
161. [161] Sandhir, R.; Yadav, A.; Mehrotra, A.; Sunkaria, A.; Singh, A.; Sharma, S. Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington’s disease. Neuromolecular Med., 2014, 16(1), 106-118.
162. [162] Hickey, M.A.; Zhu, C.; Medvedeva, V.; Lerner, R.P.; Patassini, S.; Franich, N.R.; Maiti, P.; Frautschy, S.A.; Zeitlin, S.; Levine, M.S.; Chesselet, M. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington’s disease. Mol. Neurodegener, 2012, 7, 12.
163. [163] Letenneur, L.; Proust-Lima, C.; Le Gouge, A.; Dartigues, J.F.; Barberger-Gateau, P. Flavonoid intake and cognitive decline over a 10-year period. Am. J. Epidemiol., 2007, 165(12), 1364-1367.
164. [164] Nurk, E.; Refsum, H.; Drevon, C.A.; Tell, G.S.; Nygaard, H.A.; Engedal, K.; Smith, A.D. Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J. Nutr., 2009, 139(1), 120-127.
165. [165] Shukitt-Hale, B.; Cheng, V.; Joseph, J.A. Effects of blackberries on motor and cognitive function in aged rats. Nutr. Neurosci., 2009, 12(3), 135-140.
166. [166] Beking, K.; Vieira, A. Flavonoid intake and disability-adjusted life years due to Alzheimer’s and related dementias: a population-based study involving twenty-three developed countries. Public Health Nutr., 2010, 13(9), 1403-1409.
167. [167] Malin, D.H.; Lee, D.R.; Goyarzu, P.; Chang, Y.H.; Ennis, L.J.; Beckett, E.; Shukitt-Hale, B.; Joseph, J.A. Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition, 2011, 27(3), 338-342.
168. [168] Brickman, A.M.; Khan, U.A.; Provenzano, F.A.; Yeung, L.K.; Suzuki, W.; Schroeter, H.; Wall, M.; Sloan, R.P.; Small, S.A. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat. Neurosci., 2014, 17(12), 1798-1803.
169. [169] Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr. Neurosci., 2003, 6(3), 153-162.
170. [170] Wang, Y.J.; Thomas, P.; Zhong, J.H.; Bi, F.F.; Kosaraju, S.; Pollard, A.; Fenech, M.; Zhou, X.F. Consumption of grape seed ex tract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer’s disease mouse. Neurotox Res., 2009, 15(1), 3-14.
171. [171] Reznichenko, L.; Amit, T.; Youdim, M.B.; Mandel, S. Green tea polyphenol (-)epigallocatechin-3-gallate induces neurorescue of long-term serum deprived serum deprived PC12 cells and promotes neurite outgrowth. J. Neurochem., 2005, 93: 1157-1167.
172. [172] Davinelli, S.; Sapere, N.; Zella, D.; Bracale, R.; Intrieri, M.; Sca-pagnini, G. Pleiotropic protective effects of phytochemicals in Alzheimer’s disease. Oxid. Med. Cell Longev., 2012, 2012, 386-527.
173. [173] Sokolov, A.N.; Pavlova, M.A.; Klosterhalfen, S.; Enck, P. Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior. Neurosci. Biobehav. Rev., 2013, 37: 2445-2453.
174. [174] Schimidt, H.L.; Vieira, A.; Altermann, C.; Martins, A.; Sosa, P.; Santos, F.W.; Mello-Carpes, P.B.; Izquierdo, I.; Carpes, F.P. Memory deficits and oxidative stress in cerebral ischemia-reperfusion: neuroprotective role of physical exercise and green tea supplementation. Neurobiol Learn Mem., 2014, 114, 242-250.
175. [175] van Praag, H.; Lucero, M.J.; Yeo, G.W.; Stecker, K.; Heivand, N.; Zhao, C.; Yip, E.; Afanador, M.; Schroeter, H.; Hammerstone, J.; Gage, F.H. Plant-derived flavanol (-)epicatechin enhances angio-genesis and retention of spatial memory in mice. J. Neurosci., 2007, 27(22), 5869-5878.
176. [176] Stringer, T.P.; Guerrieri, D.; Vivar, C.; van Praag, H. Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice. Transl. Psychiatry, 2015, 5, e493.
177. [177] Zeng, Y.Q.; Wang, Y.J.; Zhou, X.F. Effects of (-)Epicatechin on the Pathology of APP/PS1 Transgenic Mice. Front. Neurol., 2014, 5, 69.
178. [178] Cox, C.J.; Choudhry, F.; Peacey, E.; Perkinton, M.S.; Richardson, J.C.; Howlett, D.;, Lichtenthaler, S.F.; Francis, P.T.; Williams, R.J. Dietary (-)-epicatechin as a potent inhibitor of ßy-secretase amyloid precursor protein processing. Neurobiol Aging., 2015, 36(1), 178-187.
179. [179] Yoo, K.Y.; Choi, J.H.; Hwang, I.K.; Lee, C.H.; Lee, SO.; Han, S.M.; Shin, H.C.; Kang, I.J.; Won, M.H. Epigallocatechin-3- gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice. Phytother Res., 2010, 24(7), 1065-1070.
180. [180] Wang, Y.; Li, M.; Xu, X.; Song, M.; Tao, H.; Bai, Y. Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis. Mol. Nutr. Food Res., 2012, 56(8), 1292-1303.
181. [181] Gibbons, T.E.; Pence, B.D.; Petr, G.; Ossyra, J.M.; Mach, H.C.; Bhattacharya, T.K.; Perez, S.; Martin, S.A.; McCusker, R.H.; Kel Carmen Vivarley, K.W.; Rhodes, J.S.; Johnson, R.W.; Woods, J.A. Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and ß-alanine, improves learning, memory and hippocampal neurogenesis in aged mice. Behav. Brain Res., 2014, 272, 131-140.
182. [182] Rezai-Zadeh, K.; Arendash, G.W.; Hou, H.; Fernandez, F.; Jensen, M.; Runfeldt, M.; Shytlem R.D.; Tan, J. Green tea epigallocate-chin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res., 2008, 1214, 177-187.
183. [183] Jia, N.; Han, K.; Kong, J.J.; Zhang, X.M.; Sha, S.; Ren, G.R.; Cao, Y.P. (-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus. Mol. Cell. Biochem, 2013, 380(2), 211-218.
184. [184] Rodrigues, J.; Assuncäo, M.; Lukoyanov, N.; Cardoso, A.; Carvalho, F.; Andrade, J.P. Protective effects of a catechin-rich extract on the hippocampal formation and spatial memory in aging rats. Behav. Brain Res., 2013, 246, 94-102.
185. [185] Lim, H.J.; Shim, S.B.; Jee, S.W.; Lee, S.H.; Lim, C.J.; Hong, J.T.; Sheen, Y.Y.; Hwang, D.Y. Green tea catechin leads to global improvement among Alzheimer’s disease-related phenotypes in NSE/hAPP-C105 Tg mice. J. Nutr. Biochem., 2013, 24(7), 1302-1313.
186. [186] Ehrnhoefer, D.E.; Duennwald, M.; Markovic, P.; Wacker, J.L.; Engemann, S.; Roark, M.; Legleiter, J.; Marsh, J.L.; Thompson, L.M.; Lindquist, S.; Muchowski, P.J.; Wanker, E.E. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin mis-folding and reduces toxicity in Huntington’s disease models. Hum. Mol. Genet., 2006, 15(18), 2743-2751.
187. [187] Kumar, P.; Kumar, A. Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism. Food Chem. Toxicol, 2009, 47(10), 2522-2530.
188. [188] Wu, A.; Ying, Z.; Gomez-Pinilla, F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience, 2008, 155(3), 751-759
189. [189] Jin, K.; Peel, A.L.; Mao, X.O.; Xie, L.; Cottrell, B.A.; Henshall, D.C.; Greenberg, D.A. Increased hippocampal neurogenesis in Alzheimer’s disease. Proc. Natl. Acad. Sci. U. S. A, 2004, 101(1), 343-347.
190. [190] Perry, E.K.; Johnson, M.; Ekonomou, A.; Perry, R.H.; Ballard, C.; Attems, J. Neurogenic abnormalities in Alzheimer’s disease differ between stages of neurogenesis and are partly related to cholinergic pathology. Neurobiol. Dis, 2012, 47(2), 155-162.
191. [191] Gomez-Nicola, D.; Suzzi, S.; Vargas-Caballero, M.; Fransen, N.L.; Al-Malki, H.; Cebrian-Silla, A.; Garcia-Verdugo, J.M.; Riecken, K.; Fehse, B.; Perry, V.H. Temporal dynamics of hippocampal neu-rogenesis in chronic neurodegeneration. Brain, 2014, 137 (Pt 8), 2312-23128.